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Titanocene dichloride:A new green reagent in organic chemistry

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Chinese Journal of Catalysis 2017年第10期38卷 1659-1663页

作者： antonio rosales Martínez María Castro Rodríguez Ignacio Rodríguez-García Laura Pozo Morales Roman Nicolay Rodríguez Maecker 塞维利亚大学化学工程系富埃尔萨斯舰队大学石油工程系阿尔默大学有机化学系

Green reagents reduce or eliminate the use and generation of hazardous substances in the synthesis of chemical compounds[1].The development of new green reagents is important for the development of a more sustainable chemical industry,based on processes that follow the principles dictated by green chemistry[2].In this context,the use of green reagents,such as hydrogen peroxide and dimethyl carbonate,in reactions that can be driven by sunlight,have been widely developed over the past twenty *** methodologieshave been implemented in chemical synthesis to catalyze reactions under safe and mild reaction conditions with the use of less harmful solvents and with reduced toxic waste *** supported reagents[3]have enabled many elegant and efficient strategies for performing a range of different transformations.

关键词：绿色化学均相催化环境催化茂基钛(III) 自由基化学

Right hepatic lobe living donation: A 12 years single Italian center experience

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World Journal of Gastroenterology 2013年第38期19卷 6353-6359页

作者： Salvatore Gruttadauria Duilio Pagano Davide Cintorino antonio Arcadipane Mario Traina Riccardo Volpes Angelo Luca Giovanni Vizzini Bruno Gridelli marco Spada Istituto Mediterraneo Trapianti e Terapie ad Alta Specializzazione University of Pittsburgh Medical Center in Italy90127 PalermoItaly Department of Surgery University of Pittsburgh Medical CenterPittsburghPA 15213United States

Mini invasive techniques are taking over conventional open liver resections in the setting of left lateral segmentectomy for living liver donation,and hydride procedure are being implemented for the living related right *** center routinely performs laparoscopic left lateral segmentectomy for pediatric recipient and has been the first in the Europe performing an entirely robotic right *** emphasis is posed on living donor safety which is the first priority during the entire operation,then the most majority of our procedures are still conventional open right hepatectomy(RHLD),defined as removal of a portion of liver corresponding to Couinaud segments 5-8,in order to obtain a graft for adult to adult living related liver *** this 10 years period some changes,herein highlighted,have occurred to our surgical *** study reports the largest Italian experience with RHLD,focused on surgical technique evolution over a 10 years *** safety must be the first priority in right-lobe living-related donation:the categorization of complications of living donors,specially,after this"highly sensitive"procedure,reflects the need for prompt and detailed reports.

关键词： Adult-to-adult living-related liver transplantation Liver regeneration Liver resections Liver transplantation Liver surgery

Wear Evaluation of Copper-Nickel-Aluminum Alloys under Extreme Conditions

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Journal of Minerals and Materials Characterization and Engineering 2023年第1期11卷 16-26页

作者： Rene Guardian Isai rosales-Cadena Constancio Diaz-Reyes Juan antonio Ruiz-Ochoa Center for Research in Engineering and Applied Sciences Autonomous University of State of Morelos Cuernavaca Mexico Faculty of Sciences of the Enginery and Technology UABC Tijuana Mexico

Cu-Ni-Al alloys at different concentrations were obtained using a high frequency induction melting unit, keeping a balance in the nominal compositions. Light alloys are important to be used in industrial applications. Aluminum additions result in a positive hardness increment of the ternary alloys in comparison with the binary Cu-Ni alloys. Generalized wear mechanisms of the alloys with low aluminum content are basically type abrasive, while samples with 5 and 10 at.% Al present an oxidative-adhesive wear mechanism. Wear results have indicated that aluminum addition affects positively the wear resistance, mainly in samples with high aluminum content product of the creation during the test of different oxides corresponding to the elements present in the alloys.

关键词： Copper Nickel Alloys Hardness Mechanical Properties Heat Treatment

Thinking outside the black box:are the brain endothelial cells the new main target in Alzheimer's disease?

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Neural Regeneration Research 2023年第12期18卷 2592-2598页

作者： Enrique Estudillo Adolfo López-Ornelas Alejandro Rodríguez-Oviedo Neptali Gutiérrez de la Cruz marco antonio Vargas-Hernández Adriana Jiménez Laboratorio de Reprogramación Celular Instituto Nacional de Neurología y Neurocirugía Manuel Velasco SuárezMexico CityMexico División de Investigación Hospital Juárez de MéxicoMexico CityMexico Hospital Nacional Homeopático Hospitales Federales de ReferenciaMexico CityMexico Facultad de Ciencias Universidad Nacional Autónoma de MéxicoMexico CityMexico Laboratorio de Morfología Escuela Militar de Graduados de SanidadSecretaría de la Defensa NacionalBatalla de CelayaLomas de SoteloMiguel HidalgoMexico CityMexico Escuela Militar de Graduados de Sanidad Secretaría de la Defensa NacionalBatalla de CelayaLomas de SoteloMiguel HidalgoMexico CityMexico

