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Toward a biomarker panel measured in CnS-originating extracellular vesicles for improved differential diagnosis of Parkinson’s disease and multiple system atrophy

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Translational neurodegeneration 2023年第1期12卷 677-680页

作者： Hash Brown Taha Simon Hornung Suman Dutta Leony Fenwick Otmane Lahgui Kathryn Howe nour Elabed Irish del Rosario Darice Y.Wong Aline Duarte Folle Daniela Markovic Jose-Alberto Palma Un Jung Kang roy n.alcalay Miriam Sklerov Horacio Kaufmann Brent L.Fogel Jeff M.Bronstein Beate Ritz Gal Bitan Department of neurology David Geffen School of MedicineUniversity of California Los AngelesLos AngelesCA 90095USA Department of Integrative Biology and Physiology University of California Los AngelesLos AngelesCA 90095USA Department of Epidemiology Fielding School of Public HealthUniversity of California Los AngelesLos AngelesCA 90095USA Department of Medicine Statistics Core Division of General Internal Medicine and Health Services ResearchUniversity of California Los AngelesLos AngelesCA 90095USA Department of neurology Dysautonomia CenterNew York University School of MedicineNew YorkNY 10016USA Department of neurology Taub Institute for Research on Alzheimer’s Disease and the Aging BrainColumbia UniversityNew YorkNY 10032USA Department of neurology Tel Aviv Sourasky Medical CenterTel AvivIsrael Department of neurology University of North Carolina School of MedicineChapel HillNC 27599USA Department of neurology The Marlene and Paolo Fresco Institute for Parkinson’s and Movement DisordersNew York University School of MedicineNew YorkNY 10016USA Department of Human Genetics David Geffen School of MedicineUniversity of California Los AngelesLos AngelesCA 90095USA UCLA Clinical neurogenomics Research Center David Geffen School of MedicineUniversity of CaliforniaLos AngelesCA 90095USA Brain Research Institute University of CaliforniaLos AngelesCA 90095USA Molecular Biology Institute University of California Los AngelesLos AngelesCA 90095USA Present Address:Division of Peptide Biochemistry TUM School of Life SciencesTechnical University of Munich85354 FreisingGermany

Synucleinopathies are neurodegenerative diseases char-acterized by accumulation of misfoldedα-synuclein(α-syn)inclusions in neuronal and/or glial *** differences in the underlying pathophysiology,synucle-inopathies ... 详细信息

关键词： diagnosis atrophy diseases

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OH and O radicals production in atmospheric pressure air/Ar/H_2O gliding arc discharge plasma jet

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Plasma Science and Technology 2017年第12期19卷 71-80页

作者： n C roy M R TALUKDER A n CHOWDHURY Plasma Science and Technology Laboratory Department of Applied Physics and Electronic EngineeringUniversity of RajshahiRajshahi 6205Bangladesh Bangladesh Council of Scientific and Industrial Research Laboratory Rajshahi Rajshahi 6206Bangladesh

Atmospheric pressure air/Ar/H_2O gliding arc discharge plasma is produced by a pulsed dc power supply. An optical emission spectroscopic（OES） diagnostic technique is used for the characterization of plasmas and for identifications of OH and O radicals along with other species in the plasmas. The OES diagnostic technique reveals the excitation Tx？≈？5550–9000 K, rotational Tr？≈？1350–2700 K and gas Tg？≈？850–1600 K temperatures, and electron density n？（1.1-1.9） ′101 4 cm^（-3） e under different experimental conditions. The production and destruction of OH and O radicals are investigated as functions of applied voltage and air flow rate. Relative intensities of OH and O radicals indicate that their production rates are increased with increasing Ar content in the gas mixture and applied voltage. nereveals that the higher densities of OH and O radicals are produced in the discharge due to more effective electron impact dissociation of H_2O and O_2 molecules caused by higher kinetic energies as gained by electrons from the enhanced electric field as well as by enhanced n *** productions of OH and O are decreasing with increasing air flow rate due to removal of Joule heat from the discharge region but enhanced air flow rate significantly modifies discharge maintenance properties. Besides, Tgsignificantly reduces with the enhanced air flow rate. This investigation reveals that Ar plays a significant role in the production of OH and O radicals.

关键词： reactive oxygen species(ROS) optical emission spectroscopy(OES) gliding arc discharge plasma kinetics broadening mechanism

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Mathematical modeling of nanoscale MOS capacitance in the presence of depletion and energy quantization in a poly-silicon gate

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Journal of Semiconductors 2010年第11期31卷 5-8页

作者： Amit Chaudhry J.n.roy Institute of Engineering and Technology Panjab University Solar Semiconductor Pvt.Ltd.

A model has been developed to study the effect of depletion and energy quantization at the poly-silicon /oxide interface on the behavior of a nanometer scale n-MOSFET.A model of inversion charge density,including the inversion layer quantization using the variation approach in the substrate,has also been *** the exact calculations of the polygate potential under the depletion and quantization conditions,a C-V model has been developed. All the results have been compared with the numerical models reported in existing literature and they show good agreement.

