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Concerns about the application of resistance exercise with blood-flow restriction and thrombosis risk in hemodialysis patients

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Journal of Sport and Health Science 2024年第4期13卷 548-558,F0003页

作者： Hugo de Luca Correa Lysleine Alves Deus Dahan da Cunha Nascimento Nicholas Rolnick Rodrigo Vanerson Passos Neves Andrea Lucena Reis Thais Branquinho de Araujo Carmen Tzanno-Martins Fernanda Silveira Tavares Luiz Sinesio Silva Neto Claudio Avelino Rodrigues Santos Paolo Lucas Rodrigues-Silva Fernando Honorato Souza Vitoria Marra da Motta Vilalva Mestrinho Rafael Lavarini dos Santos rosangela vieira andrade Jonato Prestes Thiago dos Santos Rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Performance Mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home Dialysis Center and RenalClass Sao Paulo 01239-040Brazil Department of Medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Background:Hemodialysis(HD) per se is a risk factor for *** the growing body of evidence on blood-flow restriction(BFR) exercise in HD patients,identification of possible risk factors related to the prothrombotic agent D-dimer is required for the safety and feasibility of this training *** aim of the present study was to identify risk factors associated with higher D-dimer levels and to determine the acute effect of resistance exercise(RE) with BFR on this ***:Two hundred and six HD patients volunteered for this study(all with a glomerular filtration rate of 70 years old),and HD ***,RE+BFR significantly increases D-dimer after 4 *** with borderline baseline D-dimer levels(400-490 ng/mL) displayed increased risk of elevating D-dimer over the normal range(≥500 ng/mL).Conclusion:These results identified factors associated with a heightened prothrombotic state and may assist in the screening process for HD patients who wish to undergo RE+BFR.D-dimer and/or other fibrinolysis factors should be assessed at baseline and throughout the protocol as a precautionary measure to maximize safety during RE+BFR.

关键词： Blood-flow restriction Chronic kidney disease Coagulation Hemodialysis Vascular occlusion exercises

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Response to Commentary by Dr. Matthew J. Clarkson on

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Journal of Sport and Health Science 2024年第5期13卷 670-671页

作者： Hugo de Luca Corrêa Lysleine Alves Deus Dahan da Cunha Nascimento Nicholas Rolnick Rodrigo Vanerson Passos Neves Andrea Lucena Reis Thais Branquinho de Araújo Carmen Tzanno-Martins Fernanda Silveira Tavares Luiz Sinésio Silva Neto Cláudio Avelino Rodrigues Santos Paolo Lucas Rodrigues-Silva Fernando Honorato Souza Vitória Marra da Motta Vilalva Mestrinho Rafael Lavarini dos Santos rosangela vieira andrade Jonato Prestes Thiago dos Santos Rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Performance Mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home Dialysis Center and RenalClass Sao Paulo 01239-040Brazil Department of Medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil g Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Dear editor:We sincerely thank Matthew *** for his insightful commentary1 on our recent publication in the Journal of Sport and Health Science.2 Clarkson's pioneering work in the development and application of blood flow restriction (BFR) exercise protocols has undeniably laid the groundwork for subsequent investigations in this field,including our own.(3-6)His commentary not only highlights the relevance and timeliness of our study but also offers valuable perspectives on refining safety considerations for intradialytic BFR exercise among hemodialysis patients.

关键词： patients application flow

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A comparative analysis of three different methods for the estimation of the basic reproduction number of dengue

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Infectious Disease Modelling 2016年第1期1卷 88-100页

作者： rosangela Peregrina Sanches Eduardo Massad School of Medicine University of Sao PauloSao PauloSPBrazil London School of Hygiene and Tropical Diseases UK

The basic reproduction number,R0,is defined as the expected number of secondary cases of a disease produced by a single infection in a completely susceptible population,and can be estimated in several *** example,from the stability analysis of a compartmental model;through the use of the matrix of next generation,or from the final size of an epidemic,*** this paper we applied the method for estimating R0 of dengue fever from the initial growth phase of an outbreak,without assuming exponential growth of cases,a common assumption in many *** used three different methods of calculating R0 to compare the techniques'details and to evaluate how these techniques estimate the value of R0 of dengue using data from the city of Ribeir^ao Preto(SE of Brazil)in two *** results of the three methods are numerically different but,when we compare them using a system of differential equations developed for modeling only the first generation time,we can observe that the methods differ little in the initial growth *** conclude that the methods predict that dengue will spread in the city studied and the analysis of the data shows that the estimated values of R0 have an equal pattern overtime.

