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Advancing intestinal organoid technology to decipher nano-intestine interactions and treat intestinal disease

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Nano Research 2023年第3期16卷 3976-3990页

作者： Lin Bao Xuejing Cui ru bai Chunying Chen CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety&CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaChinese Academy of SciencesBeijing 100190China The GBA National Institute for Nanotechnology Innovation Guangzhou 510700China University of Chinese Academy of Sciences Beijing 100049China

With research burgeoning in nanoscience and nanotechnology,there is an urgent need to develop new biological models that can simulate native structure,function,and genetic properties of tissues to evaluate the adverse or beneficial effects of nanomaterials on a *** the current biological models,three-dimensional(3D)organoids have developed as powerful tools in the study of nanomaterial-biology(nano-bio)interactions,since these models can overcome many of the limitations of cell and animal models.A deep understanding of organoid techniques will facilitate the development of more efficient nanomedicines and further the fields of tissue engineering and personalized ***,we summarize the recent progress in intestinal organoids culture systems with a focus on our understanding of the nature and influencing factors of intestinal organoid *** also discuss biomimetic extracellular matrices(ECMs)coupled with *** particular,we analyze the application prospects for intestinal organoids in investigating nano-intestine *** integrating nanotechnology and organoid technology,this recently developed model will fill the gaps left due to the deficiencies of traditional cell and animal models,thus accelerating both our understanding of intestine-related nanotoxicity and the development of nanomedicines.

关键词： intestinal organoid biomimetic extracellular matrices(ECMs) intestinal tissue engineering nano-intestine interaction

Surveying ionizing radiations in real time using a smartphone

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Nuclear Science and Techniques 2017年第5期28卷 81-85页

作者： Qing-Yang Wei ru bai Zhen-Peng Wang ru-Tao Yao Yu Gu Tian-Tian Dai School of Automation and Electrical Engineering Beijing University of Science and Technology School of Medicine and Biological Sciences University at BuffaloState University of New York Department of Radiation Oncology China-Japan Friendship Hospital

Surveying ionizing radiations of the surrounding with a smartphone provides a low-cost and convenient utility for the general public. We developed a smartphone application(App) that uses the built-in camera with a CMOS sensor and a radiation signal extraction *** a calibration through a series of radiation exposures,the App could display radiation dose rate and cumulative dose in real time without requiring covering the camera lens. A smartphone with this App can be used as a fast survey tool for ionizing radiations.

关键词： Ionizing radiation CMOS sensor Smartphone Real time Detection

MiR-194-5p suppresses the warburg effect in ovarian cancer cells through the IGF1R/PI3K/AKT axis

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BIOCELL 2023年第3期47卷 547-554页

作者： LIJUN DU KAIKAI DOU NIANHAI LIANG JIANMIN SUN ru bai School of Basic Medicine Ningxia Medical UniversityYinchuan750004China The Fifth People’s Hospital of Ningxia Shizuishan753000China

Background:The Warburg effect is considered as a hallmark of various types of cancers,while the regulatory mechanism is poorly *** previous study demonstrated that miR-194-5p directly targets and regulates insulin-like growth factor1 receptor(IGF1R).In this study,we aimed to investigate the role of miR-194-5p in the regulation of the Warburg effect in ovarian cancer ***:The stable ovarian cell lines with miR-194-5p overexpression or silencing IGF1R expression were established by lentivirus *** generation,glucose uptake,lactate production and extracellular acidification rate(ECAR)assay were used to analyze the effects of aerobic glycolysis in ovarian cancer *** expression was analyzed by quantitative polymerase chain reaction(qPCR)and western *** assays were performed to assess the expression of the IGF1R protein in ovarian cancer ***:Overexpression of miR-194-5p or silencing IGF1R expression in ovarian cancer cells decreases ATP generation,glucose uptake,lactate production,and ECAR and inhibits both the mRNA and protein expression of PKM2,LDHA,GLUT1,and *** the knockdown of miR-194-5p expression led to opposite *** of miR-194-5p or silencing IGF1R expression suppressed the phosphatidylinositol-3-kinase/protein kinase B(PI3K/AKT)pathway,whose activation can sustain aerobic glycolysis in cancer cells,and the knockdown of miR-194-5p expression promoted the activation of the PI3K/AKT ***:Our results suggest that miR-194-5p can inhibit the Warburg effect by negative regulation of IGF1R and further repression of the PI3K/AKT pathway,which provides a theoretical basis for further test of miR-194-5p as a target in the treatment of ovarian cancer.

