检索结果-南通市图书馆

患丙型肝炎老干部未进行抗病毒治疗:对生活质量造成影响的生理和社会心理因素

世界核心医学期刊文摘（胃肠病学分册） 2006年第1期2卷 48-49页

作者： rowan p.j. Al-jurdi R. Tavakoli-Tabasi S. H.B. El-Serag 陈瑜 Houston Veterans Affairs Medical Center (152) 2002 Holcombe Blvd. Houston TX 77030 United States Dr.

Background and Aims: Treatment-naive hepatitis C virus (HCV)infected patients report impaired health-related quality of life (HRQOL), although causes are unclear. psychosocial factors may be major determinants of HRQOL. Methods: We administered a general (Short Form-36; SF-36) and a liver-specific (Chronic Liver Disease Questionnaire; CLDQ) HRQOL measure to 62 HCV-infected veterans being considered for antiviral therapy. psychosocial assessment included the Structured Clinical Interview for DSM-IV Axis I Disorders/Non-patient (SCID-VNp), Beck Depression Inventory-II (BDI-II), Beck Anxiety Inventory (BAI), Abbreviated Cook-Medley (ACM) anger measure, and Medical Outcomes Study Social Support Measure (SSM). We examined the potential determinants of HRQOL, including psychosocial measures, demographic measures (age, sex, race/ethnicity), clinical measures (presence of cirrhosis, comorbid medical conditions), and viral data (quantitative pCR). Results: SF-36 scores were significantly lower in HCV-infected patients than published U.S. population norms but similar to those reported by previous studies of HCV infected samples. CLDQ scores were very similar to those reported by previous studies. Demographic, clinical, and viral indicators were not statistically associated with HRQOL, and neither was the presence of a substance abuse or psychotic disorder. Lower BDI-II and BAI scores were associated with better general and disease-specific HRQOL. Lower SSM scores were associated with lower scores on SF-36 but not CLDQ; however, this effect did not persist in multiple linear regression analyses. In these, BDI-II was the strongest independent predictor of both SF-36 and CLDQ. Conclusions: psychosocial factors, especially depression, are strong indicators of impaired HRQOL for HCV-infected veterans not receiving antiviral therapy. Screening and treatment of psychosocial factors is recommended.

关键词：丙型肝炎抗病毒生活质量病毒学指标心理因素慢性肝病社会支持疾病特异性药物滥用医学成果

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The role of digital technologies in supporting and improving fishery and aquaculture across the supply chain-Quo Vadis?

引用

Aquaculture and Fisheries 2023年第4期8卷 365-374页

作者： Neil j.rowan Bioscience Research Institute Technological University of the ShannonMidlands Midwest(TUS)AthloneN37 HD68Ireland Empower Eco^(™)Innovation Hub TUSAthloneN37 HD68Ireland CURAM Research Centre NUIGalwayH91 TK33Ireland

Fish constitute important high protein products to meet the demands of an increasing global ***,the continued depletion of wild fish stocks is leading to increased strain on the aquaculture sector in terms of sustaining the supply of fish and seafood to global *** the fact that aquaculture is more diversified than other agriculture sectors,there are significant pressures on the industry to continue innovating in order to enable sustainability including increased fish production,improved appropriate selection of species,disease mitigation,reduced wastage,preventing environmental pollution and generating more employment *** viewpoint article addresses how digital transformation can help support and meet expansion needs of the fisheries/aquaculture industries that includes exploiting and harnessing ICT,IoT,Cloud-edge computing,AI,machine learning,immersive technologies and *** technologies are bringing significant operational benefits for global food chain,improving efficiencies and productivity,reducing waste,contamination and food *** focus on digital technologies has recently evolved to Industry 5.0 where AI and robotics are coupled with the human mind in order to advance human-centric *** viewpoint describes the role of Quadruple helix Hub(academic-industry-government and society)in delivering a convergent holistic approach to meeting the diversity of fishery industry needs by connecting and placing fisheries centrally in a defined ecosystem of *** includes specialist training,testing technologies,providing access to finance and fostering disruption through aquaculture accelerator initiatives such as that provided by Hatch *** digital Innovation Hubs trans-regionally,nationally and internationally will also help mitigate against significant risks for the fisheries and aquaculture industry including climate change,global pandemics and conflicts that can jeopardize fish an

关键词： Digital transformation Sustainability End-to-end monitoring Food processing Disruptive innovation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A review of the current evidence for the role of minimally invasive pancreatic surgery following neo-adjuvant chemotherapy

