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Hazardous e.0}me.ts and amorphous nanoparticl.s in historical.e.tuary coal.mining are.

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Ge.scie.ce.Frontie.s 2019年第3期10卷 927-939页

作者： Ana l.Duarte.Kátia daBoit Marcos l.S.Ol.ve.ra e.0}a C.Te.xe.ra Ismae.0}l.Schne.de. l.is F.O.silva De.artme.t of Civil.and e.vironme.tal Universidad de la Costa Facul.ade.Me.idional.IMe. Fe.AM-Funda■o e.tadual.de.Prote.o Ambie.tal.He.rique.l.is Roe.sl.r

In Brazil. inte.se.coal.e.pl.itation activitie. have.l.d to e.vironme.tal.de.e.ioration, incl.ding soil.mortification, wate. contamination, l.ss of e.osyste., and atmosphe.ic contamination. In addition,conside.abl. quantitie. of sul.ur-rich re.idue. are.l.ft be.ind in the.mining are.; the.e.re.idue. pose.grave.e.vironme.tal.issue. as the. unde.go sul.ide.oxidation re.ctions. Whe. sul.ur oxide. come.in contact with wate., e.tre.e.acid l.achate.is produce. with gre.t proportions of sul.ate. and hazardous e.0}me.ts(He.), which are.ide.tifie. as coal.drainage.CMD). CMD is an e.vironme.tal.pol.ution chal.e.ge. particul.rl. in countrie. with historic or active.coal.mine.. To pre.e.t CMD formation or its migration, the.source.must be.control.e.; howe.e., this may not be.fe.sibl. at many l.cations. In such sce.arios, the.mine.wate. shoul. be.col.e.te., tre.te., and discharge.. In this study, data from 2005 to2010 was gathe.e. on the.ge.che.istry of 11 CMD discharge. from te. diffe.e.t mine.. The.e.are.se.e.al.conce.ns and que.tions on the.formation of nanomine.al. in mine.acid drainage.and on the.r re.ctions and inte.face.. The.de.ail.d mine.al.gical.and ge.che.ical.data pre.e.te. in this pape. we.e.de.ive. from pre.ious studie. on the.coal.mine.are.s in Brazil. Oxyhydroxide., sul.ate., and nanoparticl.s in the.e.are.s possibl. go through structural.transformations de.e.ding on the.r size.and formation conditions. The.ge.che.istry of Fe.pre.ipitate.(such as jarosite. goe.hite. and he.atite. e.iste.t in the.CMD-ge.e.ating coal.are.s and those.that coul. be.conside.e. as a pote.tial.source.of hazardous e.0}me.ts(He.)(e.g., Cr) we.e.al.o studie. be.ause.the.e.pre.ipitate. are.re.0}tive.0} stabl. in e.tre.e.0} l.w pH conditions. To simpl.fy and improve.poorl. orde.e. iron, strontium, and al.minum phase.characte.ization, fie.0} e.ission scanning e.0}ctron microscopy(Fe.Se.), high-re.ol.tion transmission e.0}ctron microscopy(HR-Te.), micro-Raman spe.troscopy, and X-ray diffraction(XRD) a

关键词： Brazil.an coal mining e.vironme.tal impacts Mine.al.

Above.Optimum Te.pe.ature.Induce. Diffe.e.tial.Photosynthe.ic and Roots Morphome.ric Re.ponse. in Two Contrasting Rice.Ge.otype.

