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胃食管反流病患者食管体部运动障碍:这一现象真的与反流相关吗?

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世界核心医学期刊文摘（胃肠病学分册） 2005年第8期1卷 50-51页

作者： Ciriza.De Los ros C Ga.ca.Menéndez L Dez Hernándeza.程欣 C/Emilia.o Ba.ra. 13B 4 A 28043 Madrid Spain Dr

Ba.kground: Esopha.ea. motility a.norma.ities ha.e been observed in pa.ients w ith ga.troesopha.ea. reflux disea.e. Goa.s:The a.m of the present study wa. to d etermine if esopha.ea. motor disorders in pa.ients with a.positive response to t he omepra.ole test a.e rela.ed to the existence of reflux or they a.e concomita. t findings. Study: a.24-hour pH monitoring a.d a.sta.iona.y ma.ometry were perf ormed on 128 pa.ients: 49 of them ha. norma. ma.ometry, 31 hypotensive lower eso pha.ea. sphincter, 29 motor disorder in esopha.ea. body, a.d 19 hypotensive lowe r esopha.ea. sphincter a.d motor disorder in esopha.ea. body. Results: We found a. a.socia.ion between the presence of a.norma. reflux a.d motor disorder in eso pha.ea. body (χ2 test; Pa.ea. motility wa. t he disorder most strongly rela.ed to reflux, where a. the hypercontra.tile disor ders were not clea.ly a.trib- uted to it. Conclusions: Esopha.ea. ma.ometric a.nor- ma.ities should be considered ca.tiously before considering a.motor disorder a.s a.consequence of a.norma. reflux.

关键词：胃食管反流运动障碍食管括约肌管体运动异常压力过低活动异常静态压力压力正常收缩功能

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熔融纺丝法生产具有加热功能的导电纤维

国际纺织导报 2013年第9期41卷 32-32,34,44页

作者： W.Steinma.n J.ros K.Ja.sik G.Seide T.Gries 王心航亚琛工业大学纺织技术研究所

导电纤维可以由多种材料制备,包括金属涂层、金属线、自身导电的高分子和高分子纳米复合物。通常纳米复合纤维的电导率比其他几种材料的小。电流在纤维中传输的过程中,功率的损失会转化为热量,而这部分热量刚好可以作为纤维的热源。介... 详细信息

导电纤维可以由多种材料制备,包括金属涂层、金属线、自身导电的高分子和高分子纳米复合物。通常纳米复合纤维的电导率比其他几种材料的小。电流在纤维中传输的过程中,功率的损失会转化为热量,而这部分热量刚好可以作为纤维的热源。介绍了可生产这种纤维的熔融纺丝工艺。

关键词：导电纤维性能应用

Neurocognitive Disorders in Pa.ients with HIV Infection with Virologic Suppression for More tha. 10 Yea.s

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World Journa. of a.DS 2017年第1期7卷 59-66页

作者： a.dré Filipe dos Sa.tos-Silva.Joa.a.Ma.ga.ida.a.meida.a.ves Isa.el Ra.os Ma.ia.del Cármen Piñ eiro-Ca.vo Cláudia.Sousa.Ma.ia.do rosário Serr&a.ilde o a.tónio Ca.los Eugénio Megre Sa.mento Infectious Disea.es Depa.tment S&atilde o Jo&a.ilde o Hospita. Centre Oporto Portugal Fa.ulty of Medicine of the University of Oporto Oporto Portugal Psychia.ry a.d Menta. Hea.th Depa.tment S&atilde o Jo&a.ilde o Hospita. Centre Oporto Portugal Neurology Depa.tment S&atilde o Jo&a.ilde o Hospita. Centre Oporto Portugal

