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Clinicopathological and oncological significance of persistent prostate-specific antigen after radical prostatectomy:A systematic review and meta-analysis

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Asian Journal of Urology 2023年第3期10卷 317-328页

作者： Shulin Wu Sharron X.Lin kristine M.Cornejo rory k.crotty Michael L.Blute Douglas M.Dahl Chin-Lee Wu Department of Urology Massachusetts General HospitalHarvard Medical SchoolBostonMAUSA Department of Pathology Massachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Objective:To investigate the association of persistently elevated prostate-specific antigen(PSA)after radical prostatectomy(RP)with clinicopathological features and long-term oncological prognosis for the development of a potential management ***:A systematic literature search was performed using PubMed and Web of Science up to June 2021 to identify the eligible studies focusing on understanding the impact of persistent PSA in patients who underwent RP for localized prostate ***-analyses were performed on parameters with available ***:A total of 32 RP studies were identified,of which 11 included 26719 patients with consecutive cohorts and the remaining 21 comprised 24177 patients with cohorts carrying specific *** the 11 studies with consecutive cohorts,the incidence of persistent PSA varied between 3.1%and 34.6%with a median of 11.0%.Meta-analyses revealed patients with persistent PSA consistently showed unfavorable clinicopathological features and a more than 3.5-fold risk of poorer biochemical recurrence,metastasis,and prostate cancer-specific mortality prognosis independently,when compared to patients with undetectable ***,cases with persistent PSA in different specific patient cohorts with a higher risk of prostate cancer also showed a trend of worse ***:We found that the frequency of persistent PSA was about 11.0%in consecutive RP *** PSA was significantly associated with unfavorable clinicopathological characteristics and worse oncological *** with persistent PSA after RP may benefit from early salvage treatment to delay or prevent biochemical recurrence,improving oncological outcomes for these *** prospective randomized controlled trials are warranted to understand optimal systemic therapy in these patients.

关键词： Prostate cancer Radical prostatectomy Persistent prostatespecific antigen Prognosis Salvage Systematic review Meta-analysis

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Extreme developmental temperatures result in morphological abnormalities in painted turtles(Chrysemys picta):a climate change perspective

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Integrative Zoology 2013年第2期8卷 197-208页

作者： rory S.TELEMECO Daniel A.WARNER Molly k.REIDA Fredric J.JANZEN Department of Ecology Evolution and Organismal BiologyIowa State UniversityAmesIowaUSA

Increases in extreme environmental events are predicted to be major results of ongoing global climate change and may impact the persistence of *** examined the effects of heat and cold waves during embryonic development of painted turtles(Chrysemys picta)in natural nests on the occurrence of abnormal shell morphologies in *** found that nests exposed to extreme hot temperatures for>60 h produced more hatchlings with abnormalities than nests exposed to extreme hot temperatures for shorter periods,regardless of whether or not nesting females displayed abnormal *** observed no effect of extreme cold nest temperatures on the occurrence of hatchlings with ***,the frequency of nesting females with abnormal shell morphologies was approximately 2-fold lower than that of their offspring,suggesting that such abnormalities are negatively correlated with survival and *** turtles could potentially buffer their offspring from extreme heat by altering aspects of nesting behavior,such as choosing shadier nesting *** addressed this hypothesis by examining the effects of shade cover on extreme nest temperatures and the occurrence of hatchling *** shade cover was negatively correlated with the occurrence of extreme hot nest temperatures,it was not significantly correlated with ***,female choice of shade cover does not appear to be a viable target for selection to reduce hatchling *** results suggest that increases in the frequency and intensity of heat waves associated with climate change might perturb developmental programs and thereby reduce the fitness of entire cohorts of turtles.

关键词： anomaly fundamental niche incubation nesting behavior scute deformity

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SARS-CoV-2-specific T-cells in unexposed humans:presence of cross-reactive memory cells does not equal protective

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Signal Transduction and Targeted Therapy 2020年第1期5卷 635-636页

作者： rory D.de Vries Department Viroscience Erasmus MCRotterdamthe Netherlands

Using human blood samples obtained from pre-pandemic donors,a recent article by Mateus et *** Science provided new evidence that SARS-CoV-2-reactive T-cells in unexposed donors are indeed HCoV-specific T-cells.1 The rapid global spread of coronavirus disease 2019(COVID-19),caused by the newly-emerged coronavirus SARS-CoV-2,has led to millions of infections with substantial morbidity and mortality.2 Different clinical manifestations of COVID-19 have been observed:asymptomatic infections,mild self-limiting disease,acute respiratory distress syndrome and *** determinants underlying disease severity currently remain elusive;since severe patients often present with immune hyperresponsiveness,it is speculated that the host’immune response could be a contributing factor to severe disease.