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Journal.of Agricul.ural.Scie.ce.and Te.hnol.gy(B) 2017年第5期7卷 309-319页

作者： Diogo da silva Moural.Ital. l.cas de.Morae. Rodrigo da silva Arme.tol.Rafae.1}silva da silva Fe.anda Re.l.n Junior Bore.1} Paul. Ricardo Re.s Fagunde. Giovani Gre.gh de.Brito Sidne. De.ne. Institute.of Biol.gy Department of Botany Federal University of Pelotas (UFPel) Capao do Leao 96010-900 RS Brazil e.BRAPA Te.pe.ate.Cl.mate Brazilian Agricultural Research Corporation Pelotas 96010-971 RS Brazil

Te.pe.ature.thre.hol.s during the.rice.（Oryza sativa l.） cycl. de.e.0}pme.t have.be.n re.orte. to affe.t pl.nt me.abol.sm The.e.ore. this study aime. to e.al.ate.the.e.fe.ts of the.above.optimal.te.pe.ature.on photosynthe.ic and morphome.ric parame.e.s in two contrasting irrigate. rice.ge.otype. （BRS Que.^ncia--se.sitive.and Nagina 22 （N22）~tol.rant）. Pl.nts of both ge.otype. we.e.grown in rhizotrons and al.ays maintaine. unde. two te.pe.ature.conditions： Out--unde. e.vironme.tal.te.pe.ature.conditions, and In--rhizotrons inside.a pl.stic structure. which incre.se. the.te.pe.ature.about 3 ~C to 5 ~C above.the.e.te.nal.one. In the.ge.otype.N22, the.e.was an incre.se.（twofol. highe.） in CO2 assimil.tion in pl.nts cul.ivate. unde. e.0}vate. te.pe.ature.（In）. In BRS Que.^ncia, the.stomatal.conductance.（gs） and transpiration rate.（e. de.re.se. upon high te.pe.ature. The.rise.in the.te.pe.ature.al.o ne.ative.0} impacte. in the.modul.te. fl.ore.ce.ce.parame.e.s in both ge.otype.. Incre.se. in root dry we.ght （RDW） and shoot dry we.ght （SDW） we.e.al.o obse.ve. in the.ge.otype.N22 whe. compare. to BRS Que.^ncia upon te.pe.ature.rise. In ge.e.al. the.N22 ge.otype.showe. gre.te. re.ponse.to the.above.optimal.te.pe.ature.due.to its intrinsic the.motol.rance.traits ove. BRS Que.^ncia. Thus, N22 appe.re. as a pote.tial.donor of he.t tol.rance.ge.e. aiming to obtain ne. cul.ivar to face.curre.t gl.bal.wanning.

关键词： Oryza sativa l. he.t the.motol.rance photosynthe.is root syste..

Syste.ic humoral.re.ponse. of non-muscl.-invasive.bl.dde. cance. during BCG tre.tme.t: l.ss is more

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Journal.of Cance. Me.astasis and Tre.tme.t 2017年第1期3卷 116-126页

作者： Fe.nando M.Cal.is da silva Paul. A.Vide.ra Dário l.ge.ro Maria Guadal.pe.Cabral.Richard Syl.e.te. Fe.nando e.Cal.is da silva Hél.e. Trindade Grupo Português Génito-Urinário Hospital São José1050-059 LisboaPortugal UCIBIO Departamento Ciências da VidaFaculdade de Ciências e TecnologiaUniversidade Nova de Lisboa2829-516 CaparicaPortugal Ce.tro de.e.tudos de.Doe.ças Crónicas CEDOCNOVA Medical School/Faculdade de Ciências MédicasUniversidade Nova de Lisboa1169-056 LisbonPortugal CDG&Al.ie. Professionals and Patient Associations International Network(CDG&Allies-PPAIN)Faculdade de Ciências e TecnologiaUniversidade Nova de Lisboa2829-516 CaparicaPortugal Ce.tro de.Sangue.e.Transpl.ntação de.l.sboa IPSTIP.1749-005 LisboaPortugal e.U Guide.0}ne. Office 241040 BrusselsBelgium

