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Are bowel symptoms and psychosocial features different in irritable bowel syndrome patients with abdominal discomfort compared to abdominal pain?

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World Journal of Gastroenterology 2022年第33期28卷 4861-4874页

作者： Xiu-Cai Fang Wen-Juan Fan douglas d drossman Shao-Mei Han Mei-Yun Ke department of Gastroenterology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China department of Gastroenterology Tongji HospitalTongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430030Hubei ProvinceChina Center of Functional GI and Motility disorders University of North CarolinaChapel HillNC 27517United States Center for Education and Practice of Biopsychosocial Care Drossman GastroenterologyDurhamNC 27713United States Rome Foundation Rome FoundationRaleighNC 27614United States department of Epidemiology and Statistics Institute of Basic Medical SciencesChinese Academy of Medical Sciences&School of Basic MedicinePeking Union Medical CollegeBeijing 100005China

BACKGROUNd The Rome IV criteria eliminated abdominal discomfort for irritable bowel syndrome(IBS), which was previously included in Rome III. There are questions as to whether IBS patients with abdominal discomfort(seen in Rome III but not Rome IV) are different from those with abdominal pain(Rome IV).AIM To compare bowel symptoms and psychosocial features in IBS patients diagnosed with Rome III criteria with abdominal discomfort, abdominal pain, and pain &*** We studied IBS patients meeting Rome III criteria. We administered the IBS symptom questionnaire, psychological status, and IBS quality of life. Patients were classified according to the predominant abdominal symptom associated with defecation into an only pain group, only discomfort group, and pain & discomfort group. We compared bowel symptoms, extraintestinal symptoms, IBS quality of life, psychological status and healthcare-seeking behaviors, and efficacy among the three groups. Finally, we tested risk factors for symptom reporting in IBS *** Of the 367 Rome III IBS patients enrolled, 33.8%(124 cases) failed to meet Rome IV criteria for an IBS diagnosis. There were no meaningful differences between the pain group(n = 233) and the discomfort group(n = 83) for the following:(1) Frequency of defecatory abdominal pain or discomfort;(2) Bowel habits;(3) Coexisting extragastrointestinal pain;(4) Comorbid anxiety and depression;and(5) IBS quality of life scores except more patients in the discomfort group reported mild symptom than the pain group(22.9% vs 9.0%). There is a significant tendency for patients to report their defecatory and non-defecatory abdominal symptom as pain alone, or discomfort alone, or pain & discomfort(all P dominal discomfort have similar bowel symptoms and psychosocial features to those with abdominal pain. IBS symptoms manifesting abdominal pain or discomfort may primarily be due to different sensation and reporting expe

关键词： Irritable bowel syndrome Abdominal pain Abdominal discomfort diagnosis Psychosocial distress Quality of life

Noninvasive diagnosis of cirrhosis:A review of different imaging modalities

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World Journal of Gastroenterology 2014年第23期20卷 7231-7241页

作者： Riccardo de Robertis Mirko d'Onofrio Emanuele demozzi Stefano Crosara Stefano Canestrini Roberto Pozzi Mucelli department of Radiology G.B.Rossi HospitalUniversity of Verona37134 VeronaItaly

Progressive hepatic fibrosis can lead to cirrhosis,so its early detection is *** fibrosis is also critical for prognosis and *** gold standard for these aims is liver biopsy,but it has several drawbacks,as it is invasive,expensive,has poor acceptance,is prone to inter observer variability and sampling errors,has poor repeatability,and has a risk of complications and ***,non-invasive imaging tests have been *** review mainly focuses on the role of transient elastography,acoustic radiation force impulse imaging,and magnetic resonance-based methods for the noninvasive diagnosis of cirrhosis.

关键词： Liver Cirrhosis Elastography Acoustic radiation force impulse imaging Magnetic resonance elastography

ORdEREd STRUCTURAL EVOLUTION ANd RELAXATION BEHAVIORS OF A SERIES MICROPHASE SEPARATEd“HAIRY-ROd”POLYIMIdES WITH MULTIPLE ALKYL SIdE CHAINS

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Chinese Journal of Polymer Science 2005年第2期23卷 171-186页

作者： Zhi-haoShen AlexanderJ.Jing ShiJin Hua-binWang FrankW.Hams StephenZ.d.Cheng MauriceMortonInstituteanddepartmentofPolymerScience -TheUniversityofAkronAkronOhio44325-3909USA departmentofChemistry CollegeofStatenIslandtheCityUniversityofNewYork2800VictoryBoulevardStatenlslandNY10314USA