关键词： Basic reproduction number Dengue Mathematical models Likelihood-based model

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Optimizing the solar energy capture of residential roof design in the southern hemisphere through Evolutionary Algorithm

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能源与人工环境(英文) 2021年第4期2卷 406-424页

作者： Saleh Kaji Esfahani Ali Karrech Robert Cameron Mohamed Elchalakani rosangela Tenorio Fernando Jerez The Faculty of Arts BusinessLaw and EducationSchool of DesignUniversity of Western Australia6009 PerthWestern AustraliaAustralia Faculty of Engineering and Mathematical Sciences School of EngineeringUniversity of Western Australia6009 PerthWestern AustraliaAustralia The Australian Urban Design Research Centre University of Western Australia6000 PerthWestern AustraliaAustralia

Australia’s national energy system is heavily reliant on coal-fired power plants and requires quick action to de-crease CO_(2)emissions in order to meet the Paris climate change agreement by *** a good alternative to coal power,renewable resources can produce the required energy for Australia while keeping the environment *** annual amount of falling solar irradiation in Australia is a few thousand times higher than its energy consumption,but the amount of the collected solar energy is *** Perth,the sunniest city in Aus-tralia,one-third of the residential dwellings have roof-mounted solar collector ***,there have been limited studies into the integration of these systems in building design and it is still unknown which roof design can deliver maximum efficiency based on the local environmental ***,the aims of this study are to determine the optimum residential roof design in Perth,Western Australia and to maximise extracted solar power throughout a *** reach this aim,a combination of analytical modelling,numerical simulation,and evolutionary algorithm methods have been *** first,a series of detailed mathematical calculations were performed in Excel to find the optimum solar collector mounting *** the numerical simulation,the exam-ination was repeated in the Rhino-Grasshopper interface to verify the earlier findings and calibrate the chosen simulation package with the help of parametric *** the last step,a wide range of housing roof shapes has been tested by evolutionary algorithm plugin-Galapagos,to find the optimum roof shape design in the given *** results show that,unlike the traditional approach and common belief,a roof shape with a 25-degree tilt angle,170-175 azimuth angle,and aspect ratio of 1:1.2 is optimum to gain maximum solar gaining ***,this study advances the knowledge of solar capturing by suggesting a new parameter-oblique angle-in finding the op

关键词： Parametric architecture Solar gaining Roof form optimization Evolutionary algorithm

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ESWL for difficult bile duct stones:A 15-year single centre experience

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World Journal of Gastroenterology 2010年第33期16卷 4159-4163页

作者： rosangela Muratori Francesco Azzaroli Federica Buonfiglioli Flavio Alessandrelli Paolo Cecinato Giuseppe Mazzella Enrico Roda Department of Digestive Diseases and Internal Medicine S.Orsola-Malpighi HospitalUniversity of Bologna

AIM:To evaluate the efficacy of extracorporeal shock wave lithotripsy(ESWL)for the management of refractory bile duct cholelithiasis in a third level referral ***:The clinical records of all patients treated with a second generation electromagnetic lithotripter (Lithostar Plus,SIEMENS)from October 1990 to April 2005 were *** patients were monitored during the procedure and antibiotics were administered in case of ***χ 2 test and logistic regression analysis were performed as ***:Two hundred and fourteen patients(102 males,112 females;mean age 74.8±0.84 years-single stone 97,multiple stones 117)underwent *** mean number of sessions and shock waves were 3.5 ±0.13 and 3477.06±66.17,*** maximum stone size was 5 *** stone clearance was achieved in 192(89.7%)*** the remain-ing patients 15 required surgery,2 a palliative stent and in 5 patients stone fragmentation led to effective bile drainage with clinical resolution despite incomplete ***,sex and stone characteristics were not related to treatment *** complications occurred in two patients(haemobilia and rectal bleeding) and minor complications in 25(3 vomiting,22 arrhythmias).No procedure-related deaths ***:ESWL is a safe and effective technique for clearance of refractory bile duct stones.

关键词： Difficult bile duct stones Extracorporeal shock wave lithotripsy

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Metabolic and nutritional triggers associated with increased risk of liver complications in SARS-CoV-2

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World Journal of Hepatology 2022年第1期14卷 80-97页

作者： rosangela Passos de Jesus Jozélio Freire de Carvalho Lucivalda Pereira Magalhães de Oliveira Carla de Magalhães Cunha Thaisy Cristina Honorato Santos Alves Sandra Tavares Brito vieira Virginia Maria Figueiredo Allain Amador Bueno Postgraduate Program in Food Nutrition and Health at the School of Nutrition of the Federal University of BahiaSalvador 40.110-150BahiaBrazil Institute of Health Sciences Federal University of BahiaSalvador 40231-300BahiaBrazil Institute of Life Sciences State University of BahiaSalvador 41.150-000BahiaBrazil Department of Gastroenterology IPEMEDIpemed Faculty of Medical SciencesSalvador 40170-110BahiaBrazil College of Health Life and Environmental SciencesUniversity of WorcesterWorcester WR26AJUnited Kingdom