关键词： BSIM inversion layers MOS devices quantization poly-depletion poly-quantization

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nanoscale strained-Si MOSFET physics and modeling approaches:a review

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Journal of Semiconductors 2010年第10期31卷 19-23页

作者： Amit Chaudhry J.n.roy Garima Joshi University Institute of Engineering and Technology Panjab University Solar Semiconductor Private Limited

An attempt has been made to give a detailed review of strained silicon technology. Various device models have been studied that consider the effect of strain on the devices, and comparisons have been drawn. A review of some modeling issues in strained silicon technology has also been outlined. The review indicates that this technology is very much required in nanoscale MOSFETs due to its several potential benefits, and there is a strong need for an analytical model which describes the complete physics of the strain technology.

关键词： mobility SiGe strained-Si technology CAD

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Detection of thermonuclear X-ray bursts and dips from the X-ray binary 4U 1323-62 with AstroSat/LAXPC

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Research in Astronomy and Astrophysics 2020年第6期20卷 281-292页

作者： Yashpal Bhulla Jayashree roy S.n.A.Jaaffrey Pacific Academy of Higher Education and Research University Udaipur-313003India Inter-University Center for Astronomy and Astrophysics Pune-411007India

Using data from the Large Area X-ray Proportional Counter(LAXPC)on the AstroSat satellite,we observed Type-1 thermonuclear X-ray bursts from the low mass X-ray binary neutron star 4 U *** of 4 U 1323-62 that were carried out during the performance verification phase of the AstroSat satellite indicated six thermonuclear X-ray bursts in a total effective exposure of^49.5 ks for about two consecutive *** time of the detected thermonuclear bursts is in accordance with the orbital period of the source,~9400 ***,the light curve of 4 U 1323-62 revealed the presence of two *** present the results from time-resolved spectroscopy performed during all of the six X-ray bursts and also report the detection of a known low frequency quasi-periodic oscillation(LFQPO)at^1 Hz from the ***,any evidence of kilohertz QPO was not *** have shown the burst profile at different energy *** a distance of 10 kpc,we observed a mean flux of^1.8×10^-9 erg cm^2 s^-*** radius of the blackbody is found to be highly consistent with the blackbody temperature and the blackbody flux of the bursts.

关键词： accretion-accretion disc-stars neutron star-X-rays binaries-X-rays thermonuclear bursts-individual 4U 1323–62

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SPICE compatible analytical electron mobility model for biaxial strained-Si-MOSFETs

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Journal of Semiconductors 2011年第5期32卷 36-41页

作者： Amit Chaudhry J.n.roy S.Sangwan UIET Panjab UniversityChandigarhIndia Solar Semiconductro Pvt.Ltd HyderabadIndia

This paper describes an analytical model for bulk electron mobility in strained-Si layers as a function of strain. Phonon scattering, columbic scattering and surface roughness scattering are included to analyze the full mobility model. Analytical explicit calculations of all of the parameters to accurately estimate the electron mobility have been made. The results predict an increase in the electron mobility with the application of biaxial strain as also predicted from the basic theory of strain physics of metal oxide semiconductor （MOS） devices. The results have also been compared with numerically reported results and show good agreement.

关键词： mobility SiGe strained-Si phonon surface roughness columbic

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Carcinoid tumor of the common bile duct: A rare complication of von Hippel-Lindau syndrome

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World Journal of Gastroenterology 2008年第8期14卷 1299-1301页

作者： Otmane nafidi Bich n nguyen André roy Department of Surgery Saint-Luc Hospital CHUM Montréal Québec H2X 3J4 Canada Department of Pathology Saint-Luc Hospital CHUM Montréal Québec H2X 3J4 Canada Department of Surgery Saint-Luc Hospital CHUM 1058 Saint-Denis Street Montréal Québec H2X 3J4 Canada

Von HippeI-Lindau syndrome （VHL） is a rare autosomal-dominant, inherited familial cancer syndrome. Hemangioblastomas, pheochromocytomas and renal carcinoma are the frequent reported VHL tumors. neuroendocrine tumors have also been described, mostly in the pancreas and rarely in the biliary trees. We report the second case of bile duct carcinoid in a 31-year-old VHL woman. She underwent right adrenalectomy for a pheochromocytoma in the past. She also had a positive family history of phenotypic expression of VHL syndrome. The patient presented with biliary colic. Endoscopic retrograde cholangio-pancreatography showed intraluminal bile duct mass. Surgical exploration identified a beige nodular lesion that was a carcinoid tumor on histology. This new association should be clarified by further genetic investigations.