引用

Laparoscopic, Endoscopic and Robotic Surgery 2022年第2期5卷 47-51页

作者： Francis p.Robertson rowan W.parks Department of Hepatobiliary and Transplant Surgery Freeman HospitalNewcastleUnited Kingdom Department of Clinical Surgery Royal Infirmary of EdinburghEdinburghUnited Kingdom Division of Surgical and Interventional Science Royal Free CampusUniversity College LondonLondonUnited Kingdom

Objective:Surgical resection of pancreatic cancer remains the only potentially curative treatment for pancreatic ductal *** robotic platform has been introduced to surgical practice and recent large studies from national registries have demonstrated similar or improved peri-operative outcomes compared to the standard open ***-adjuvant chemotherapy is increasingly being offered to patients with borderline resectable/locally advanced disease but this has led to more challenging *** of patients undergoing minimally invasive resection following neo-adjuvant chemotherapy remain *** aim of this review is to assess the current evidence for the peri-operative safety and long-term oncological outcomes associated with minimally invasive pancreatic resection following neo-adjuvant ***:Medline,Embase and Cochrane Central Register for Clinical Trials were searched up until 31st October *** search terms include“minimally invasive”,“robotic”,“laparoscopic”,“pancreatectomy”,“pancreatic resection”,“whipple's pancreaticoduodenectomy”,“distal pancreatectomy”,“chemotherapy”,“neo-adjuvant chemotherapy”,“radiotherapy”,“neo-adjuvant chemoradiotherapy”,“induction therapy”,and“conversion surgery”.All studies including patients undergoing pancreatic resections were *** which did not clearly state the approach to resection(minimally invasive or open)were ***:Seventy-eight studies were identified of which 8 compared open and minimally invasive resection following neo-adjuvant *** was insufficient data to perform a *** surgery was associated with lower blood loss and shorter length of hospital ***-year overall survival rates were similar between patients who underwent robotic or open resection however the robotic approach was associated with higher lymph node yield and a lower R1 resection ***:Currently the evidence for minimally invasive surgery foll

关键词： pancreatic resection Minimally invasive Robotic Neo-adjuvant chemotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Do tau-synaptic long-term depression interactions in the hippocampus play a pivotal role in the progression of Alzheimer’s disease?

引用

Neural Regeneration Research 2023年第6期18卷 1213-1219页

作者： Zhengtao Hu Tomas Ondrejcak pengpeng Yu Yangyang Zhang Yin Yang Igor Klyubin Sean p.Kennelly Michael j.rowan Neng-Wei Hu Department of physiology and Neurobiology School of Basic Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Wannan Medical CollegeWuhuAnhui ProvinceChina Department of pharmacology&Therapeutics and Institute of Neuroscience Trinity CollegeDublinIreland Department of Age-Related Healthcare Tallaght University HospitalDublinIreland Department of Medical Gerontology Trinity CollegeDublinIreland

Cognitive decline in Alzheimer’s disease correlates with the extent of tau pathology,in particular tau hyperphosphorylation that initially appears in the transentorhinal and related regions of the brain including the *** evidence indicates that tau hyperphosphorylation caused by either amyloid-βor long-term depression,a form of synaptic weakening involved in learning and memory,share similar *** from our group and others demonstrate that long-term depression-inducing low-frequency stimulation triggers tau phosphorylation at different residues in the hippocampus under different experimental conditions including ***,certain forms of long-term depression at hippocampal glutamatergic synapses require endogenous tau,in particular,phosphorylation at residue *** the exact mechanisms of interaction between tau and long-term depression may help our understanding of the physiological and pathological functions of tau/tau(hyper)*** first summarize experimental evidence regarding tau-long-term depression interactions,followed by a discussion of possible mechanisms by which this interplay may influence the pathogenesis of Alzheimer’s ***,we conclude with some thoughts and perspectives on future research about these interactions.

