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Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu Na Li Zhengxiang Zhou ru ye Liyan Zhong Yashuang Xu Junhui Ren Yi Liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

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Dynamics of a prestressed Timoshenko beam subject to arbitrary external load

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第11期11卷 898-907页

作者： Ji-qing JIANG Gui-ru ye Department of Civil Engineering Zhejiang University Hangzhou 310058 China

The free vibration and transient wave in a prestressed Rayleigh-Timoshenko beam subject to arbitrary transverse forces are analyzed by the newly developed method of reverberation-ray matrix (MRRM). The effects of shear deformation and rotational inertia are taken into consideration. With a Fourier transform technique, the general wave solutions with two sets of unknown amplitude coefficients are obtained in the transformed domain for an unbonded prestressed beam under the action of arbitrary external excitations. From the coupling at joints and the compatibility of displacements in each member, the free and forced vibration responses of a beam with various boundary conditions are finally evaluated through certain numerical algorithms. Results are presented for a simply-supported beam subject to either a point fixed load or moving load. Good agreement with the finite element method (FEM) is obtained. The present work is instructive for high-speed railway bridge design and structural health monitoring.

关键词： Reverberation-ray analysis Prestressed Timoshenko beam Free vibration Dynamic responses

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Preliminary study on broadband antireflection coatings for large aperture telescopes

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Research in Astronomy and Astrophysics 2017年第12期17卷 53-64页

作者： ye-ru Wang Xin-Nan Li Jin-Feng Wang Jie Tian National Astronomical Observatories/Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210042China Key Laboratory of Astronomical Optics&Technology Nanjing Institute of Astronomical Optics&TechnologyChinese Academy of SciencesNanjing 210042China University of Chinese Academy of Sciences Beijing 100049China

A broadband anti-reflective（AR） coating design for astronomical large-aperture telescopes is proposed. We give simulations of two-, three-and four-layer silica sol-gel on fused silica and finally get the optimal optical constants. As a comparison, we discuss the traditional dielectric material that has been applied to broadband AR coatings. To better guide the following experiment, we also conduct error analysis and feasibility analysis, combining with the technological characteristics of sol-gel. The analytical method is suitable for other wavebands and substrates. It is also instructive for large area AR coatings in the field of solar cells.

关键词： instrumentation:miscellaneous methods:numerical techniques:spectroscopic

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Incidence of surgical site infection in minimally invasive colorectal surgery

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1121-1129页

作者： Lu-Ting Ni ru Zhao Yi-ru ye Yi-Ming Ouyang Xin Chen Department of Surgery The First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Surgical site infection(SSI)is a common complication of colorectal *** invasive surgery notably reduces the incidence of *** study aimed to compare the incidences of SSI after robot-assisted colorectal surgery(RACS)vs that after laparoscopic assisted colorectal surgery(LACS)and to analyze associated risk factors for SSI in minimally invasive colorectal *** To compare the incidences of SSI after RACS and LACS,and to analyze the risk factors associated with SSI after minimally invasive colorectal *** Clinical data derived from patients who underwent minimally invasive colorectal surgery between October 2020 and October 2022 at the First Affiliated Hospital of Soochow University were *** in clinical characteristics and surgeryrelated information associated with RACS and LACS were compared,and possible risk factors for SSI were *** A total of 246 patients(112 LACS and 134 RACS)were included in the ***(17.5%)developed *** proportions of patients who developed SSI were similar in the two groups(17.9%vs 17.2%,P=0.887).Diabetes mellitus,intraoperative blood loss≥100 mL,and incision length were independent risk factors for *** additional risk factors included neoadjuvant therapy,lesion site,and operation *** There was no difference in SSI incidence in the RACS and LACS *** mellitus,intraoperative blood loss≥100 mL,and incision length were independent risk factors for postoperative SSI.

关键词： Colorectal surgery Minimally invasive surgery Surgical site infection

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Content-Based Hierarchical Analysis of News Video Using Audio and Visual Information

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Wuhan University Journal of Natural Sciences 2001年第4期6卷 779-783页

作者： Yu Jun-qing Zhou Dong-ru Jin ye Liu Hua-yong School of Computer Wuhan University Wuhan 430072 China

A schema for content-based analysis of broadcast news video is presented. First, we separate commercials from news using audiovisual features. Then, we automatically organize news programs into a content hierarchy at various levels of abstraction via effective integration of video, audio, and text data available from the news programs. Based on these news video structure and content analysis technologies, a TV news video Library is generated, from which users can retrieve definite news story according to their demands.