关键词： Carcinoid tumor Bile duct tumor von Hippel-Lindau syndrome

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Systematic Assessment of Synthesized Tri-magnesium Phosphate Powders(Amorphous,Semi-crystalline and Crystalline) and Cements for Ceramic Bone Cement Applications

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Journal of Materials Science & Technology 2015年第5期31卷 437-444页

作者： nicole Ostrowski Vidisha Sharma Abhijit roy Prashant n.Kumta Department of Bioengineering University of Pittsburgh Center of Complex Engineered Multifunctional Materials University of Pittsburgh Department of Chemical and Petroleum Engineering University of Pittsburgh Department of Mechanical Engineering and Materials Science University of Pittsburgh

Magnesium phosphate cements have come under investigation in recent years for use as an alternative to calcium phosphate cements for bone void repair *** indicates that magnesium phosphate cements obtain higher initial strengths after cement reaction and resorption in more clinically appropriate time frames than commercially available calcium phosphate *** this study,amorphous,partially amorphous and crystalline tri-magnesium phosphate powders were synthesized via an aqueous precipitation reaction with subsequent thermal treatment,and characterized using techniques such as X-ray diffraction and Fourier transform infrared *** materials were assessed for their functionality in cementing reaction with a 3.0 mol/L,pH 7.0 ammonium phosphate solution,including setting time and pH evolution in phosphate buffered saline *** indicated that the amorphous and semi-crystalline tri-magnesium phosphate powders were highly reactive with the setting solution but resulted in mechanically weak cements,while the crystalline tri-magnesium phosphate powder reacted efficiently with the cement solution and were mechanically strong following the cement reaction.X-ray diffraction and scanning electron microscopy analyses indicated significant changes in the phase composition and morphology of the cements following incubation in phosphate buffered *** were perceived to be detrimental to the integrity of the amorphous and semi-crystalline tri-magnesium phosphate derived cements but not to those created with fully crystalline tri-magnesium *** crystalline tri-magnesium phosphate material resulted in the most functional cement as this embodiment displayed the most clinically relevant setting time as well as the highest mechanical resilience and neutral pH during incubation in saline solution rendering them potentially viable as bone void fillers.

关键词： Amorphous magnesium phosphate Tri-magnesium phosph

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Correlating mode-I fracture toughness and mechanical properties of heat-treated crystalline rocks

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第1期10卷 91-101页

作者： Mayukh Talukdar Debanjan Guha roy T.n.Singh Indian Institute of Technology Bombay PowaiMumbai400076India IITB-Monash Research Academy Indian Institute of Technology BombayPowaiMumbai400076India

For the effect of thermal treatment on the mode-I fracture toughness(FT), three crystalline rocks(two basalts and one tonalite) were experimentally investigated. Semi-circular bend specimens of the rocks were prepared following the method suggested by the International Society for Rock Mechanics(ISRM)and were treated at various temperatures ranging from room temperature(25 ℃) to 600 ℃. Mode-I FT was correlated with tensile strength(TS), ultrasonic velocities, and Young’s modulus(YM). Additionally,petrographic and X-ray diffraction analyses were carried out to find the chemical changes resulting from the heat treatment. Further, scanning electron microscopy(SEM) was conducted to observe the micro structural changes when subjected to high temperatures. These experiments demonstrate that heat treatment has a strong negative impact on the FT and mechanical properties of the rocks. From room temperature to 600 ℃, mode-I FT values of massive basalt, giant plagioclase basalt, and tonalite were reduced by nearly 52%, 68%, and 64%, respectively. Also, at all temperature levels, FT and mechanical properties are found to be exponentially correlated. However, the exact nature of the relationship mainly depends on rock type. Besides, TS was found to be a better indicator of degradation degree than the mode-I FT. SEM images show that micro crack density and structural disintegration of the mineral grains increase with temperature. These physical changes confirm the observed reduction in the stiffness of heat-treated crystalline rocks.

关键词： Fracture toughness(FT) Tensile strength(TS) Ultrasonic velocity Young's modulus(YM) Crystalline rocks

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Atmospheric pressure gliding arc discharge plasma treatments for improving germination, growth and yield of wheat

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Plasma Science and Technology 2018年第11期20卷 90-100页

作者： n C roy M M HASAn A H KABIR M A REZA M R TALUKDER A n CHOWDHURY Plasma Science and Technology Laboratory Department of Applied Physics and Electronic EngineeringUniversity of Rajshahi Rajshahi 6205 Bangladesh Department of Agronomy and Agricultural Extension University of Rajshahi Rajshahi 6205 Bangladesh Depatment of Botany University of Rajshahi Rajshahi 6205Bangladesh Department of Genetic Engineering and Biotechnology University of Rajshahi Rajshahi 6205Bangladesh Bangladesh Council of Scientific and Industrial Research Laboratory Rajshahi Rajshahi 6206Bangladesh

Wheat （Triticum aestivum） seeds were treated with atmospheric pressure gliding arc discharge plasmas to investigate the effects on water absorption, seed germination rate, seedling growth and yield in wheat. The surface architectures and functionalities of the seeds were found to modify due to plasma treatments. 6 rain treatment was provided 95%-100% germination rate. For the treatment duration of 3 and 9 rain the growth activity, dry matter accumulation, leaves chlorophyll contents, longest spikes, number of spikes/spikelet and total soluble protein content in shoots were improved. The grain yield of wheat was increased ,--20% by 6 min treatment with H2O/O2 plasma with respect to control.

关键词： atmospheric pressure gliding arc discharge plasmas wheat germination growth improvement total soluble protein

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