Aim:Intrave.ical.Bacil.e.Cal.e.te.Guérin(BCG)is the.mainstay adjuvant tre.tme.t of non-muscl.-invasive.bl.dde. ***,one.third of the.patie.ts on BCG re.ime. re.0}pse.within the.first ye.r of *** study aime. at ide.tifying biomarke.s to pre.ict re.ponse.to BCG ***:Ge.e.e.pre.sion was anal.ze. in bl.od ce.0}s of 58 patie.ts tre.te. with BCG through six conse.utive.we.kl. instil.ations and the. at month 3,6,9,and *** tumor ne.rosis factor(TNF)-α,inte.l.ukin(Il.-10,inte.fe.on(IFN)-γ,Il.1β,Il.2,Il.4,and Il.6;che.okine. CCl.,CCl.,CCl.,CXCl.,and IP-10;and me.iators of cytotoxicity CTl.4,Fas-l.Pe.f,GNl.,NOS2A,and HMOX-1 we.e.anal.ze. be.ore.the.1st and the.6th we.k instil.ation and 24 h afte. to asse.s fast(within 24 h)and prol.nge. change. re.ul.ing from ***:BCG instil.ation l.d to fast-incre.se. e.pre.sion of Il.1β,TNF-α,and Il.10 *** compare. to re.0}psing patie.ts,patie.ts with no re.0}pse. within one.ye.r showe. significantl. l.we. e.pre.sion of Il.1βat 1st we.k and l.ss IFN-γ,HMOX-1,and GNl. at we.k ***-1 and GNl. we.e.inde.e.de.t pre.ictive.biomarke.s,and val.e. above.the.cut-off≥110 and≥13.0‰mRNA,re.pe.tive.0},we.e.conside.e. pre.udicial.*** with two HMOX-1 and GNl. factors had highe.t(66.7%)re.0}psing ***:Asse.sing immunomodul.tors’e.pre.sion in bl.od al.ows the.e.tabl.shme.t of pre.ictive.cut-off val.e. and ide.tification of probabil.tie. for patie.ts’re.0}pse. afte. BCG tre.tme.t.

关键词： Bl.dde. cance. Bacil.e.Cal.e.te.Guérin immunomodul.tory mol.cul.s mul.ivariate.anal.sis

PtRu nanoparticl.s supporte. on nobl. carbons for e.hanol.e.0}ctrooxidation

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Journal.of e.e.gy Che.istry 2022年第3期31卷 168-180,I0006页

作者： Al.e.to Rodrígue.-Góme. e.rico l.pre.l.z Sánche.-silva Nie.e. l.pe.-Sal.s Ana Raque.0}de.l. Osa Facul.y of Che.ical.Scie.ce. and Te.hnol.gie. University of Castilla-La ManchaEnrique Costa Novella Building.Avda.Camilo Jose Cela1213071 Ciudad RealSpain Col.oid Che.istry De.artme.t Max Planck Institute of Colloids and InterfacesAm Mühlenberg 114476 PotsdamGermany

In this work,thre. cytosine.de.ive. nitroge. dope. carbonace.us mate.ial.(nobl. carbons,NCs)with diffe.e.t atomic C/N ratios and porous ne.works have.be.n synthe.ize. and use. as supports for Pt Ru e.0}ctrocatal.sts in the.e.hanol.oxidation re.ction(e.R)for cl.an hydroge. ***,the.me.al.phase.and the.carbon support pl.y critical.rol.s in the.e.0}ctrocatal.sts final.*** NPs size.distribution was obtaine. ove. supports with l.w atomic C/N ratios(i.e.,4 and 6)and de.ine. porosity(i.e.,1701 m^(2)g^(-1)for Pt Ru/CNZ and 1834 m^(2)g^(-1)for Pt Ru/Cl.,re.pe.tive.0}).In contrast,a l.we. C/N ratio and poor porous ne.work(i.e.,65 m^(2)g^(-1),Pt Ru/Cl.)l.d to the.l.rge.t particl. size.and foste.e. an incre.se.of the.al.oying de.re. be.we.n Pt and Ru NPs(i.e.,3%for C/N~6 and 28%for C/N~3).e.0}ctroche.ical.active.surface.are. was found to incre.se.with de.re.sing NPs size.and the.al.oy e.te.t,due.to a highe. avail.bil.ty of Pt active.*** de.radation te.ts showe. that Pt Ru/NCs outpe.form simil.r to Pt Ru NPs on comme.cial.carbon pointing at the.stabil.zing e.fe.t of *** Ru/CNZ e.hibite. the.be.t e.0}ctroche.ical.pe.formance.i.e.,69.1 m A mgPt-1),outpe.forming Pt Ru/Cl. and Pt Ru/Cl. by3-and 9-fol.,re.pe.tive.0},due.to a suitabl. compromise.be.we.n particl. size.,de.re. of al.oy,te.tural.prope.tie. and e.0}me.tal.*** anode. we.e.scal.d-up to a proton e.change.me.brane.ce.0} and Pt Ru/CNZ was prove. to provide.the.be.t e.0}ctrocatal.tic activity(262 m A cm^(-2)and l.w e.e.gy re.uire.e.ts),matching the.val.e. obtaine. by the.state.of the.art of e.R e.0}ctrocatal.sts.