关键词： aging Alzheimer’s disease amyloid-β Aβoligomers hippocampus long-term depression long-term potentiation LTD LTp metabotropic glutamate receptor N-methyl-D-aspartate receptor tau hyperphosphorylation tau phosphorylation tau

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Emerging concepts in the management of pancreatic ductal adenocarcinoma

引用

Laparoscopic, Endoscopic and Robotic Surgery 2019年第4期2卷 83-88页

作者： Sanket Srinivasa rowan parks HpB Surgery Royal Infirmary of EdinburghEdinburghUK Department of Clinical Surgery University of EdinburghEdinburghUK

pancreatic ductal adenocarcinoma is characterised by poor oncological outcomes with curative treatment only possible for a *** are dependent on the stage of the disease and location within the pancreas with constitutional decline often *** require biochemical investigations and accurate imaging with CT to determine stage of disease and local ***-pET and endoscopic ultrasound are increasingly used *** remains the cornerstone of curative management and can be performed using minimally invasive *** resection and combination treatment with chemoradiotherapy are also utilised for suitable *** outcomes may be optimised using enhanced recovery *** standards have been defined for individual clinicians and units to benchmark their clinical *** developments described hold promise in improving outcomes from pancreatic ductal adenocarcinoma.

关键词： pancreatic ductal adenocarcinoma pancreatic resection Laparoscopic surgery Robotic surgery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Does prophylactic antidepressant treatment boost interferon-alpha treatment completion in HCV?

引用

World journal of Virology 2013年第4期2卷 139-145页

作者： paul j rowan Division of Management Policy and Community Health University of Texas Health Sciences Center at Houston School of Public HealthHouston TX 77030 United States

Depression is often a side effect of interferon-alpha treatment for hepatitis C, and is recognized as a cause for treatment discontinuation. When detected, antidepressant treatment begins promptly. In contrast to this rescue approach, prophylactic antidepressant treatment has been considered as a superior approach. While studies indicate that depression is lower with prophylaxis, no study has prospectively evaluated the degree that treatment completion might be boosted by the prophylactic strategy. A structured literature search was conducted to discover all trials of antidepressant prophylaxis for patients undergoing antiviral treatment for chronic hepatitis C. Selection criteria included: antidepressant prophylaxis study; report of depression treatment outcome; report of numbers discontinuing and reason for discontinuation(including any of the following: discontinuation data for medical side effects(i.e., thrombocytopenia); discontinuation due to lack of antiviral response; discontinuation due to lack of antidepressant effect; discontinuation due to antidepressant side effects; discontinuation due to patient preference; discontinuation due to loss to follow-up; or unspecified discontinuation). Across the studies, total enrollees were determined for the prophylaxis arms and the rescue arms, and then, again across studies,those discontinuing for reasons other than lack of antiviral response or medical side effect were summed for each of these two arms. Twelve studies were discovered. One was a retrospective chart review, one was an uncontrolled trial, and ten were controlled trials. Discontinuation of antiviral therapy was not less common in the prophylaxis arms: of the 396 patients treated by the prophylaxis strategy, 47(11.9%) discontinued; of the 380 patients in the rescue strategy, 45(11.8%) discontinued. While the prophylaxis strategy seems to manage depression symptoms, it does not seem to boost treatment completion. Rescue was a very successful strategy when

关键词： Depression Therapy Clinical psychiatry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Assessing parameter sensitivity in a university campus COVID-19 model with vaccinations

引用

Infectious Disease Modelling 2023年第2期8卷 374-389页

作者： Meghan rowan Childs Tony E.Wong Rochester Institute of Technology 1 Lomb Memorial DrRochesterNY14623USA

From the beginning of the COVID-19 pandemic,universities have experienced unique challenges due to their dual nature as a place of education and *** research has explored non-pharmaceutical approaches to combating COVID-19,including representing in models different categories such as age *** key area not currently well represented in models is the effect of pharmaceutical preventative measures,specifically vaccinations,on COVID-19 spread on college *** remain key questions on the sensitivity of COVID-19 infection rates on college campuses to potentially time-varying vaccine *** we introduce a compartment model that decomposes a campus population into constituent subpopulations and implements vaccinations with timevarying *** use this model to represent a campus population with both vaccinated and unvaccinated individuals,and we analyze this model using two metrics of interest:maximum isolation population and symptomatic *** demonstrate a decrease in symptomatic infections occurs for vaccinated individuals when the frequency of testing for unvaccinated individuals is *** find that the number of symptomatic infections is insensitive to the frequency of testing of the unvaccinated subpopulation once about 80%or more of the population is *** a Sobol’global sensitivity analysis,we characterize the sensitivity of modeled infection rates to these uncertain *** find that in order to manage symptomatic infections and the maximum isolation population campuses must minimize contact between infected and uninfected individuals,promote high vaccine protection at the beginning of the semester,and minimize the number of individuals developing symptoms.