Obesity,diabetes,cardiovascular and respiratory diseases,cancer and smoking are risk factors for negative outcomes in severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which can quickly induce severe respiratory failure in 5%of *** disease-associated liver injury may occur during progression of SARS-CoV-2 in patients with or without pre-existing liver disease,and damage to the liver parenchyma can be caused by infection of *** patients may be particularly vulnerable to SARS-CoV-2 if suffering with cirrhosis-associated immune ***,pharmacotherapies including macrolide or quinolone antibiotics and steroids can also induce liver *** this review we addressed nutritional status and nutritional interventions in severe SARS-CoV-2 liver *** guidelines for SARS-CoV-2 in intensive care(IC)specifically are not yet available,strategies for management of sepsis and SARS are suggested in *** enteral nutrition(EN)should be started soon after IC admission,preferably employing iso-osmolar polymeric formula with initial protein content at 0.8 g/kg per day progressively increasing up to 1.3 g/kg per day and enriched with fish oil at 0.1 g/kg per day to 0.2 g/kg per *** is necessary to identify signs of intolerance,hemodynamic instability and metabolic disorders,and transition to parenteral nutrition should not be delayed when energy and protein targets cannot be met via *** including vitamins A,C,D,E,B6,B12,folic acid,zinc,selenium andω-3 fatty acids have in isolation or in combination shown beneficial effects upon immune function and inflammation *** and monitored supplementation up to upper limits may be beneficial in management strategies for SARS-CoV-2 liver patients.

关键词： COVID-19 SARS-CoV-2 Enteral nutrition Parenteral nutrition Hepatic failure

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Carbon sequestration capability of Fagus sylvatica forests developing in the Majella National Park (Central Apennines,Italy)

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Journal of Forestry Research 2018年第6期29卷 1627-1634页

作者： Loretta Gratani Luciano Di Martino Anna Rita Frattaroli ANDrea Bonito Valter Di Cecco Walter De Simone Giorgia Ferella rosangela Catoni Department of Environmental Biology Sapienza University of Rome Majella Seed Bank Majella National Park Department of Life Health and Environmental Sciences University of L'Aquila

Terrestrial ecosystems represent a major sink for atmospheric carbon(C) and temperate forests play an important role in global C cycling, contributing to lower atmospheric carbon dioxide(CO2) concentration through photosynthesis. The Intergovernmental Panel of Climate Change highlights that the forestry sector has great potential to decrease atmospheric CO2concentration compared to other sectoral mitigation activities. The aim of this study was to evaluate CO2sequestration(CO2S)capability of Fag us sylvatica(beech) growing in the Orfento Valley within Majella National Park(Abruzzo,Italy). We compared F. sylvatica areas subjected to thinning(one high-forest and one coppice) and no-management areas(two high-forests and two coppices). The results show a mean CO2S of 44.3 ± 2.6 Mg CO2ha-1a-1,corresponding to 12.1 ± 0.7 Mg C ha-1a-1the no-managed areas having a 28% higher value than the managed areas. The results highlight that thinning that allows seed regeneration can support traditional management practices such as civic use in some areas while no management should be carried out in the reserve in order to give priority to the objective of conservation and naturalistic improvement of the forest heritage.

关键词： Beech Carbon sequestration Coppice High-forest Leaf area index

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Tumor budding predicts response to anti-EGFR therapies in metastatic colorectal cancer patients

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World Journal of Gastroenterology 2010年第38期16卷 4823-4831页

作者： Inti Zlobec Francesca Molinari Vittoria Martin Luca Mazzucchelli Piercarlo Saletti rosangela Trezzi Sara De Dosso Tatjana Vlajnic Milo Frattini Alessandro Lugli Institute for Pathology University Hospital Basel Institute of Pathology Division of Medical Oncology Institute of Southern Switzerland

