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Light sheet microscope scanning of biointegrated microlasers for localized refractive index sensing

第七届中国畜牧科技论坛

作者： Ma mingfang Wen kai ross c.beier Sergei A.Eremin Li chenglong Zhang suxia Wang zhanhui Shen jianzhong

We describe here a new strategy for the use of chemiluminescence resonance energy transfer(cRET)by usinghapten-functionalized quantum dots(QDs)as the acceptor in a competitive immunoassay for the detection of a chemic...

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Photonics Research 2024年第8期12卷 1673-1680页

作者： ross c.cOWIE MARcEL ScHUBERT SUPA School of Physics and AstronomyUniversity of St AndrewsSt AndrewsUK Humboldt centre for Nano and Biophotonics Department of ChemistryUniversity of CologneCologneGermany

Whispering gallery mode(WGM)microlasers are highly sensitive to localized refractive index changes allowing to link their emission spectrum to various chemical,mechanical,or physical *** recently found applications in biological studies within single cells,in three-dimensional samples such as multicellular spheroids,or in ***,detailed studies of biological samples also need to account for the structural heterogeneity of tissues and live animals,therefore requiring a combination of high-resolution microscopy and laser ***,we design and construct a light sheet fluorescence microscope with a coupled spectrometer for use in microlaser studies for combined high-resolution,high-speed imaging and WGM spectral *** light sheet illumination profile and the decoupled geometry of excitation and emission hereby directly affect the lasing and sensing properties,mainly through geometric constraints and by light coupling *** demonstrate the basic working principle of microlaser spectroscopy under light sheet excitation and measure the absolute refractive index within agarose and in zebrafish tail muscle *** further analyze the light coupling conditions that lead to the occurrence of two separate oscillation *** so-called cross modes can be scanned around the entire microlaser surface,which allows to estimate a surface-averaged refractive index profile of the microlaser environment.

关键词： refractive index excitation

Limosilactobacillus mucosae FZJTZ26M3 prevents NAFLD in mice through modulation of lipid metabolism and gut microbiota dysbiosis

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Food Science and Human Wellness 2024年第3期13卷 1589-1601页

作者： Danting Dang Bowen Li Mengfan Ding RPaul ross catherine Stanton Jianxin Zhao Bo Yang Wei chen State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China International Joint Research center for Probiotics&Gut Health Jiangnan UniversityWuxi 214122China APc Microbiome Ireland University College CorkCork T12 YT20Ireland Teagasc Food Research centre MooreparkFermoyCork T12 YT20Ireland National Engineering Research center for Functional Food Jiangnan UniversityWuxi 214122China

Lactobacillus are considered promising therapeutic methods for nonalcoholic fatty liver disease(NAFLD).The effects of two strains of Ltmosilactobacillus mucosae on NAFLD were investigated in this ***-old male c57BL/6J mice were divided into 4 groups(n=8 per group,control,Model,FZJTZ26M3,FGSYc17L3).*** FZJTZ26M3 reduced the mice 's body weight,liver weight,and adipose tissue weight after 12 weeks of *** to serum analysis,total cholesterol,triacylglycerol,and low-density lipoprotein cholesterol significantly decreased after *** FZJTZ26M3 *** pathology showed that *** FZJTZ26M3 was effective to ameliorate lipid deposition in NAFLD ***,the expression of the gene related to lipid metabolism in the liver and adipose tissue was analyzed,and the results indicated that *** FZJTZ26M3 could alleviate NAFLD by regulating lipid ***,the results of 16S rRNA gene sequencing revealed a drop in the relative abundance of Ruminococcaceae,which is linked to inflammation,but the relative abundance of a potential probiotic Akkermansia significantly increased after *** FZJTZ26M3 ***,*** FZJTZ26M3 could be a candidate to prevent NAFLD.

关键词： Limosilactobacillus mucosae Nonalcoholic fatty liver disease(NAFLD) Probiotic Lipid metabolism Gut microbiota

Bifidobacterium breve ccFM1078 regulates bone development in growing BALB/c mice via gut microbiota and metabolites to balance bone formation and resorption

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Food Science and Human Wellness 2024年

作者： Bowen Li Mengfan Ding Xiaoming Liu Haiqin chen Jianxin Zhao R.Paul ross catherine Stanton Shilong Jiang Wei chen Bo Yang Nutrition and Metabolism Research Division， Innovation center， Heilongjiang Feihe Dairy co.， Ltd. National Engineering Research center for Functional Food， Jiangnan University State Key Laboratory of Food Science and Technology， Jiangnan University PKUHSc-china Feihe Joint Research Institute of Nutrition and Healthy Lifespan Development APc Microbiome Ireland， University college cork School of Food Science and Technology， Jiangnan University International Joint Research center for Probiotics & Gut Health， Jiangnan University Teagasc Food Research centre

