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Dietary fatty acids and adipose tissue inflammation at the crossroad between obesity and colorectal cancer

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Journal of Cancer Metastasis and Treatment 2019年第8期4卷 29-40页

作者： Lucia Conti Manuela Del Cornò Beatrice Scazzocchio rosaria varì Massimo D'Archivio Barbara varano Roberta Masella Sandra Gessani Center for Gender-specific Medicine Istituto Superiore di Sanità 00161 Rome Italy

Excess adiposity, a worldwide-growing pathological condition, is now recognized as a main risk factor for most chronic diseases including colorectal cancer (CRC). Obese subjects show an increased cancer incidence with obesity representing an important indicator of survival, prognosis, recurrence and response to therapy. A low-grade chronic inflammation of metabolically active tissues including the adipose tissue (AT), defined as meta-inflammation, is a main feature of obesity. Fatty acids (FA), the main AT components, are important modulators of inflammation, and the type of FA stored in AT critically affects tissue functions. Their profile within AT mirrors FA dietary intake but also depends on a metabolic control. Obesity, changes in the habitual diet, weight loss or pathological conditions like CRC influence FA profile of AT pointing to these molecules as important actors in AT dysfunction and meta-inflammation, that characterize metabolic diseases and may favor cancer development. Worth of note, diet is receiving growing attention as a main determinant in cancer prevention due to its capacity to modulate immune response and inflammation. Alterations in the balance between different families of FA may contribute to generate a pro-inflammatory profile with deleterious effects on metabolic and immune homeostasis at both local and systemic levels. This review focuses on FA as regulators of human AT inflammation discussing the role of obesity-, diet-, and weight loss-associated changes in FA profile in this process. The relevance of FA composition of AT in linking diet, obesity and CRC will be also reviewed.

关键词： Obesity adipose tissue inflammation diet weight loss fatty acids colorectal cancer

Heterogeneous catalysis under flow for the 21st century fine chemical industry

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Green Energy & Environment 2021年第2期6卷 161-166页

作者： rosaria Ciriminna Mario Pagliaro Rafael Luque Istituto per Io Studio dei Mate riali Nanostnuturati CNRwia U.La Malfa 15390146PulemoItaly Deparamento de Quimica Orginica Univeridad de CordobaCampus de RabonalesEdificio Marie Curie(C-3)Cra Nnal IV-Akm 396Cordoba14014Spain Peoples Friendship University of Russia(RUDN Universiy) 6 Miklukho Maklaya St117198MoscowRussia

Due to metal leaching and poor catalyst stability, the chemical industry's fine chemical and pharmaceutical sectors have been historically reluctant to use supported transition metal catalysts to manufacture fine chemicals and active pharmaceutical ingredients. With the advent of new generation supported metal catalysts and flow chemistry, we argue in this study, this situation is poised to quickly change. Alongside heterogenized metal nanoparticles, both single-site molecular and single-atom catalyst will become ubiquitous. This study offers a critical outlook taking into account both technical and economic aspects.

关键词： Fine chemical Heterogeneous catalysis Single atom catalysis Green chemistry Chemical industry

Convex Analysis and Duality over Discrete Domains

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Journal of the Operations Research Society of China 2018年第2期6卷 189-247页

作者： Murat Adıvar Shu-Cherng Fang Department of Management Marketing and EntrepreneurshipFayetteville State UniversityFayettevilleNC 28301USA Industrial and Systems Engineering College of EngineeringNorth Carolina State UniversityRaleighNC 27695-7906USA

The aim of this paper is to establish a fundamental theory of convex analysis for the sets and functions over a discrete *** introducing conjugate/biconjugate functions and a discrete duality notion for the cones over discrete domains,we study duals of optimization problems whose decision parameters are *** particular,we construct duality theory for integer linear programming,provide a discrete version of Slater’s condition that implies the strong duality and discuss the relationship between integrality and discrete convexity.

