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Antidiarrhoeal activity of leaf methanolic extract of Rauwolfia serpentina

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Asian Pacific Journal of Tropical Biomedicine 2012年第6期2卷 430-432页

作者： Ezeigbo II Ezeja MI Madubuike KG Ifenkwe DC Ukweni ia Udeh NE Akomas SC Department of Veterinary Physiology Biochemistry and Pharmacology College of Veterinary Medicine Michael Okpara University of Agriculture

Objective:To evaluate the antidiarrhoeal property of methanol extract of the leaves of Rauwolfia serpentina(R. serpentina) in experimental diarrhoea induced by castor oil in ***:Doses of 100, 200 and 400 mg/kgR. serpentinaleaf methanol extracts were administered to castor oil induced diarrhoea mice to determine its antidiarrhoeal ***:All doses of the extract and the reference drug atropine sulphate(3 mg/kg, i.p.) produced a dose-dependent reduction in intestinal weight and fluid volume. The extracts also significantly reduced the intestinal transit in charcoal meal test when compared to diphenoxylate Hcl(5 mg/kg, p.o.).Conclusions:The results show that the extract of R. serpentin a leaves has a significant antidiarrhoeal activity and supports its traditional uses in herbal medicine.

关键词： Rauwolfia serpentina Castor oil Antidiarrhoeal activity Intestinal transit

Epidemiological, prevention and control updates of yellow fever outbreak in Brazil

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Asian Pacific Journal of Tropical Medicine 2019年第2期12卷 49-59页

作者： Marli do Carmo Cupertino Rebeca Garcia Andréia Patrícia Gomes Sérgio Oliveira de Paula Nicholas Mayers Rodrigo Siqueira-Batista Medical School Dinamica College of the Piranga Valley Laboratory of Epidemiological and Computational Methods in Health Department of Medicine and Nursing Federal University of Vicosa Laboratory of Immunovirology Department of General Biology Federal University of Vicosa Department of Veterinary Medicine Universidade Federal de Vicosa

Yellow fever is an acute viral disease endemic to tropical countries, like Brazil, where, since the 1940 s, has no significant documented outbreaks similar to that observed between 2016/2018(2 045 confirmed cases and 677 deaths; caused by the sylvatic form).The principal manipulating factors inciting this change were absence of appropriate vaccination campaigns and increased urbanization & population growth in forest areas, with prevalence of the virus in the species inhabiting of these *** 2016/2018 outbreaks exhibited incidence in areas with historically low or no yellow fever virus activity, triggering a surge in recorded deaths-mainly in the Southeastern states of *** Brazilian government aggressively responded, reforming the countries' prophylactic measures, including vaccine implementation-as of March, 2018, switching from the former double dose regimen of the vaccine, to a single dose protocol, deemed as ***, some states appropriated the fractionated dosage(1/5 of the standard dose), in foresight of potential vaccine *** prevent the uprising of new sylvatic yellow fever cases in Brazil, it's obligatory the development of effective combative plans, including adaptation of prophylactic measures individually(use of repellents, protective clothing etc.), applicable vaccination campaigns in every endemic region, to raise awareness to locals and visitors *** these preventative strategies, the persistence of cases and the recent outbreaks in Brazil, highlight the possible ineffectiveness of combative *** on these considerations, the objective of this review was to raise more awareness of the epidemiological impact of the disease in Brazil.

关键词： Infectious disease Epidemiology Arboviruses Yellow fever Aedes aegypti

Creatine supplementation in trained rats causes changes in myenteric neurons and intestinal wall morphometry

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BioCELL 2013年第2期37卷 37-43页

作者： SOLANGE MARTA FRANZOI DE MORAES THAIS ANDRÉia BROGio JACQUELINE NELISIS ZANONI MARiaNA CRISTINA VICENTE UMADA ZAPATER SIDNEY BARNABÉPERES LUZMARINA HERNANDES Universidade Estadual de Maringá Avenida Colombo 5790Bloco H79sala 108 MaringáParanáBrazil87020900

Creatine is widely used by athletes as an ergogenic *** aim of this study was to evaluate the infl uence of creatine supplementation on the duodenum of rats submitted to physical *** number and myenteric neuronal cell bodies as well mucosal and muscular tunic morphometry were *** animals received a standard chow for 8 weeks,and the treated ones received the standard chow for 4 weeks and were later fed with the same chow but added with 2%*** were divided in groups:sedentary,sedentary supplemented with creatine,trained and trained supplemented with *** training consisted in treadmill running for 8 *** samples were either processed for whole mount preparations or for paraffi n embedding and hematoxylin-eosin staining for histological and morphometric studies of the mucosa,the muscular tunic and myenteric *** was observed that neither creatine nor physical training alone promoted alterations in muscular tunic thickness,villus height or crypts depth,however,a reduction in these parameters was observed when both were *** number of myenteric neurons was unchanged,but the neuronal cell body area was reduced in trained animals but not when training and creatine was associated,suggesting a neuroprotector role of this substance.