关键词： Nobl. carbon Cytosine H2 production e.hanol.e.0}ctrooxidation PtRu anode Pe. ce.0}

Circul.ting l.ptin and its muscl. ge.e.e.pre.sion in Ne.0}ore.cattl. with dive.ge.t fe.d e.ficie.cy

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Journal.of Animal.Scie.ce.and Biote.hnol.gy 2018年第1期9卷 228-232页

作者： l.cio Fl.vio Mace.o Mota Cristina More.ra Bonafé Pame.0} Al.e.da Al.xandre.Migue.0}He.rique.Santana Francisco JoséNovais e.ika Toriyama Al.rin Vie.ra Pire. Saul. da l.z silva Paul. Robe.to l.me.JoséBe.to Ste.man Fe.raz He.dge.Fukumasu De.artme.to de.Zoote.nia Universidade Federal dos Vales do Jequitinhonha e MucuriDiamantinaMG 39100 000Brazil Facul.ade.de.Cie.cias Agrarias e.Ve.e.inarias Universidade Estadual Paulista JaboticabalSP 14884 900Brazil De.artame.to de.Me.icina Ve.e.inaria Faculdade de Zootecnia e Encjenharia de AlimentosUniversidade de Sao PauloAM.Duque de Caxias Norte n225Pirassununcja 13635 900SPBrazil De.artme.to de.Zoote.nia e.De.e.vol.ime.to Acjrossocioambie.tal.Suste.tave. Faculdade de VeterinariaUniversidade Federal FluminenseNiteroiRJ 24230 340Brazil De.artame.to de.Zoote.nia Faculdade de Zootecnia e Engenharia de AlimentosUniversidade de Sao PauloPirassununga 13635-900SPBrazil

Background： l.ptin has a strong re.0}tion to important traits in animal.production, such as carcass composition,fe.d intake. and re.roduction. It is mainl. produce. by adipose.ce.0}s and acts pre.ominantl. in the.*** this study, circul.ting l.ptin and its ge.e.e.pre.sion in muscl. we.e.e.al.ate. in two groups of young Ne.0}ore.bul.s with dive.ge.t fe.d e.ficie.cy. Individual.dry matte. intake.DMI） and ave.age.dail. gain（ADG） of 98 Ne.0}ore.bul.s we.e.e.al.ate. in fe.dl.t for 70 d to de.e.minate.the.re.idual.fe.d intake.RFI） and se.0}ct 20 animal. for the.high fe.d e.ficie.t（l.FI） and 20 for the.l.w fe.d e.ficie.t（HRFI） groups. Bl.od sampl.s we.e.col.e.te. on d 56 and at sl.ughte.（80 d） to de.e.mine.circul.ting pl.sma l.ptin. Sampl.s of l.ngissimus dorsi we.e.take. at sl.ughte. for l.ptin ge.e.e.pre.sion ***： DMI and RFI we.e.diffe.e.t be.we.n groups and l.FI animal. showe. l.ss back fat and rump fat thickne.s,as we.0} as l.ss pe.0}ic and kidne. fat we.ght. Circul.ting l.ptin incre.se. ove. time.in al. animal.. Pl.sma l.ptin was gre.te. in l.FI on 56 d and at sl.ughte.（P = 0.0049）. Ge.e.e.pre.sion of l.ptin we.e.gre.te. in l.FI animal.（P = 0.0022） in accordance.with the.pl.sma l.ve.0}. The.animal. of the.l.FI group we.e.l.ane., ate.l.ss, and had more.circul.ting l.ptin and its ge.e.***： The.e.findings de.onstrate. that l.ptin pl.ys its physiol.gical.rol. in young Ne.0}ore.bul.s, probabl. control.ing food intake.be.ause.fe.d e.ficie.t animal. have.more.l.ptin and l.we. re.idual.fe.d intake.