关键词： Discrete convex analysis Discrete Lagrangian duality Discrete Slater’s condition Discrete strong duality Integer programming Integrality

Groups with Cyclic Outer Automizers

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Algebra Colloquium 2014年第3期21卷 381-398页

作者： Maria rosaria Celentani Giovanni Cutolo Antonella Leone Dipartimento di Matematica e Applieazioni 'R .Caccioppoli' Universita degli Studi di Napoli 'Federico II' Via Cintia Monte S. Angelo 1-80126 Napoli Italy

We consider groups G such that NG（H）/HCG（H） is cyclic for all H ≤ G. More specifically, we characterise locally nilpotent and supersoluble groups with this property.

关键词： automizers locally nilpotent supersoluble soluble groups

Size contrast of Pt nanoparticles formed on neighboring domains within suspended and supported graphene

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Nano Research 2018年第3期11卷 1589-1598页

作者： Dario Roccella Matteo Amati Hikmet Sezen rosaria Brescia Luca Gregoratti Universita degli Studi di Genova - Facolta di Scienze Matematiche Fisiche e Naturali Viale Benedetto XV Genova 3-16132 Italy Elettra - Sincrotrone Trieste S.C.p.A. in Area Science Park SS 14-Km 163.5 Trieste 34149 Italy Electron Microscopy Facility Istituto Italiano di Tecnologia (liT) via Morego 30 Genova 16163 Italy

The relatively small size of thin （one or few layers） graphene flakes makes it extremely difficult to study the behavior of suspended graphene by characterization techniques other than the electron microscopies. Herein, we exploited the capability of spatially resolved photoemission in combination with high resolution transmission electron microscopy to investigate the interaction of thermally evaporated Pt atoms on suspended and supported graphene. Spectroscopic and microscopic analyses reveal that the nucleation of nanometer- sized Pt particles in these two regions exhibit different trends. While only small nanometer-sized islands are present on the supported graphene, relatively larger clusters of islands were also found on the suspended flakes. The X-ray photoemission C ls core levels acquired after the Pt deposition show an increase in the number of vacancies in the graphene sheets.

关键词： graphene X-ray photoemissionspectroscopy scanning photoelectron microscop nanoparticles platinum suspended films

High Responsivity and Ultra-Low Detection Limits in Nonlinear a-Si:H p-i-n Photodiodes Enabled by Photogating

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Photonic Sensors 2023年第4期13卷 27-38页

作者： Andreas BABLICH Maurice MÜLLER Rainer BORNEMANN Andreas NACHTIGAL Peter HARING BOLÍvar Institute of Graphene-Based Nanotechnology University of SiegenHölderlinstr.357076 SiegenGermany Institute of High Frequency and Quantum Electronics University of SiegenHölderlinstr.357076 SiegenGermany

Photodetectors operating at the wavelength in the visible spectrum are key components in high-performance optoelectronic *** this work,massive nonlinearities in amorphous silicon p-i-n photodiodes enabled by the photogating are presented,resulting in responsivities up to 744 mA/W at blue *** detectors exhibit significant responsivity gains at optical modulation frequencies exceeding MHz and a more than 60-fold enhanced spectral response compared to the non-gated *** detection limits down to 10.4 nW/mm^(2) and mean signal-to-noise ratio enhancements of 8.5dB are demonstrated by illuminating the sensor with an additional 6.6μW/mm^(2) red ***-optical simulations verify photocarrier modulation due to defect-induced field screening to be the origin of such high responsivity *** experimental results validate the theory and enable the development of commercially viable and complementary metal oxide semiconductor(CMOS)compatible high responsivity photodetectors operating in the visible range for low-light level imaging and detection.