Ba.kground: HIV-a.socia.ed neurocognitive disorder (Ha.D) ma. a.pea. in pa.ients with vira. a.d immunologica. response to trea.ment a.d rema.n unnoticed during the initia. sta.e of the infection. The goa. of this study is to eva.ua.e the development a.d/or progression of Ha.D in pa.ients with undetecta.le vira. loa. for more tha. ten yea.s. Methods: We included a.ult HIV-infected pa.ients who were under a.tiretrovira. trea.ment a.d ha. undetecta.le pla.ma.vira. loa. for more tha. ten yea.s (blips were included). These pa.ients ha. a.rea.y been subjected to neurocognitive eva.ua.ion five yea.s previously. Demogra.hic, clinica. a.d a.a.ytica. da.a.were a.a.ysed. For the neurocognitive eva.ua.ion, the Wa.S-III subtests (digit symbol coding a.d symbol sea.ch), tra.l ma.ing test (TMT) a.a.d B, Stroop test a.d ca.egorica. verba. fluency (a.ima.s) tests were used. SPSS??version 22.0 for Windows wa. used for sta.istica. a.a.ysis. Results: In this re-eva.ua.ion, performed 4.76 (±1.82) yea.s a.ter the first one, 9 (36%) pa.ients showed deficits in processing speed (Wa.S-III a.d TMT a., 8 (32%) executive function (TMT B a.d Stroop) a.d 12 (48%) verba. fluency. There were significa.t sta.istica. differences between the pa.t a.d current executive function tests (p = 0.029 a.d p = 0.01), highlighting worsening of deficits. No differences were found for the other tests. No a.socia.ion wa. found between deficit progression a.d the studied va.ia.les. Conclusions: a.though not genera.ly noticed on regula. a.pointments, in this sma.l popula.ion, worsening of executive function deficits (menta. flexibility a.d divided a.tention) wa. found. Cla.sica. risk fa.tors for Ha.D did not a.pea. to interfere in its progression. Speed of informa.ion processing a.d ca.egorica. verba. fluency rema.ned sta.le.

关键词： HIV Ha.D Dementia Impa.rment

p53 promotes a.T a.d SP1-dependent meta.olism through the pentose phospha.e pa.hwa. tha. inhibits a.optosis in response to Nutlin-3a

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Journa. of Molecula. Cell Biology 2018年第4期10卷 331-340页

作者： Text Lei Dua. Rica.do E. Perez Ling Chen Lotha. a. Bla.ter Ca.l G. Ma.i Depa.tment of Cell & Molecula. Medicine Rush University Medical Center Chicago IL 60612 USA Depa.tment of La.ora.ory Medicine Shiyan Taihe Hospital College of Biomedical Engineering Hubei University of Medicine Shiyan 442000 China Depa.tment of Physiology & Biophysics Rush University Medical Center Chicago IL 60612 USA

Nutlin-3a.is a.MDM2 a.ta.onist a.d preclinica. drug tha. a.tiva.es p53. Cells with MDM2 gene a.plifica.ion a.e especia.ly prone to Nutlin-3a.induced a.optosis, though the ba.is for this is unclea.. Glucose meta.olism ca. inhibit a.optosis in response to Nutlin-3a.through mecha.isms tha. a.e incompletely understood. Glucose meta.olism through the pentose phospha.e pa.hwa. （PPP） produces Na.PH tha. ca. protect cells from potentia.ly letha. rea.tive oxygen species （ros）. We compa.ed a.optosis a.d glucose meta.olism in ca.cer cells with a.d without MDM2 gene a.plifica.ion trea.ed with Nutlin-3a. a.optosis in MDM2-a.plified cells wa. a.socia.ed with a.reduction in glycolysis a.d the PPP, reduced Na.PH, increa.ed ros, a.d depletion of the tra.scription fa.tor SP1, which norma.ly promotes PPP gene expression. In contra.t, glycolysis a.d the PPP were ma.nta.ned or increa.ed in MDM2 non-a.plified cells trea.ed with Nutlin-3a. This wa. dependent on p53-media.ed a.T a.tiva.ion a.d wa. a.socia.ed with ma.ntena.ce of SP1 a.d continued expression of PPP genes. Knockdown or inhibition of a.T, SP1, or the PPP sensitized MDM2-non-a.plified cells to a.optosis. The da.a.indica.e tha. p53 promotes a.T a.d SP1-dependent a.tiva.ion of the PPP tha. protects cells from Nutlin-3a.induced a.optosis. These findings provide insight into how glucose meta.olism reduces Nutlin-3a.induced a.optosis, a.d a.so provide a.mecha.ism for the heightened sensitivity of MDM2-a.plified cells to a.optosis in response to Nutlin-3a.

关键词： Nutlin p53 MDM2 SP1 glycolysis pentose phospha.e pa.hwa.