This study endeavors to investigate the effects of Bifidobacterium breve ccFM1078 on bone formation and resorption balance in growing BALB/c mice. Newborn BALB/c mice were assigned to the control group (administration saline) and the ccFM1078 group (administration B. breve ccFM1078， 3 × 109cFU/day) in 3-， 4-， and 5-week tests. All the groups have male and female distinctions. Our findings demonstrate that B. breve ccFM1078 exerts on the dynamic equilibrium between bone formation and resorption during the critical period of growth in mice by modulating the composition of gut microbiota and metabolites (hexadecanamide， linoleoyl ethanolamide， and palmitoyl ethanolamide)， the genes and proteins expression related to the GH/IGF-1 axis and Gs/PKA/cREB signaling pathways， as well as downstream osteogenic and osteoclastic differentiation factors. The effects of B. breve ccFM1078 were different with age and gender dependent. This finding suggests B. breve ccFM1078 may have potential applications in regulating bone metabolism in the growth period population.

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Development of An Enzyme-Linked Immunosorbent Assay for Determination of the Furaltadone Etabolite,3-Amino-5-Morpholinomethyl-2-Oxazolidinone(AMOZ) in Animal Tissues

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Biomedical and Environmental Sciences 2012年第4期25卷 449-457页

作者： LUO Peng Jie JIANG Wen Xiao beier ross c. SHEN Jian Zhong JIANG Hai Yang MIAO Hong ZHAO Yun Feng cHEN Xia WU Yong Ning Ministry of Health Key Laboratory China National Center for Food Safety Risk AssessmentBeijing 100021China Department of Veterinary Pharmacology and Toxicology College of Veterinary MedicineChina Agricultural UniversityBeijing 100193China Southern Plains Agricultural Research center Agricultural Research ServiceU.S.Department of AgricultureCollege StationTexas 77845-4988USA State Key Laboratory for Infectious Disease Prevention and control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

Objective To determine 3-amino-5-morpholinomethyl-2-oxazolidinone （AMOZ） residues released from protein bound AMOZ in animal tissues. Methods Polyclonal and monoclonal antibodies were produced in this study. A rapid, sensitive, and specific competitive direct enzyme-linked immunosorbent assay （cdELISA） was developed. Results Rabbit polyclonal antibodies were used in the optimized cdELISA method, and exhibited negligible cross-reactivity with other compounds structurally related to AMOZ. The Ic50 of the polycional antibody was 0.16 ng/mL The method limit of detection in four different types of animal and fish tissues was less than 0.06 μg/kg. Recoveries ranged from 80% to 220% for fortified samples with the coefficient of variation values less than 15%. The results of the cdELISA method were in good agreement with the results from an established liquid chromatography-tandem mass spectrometry confirmatory method used for AMOZ residues. conclusion The cdELISA method developed in the present study is a convenient practical tool for screening large numbers of animal and fish tissue samples for the the detection of released protein bound AMOZ residues.

关键词： AMOZ Animal tissue ELISA Fish tissue Furaltadone

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岩藻多糖对溃疡性结肠炎小鼠肠道菌群的影响

食品与发酵工业 2024年第10期50卷 266-272页

作者：万雨徐张扬闵天骄何颖吴文惠蒋蓓尔上海海洋大学食品学院上海201306 海军特色医学中心海洋生物医药与极地医学研究室上海200433

该研究采用3%(质量分数)右旋葡萄糖酸钠(dextran sodium sulfate,DSS)诱导建立溃疡性结肠炎(ulcerative colitis,Uc)小鼠模型,探究岩藻多糖对Uc的治疗作用及对肠道菌群的影响。将40只雄性c57BL/6小鼠随机分为对照组、模型组、美沙拉嗪... 详细信息

该研究采用3%(质量分数)右旋葡萄糖酸钠(dextran sodium sulfate,DSS)诱导建立溃疡性结肠炎(ulcerative colitis,Uc)小鼠模型,探究岩藻多糖对Uc的治疗作用及对肠道菌群的影响。将40只雄性c57BL/6小鼠随机分为对照组、模型组、美沙拉嗪组和岩藻多糖组,通过自由饮用3%(质量分数)DSS建立Uc小鼠模型。自造模第1天起,美沙拉嗪组和岩藻多糖组灌胃给予剂量为10 mg/kg的相应药物,对照组和模型组给予相同体积的生理盐水,连续给药9 d。每日监测小鼠的一般情况如体质量变化、粪便状态;观察小鼠结肠组织病变情况;测定小鼠结肠组织中炎症因子分泌情况;对小鼠粪便样品进行16S rRNA高通量测序。与模型组相比,岩藻多糖能够有效缓解Uc小鼠症状,减轻结肠组织病理损伤(Pc小鼠肠道菌群的多样性及丰度提高,在门水平上,厚壁菌门/拟杆菌门的值降低;在属水平上,致病菌幽门螺杆菌的相对丰度降低,有益菌Muribaculaceae_unclassified、Alistipes和Alloprevotella相对丰度增加。岩藻多糖可有效缓解Uc小鼠病症,其可能通过恢复肠道菌群多样性及丰度,调节肠道菌群的组成,发挥对Uc的治疗作用。