AIM:To investigate whether the evaluation of tumor budding can complement K-RAS analysis to improve the individualized prediction of response to anti-epidermal growth factor receptor based therapies in metastatic colorectal cancer (mCRC) patients. METHODS:Forty-three patients with mCRC treated with cetuximab or panitumumab were entered into this study. According to the Response Evaluation Criteria in Solid Tumors criteria, 30 patients had stable or progressive disease (non-responsive), while 13 patients had a partial response. Tumor buds were evaluated from whole tissue sections stained for pan-cytokeratin, evaluated in the densest region using a 40 × objective and "high-grade" tumor budding was defi ned as 15 buds/high-power f ***: Tumor buds and K-RAS mutation both correctly classif ied 68% of patients. All patients with K-RAS mutation (n=7) or high-grade tumor budding (n=11) were non-responsive, of which 4 patients had both features. All 13 partial responders were K-RAS wild-type with low-grade tumor budding. Combined, the predictive value of K-RAS and tumor budding was 80%. Additionally, high-grade tumor budding was significantly related to worse progression-free survival [HR (95% CI): 2.8 (1.3-6.0, P=0.008)].CONCLUSION: If confirmed in larger cohorts, the addition of tumor budding to K-RAS analysis may represent an effective approach for individualized patient management in the metastatic setting.

关键词： Anti-epidermal growth factor receptor therapy Colorectal cancer K-RAS Prognosis Tumor budding

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A Local Ensemble Transform Kalman Filter Data Assimilation System for the Global FSU Atmospheric Model

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Journal of Mechanics Engineering and Automation 2015年第3期5卷 185-196页

作者： rosangela Saher Cintra Steve Cocke Laboratory of Computation and Applied Mathematics National Institute for Space Research S6o Jos~ dos Campos 12227010 Brazil Center of Ocean-Atmospheric Prediction Studies Florida State University Tallahassee Florida USA

Data assimilation is the process by which measurements and model predictions are combined to obtain an accurate representation of the state of the modeled system. We implemented a data assimilation scheme called LETKF （local ensemble transform Kalman filter） with FSUGSM （Florida State University Global Spectral Model） and made an experiment to evaluate the initial condition generated to numerical weather prediction to FSUGSM model. The LETKF analysis carries out independently at each grid point with the use of ＂local＂ observations. An ensemble of estimates in state space represents uncertainty. The FSUGSM is a multilevel （27 vertical levels） spectral primitive equation model, where the variables are expanded horizontally in a truncated series of spherical harmonic functions （at resolution T63） and a transform technique is applied to calculate the physical processes in real space The assimilation cycle runs on the period 01/01/2001 to 31/01/2001 at （00, 06, 12 and 18 GMT） for each day. We examined the atmospheric fields during the period and the OMF （observation-minus-forecast） and the OMA （observation-minus-analysis） statistics to verify the analysis quality comparing with forecasts and observations. The analyses present stability and show suitable to initiate the weather predictions.

关键词： Data assimilation Kalman filter numerical weather prediction global atmospheric model.

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Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis

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World Journal of Gastroenterology 2017年第27期23卷 5004-5017页

作者： Camila Ribeiro de Avelar Emile Miranda Pereira Priscila Ribas de Farias Costa rosangela Passos de Jesus Lucivalda Pereira Magalhaes de Oliveira Postgraduation Program Federal University of Bahia Departament of Science Nutrition Federal University of Bahia

To evaluate the effect of silymarin on the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma glutamyl transpeptidase (γGT) in patients with liver diseases. METHODSA systematic review with meta-analysis of ramdomized and controlled clinical trials was performed, evaluating the effects of sylimarin in patients with hepatic diseases, published by January 31, 2016. Clinical trials were sought on the basis of The Cochrane Central Register of Controlled Trials in the Cochrane Library, PubMed/Medline, Scopus, Web of Science, Lilacs and Clinical Trials. The trials with adult and elderly patients of both sexes, with Liver Diseases who took oral silymarin supplementation, as extract or isolated, as well as Silymarin combined with other nutrients, were included. The trials should provide information about the intervention, such as dosages and detailing of the product used, besides the mean and standard deviation of serum levels of ALT, AST and γGT of the baseline and at the end of the intervention. RESULTSAn amount of 10904 publications were identified. From those, only 17 were included in the systematic review and 6 in the meta-analysis, according to the used selection criteria. In this meta-analysis, the results indicated a reduction of 0.26 IU/mL (95%CI: -0.46-0.07, P = 0.007) at the level of ALT and 0.53 IU/mL (95%CI: -0.74-0.32, P = 0.000) at the serum levels of AST after using the silymarin, both, statistically significant, but with no clinical relevance. There was no significant change in the γGT levels. Subgroup analyzes were also performed for the biochemical markers in relation to the type of intervention, whether silymarin isolated or associated with other nutrients and the time of intervention (whether ≥ 6 mo or < 6 mo). Significant differences were not found. The evaluated studies presented a high degree of heterogeneity and low methodological quality in the carried out analysis. CONCLUSIONSilymarin minimally reduced, but w

关键词： Systematic review Liver diseases Milk thistle Silymarin Meta-analysis

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