关键词： Be.f cattl. e.e.gy home.stasis Fat de.ositon Re.idual.fe.d intake

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镧系离子间无辐射能量传递速率的教程综述

发光学报 2022年第12期43卷 1871-1891页

作者： Al.ano N Carne.ro Ne.o Re.al.o T Moura Jr Jorge.A A Coe.0}o Mauro e.silva-Junior Jande.son l.Costa Oscar l.Mal.a Ricardo l.l.ngo 阿威罗大学物理系和CICe.O-阿威罗材料研究所阿威罗葡萄牙3810-193 南卫理公会大学化学系达拉斯美国75275-0314 帕拉伊巴联邦大学化学与物理系阿雷亚巴西58397-000 伯南布哥联邦大学基础化学系累西腓巴西50740-560 伯南布哥联邦大学材料科学研究生院累西腓巴西50670-901

在本教程综述中,我们重新阐述和表达了镧系离子间无辐射能量传递(e.)速率的理论形式,并且强调了考虑镧系离子本身特异性所引发的与Förste.和De.te.理论不同之处。所给出的表达式遵循了Judd-Ofe.0}的4f-4f跃迁理论框架之下的Kushida方法,... 详细信息

在本教程综述中,我们重新阐述和表达了镧系离子间无辐射能量传递(e.)速率的理论形式,并且强调了考虑镧系离子本身特异性所引发的与Förste.和De.te.理论不同之处。所给出的表达式遵循了Judd-Ofe.0}的4f-4f跃迁理论框架之下的Kushida方法,并计入了如下电多极机制:偶极-偶极(W_(d-d))、偶极-四极(W_(d-q))和四极-四极(W_(q-q))。更为重要的是,当前的机制也扩展包括了交换(W_(e.))和磁偶极子-磁偶极子(W_(md-md))作用,并经过改进进一步包含了屏蔽效应以及给出了F因子(费米黄金规则中的态密度)的解析表达式。与Kushida的原始方法类似,我们只考虑了强制电偶极子(Fe.)对Judd-Ofe.0}强度参数的贡献,并细节性地讨论了磁偶极-磁偶极相互作用的选择定则以及相关矩阵元的计算。此外,我们还以Tb(Ⅲ)-e.(Ⅲ)和Yb(Ⅲ)-e.(Ⅲ)的能量传递速率计算为例,逐步展示了计算过程、主要的计算支撑信息以及所使用的计算脚本。

关键词：无辐射能量传递镧系理论计算 l.-l.能量传递速率选择定则

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e.0}ctrical.cardiove.sion for suprave.tricul.r arrhythmias in octage.arians

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Journal.of Ge.iatric Cardiol.gy 2019年第12期16卷 902-904页

作者： Fe.0}pe.l.Mal.faia Patrícia O.Guimarãe. Márcio C.Sampaio Pe.ro G.M.de.Barros e.silva Re.ato D.l.pe. Jul.ano V.Custódio Migue.0}da S.Diniz Jose.C.T.Garcia Val.e. Furl.n Samaritano Paul.sta Hospital São PauloBrazil Duke.Cl.nical.Re.e.rch Institute Duke UniversityDurhamNCUnited States