关键词： COVID-19 Vaccination Subpopulation Modeling Sensitivity analysis University

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

What psychiatric screening and monitoring might be needed with the new generation of hepatitis C treatments?

引用

World journal of Virology 2015年第1期4卷 13-16页

作者： paul j rowan University of Texas Health Sciences Center at Houston School of public Health

psychiatric difficulties, including depression and alcohol use disorders, pose a challenge to treatment decisionmaking for chronic hepatitis C. This is especially made worse because interferon-alpha, as part of the standard of care, may exacerbate depressive symptoms and cause suicidal symptoms to appear. This requires a treatment setting that has the capacity to carry out psychiatric assessment and monitoring, and the capability to deliver patient education regarding these aspects of care. psychiatric comorbidities create a challenging decisionmaking situation, especially since success rates for the most common hepatitis C genotype, genotype 1, hover around 40%. In recent years, new treatmentshave emerged. These significantly boost the likelihood of sustained viral response, including for genotype 1, and do not seem to have the side effects of interferonalpha or ribavirin. Relevant data are reviewed to assess the degree that these new treatments might reduce the portion not eligible for treatment due to psychiatric comorbidities, and might reduce the emergence of psychiatric symptoms during treatment. Several organizations have recently released evidence-based treatment recommendation guidelines. It is apparent that interferon-alpha continues to be a standard of care, with the new drugs added to this recognized regimen in order to shorten treatment and to boost efficacy. Clinical settings must continue to assess appropriateness for treatment, including current or recent psychiatric comorbidities, and must continue to closely monitor patients for the emergence of psychiatric side effects. The newly developed hepatitis C treatments may affect the metabolism of several categories of psychiatric drugs, and so drug-drug interactions must also be considered and monitored. With many promising drugs under development, an all-pill regimen, with no interferon-alpha and no ribavirin, may emerge in the near future. This will greatly change the challenge of treatment decision-m

关键词： Depression Therapy psychiatry Review Clinical

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Surgical management of pancreatic neuroendocrine neoplasms

引用

Laparoscopic, Endoscopic and Robotic Surgery 2023年第3期6卷 83-90页

作者： piero Alberti David Martin Georgios Gemenetzis rowan parks General Surgery(Hepatopancreatobiliary Surgery) Royal Infirmary of EdinburghEdinburghUK Department of Visceral Surgery and Transplantation University Hospital CHUVUniversity of Lausanne(UNIL)LausanneSwitzerland Ninewells Hospital and Medical School DundeeUK University of Edinburgh Medical SchoolEdinburghUK

pancreatic neuroendocrine neoplasms are a rare and complex group of neoplastic lesions that develop from pancreatic islet *** incidence has dramatically increased during the last two *** to its complex nature and pathophysiological behaviour,surgical management continues to *** remains the cornerstone of treatment for most non-functional and functional pancreatic neuroendocrine tumours,while lymphadenectomy remains a controversial *** techniques,such as pancreas-preserving and minimally invasive approaches,continue to evolve and offer the same overall outcomes as open *** comprehensive review describes in detail the current and most up-todate classification and staging of pancreatic neuroendocrine tumours,explores the rationale for nonsurgical and surgical management,and focuses on surgical treatment and more specifically,on minimally invasive approaches.

关键词： pancreatic neuroendocrine neoplasms Non-functional pancreatic neuroendocrine tumours Functional pancreatic neuroendocrine tumours Lymphadenectomy Minimally invasive surgery pancreas preserving techniques

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nanoscale electron tomography and atomic scale high-resolution electron microscopy of nanoparticles and nanoclusters:A short survey

引用

progress in Natural Science:Materials International 2013年第3期23卷 222-234页

作者： john Meurig Thomas paul A.Midgley Caterina Ducati rowan K.Leary Department of Materials Science and Metallurgy University of CambridgePembroke StreetCambridgeCB2 3QZUK

The outstanding merits of scanning transmission electron tomography as a technique for the investigation of the internal structure and morphology of nanoparticle and nanocluster materials are summarized with the aid of numerous typical *** is made also to the significant advances that have arisen in probing ultrastructural characteristics of nanoscale solids using aberrationcorrected(AC) electron microscopy(EM).Information of a unique kind may be retrieved by combining the imaging and analytical power of ACEM.

关键词： Nanoclusters Nanoparticles Atomic structure Electron tomography Aberration-corrected electron microscopy

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：