A series of“hairy-rod”polyimides,BBPA(n),with multiple alkyl side chains was prepared from 3,3',4,4'-biphenyltetracarboxylic dianhydride(BPdA)and 4,4'-biphenyldiamine substituted in the 2,2'-positions with benzoate,whichwas substituted in the 3,4,5-positions with ether side chains of varying *** number of the methylene units,n,inthese alkyl side chains were in even numbers ranging from 8 to *** techniques of one-dimensional(1d)and 2dwide angle x-ray diffraction,1d small angle X-ray scattering,differential scanning calorimetry experiments,it was found thatthis series of“hairy-rod”polyimides possess a micro-phase separation between the backbones and side *** led to theformation of ordered structures in two different length scales,of which both are hexagonal packing:one is attributed to thealkyl side chains on the sub-nanometer scale,and another is for the whole polymer chains on the nanometer ***development of the hexagonal structure on the sub-nanometer scale was critically dependent upon the lengths of the alkylside *** relaxation processes were captured by dynamic mechanical analysis,i.e.,segmental motion of thebackbones,α,the melting of the side chain crystals,β_1,which exits only for the materials with longer side chains(n=18,16);and the subglass relaxation of side chains,β_*** peak relaxation temperature of the α process decreased withincreasing the length of side chains,while the one of the β_2 process *** activation energy of the α relaxation wasrelatively independent on the length of side chain,whereas,β_2 process showed the increasing of activation energy withincreasing the length of side chains.

关键词： Polyimides Hairy-rod Microphase separation.

Gastric neuroendocrine tumor: A practical literature review

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World Journal of Gastrointestinal Oncology 2020年第8期12卷 850-856页

作者： Gabriel Antonio Roberto Carolina Magalhães Britto Rodrigues Renata d’Alpino Peixoto Riad Naim Younes Bachelor Medicine União das Faculdades dos Grandes LagosSão Josédo Rio Preto15030070Brazil department of Oncology Hospital Alemão Oswaldo CruzSão Paulo 01327001Brazil Universidade Nove de Julho São Paulo 01327001Brazil department of Thoracic Surgery Hospital Alemão Oswaldo CruzSão Paulo 01327001Brazil

Gastric neuroendocrine tumors are gastric neoplasms originating from enterochromaffin type cells and are inserted in a larger group,named gastroenteropancreatic neuroendocrine *** are considered rare and variable in terms of their clinical,morphological and functional characteristics and may be indolent or *** are classified into types I,II and III,according to their pathophysiology,behavior and *** diagnosis occurs,in most cases,incidentally during upper digestive endoscopies,presenting as simple gastric *** cases(type I and type II)are related to hypergastrinemia,can be multiple and are treated by endoscopic resection,whenever *** use of somatostatin analogs for tumor control may be one of the options for therapy,in addition to total or subtotal gastrectomy for selected *** chemotherapy is only reserved for poorly differentiated neuroendocrine *** rare,gastric neuroendocrine tumors have an increasing incidence over the years,therefore deserving more comprehensive studies on its adequate *** present study reviews and updates management recommendations for gastric neuroendocrine tumors.

关键词： Gastric neuroendocrine tumor Gastroenteropancreatic tumor Hypergastrinemia Gastric carcinoid Endoscopic resection

dusty Sheaths in Magnetized Plasmas

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Plasma Science and Technology 2004年第4期6卷 2377-2382页

作者： Yu.I.Chutov O.Yu.Kravchenko S.Masuzaki A.Sagara R.d.Smirnov Yu.Tomita Taras Shevchenko Kiev University KievUkraineTaras Shevchenko Kiev UniversityKievUkraineNational Institute for Fusion ScienceJapanNational Institute for Fusion ScienceJapanThe Graduate University for Advanced StudiesJapanNational Institute for Fusion ScienceJapan

Parameters of self-consistent magnetized dusty sheaths are investigated usingcomputer simulations of a temporal evolution of one-dimensional slab plasma with dust *** evolution is caused by a collection of electrons and ions by both a wall (electrode) and dustparticles, which are initially immersed into plasma and distributed in front of the *** results show the existence of oscillations of a self-consistent potential in magnetizeddusty sheaths including boundary potentials. dust particles weaken magnetized sheaths and createadditional sheaths close to a boundary of dust particles. The magnetic field does not influence onthe dust particle charge.

关键词： dusty sheaths magnetized plasmas computer simulations

development and application of functional gene arrays for microbial community analysis

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中国有色金属学会会刊：英文版 2008年第6期18卷 1319-1327页

作者： Z. L. HE J. d. VAN NOSTRANd L.Y. WU J. Z. ZHOU Institute for Environmental Genomics Department of Botany and Microbiology University of Oklahoma Norman OK 73019 USA

功能的基因标记能关于功能的基因差异和微生物引起的社区的潜在的活动提供重要信息。尽管 microarray 技术成功地被使用了为纯文化学习基因表示，简单、人工的微生物引起的社区，改编如此的一种技术分析复杂微生物引起的社区仍然以设计... 详细信息