关键词： nutritional supplementation duodenum exercise

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陕西彬县断泾遗址发掘报告

考古学报 1999年第1期 73-96,123-126页

作者： Jing-Wei Archaeological Team, ia, CASS 中国社会科学院考古研究所泾渭工作队

The Duanjing-cun site is on the right bank of the Jinghe River,under the juristiction of Xinbaozi township,Binxian county, Shaanxi province, and in the territory of Binyi recorded in ancient texts. In order to explore the predynastic Zhou culture of the time when the Zhou people lived in the Bin area,the Jing-Wei Archaeological Team,ia,CASS,excavated the site in 1995. Six squares were excavated, and one ash-trench, 22 ash-pits and four graves of the Shang period were revealed. The ash-pits are generally oval in plan. The graves are all rectangular earth shafts and measure 4. 92m in length and 3.8m in width for the largest. Among the artifacts, including excavated and collected, there are bronze axes, knives and arrowheads, gold ornaments, pottery li tripods, yan steamers, gui basins, dou stemmed vessels and jars, stone axes and knives, and bone spades and oracle bones. The Shang period remains at the site can be divided into two stages. The first stage, characterized by the li with a decorative border appliqued along the rim, a high collar, a split crotch and pointed hollow legs, is estimated to be of roughly the same date as the first phase of the Yin Ruins at Anyang. This must be the predynastic Zhou culture of the Bin-occupied period. In the second stage, the li was slightly changed, with cord design appliqued on the neck and the crotch becoming arched. Its date roughly corresponds to that of the predynastic Zhou culture remains of the Qi-occupied period. Meanwhile, the foot-pit in the tombs and the shapes of gold ornaments and bronze axes all show distinct stylistic features of the Rong, Di and Gulf aug cultures. The whole batch of material may verify the historical records on the Zhou people once living in the Bin area and provides important clues for further identifying the location of Binyi.

关键词：陕西彬县绳纹陶器残片二层台遗存先周文化遗址口部附加图版

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LT码中一种新的开关度分布

西安电子科技大学学报 2015年第5期42卷 43-47页

作者：任鹏相征西安电子科技大学通信工程学院陕西西安710071

针对LT喷泉码,为进一步增加小度值的可译码集出现概率,限制二进制指数度分布的最大度值,提出了截短二进制指数度分布;为进一步增加大度值的可译码集出现概率,改变鲁棒孤子度分布的分布值,提出了滑动的鲁棒孤子度分布.结合这两种度分布,... 详细信息

针对LT喷泉码,为进一步增加小度值的可译码集出现概率,限制二进制指数度分布的最大度值,提出了截短二进制指数度分布;为进一步增加大度值的可译码集出现概率,改变鲁棒孤子度分布的分布值,提出了滑动的鲁棒孤子度分布.结合这两种度分布,建立了一种新的开关度分布.仿真结果表明,新的开关度分布进行LT编码时的初始译码成功率达到了56%,整体译码成功率高于原始的开关度分布约9%~12%.

关键词：数字喷泉码二进制指数度分布鲁棒孤波度分布开关度分布

Long-Term Clinical Outcome of Patients Using Risperidone Long-Acting Injectable: The Romanian e-STAR Database

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Open Journal of Psychiatry 2015年第2期5卷 153-164页

作者： ioana Micluţia Madalina Vrabie Roxana Ciungu Department of Neurosciences Discipline of Psychiatry“Iuliu Hatieganu”University of Medicine&PharmacyEmergency County Hospital ClujSecond Psychiatric ClinicCluj-NapocaRomania Medical Affairs JanssenDivision of Johnson&Johnson RomaniaBucharestRomania

The objectives of e-STAR Romania (NCT00283517) were to collect clinical outcome data of Romania schizophrenia or schizo-affective disorder patients;prospectively to assess the reasons of treatment initiation, medication usage patterns;to document (long-term) clinical efficacy;and to collect safety data, as well as recording 2-year corresponding retrospective data. In total, 378 eligible subjects were enrolled who were initiated either on risperidone long-acting injectable (RLAI) (290) or on an oral antipsychotic (OA) (88) at baseline as required by the local Summary of the Product Characteristics. Data were collected from per patient both retrospectively and prospectively over a 24-month period at 3-month intervals after starting treatment. The results indicated that subjects suffering from schizophrenia or schizo-affective disorder initiated on RLAI were less likely to be hospitalized within the first 24 months after the initiation of treatment. Moreover, subjects treated with RLAI experienced significant improvements in their illness severity and functioning. Discontinuation rates for RLAI were low and doses were stable throughout the 24 months following the initiation of treatment. In addition, the necessity for supplementary concomitant medication was reduced. Adverse events were reported in 20.3% (RLAI) and 11.4% (OA) of the subjects. In general, patients initiated on RLAI and OA at baseline both clinically improved on all assessed parameters but a larger improvement was observed for patients on RLAI. Incidences of reported AEs during the use of RLAI in a naturalistic setting are comparable with those described in clinical studies;however, the incidence of extrapyramidal signs and weight gain was lower than expected.

关键词： Schizophrenia Registry Risperidone Long-Acting Injectable Hospitalizations Clinical Outcome Safety

A priori estimates for classical solutions of fully nonlinear elliptic equations

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Science China Mathematics 2011年第3期54卷 457-462页

作者： CAO Yi1, LI DongSheng1 & WANG LiHe1,2 1College of Science, Xi’an Jiaotong University, Xi’an 710049, China 2Department of Mathematics, The University of iowa, iowa City, ia 52242-1419, USA College of Science Xi’an Jiaotong University Xi’an China Department of Mathematics The University of Iowa Iowa City USA

For the fully nonlinear uniformly elliptic equation F(D2u) = 0, it is well known that the viscosity solutions are C2,α if the nonlinear operator F is convex (or concave). In this paper, we study the classical solutions for the fully nonlinear elliptic equation where the nonlinear operator F is locally C1,β a.e. for any 0 ions u are C2,α. Moreover, the C2,α norm of u depends on n,F and the continuous modulus of D2u.

关键词：非线性椭圆方程解的先验估计非线性算子大肠杆菌粘性解连续模