关键词： Ovarian cancer Aerobic glycolysis microRNA

Structural and Thermodynamic Properties of Wurtzitic Boron Nitride from First-Principle Calculations

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Communications in Theoretical Physics 2007年第5X期48卷 925-929页

作者： YU bai-ru ZENG Zhao-Yi GUO Hua-Zhong CHEN Xiang-Rong College of Physical Science and Technology Sichuan University Chengdu 610064 China International Centre for Materials Physics the Chinese Academy of Sciences Shenyang 110016 China

Using ab initio plane-wave pseudopotential density functional theory method, we have studied the structural and thermodynamic properties of the wurtzite boron nitride （w-BN）. Through the quasi-harmonic Debye model, in which the phononic effects are considered, the dependencies of the normalized lattice parameters a/ao and c/co, the axial ratio c/a, and the normalized primitive cell volume V/Vo on pressure P and temperature T are investigated. Furthermore, the Debye temperature θ, the variation of thermal expansion α, as well as the heat capacity Cv as functions of P and T are studied systematically.

关键词： density functional theory thermodynamic properties w-BN

First-Principle Calculations of Elastic Properties of Wurtzite-Type Aluminum Nitride Under Pressure

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Communications in Theoretical Physics 2008年第2期49卷 489-492页

作者： WANG Yong-Liang CUI Hong-Ling YU bai-ru CHEN Xiang-Rong College of Physical Science and Technology Sichuan University Chengdu 610064 China Institute of Atomic and Molecular Physics Sichuan University Chengdu 610065 China International Centre for Materials Physics the Chinese Academy of Sciences Shenyang 110016 China

The elastic properties of the wurtzite-type aluminum nitride （w-AlN） are investigated by ab initio plane-wave pseudopotential density functional theory method. The pressure dependences of the normalized primitive cell volume V/Vo, the elastic constants cij, the aggregate elastic modulus （B, G, E）, the Poisson＇s ratio （v）, and the Debye temperature θD are successfully obtained. From the elastic constants of the w-AlN under pressure, we find that the w-AlN should be unstable at higher pressure than 61.33 GPa.

关键词： density functional theory elastic properties w-AlN

Two New Acetyl Cimicifugosides from the Rhizomes of Cimicifuga Racemosa

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Chinese Chemical Letters 2006年第3期17卷 347-350页

作者： Chun DAN rui WANG Shu Lin PENG Bing ru bai Li Sheng DING Chengdu Institute of Biology Chinese Academy of Sciences Chengdu 610041

Two new acetyl cimicifugosides were isolated from the rhizomes of Cimicifuga racemosa. Their structures were elucidated as 2＇-O-acetyl cimicifugoside H-1 1 and 3＇-O-acetyl cimicifugoside H-1 2 by the spectroscopic e... 详细信息

关键词： Cimicifuga racemosa cimicifugoside 2'-O-acetyl cimicifugoside H-1 3'-O-acetyl cimicifugoside H- 1.