关键词： Photogating amorphous silicon a-Si:H nonlinearity photodetector responsivity gain

Ferrofluid measurements of bottom velocities and shear stresses

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Journal of Hydrodynamics 2015年第1期27卷 150-158页

作者： MUSUMECI rosaria E. MARLETTA Vincenzo ANDò Bruno BAGLIO Salvatore FOTI Enrico Department of Civil Engineering and Architecture University of Catania Department of Electric Electronic and Computer Science Engineering University of Catania

A novel direct measurement strategy of bottom velocities and shear stresses based on the use of ferrofluids is presented. Such a strategy overcomes some of the limits of state-of-the-art instruments. A preliminary experimental campaign has been carried out in the presence of currents in steady flow conditions in order to test the effects of ferrofluid quantity and of the controlling permanent magnetic force. An alternating current （AC） circuit and a direct current （DC） conditioning circuit have been tested. For velocities larger than 0.05 m/s, the near-bottom velocity-output voltage calibration curve has a monotone parabolic shape. The sensitivity of the instrument is increased by a factor of 30 when the DC circuit is used.

关键词： magnetofluids Rosensweig effect flow resistances bed shear stresses bottom velocities

The Recent Uses of Sol-Gel Doped Catalysts in Fine Chemistry

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复旦学报（自然科学版） 2005年第5期44卷 760-761页

作者： Mario Pagliaro rosaria Ciriminna Istituto per lo Studio dei Materiali Nanostrutturati CNR via Ugo La Malfa 153 90146 Palermo ItalyIstituto per lo Studio dei Materiali Nanostrutturati CNR via Ugo La Malfa 153 90146 Palermo Italy

A variety of sol-gel entrapped catalysts is available on the chemical market due to the unique advantages offered by these highly porous oxides doped with transition metal catalyst, enzymes or even living cells[1].Catalytic sol-gel lipase immobilizates were rapidly commercialized by Fluka after their invention by Reetz and coworkers in 1995 and have now reached a 2nd generation level of performance[2]. Besides esterification reactions these materials are also excellent catalysts in the kinetic resolution of chiral alcohols and amines, and are recyclable without any substantial loss in enantioselectivity (residual activity of 70% even after 20 reaction cycles).

关键词：溶胶凝胶体生物催化处理 CACHy 催化剂脂肪酶

Neurological diseases associated with autoantibodies targeting the voltage-gated potassium channel complex:immunobiology and clinical characteristics

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Neuroimmunology and Neuroinflammation 2016年第1期3卷 69-78页

作者： Domenico Plantone rosaria Renna Tatiana Koudriavtseva Multiple Sclerosis Center Unit of NeurologyRegina Elena National Cancer Institute00144 RomeItaly

Voltage-gated potassium channels(VGKCs)represent a group of tetrameric signaling proteins with several functions,including modulation of neuronal excitability and neurotransmitter ***,VGKCs give a key contribution to the generation of the action *** are complexed with other neuronal proteins,and it is now widely known that serum autoantibodies directed against VGKCs are actually directed against the potassium channel subunits only in a minority of *** contrast,these autoantibodies more commonly target three proteins that are complexed with alpha-dendrotoxin-labeled potassium channels in brain *** three proteins are contactin-associated protein-2(Caspr-2),leucine-rich,glioma inactivated 1(LGI-1)protein and the protein Tag-1/*** are detected only in a minority of seropositive patients for VGKC complex-IgG and do not significantly associate with Caspr-2 or *** all the cancers described in association with VGKC complex-IgG,lung carcinoma,thymoma,and hematologic malignancies are the most commonly *** will review all the major neurological conditions associated with VGKC *** include Isaacs’syndrome,Morvan syndrome,limbic encephalitis,facio-brachial dystonic seizures,chorea and other movement disorders,epilepsy,psychosis,gastrointestinal neuromuscular diseases,a subacute encephalopathy that mimics Creutzfeldt-Jakob prion disease both clinically and radiologically and autoimmune chronic *** vast majority of these conditions are reversible by immunotherapy,and it is becoming increasingly recognized that early diagnosis and detection of VGKC complex-IgG is critical in order to rapidly start the *** a result,VGKC complex-IgG are now part of the investigation of patients with unexplained subacute onset of epilepsy,memory or cognitive problems,or peripheral nerve hyperexcitability syndromes.

关键词： Chronic pain,epilepsy facio-brachial dystonic seizures leucine-rich glioma inactivated 1 protein limbic encephalitis movement disorders neuromyotonia voltage-gated potassium channels