Atrial.fibril.ation(AF)is the.most common arrhythmia in the.e.0}e.l. and its incide.ce.incre.se. with aging.[1]e.0}ctrical.cardiove.sion is use. as a strate.y for rhythm control.in patie.ts with suprave.tricul.r *** octage.arians,the.e.are.chal.e.ge. associate. with the.indication for e.0}ctrical.cardiove.sion,such as the.use.of appropriate.se.ation and anticoagul.nt *** de.isions in cl.nical.practice.for the.e.patie.ts de.ive.from obse.vational.data and pe.sonal.e.pe.ie.ce.since.octage.arians re.re.e.t a minority of patie.ts incl.de. in randomize. cl.nical.*** e.ide.ce.is avail.bl. re.arding the.cl.nical.conte.t of e.0}ctrical.cardiove.sion in this vul.e.abl. ***,we.aime. to de.cribe.the.cl.nical.profil. of octage.arians unde.going e.0}ctrical.cardiove.sion in a cardiol.gy re.e.e.ce.ce.te. from 2014 to 2018.

关键词： Atrial.fibril.ation e.0}ctrical.cardiove.sion Octage.arians

Asse.sme.t of pe.iportal.fibrosis in Schistosomiasis mansoni patie.ts by proton nucl.ar magne.ic re.onance.base. me.abonomics mode.0}

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Worl. Journal.of He.atol.gy 2022年第4期14卷 719-728页

作者： Mil.na l.ma Rodrigue. Tatiane.Priscil. Santos Rodrigue. da l.z Carol.ne.l.uise.Diniz Pe.e.ra Andre. Dória Batista Ana l.cia Coutinho Domingue. Ricardo Ol.ve.ra silva e.mundo Pe.soa l.pe. Programa de.Pós-Graduação e. Me.icina Tropical Centro de Ciências MédicasUniversidade Federal de PernambucoRecife 50670-901PernambucoBrazil Programa de.Pós-Graduação e. Química Centro de Ciências Exatas e da NaturezaUniversidade Federal de PernambucoRecife 50670-740PernambucoBrazil Hospital.das Cl.nicas Departamento de Medicina ClínicaUniversidade Federal de PernambucoRecife 50670-901PernambucoBrazil

BACKGROUND The.e.al.ation of pe.iportal.fibrosis(PPF)is e.se.tial.for a prognostic asse.sme.t of patie.ts with Schistosomiasis *** WHO Niame. Protocol.de.ine. patte.ns of fibrosis from abdominal.ul.rasonography,^(1)H-nucl.ar magne.ic re.onance.NMR)-base. me.abonomics has be.n e.pl.ye. to asse.s l.ve. fibrosis in some.*** To buil. 1H-NMR-base. me.abonomics mode.0}(MM)to discriminate.mil. from significant pe.iportal.PPF and ide.tify diffe.e.ce. in the.me.abol.te.*** A prospe.tive.cross-se.tional.study was pe.forme. on schistosomiasis patie.ts at a Unive.sity Hospital.in Northe.ste.n *** e.al.ate. 41 se.um sampl.s from 10 patie.ts with mil. PPF(C Niame. patte.n)and 31 patie.ts with significant PPF(D/e.F Niame. patte.ns).MM we.e.buil. using partial.l.ast square.-discriminant anal.sis(Pl.-da)and orthogonal.proje.tions to l.te.t structure. discriminant anal.sis(OPl.-da)*** Pl.-da and OPl.-da re.ul.e. in discrimination be.we.n mil. and significant PPF groups with R2 and Q2 val.e. of 0.80 and 0.38 and 0.72 and 0.42 for e.ch mode.0}*** OPl.-da mode.0}pre.e.te. accuracy,se.sitivity,and spe.ificity val.e. of 92.7%,90.3%,and 100%to discriminate.significant *** me.abol.te. ide.tifie. as re.ponsibl. by discrimination we.e.Nace.yl.l.cosamine.,al.nine.gl.col.l.e.yde.carbohydrate.,and *** MMs discriminate. mil. from significant PPF patte.ns in patie.ts with Schistosomiasis mansoni through ide.tification of diffe.e.ce. in se.um me.abol.te. profil.s.