功能的基因标记能关于功能的基因差异和微生物引起的社区的潜在的活动提供重要信息。尽管 microarray 技术成功地被使用了为纯文化学习基因表示，简单、人工的微生物引起的社区，改编如此的一种技术分析复杂微生物引起的社区仍然以设计，样品准备，和数据分析提出很多挑战。这个工作集中于功能的基因数组(FGA ) 的开发和应用程序为微生物引起的社区研究指向关键功能的基因标记。一些与 FGA 有关明确地给问题调音，例如 oligonucleotide 探查设计， nucleic 酸抽取和纯化，数据分析，特性，敏感，和量的能力详细被讨论。最近的研究证明了 FGA 能从许多自然环境关于微生物引起的社区提供特定、敏感、潜在地量的信息并且控制生态系统。这种技术被期望革命化微生物引起的社区的分析，并且连接微生物引起的结构到生态系统工作。

关键词：微数列应用函数基因标记微生物种群

Sexual Morph of Furcasterigmium furcatum (Plectosphaerellaceae) from Magnolia liliifera Collected in Northern Thailand

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Phyton-International Journal of Experimental Botany 2020年第3期89卷 765-777页

作者： Jutamart Monkai Ruvishika S.Jayawardena Sajeewa S.N.Maharachchikumbura Kevin d.Hyde Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai57100Thailand School of Science Mae Fah Luang UniversityChiang Rai57100Thailand School of Life Science and Technology University of Electronic Science and Technology of ChinaChengdu611731China

We isolated an interesting fungus from dead leaves of Magnolia liliifera collected from Chiang Mai,*** novel strain is related to Plectosphaer-ellaceae based on the morphology of its asexual morph and the analysis of sequence *** analyses using a combined gene analysis of LSU and ITS sequence data showed that this strain is clustered in the same clade with Furcasterigmium furcatum with high statistical *** new strains produced the asexual morph in culture which is morphologically similar to ***,we identified this strain as the sexual morph of *** is the first record of sexual morph for the monotypic genus Furcasterigmium and the first record of this genus on Magnolia.

关键词： Acremonium phylogeny sexual morph sordariomycetes taxonomy

Computational design for 4d printing of topology optimized multi-material active composites

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npj Computational Materials 2023年第1期9卷 2342-2350页

作者： darshan Athinarayanarao Romaric Prod’hon dominique Chamoret H.Jerry Qi Mahdi Bodaghi Jean-Claude André Frédéric demoly ICB UMR 6303 CNRS Univ.Bourgogne Franche-ComtéUTBM90010 BelfortFrance The George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA department of Engineering School of Science and TechnologyNottingham Trent UniversityNottingham NG118NSUK LRGP UMR 7274 CNRS University of LorraineNancyFrance

Recent efforts on design for four-dimensional(4d)printing have considered the spatial arrangement of smart materials and energy *** development of multifunctional structures and their desired mechanical/actuation performances require tackling 4d printing from a multi-material design *** the materials distributions there is an opportunity to increase the spectrum of design concepts with computational *** main goal being to achieve the“best”distribution of material properties in a voxelized structure,a computational framework that consists of a finite element analysis-based evolutionary algorithm is *** fuses the advantages of optimizing both the materials distribution and material layout within a design space via topology optimization to solve the inverse design problem of finding an optimal design to achieve a target shape change by integrating void *** results demonstrate the efficacy of the proposed method in providing a highly capable tool for the design of 4d-printed active composites.

关键词： composites printing topology

Polymersomes scalably fabricated via flash nano- precipitation are non-toxic in non-human primates and associate with leukocytes in the spleen and kidney following intravenous administration

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Nano Research 2018年第10期11卷 5689-5703页

作者： Sean d. Allen Yu-Gang Liu Sharan Bobbala Lei Cai Peter I. Hecker Ryan Temel Evan A. Scott Interdisciplinary Biological Sciences Northwestern University IL 60208 USA department of Biomedical Engineering Northwestern University IL 60208 USA Saha Cardiovascular Research Center University of Kentucky KY40506 USA department of Pharmacology and Nutritional Sciences University of Kentucky KY40506 USA

Vesicular nanocarrier formulations confer the ability to deliver hydrophobic and hydrophilic cargos simultaneously to cells of interest in vivo. While liposomal formulations reached the clinic long ago, younger technologies such as polymeric vesicles （polymersomes） have yet to make the transition to clinical approval and use, in part due to difficulties in ensuring their safe and scalable production. In this work, we demonstrate the scalable production of poly（ethylene glycol）-block-poly（propylene sulfide）（PEG-bl-PPS） polymersomes via flash nanoprecipitation, and further show the safe administration of these nanocarriers to mice and non-human primates. In mice, PEG-bl-PPS polymersomes were found to be well tolerated at up to 200 mg/（***）. Following the administration of a more relevant 20 mg/（***） dosage in non-human primates, polymersomes were found to associate with numerous phagocytic immune cell populations, including a remarkable 68% of plasmacytoid dendritic cells and 〉 95% of macrophages in the spleen, while showing no toxicity or abnormalities in the liver, kidney, spleen, or blood. despite the presence of a dense PEG corona, neither anti-PEG antibodies nor complement activation were detected. This work provides evidence of the translatability of PEG-bI-PPS polymersomes into the clinic for therapeutic applications in humans.

关键词： polymersome non-human primate nanoprecipitation toxicity biodistribution