关键词： content-based audio news video segmentation

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Multi-stimuli-responsive aggregation-induced emission copper iodide cluster

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Science China Chemistry 2024年第4期67卷 1193-1197页

作者： Bo Li Yuan-Yuan Liu Peng Luo ye-ru Liu Ying-Jun Chen Kai Li Shuang-Quan Zang College of Chemistry and Pharmacy Engineering Nanyang Normal UniversityNanyang 473061China Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001China

Stimuli-responsive luminescent materials have attracted significant attention in the development of smart photoactive materials for both fundamental research and technological *** this work,a new copper iodide cluster(1)with aggregationinduced emission(AIE)characteristic,was obtained combining Cu_(4)I_(4) core with rhodamine B derivative ligand.1 has reversible and distinct multi-stimuli-responsive luminescence for external temperature,volatile organic compound,and mechanical ***,1 exhibited unusual large blue shift(84 nm)after being ground,which originated from the change of intermolecular ***,1 exhibits high oxygen quenching efficiency for 82.2% at 1 *** studies showed that the multi-stimuli-responsive luminescence properties of 1 can be attributed to the regulation of cluster-centered luminescence process,metal-to-ligand charge transfer process,halide-to-metal charge transfer luminescence process and aggregationinduced barrier to oxygen *** work not only reports an AIE copper iodide cluster,but also provides a new strategy to develop multi-stimuli-responsive luminescence materials.

关键词： copper iodide cluster aggregation-induced emission multi-stimuli-response

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Synthesis of 2-[^2H]-2-（1-methylalkyl）succinic acids

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Chinese Chemical Letters 2015年第5期26卷 619-622页

作者： Xin-Yu Bian Serge Maurice Mbadinga Shi-Zhong Yang ru-Qiang ye Ji-Dong Gu Bo-Zhong Mu State Key Laboratory of Bioreactor Engineering and Institute of Applied Chemistry East China University of Science and Technology School of Biological Sciences The University of Hong Kong

We describe a specific procedure for the synthesis of deuterium-labelled 2-（1-methylalkyl）succinate established via alkylation of diethyl malonate, Krapcho decarboxylation reaction with D20 and hydrolysis reaction. Two novel compounds, 2-[^2H]-2-ethylsuccinic acid and 2-[^2H]-2-（1-methylhep- tyl）succinic acid were prepared via this synthetic route and characterized by mass spectrometry and ^1H NMR. The results showed that the 2-（1-methylalkyl）succinic acids were deuterated at the β-position, which is considered as an important reaction centre in the anaerobic degradation of n-alkanes.

关键词： Deuterium-labelled biomarkers 2-(l-Methylalkyl)succinates Fumarate addition Anaerobic degradation of alkanes

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Spinal anesthesia alleviates dextran sodium sulfate-induced colitis by modulating the gut microbiota

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World Journal of Gastroenterology 2022年第12期28卷 1239-1256页

作者： Yu Hong Jie Zhao ye-ru Chen Zi-Hao Huang Li-Dan Hou Bo Shen Yu Xin Department of General Surgery Sir Run Run Shaw Hospital of Zhejiang UniversityHangzhou 310012Zhejiang ProvinceChina Department of Anaesthesiology Sir Run Run Shaw Hospital of Zhejiang UniversityHangzhou 310012Zhejiang ProvinceChina College of Medicine Zhejiang UniversityHangzhou 310012Zhejiang ProvinceChina Biomedical Research Center Sir Run Run Shaw Hospital of Medical SchoolZhejiang UniversityHangzhou 310012Zhejiang ProvinceChina Department of Anesthesiology Sir Run Run Shaw Hospital of Zhejiang UniversityHangzhou 310012Zhejiang ProvinceChina