关键词：岩藻多糖溃疡性结肠炎炎症因子 16S rRNA 肠道菌群

Seeing through a new lens: exploring the potential of city walking tour videos for urban analytics

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International Journal of Digital Earth 2023年第1期16卷 2555-2573页

作者： Maximilian c.Hartmann ross S.Purves Department of Geography University of ZurichZurichSwitzerland

city Walking Tour Videos(cWTVs)are a novel source of Volunteered Geographic Information providing street-level imagery through video sharing platforms such as *** demonstrate that these videos contain rich information for urban analytical applications,by conducting a mobility *** detect transport modes with a focus on active(pedestrians and cyclists)and motorised mobility(cars,motorcyclists and trucks).We chose the city of Paris as our area of interest given the rapid expansion of the bicycle network as a response to the covid-19 pandemic and compiled a video corpus encompassing more than 66 hours of video *** the detection of street names in the video and placename containing timestamps we extracted and georeferenced 1169 locations at which we summarise the detected transport *** results show high potential of cWTVs for studying urban mobility *** detected significant shifts in the mobility mix before and during the pandemic as well as weather effects on the volumes of pedestrians and *** with the observed increase in data availability over the years we suggest that cWTVs have considerable potential for other applications in the field of urban analytics.

关键词： Street-level imagery city walking tour videos transport modes mobility object detection geolocation

Fit to fight——from military hygiene to wellbeing in the British Army

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Military Medical Research 2020年第4期7卷 482-488页

作者： Martin c.M.Bricknell colonel David A.ross Health and Military Medicine Conflict and Health Research GroupSchool of Security StudiesKing’s College LondonStrand CampusLondon WC2R 2LSUK Parkes Professor of Preventive Medicine Robertson HouseCamberley GU154NAUK

This paper reviews the historical evolution of the language and organization surrounding the health of personnel in the British Army from‘hygiene’through to‘wellbeing’.It starts by considering the health of the army in the midnineteenth century and the emergence of military hygiene as a professional *** continues by looking at advances in military hygiene in the two world *** was replaced by the term‘health’in the 1950 s as the collective noun used by professionals working in this *** unity split when the professions of occupational medicine and public health established separate faculties and training ***,the health issues for the armed forces remain fundamentally *** forward,the term‘wellbeing’is helping to refresh the close relationships between executives,their medical advisers and those within the population of health professions charged with keeping the British Army *** core theme is the collaborations between civil society,executive leadership and medical services in maximizing the health of the military population from recruitment through to life as a veteran.

关键词： Public health Hygiene Occupational medicine

Pyogenic liver abscess:An audit of 10 years’experience

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World Journal of Gastroenterology 2011年第12期17卷 1622-1630页

作者： Tony cY Pang Thomas Fung Jaswinder Samra Thomas J Hugh ross c Smith Upper Gastrointestinal Surgical Unit Royal North Shore HospitalUniversity of SydneySt Leonards NSW 2065Australia

AIM:To describe our own experience with pyogenic liver abscesses over the past 10 years and investigate the risk factors associated with failure of initial percutaneous ***:A retrospective study of records of 63 PLA patients presenting between 1998 and 2008 to Australian tertiary referral centre,were *** and hydatid abscesses were ***,clinical,radiological,and microbiological characteristics,as well as surgical/radiological interventions,were ***:Sixty-three patients(42 males,21 females) aged 65(±14) years[mean±(SD) ]had prodromal symptoms for a median(interquartile range;IQR) of 7(5-14) *** 59%of patients were febrile at presentation;however,the serum c-reactive protein was elevated in all 47 in whom it was *** function tests were non-specifically abnormal.67%of patients had a solitary abscess,while 32%had>3 abscesses with a median(IQR) diameter of 6.3(4-9) *** organisms were:Streptococcus milleri 25%,Klebsiella pneumoniae 21%,and Escherichia coli 16%.A presumptive cryptogenic cause was most common (34%).Four patients died in this series:one from sepsis,two from advanced cancer,and one from acute myocardial *** initial procedure was radiological aspiration±drainage in 54 and surgery in two patients.17%underwent surgical management during their *** hypoalbuminaemia[mean (95%cI) :32(29-35) g/L vs 28(25-31) g/L,P=0.045] on presentation was found to be the only factor related to failure of initial percutaneous therapy on univariate ***:PLA is a diagnostic challenge,because the presentation of this condition is *** antibiotics and radiological drainage in the first instance allows resolution of most PLAs;However,a small proportion of patients still require surgical drainage.

关键词： Pyogenic liver abscess Image guided drainage Surgical drainage c-reactive protein Hypoalbuminaemia