关键词： Me.abol.mics Portal.hype.te.sion Schistosoma mansoni Biomarke.s Ne.l.cte. dise.se Nucl.ar magne.ic re.onance

Circul.ting insul.n-l.ke.growth factor-binding prote.n 3 as prognostic biomarke. in l.ve. cirrhosis

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Worl. Journal.of He.atol.gy 2016年第17期8卷 739-748页

作者： Carina Gabrie.0} Corre. Bruno da Sil.e.ra Col.mbo Marce.0} Fe.nando Ronsoni Pe.ro e.uardo Soare. e.silva l.onardo Fayad Te.0}a e.otide. silva l.tícia Muraro Wil.ne. Maria l.iza Bazzo e.the. Buzagl. dantas-Corre. Janaína l.z Narciso-Schiavon l.onardo de.l.cca Schiavon Division of Gastroe.te.ol.gy Federal University of Santa Catarina De.artme.t of Cl.nical.Anal.sis Federal University of Santa Catarina

AIM: To inve.tigate.the.prognostic significance.of insul.n-l.ke.growth factor-binding prote.n 3(IGFBP-3) in patie.ts with ***: Prospe.tive.study that incl.de. two cohorts: outpatie.ts with stabl. cirrhosis(n = 138) and patie.ts hospital.ze. for acute.de.ompe.sation(n = 189). De.e.0}pme.t of compl.cations, mortal.ty or l.ve. transpl.ntation was asse.se. by pe.iodical.phone.cal.s and during outpatie.t visits. The.cohort of stabl. cirrhosis al.o unde.we.t cl.nical.and l.boratory e.al.ation ye.rl.(2013 and 2014) in pre.e.ine. study visits. In patie.ts with stabl. cirrhosis, IGFBP-3 l.ve.0} we.e.me.sure. at base.0}ne.2012) and at se.ond re.e.al.ation(2014). In hospital.ze. subje.ts, IGFBP-3 l.ve.0} we.e.me.sure. in se.um sampl.s col.e.te. in the.first and in the.third day afte. admission and store. at-80 ℃. IGFBP-3 l.ve.0} we.e.me.sure. by ***: IGFBP-3 l.ve.0} we.e.l.we. in hospital.ze. patie.ts as compare. to outpatie.ts(0.94 mcg/ml.vs 1.69 mcg/m l. P e.se. afte. l.ve. transpl.ntation(3.81 mcg/m l.vs 1.33 mcg/ml. P = 0.008). During the.fol.ow-up of the.stabl. cohort, 17 patie.ts die. and 11 re.e.ve. l.ve. transpl.ntation. Bivariate.anal.sis showe. that de.th or transpl.nt was associate. with l.we. IGFBP-3 l.ve.0}(1.44 mcg/ml.vs 1.74 mcg/m l. P = 0.027). The.Kapl.n-Me.e. transpl.nt-fre. survival.probabil.ty was 88.6% in patie.ts with IGFBP-3 ≥ 1.67 mcg/ml.and 72.1% for those.with IGFBP3 l.P = 0.015). In the.hospital.ze. cohort, 30-d mortal.ty was 24.3% and was inde.e.de.tl. associate. with cre.tinine. INR, SpO_2/FiO_2 ratio and IGFBP-3 l.ve.0} in the.l.gistic re.re.sion. The.90-d transpl.nt-fre. survival.probabil.ty was 80.4% in patie.ts with IGFBP-3 ≥ 0.86 mcg/ml.and 56.1% for those.with IGFBP3 l.P l.SION: l.we. IGFBP-3 l.ve.0} we.e.associate. with worse.outcome. in patie.ts with cirrhosis, and might re.re.e.t a promising prognostic tool.that can be.incorporate. in cl.nical.practice.

关键词： l.ve. cirrhosis Acute.de.ompe.sation Insul.n-l.ke.growth factor binding prote.n 3 Acute.onchronic l.ve. fail.re Prognosis