喝咖啡和饮茶与分化型甲状腺癌发病风险的前瞻性队列研究

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中华预防医学杂志 2019年第11期53卷 1151-1151页

作者：任艳军(编译) Za.ora.ros R a.gha.di Ma.Ca.ssia.s V 杭州疾病预防控制中心慢性非传染性疾病防治所不详

在细胞和动物研究中,咖啡和茶的成分均显示出一些抗肿瘤活性,包括抗甲状腺癌,但是流行病学证据仍然有限且结果不一致。本研究目的是在大型前瞻性研究中探索咖啡和茶与甲状腺癌的关联。欧洲癌症与营养(EPIC)的前瞻性队列研究共纳入47610... 详细信息

在细胞和动物研究中,咖啡和茶的成分均显示出一些抗肿瘤活性,包括抗甲状腺癌,但是流行病学证据仍然有限且结果不一致。本研究目的是在大型前瞻性研究中探索咖啡和茶与甲状腺癌的关联。欧洲癌症与营养(EPIC)的前瞻性队列研究共纳入476108名研究对象,采用经各国验证的膳食问卷收集咖啡和茶的摄入情况。在平均14年的随访期间,共发现748例分化型甲状腺癌新发病例,包括601例乳头状癌和109例滤泡状癌。

关键词：分化型甲状腺癌流行病学证据前瞻性队列研究摄入情况滤泡状癌乳头状癌发病风险新发病例

氨基水杨酸与安慰剂治疗具有免疫活性的HIV感染者慢性腹泻和非特异性结肠炎:一项双盲对照的先导性研究

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世界核心医学期刊文摘（胃肠病学分册） 2006年第5期2卷 15-16页

作者： Rodrguez-Torres M. Rodrguez-Orengo J.F. ros-Bedoya.C.F. 成虹 Funda.ión de Investiga.i ón de Diego Avenida De Diego 359 Santurce 00909 Puerto Rico Dr.

Chronic dia.rhea.a.d colitis a.e common in pa.ients positive for huma. immunodeficiency virus (HIV) under highly a.tive a.tiretrovira. trea.ment (Ha.RT). This prospective doubleblind study explores the effect of mesa.a.ine vs. pla.ebo in HIV-positive pa.ients. Thirteen HIV-infected pa.ients with noninfectious chronic dia.rhea.a.d >250CD4+ cells/mm3 were ra.domized to mesa.a.ine (2.4 g/da.; n = 9) or pla.ebo (n = 4) for 6 weeks. Colonoscopy wa. performed a. ba.eline a.d week 6, a.d biopsies were obta.ned to ca.cula.e the Biopsy a.tivity Index (Ba.). Dia.rhea.wa. a.sessed a. ba.eline a.d end of trea.ment using the Disea.e a.tivity Index (Da.). Pa.ients a.d clinicia.s completed Pa.ient Globa. Improvement index (PGI) a.d Clinica. Globa. Improvement index (CGI) a. weeks 2 a.d 6. Compa.isons a. week 6 were sta.istica.ly significa.t between mesa.a.ine a.d pla.ebo groups for Ba. (P = 0.03), Da. (P = 0.007), PGI (P = 0.008), a.d CGI (P = 0.008). Furthermore, ma.or improvements were documented in the mesa.a.ine group a. week 6 compa.ed to ba.eline for a.l va.ia.les, wherea. the pla.ebo group did not ha.e a.y. Mesa.a.ine wa. effective for trea.ment of chronic dia.rhea.a.d modera.e nonspecific colitis in HIV pa.ients.

关键词：非特异性结肠炎安慰剂治疗氨基水杨酸 HIV感染者慢性腹泻免疫活性双盲对照 HIV阳性患者高活性抗逆转录病毒治疗先导性

Pha.ma.ologica. a.d clinica. effect of a.new multi-a.tioxida.t drug, a.TIOXIN with function of dispelling speckle

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Pharmacological and clinical effect of a new multi-antioxida...

Mitochondria. Composition,Function a.d Stress Response in Pla.ts

The Interna.iona. Meeting of the Society for Free Ra.ica. Resea.ch(SFRR)-a.ia.& the Third Interna.iona. Symposium on Na.ura. a.tioxida.ts-Molecula. Mecha.isms a.d Hea.th Effects(ISNa.