The blood-brain barrier is the interface through which the brain interacts with the milieu and consists mainly of a sophisticated network of brain endothelial cells that forms blood vessels and selectively moves molecules inside and outside the brain through multiple mechanisms of *** brain endothelial cell function is crucial for brain homeostasis,their role in neurodegenerative diseases has historically not been considered with the same importance as other brain cells such as microglia,astroglia,neurons,or even molecules such as amyloid beta,Tau,or ***'s disease is the most common neurodegenerative disease,and brain endothelial cell dysfunction has been reported by several ***,its impairment has barely been considered as a potential therapeutic *** we review the most recent advances in the relationship between Alzheimer's disease and brain endothelial cells commitment and analyze the possible mechanisms through which their alterations contribute to this neurodegenerative disease,highlighting their inflammatory phenotype and the possibility of an impaired secretory pattern of brain endothelial cells that could contribute to the progression of this ***,we discuss why shall brain endothelial cells be appreciated as a therapeutic target instead of solely an obstacle for delivering treatments to the injured brain in Alzheimer's disease.

关键词： dementia endothelial cells neurodegeneration neuroinflammation neuronal death paracellular transport transcellular transport

Chemotherapy for Hepatocellular Carcinoma: Current Evidence and Future Perspectives

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Journal of Clinical and Translational Hepatology 2017年第3期5卷 235-248页

作者： Emanuele Rinninella Lucia Cerrito Irene Spinelli marco Cintoni Maria Cristina Mele Maurizio Pompili antonio Gasbarrini Internal Medicine and Gastroenterology Unit Gastroenterology Area Fondazione Policlinico Universitario Agostino GemelliCatholic University of Sacred Heart Rome Italy Clinical Nutrition Unit Gastroenterology Area Fondazione Policlinico Universitario Agostino Gemelli Catholic University of Sacred Heart Rome Italy Internal Medicine and Gastroenterology Unit Gastroenterology Area Fondazione Policlinico Universitario Agostino GemelliCatholic University of Sacred Heart Rome Italy Clinical Nutrition Unit Gastroenterology Area Fondazione Policlinico Universitario Agostino Gemelli Catholic University of Sacred Heart Rome Italy

Hepatocarcinogenesis is a multistep process,heralded by abnormalities in cell differentiation and proliferation and sustained by an aberrant *** the underlying molecular pathogenesis leading to hepatocellular carcinoma is a prerequisite to develop new drugs that will hamper or block the steps of these *** hepatocellular carcinoma has higher arterial vascularization than normal liver,this could be a good target for novel molecular *** of the antiangiogenic drug sorafenib into clinical practice since 2008 has led to new perspectives in the management of this *** importance of this drug lies not only in the modest gain of patients' survival,but in having opened a roadmap towards the development of new molecules and ***,after the introduction of sorafenib,during the last years,a wide number of clinical trials on antiangiogenic therapies failed in achieving significant ***,many of these trials are still ongoing and promise to improve overall survival and progression-free survival.A recent clinical trial has proven regorafenib effective in patients showing tumor progression under sorafenib,thus opening new interesting therapeutic *** other expectations have been borne from the discovery of the immune checkpoint blockade,already known in other solid ***,a potential role in hepatocellular carcinoma therapy may derive from the use of branched-chain amino acids and of nutritional *** review analyses the biomolecular pathways of hepatocellular carcinoma and the ongoing studies,the actual evidence and the future perspectives concerning drug therapy in this open field.

关键词： Hepatocellular carcinoma Molecular target therapies Immunotherapy Branched-chain amino acids

Assessment of small intestinal bacterial overgrowth in uncomplicated acute diverticulitis of the colon

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World Journal of Gastroenterology 2005年第18期11卷 2773-2776页

作者： antonio Tursi Giovanni Brandimarte Gian marco Giorgetti Walter Elisei Digestive Endoscopy Unit "Lorenzo Bonomo" Hospital Andria Italy Department of Internal Medicine Division of Gastroenterology "Cristo Re" Hospital Rome Italy Clinical Nutrition Unit "S. Eugenio" Hospital Rome Italy

AIM: Small intestinal bacterial overgrowth (SIBO) maycontribute to the appearance of several gastrointestinal nonspecific symptoms. Acute diverticulitis is affected by some similar symptoms and bacterial colonic overgrowth. We assessed the prevalence of SIBO in acute uncomplicated diverticulitis and evaluated its influence on the clinical course of the ***: We studied 90 consecutive patients (39 males, 51 females, mean age 67.2 years, range 32-91 years). Sixty-one patients (67.78%) and 29 patients (32.22%) were affected by constipation-or diarrhea-prevalent diverticulitis respectively. All subjects were investigated by lactulose H2-breath test at the entry and at the end of treatment. We also studied a control group of 20 healthy subjects (13 males, 7 females, mean age 53 years, range 22-71 years).RESULTS: Oro-cecal transit time (OCTT) was delayed in67/90 patients (74.44%) (range 115-210 min, mean 120 min). Fifty-three of ninety patients (58.88%) showed SIBO, while OCTT was normal in 23/90 patients (25, 56%). In the control group, the mean OCTT was 88.2 min (range 75-135 min). The difference between diverticulitic patients and healthy subjects was statistically significant (P＜0.01). OCTT was longer in constipation-prevalent disease than in diarrheaprevalent disease [180.7 min (range 150-210 min) vs 121 min (range 75-180 min) (P＜0.001)], but no difference in bacterial overgrowth was found between the two forms of *** treatment with rifaximin plus mesalazine for 10 d, followed by mesalazine alone for 8 wk, 70 patients (81.49%) were completely asymptomatic, while 16 patients (18.60%) showed only slight symptoms. Two patients (2.22%) had recurrence of diverticulitis, and two other patients (2.22%) were withdrawn from the study due to side-effects. Seventy-nine of eighty-six patients (91.86%) showed normal OCTT (range 75-105 min, mean 83 min), while OCTT was longer, but it was shorter in the remaining seven (8.14%) patients (range 105-115 min