BACKGROUND Inflammatory bowel disease(IBD)is a chronic disease with recurrent intestinal *** the exact etiology of IBD remains unknown,the accepted hypothesis of the pathogenesis to date is that abnormal immune responses to the gut microbiota are caused by environmental *** role of the gut microbiota,particularly the bidirectional interaction between the brain and gut microbiota,has gradually attracted more *** To investigate the potential effect of spinal anesthesia on dextran sodium sulfate(DSS)-induced colitis mice and to detect whether alterations in the gut microbiota would be crucial for *** A DSS-induced colitis mice model was *** anesthesia was administered on colitis mice in combination with the methods of cohousing and fecal microbiota transplantation(FMT)to explore the role of spinal anesthesia in IBD and identify the potential mechanisms *** We demonstrated that spinal anesthesia had protective effects against DSS-induced colitis by alleviating clinical symptoms,including reduced body weight loss,decreased disease activity index score,improved intestinal permeability and colonic morphology,decreased inflammatory response,and enhanced intestinal barrier ***,spinal anesthesia significantly increased the abundance of Bacteroidetes,which was suppressed in the gut microbiota of colitis ***,cohousing with spinal anesthetic mice and FMT from spinal anesthetic mice can also alleviate DSS-induced colitis by upregulating the abundance of *** further showed that spinal anesthesia can reduce the increase in noradrenaline levels induced by DSS,which might affect the gut *** These data suggest that microbiota dysbiosis may contribute to IBD and provide evidence supporting the protective effects of spinal anesthesia on IBD by modulating the gut microbiota,which highlights a novel approach for the treatment of IBD.

关键词： Spinal anesthesia Inflammatory bowel disease Gut microbiota Intestinal barrier Intestinal inflammation Intestinal immune

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Relationship Between Myocardial Injury and Expression of PGC-1α and Its Coactivators in Chronic Keshan Disease

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Current Medical Science 2022年第1期42卷 85-92页

作者： Shuai JIANG Qian-ru ye Rong-xia ZHEN Juan-niu ZHANG Yi-yi ZHANG Xu LIU Jie HOU Institute of Keshan Disease Chinese Center for Endemic Disease ControlHarbin Medical UniversityHarbin 150081China Affiliated Hospital of Jilin Medical College Jilin 132013China Hangzhou Center for Disease Control and Prevention Hangzhou 310021China Sanya Institute of Technology Sanya 572022 China Inner Mongolia Autonomous Region Mental Health Center Hohhot010010China

Objective:Keshan disease(KD)is a mitochondrial *** present study explored the roles of peroxisome proliferator-activated receptor(PPAR)-y coactivator-la(PGC-la),the key regulator of mitochondrial structure and function,and its coactivators in myocardial injury in chronic ***,the usefulness of these molecules in the diagnosis of chronic KD was assessed.

关键词： Keshan disease peroxisome proliferator-activated receptor-y coactivator-la myocardial injury lactate dehydrogenase

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Differentiating structure of in situ and ex situ formation of laser-induced graphene hybrids

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Rare Metals 2022年第9期41卷 3035-3044页

作者： Li-Bei Huang Wei-Hua Guo Le Cheng Jian-Jun Su Yun Song Fei-Jun Hu Ying Lo Law Zheng Yan Jian Lin ru-Quan ye State Key Laboratory of Marine Pollution Department of ChemistryCity University of Hong KongHong Kong999077China Department of Mechanical and Aerospace Engineering University of MissouriColumbiaMO65211USA Department of Biomedical Biological&Chemical EngineeringUniversity of MissouriColumbiaMO65211USA Department of Electrical Engineering and Computer Science University of MissouriColumbiaMO65211USA City University of Hong Kong Shenzhen Research Institute Shenzhen518057China

Laser-induced graphene(LIG)has been exploited in various fields,such as batteries,water treatment,and flexible actuators and sensors,with the advantages of ease in patternable fabrication and graphene/metal hybrid *** in situ method which includes a single lase step and the ex situ method which uses two lase steps are both widely implemented to synthesize graphene/metal ***,the differences in the structures and properties of the resulting hybrids are not fully ***,we investigate the advantages of ex situ and in situ methods for preparing LIG hybrids using NiFe/LIG as an *** morphology,elemental composition,resistance to strong acid,and application in electrocatalysis and dye adsorption of ex situ and in situ NiFe/LIG hybrids were systematically studied and ***-dispersive X-ray spectrometry(EDS)and vibrating sample magnetometry(VSM)results confirmed the structural differences between the NiFe/LIG *** nanoparticles are mostly wrapped by carbon layers in the in situ NiFe/LIG hybrid,while the ex situ NiFe/LIG hybrid largely exposes the metal *** structural differences are significant for tailoring performance in applications,such as wastewater treatment and *** work provides insights into the synthesis and properties of LIGs and has important implications for future applications.

关键词： Ex situ In situ Laser-induced graphene Metal-containing hybrids Oxygen evolution reaction Dye adsorption

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