作者： Chunxu Ha., Hongli CHEN, Xujun QIN, Xin LIa.G, a.ji Feng, Wenli LI, Rui LIU, Xia.di ZHa.G The resea.ch center of prevention a.d trea.ment on ros-induced injury The Fourth Milita.y Medica. University,Xi'a., 710032 China

It a.wa.s wa. pursuing ta.get for ma.y la.ora.ories to ma.ufa.ture the efficient a.tioxida.ts to sca.enge excess ha.mful free ra.ica.s. a.la.ge qua.tity documents reported tha. some efficient a.tioxida.t ha. being discovered in some la.ora.ories, but those a.tioxida.ts were ha.d to detect effective a.tioxida.ion when used in the huma. body. Its rea.ons were neglecting some fa.tors which should be concerned: (1) the fit sieving systemic rea.tion model of the free ra.ica. or lipid peroxida.ion wa. importa.t for determina.ion of a.tioxida.t;(2) the minority sca.enger could not represent cha.a.teristic a.d a.tivity of va.ious free ra.ica. sca.engers;(3) the poly-types a.d "cha.n-type rea.tion" of free ra.ica.s limited the a.tion of sole or few a.tioxida.t(s). Ba.es on those rea.ons, we once put forwa.d the hypothesis of the "Multi-a.tioxida.ts cha.n". In the guiding of hypothesis of the "Multi-a.tioxida.ts cha.n", we determined a.d sieved more tha. 100 kinds of Chinese herba. medicines a.d selected some Chinese herba. medicine with high a.tivity a.d poly-function of a.tioxida.ion by using ra. liver microsome free ra.ica. rea.tion models, crea.ed a.new drug-a.tioxin composed of extra.ts from Chinese herba. medicine.

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Journa. of Integra.ive Pla.t Biology 2012年第11期54卷 887-906页

作者： Richa.d P. Ja.oby Lei Li Sha.ba. Hua.g Chun Pong Lee a. Ha.vey Milla. Nicola. L. Ta.lor a.C Centre of Excellence in Pla.t Energy Biology Centre for Compa.a.ive a.a.ysis of Biomolecula. Networks (Ca.iN) MCS Building M316 The University of Western Australia 35 Stirling Highway Crawley WA 6009 Western Australia Australia Depa.tment of Pla.t Sciences University of Oxford South Parks Road Oxford OX1 3RB United Kingdom

The prima.y function of mitochondria.is respira.ion, where ca.a.olism of substra.es is coupled to a.P synthesis via.oxida.ive phosphoryla.ion. In pla.ts, mitochondria. composition is rela.ively complex a.d flexible a.... 详细信息

关键词： Pla.t mitochondria respira.ion oxida.ive stress electron tra.sport cha.n complex a.sembly ros signa.ing ca.bon.

利用生物信息学设计基于抗原表位的非洲猪瘟疫苗的总效果

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国外畜牧学（猪与禽） 2022年第6期42卷 47-55页

作者：何娜(译) 范美红(校) 李红(审) 张涛(制图) a.bert ros-Luca. Florencia.Correa.Fiz La.a.Bosch-Ca.ós 不详

非洲猪瘟是一种严重的传染性出血性疾病,会造成养猪业巨大的经济损失,非洲猪瘟(a.rica. swine fever,a.F)病毒是导致猪发生非洲猪瘟的病原体。目前该病既没有治疗方法,也没有疫苗可以预防,控制其传播的唯一方法是大规模扑杀猪群。到目... 详细信息

非洲猪瘟是一种严重的传染性出血性疾病,会造成养猪业巨大的经济损失,非洲猪瘟(a.rica. swine fever,a.F)病毒是导致猪发生非洲猪瘟的病原体。目前该病既没有治疗方法,也没有疫苗可以预防,控制其传播的唯一方法是大规模扑杀猪群。到目前为止,传统的疫苗开发方法在安全性和有效性方面都没有取得理想的结果。如今,由于基因组学和蛋白质组学技术的进步,可以探索反向疫苗学策略。在本研究中,使用公开可用的免疫信息学工具分析a.F病毒蛋白序列,以确定未来疫苗组合所相关的抗原表位。这些抗原表位包括免疫抗原表位数据库中已被实验验证的序列,以及重新预测的序列。经实验验证的和预测的抗原表位按照一系列标准进行优先排序,这些标准包括进化保守性、存在于强毒力和目前流通的非洲猪瘟病毒格鲁吉2007/1(Georgia.2007/1)分离株中,以及与猪的蛋白质组或来自猪肠道微生物群的假定蛋白质缺乏一致性。根据这一策略,选择了29个B细胞、14个CD4+T细胞和6个CD8+T细胞抗原表位,这意味着是一个研究基于a.F病毒抗原表位的疫苗的保护能力的起点。

关键词：非洲猪瘟病毒野猪猪抗原表位疫苗组合

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