Synthesis and Biological Evaluation of a Highly Constrained Analogue of Methylthioadenosine (MTA)

作     者：Gustavo Senra G. de Carvalho Rafael Mafra de P. Dias Jean-Louis Fourrey Vania L. Silva Cláudio G. Diniz Adilson D. da Silva 

作者机构：Departamento de Parasitologia Microbiologia e Imunologia Instituto de Ciências Biológicas (ICB) Universidade Federal de Juiz de Fora Juiz de Fora-MG Brasil Departamento de Química Instituto de Ciências Exatas (ICE) Universidade Federal de Juiz de Fora Juiz de Fora-MG Brasil Institut de Chimie des Substances Naturelles Gif-sur-Yvette Cedex France 

出 版 物：《International Journal of Organic Chemistry》 (有机化学国际期刊（英文）)

年 卷 期：2012年第2卷第4期

页      面：398-403页

学科分类：07[理学] 0703[理学-化学] 

主　　题：Synthesis Biological Evaluation Antibacterial Analogue Methylthioadenosine 

摘      要：We describe the synthesis and the antibacterial evaluation 2’,N3-cyclonucleoside 3 analogue of MTA that is characterized by the presence of an additional linkage between the heterocyclic ring and the sugar moiety.