Connexin 40-formed GJIC increases the phototoxicity of photodynamic therapy through ROS-and calcium-mediated pathways

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中国药理学与毒理学杂志 2017年第10期31卷 1026-1027页

作者： Deng-pan WU Li-ru bai Jin-lan HUANG Pharmacy School of Xuzhou Medical University Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Pharmacy School of Xuzhou Medical University Department of Pharmacology

OBJECTIVE To explore the effect of connexin(Cx)40-formed gap junctional intercellular communication(GJIC)on Photofrin-photodynamic therapy(PDT)phototoxicity in Cx40-transfected He La cells and its potential *** He La cell line stably transfected to express Cx40 was seeded at high and low cell density,respectively,to assess in vitro photosensitivity using CCK8 *** blot assay was performed to detect the expression of *** intracellular ROS and Ca^(2+) concentrations were determined using flow cytometer.4-HNE and ceramide were measured using ELISA *** Cx40-composed GJ formation at high density enhances the phototoxicity of *** the Cx40 is not expressed or Cx40 channels are blocked,the phototoxicity in high-density cultures substantially reduces,indicating that the enhanced PDT phototoxicity at high density is mediated by Cx40-composed *** GJIC-mediated increase in PDT phototoxicity was associated with ROS and calcium-mediated stress signaling *** The work uniquely presents the ability of Cx40-composed GJIC to enhance the sensitivity of malignant cells to PDT,and indicates that maintenance or increase of Cx40-formed GJIC may be a profitable strategy towards the enhancement of PDT therapeutic efficiency.

关键词： photodynamic therapy gap junctional intercellular communication connexin40 phototoxicity

STING and TLR9 agonists synergistically enhance the immunogenicity of SARS-CoV-2 subunit vaccine

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Nano Research 2023年第12期16卷 13322-13334页

作者： Yang Li Ziwei Chen Xinyi Lu Jiufeng Sun Mengyu Guo Huige Zhou ru bai Yuliang Zhao Chunying Chen Yaling Wang CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China The GBA National Institute for Nanotechnology Innovation Guangzhou 510700China Guangdong Provincial Institute of Public Health Guangdong Provincial Center for Disease Control and PreventionGuangzhou 511430China Research Unit of Nanoscience and Technology Chinese Academy of Medical SciencesBeijing 100049China

Vaccines that are reliable and efficacious are essential in the fight against the COVID-19 *** this study,we designed a dual-adjuvant system with two pathogen-associated molecular patterns(PAMPs),MnOx and *** system can improve the retention of antigens at the injection site,facilitate pro-inflammatory cytokines secretion,further recruit and activate dendritic cells(DCs).As a result,antigens can be delivered to lymph nodes specifically,and adaptive immunity was *** immunized group showed an enhanced and broadened humoral and cellular immune response in systemic immunity and lung protection when combined with a tandem repeat-linked dimeric antigen version of the SARS-CoV-2 receptor binding domain(RBDdimer).Remarkably,even with a significant reduction in antigen dosage(three times lower)and a decrease in injection frequencies,our nanovaccine was able to produce the highest neutralizing antibody titers against various *** titers were four-fold higher for the wild-type strain and two-fold higher for both the Beta and Omicron variants in comparison with those elicited by the Alum adjuvant *** conclusion,our dual-adjuvant formulation presents a promising protein subunit-based candidate vaccine against SARS-CoV-2.

关键词： dual-adjuvant system synergistic immune activation antigen dosage reducing variants neutralizing

Two new isoflavonoids from the rhizomes of Belamcanda chinensis

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Chinese Chemical Letters 2007年第6期18卷 694-696页

作者： Zhi Jun Song Fan Luo Yan Zhou Bin ru bai Shu Lin Peng Li Sheng Ding Chengdu Institute of Biology Chinese Academy of Sciences Chengdu 610041 China College of Life Science and Technology Southwest University for Nationalities Chengdu 610041 China

Two new isoflavonoids, 6-methoxy-5,7,8,4′-tetrahydryoxyisoflavone (1) and 4′-methoxy -5,6-dihydroxyisoflavone-7-O-β-d-glucopyranoside (2), were isolated from the rhizomes of Belamcanda chinensis (L.) DC. Their stru... 详细信息

关键词： Belamcanda chinensis Isoflavanoid 6-Methoxy-5,7,8,4′-tetrahydryoxyisoflavone 4′-Methoxy-5,6-dihydroxyisoflavone-7-O-β-d-glucopyranoside