关键词： Small intestinal bacterial overgrowth Oro-oecal transit time

Tumors of ampulla of Vater: A case series and review of chemotherapy options

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World Journal of Gastrointestinal Oncology 2012年第3期4卷 60-67页

作者： Adriana Romiti Viola Barucca Angelo Zullo Ida Sarcina Roberta Di Rocco Chiara D'antonio marco Latorre Paolo Marchetti Oncology Unit University "La Sapienza" Sant'Andrea Hospital via di Grottarossa 1035 00189 Rome Italy Gastroenterology and Digestive Endoscopy "Nuovo Regina Margherita" Hospital via Morosini 30 00185 Rome Italy Department of General Surgery University "La Sapienza" Sant'Andrea Hospital via di Grottarossa 1035 00189 Rome Italy

Carcinomas of the Ampulla of Vater are rare tumors, accounting for 0.2% of gastrointestinal cancers. Compared with other biliary tract neoplasms, these tumors have a relatively favorable prognosis after surgical resection. Based on their epithelium of origin, two subtypes of ampullary carcinoma have been recently distinguished: intestinal and pancreatobiliary. This study evaluates histopathological features and outcomes of ampullary carcinoma and to compares the survival of these tumors to that of other biliary tract tumors. The chemotherapic options available for ampullary cancer are also reviewed. We analyzed data from 20 consecutive patients with ampullary carcinomas and 26 patients with other biliary tract carcinomas, observed in our Institution. Statistical analysis was performed by using either Fisher's exact test or χ2 test for categorical variables. Median time of survival was calculated and compared using the Log-Rank test. Similar distribution of demographic characteristics and stage between ampullary and other biliary tract cancers was observed. Patients with ampullary cancer underwent surgery more frequently than other biliary cancers while chemotherapy and radiotherapy were used equally. In accordance with the literature, a longer median survival was observed in the group of ampullary carcinomas.

关键词： Ampullary carcinoma Chemotherapy Radiotherapy Biliary tract cancer

Modeling of recrystallization behaviour of AA6XXX aluminum alloy profile during extrusion process

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Transactions of Nonferrous Metals Society of China 2024年

作者： marco Negozio antonio Segatori Riccardo Pelaccia Barbara Reggiani Sara Di Donato Lorenzo Donati University of Parma-Department of Engineering and Architecture， Parco Area delle Scienze Hydro， Innovation and Technology DISMI Department of Sciences and Methods for Engineering， University of Modena and Reggio Emilia InterMech-MO.RE – University of Modena and Reggio Emilia DIN Department of Industrial Engineering – University of Bologna

An innovative approach was introduced for the development of a AA6063 recrystallization model. This method incorporated a regression-based technique for the determination of material constants and introduced novel equations for assessing the grain size evolution. Calibration and validation of this methodology involved a combination of experimentally acquired microstructural data from the extrusion of three different AA6063 profiles and results from the simulation using the Qform Extrusion UK finite element code. The outcomes proved the agreement between experimental findings and numerical prediction of the microstructural evolution. The trend of the grain size variation based on different process parameters has been accurately simulated， both after dynamic and static recrystallization， with an error rate of less than 25% in almost the whole sampling computations.

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Finite Elements Based on Deslauriers-Dubuc Wavelets for Wave Propagation Problems

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Applied Mathematics 2016年第14期7卷 1490-1497页

作者： Rodrigo Bird Burgos marco antonio Cetale Santos Department of Structures and Foundations Rio de Janeiro State University (UERJ) Rio de Janeiro Brazil Department of Geology and Geophysics Fluminense Federal University (UFF) Niterói Brazil

This paper presents the formulation of finite elements based on Deslauriers-Dubuc interpolating scaling functions, also known as Interpolets, for their use in wave propagation modeling. Unlike other wavelet families like Daubechies, Interpolets possess rational filter coefficients, are smooth, symmetric and therefore more suitable for use in numerical methods. Expressions for stiffness and mass matrices are developed based on connection coefficients, which are inner products of basis functions and their derivatives. An example in 1-D was formulated using Central Difference and Newmark schemes for time differentiation. Encouraging results were obtained even for large time steps. Results obtained in 2-D are compared with the standard Finite Difference Method for validation.

关键词： Wavelets Interpolets Deslauriers-Dubuc Wavelet Finite Element Method Wave Propagation