关键词： protective distress reactive

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Integration of Indigenous knowledge and Disaster Risk Reduction: A Case Study from Baie Martelli, Pentecost Island, Vanuatu

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International Journal of Disaster Risk Science 2012年第4期3卷 185-194页

作者： rory A.Walshe Patrick D.Nunn Department of Geography Environment and Disaster ManagementCoventry UniversityCoventry CV15FBUnited Kingdom School of Behavioural Cognitive and Social SciencesUniversity of New EnglandArmidaleNew South Wales 2351Australia

Despite reaching heights of >6 m and destroying a sizeable coastal settlement at the head of Baie Martelli(Pentecost Island, Vanuatu, South Pacific), the 26 November 1999 tsunamis caused only five fatalities from a threatened population of about 300 persons, most of whom fled inland and upslope before the waves struck. This remarkable survival rate is attributed to both indigenous knowledge, largely in the form of kastom knowledge, and information obtained from a video about tsunamis that was shown in the area three weeks earlier. Interviews with 55 persons who experienced this tsunami suggest that indigenous knowledge about tsunami risk and response in Baie Martelli was well known among key members of the community and was probably largely responsible for the appropriate response. Future strategies for disaster risk reduction should involve maintaining such indigenous knowledge in such communities and supplementing this where needed with scientific knowledge filtered through indigenous culture and language.

关键词： Island cost inland

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Two-dimensional gel electrophoresis in bacterial proteomics

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Protein & Cell 2012年第5期3卷 346-363页

作者： Shirly O.T.Curreem rory M.Watt Susanna k.P.Lau Patrick C.Y.Woo Department of Microbiology The University of Hong KongQueen Mary HospitalHong KongChina Oral Biosciences Faculty of DentistryThe University of Hong KongQueen Mary HospitalHong KongChina State key Laboratory of Emerging Infectious Diseases Department of MicrobiologyThe University of Hong KongQueen Mary HospitalHong KongChina Research Centre of Infection and Immunology The University of Hong KongQueen Mary HospitalHong KongChina Carol Yu Centre of Infection The University of Hong KongHong KongChina

Two-dimensional gel electrophoresis(2-DE)is a gel-based technique widely used for analyzing the pro-tein composition of biological *** is capable of resolving complex mixtures containing more than a thousand protein components into individual protein spots through the coupling of two orthogonal bio-physical separation techniques:isoelectric focusing(first dimension)and polyacrylamide gel electrophore-sis(second dimension).2-DE is ideally suited for ana-lyzing the entire expressed protein complement of a bacterial cell:its *** relative simplicity and good reproducibility have led to 2-DE being widely used for exploring proteomics within a wide range of envi-ronmental and medically-relevant *** we give a broad overview of the basic principles and his-torical development of gel-based proteomics,and how this powerful approach can be applied for studying bacterial biology and *** highlight specific 2-DE applications that can be used to analyze when,where and how much proteins are *** links between proteomics,genomics and mass spectrometry are *** explore how proteomics involving tandem mass spectrometry can be used to analyze(post-translational)protein modifications or to identify proteins of unknown origin by de novo peptide *** use of proteome fractionation tech-niques and non-gel-based proteomic approaches are also *** highlight how the analysis of pro-teins secreted by bacterial cells(secretomes or exo-proteomes)can be used to study infection processes or the immune *** review is aimed at non-specialists who wish to gain a concise,compre-hensive and contemporary overview of the nature and applications of bacterial proteomics.

关键词： two-dimensional gel electrophoresis bacte-ria proteomics

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Envita’s Precision Cancer Care: 35-Fold Improvement in Response Rates

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Journal of Cancer Therapy 2024年第4期15卷 99-120页

作者： Sheba Goklany John C. Oertle III Ronald Matthias Jr. Daniel Warren David Medina rory Sears Robert Zieve kendra Quart Christopher Aussems Jon Moma Shannon Miller Zach Poteet Conner Coffin Courtney Middleton Erika Ware Phylicia Zarnosky Julie Nowak Winlove Suasin Daniel Conway Chad Burk Ruth Tan-Lim Dino Prato Envita Medical Centers Scottsdale AZ USA

New clinical approaches are imperative beyond the widely adopted National Comprehensive Cancer Network (NCCN) guidelines, utilized by prominent cancer institutions. Cancer is the leading cause of death among individuals younger than 85 years within the United States. Despite significant technological advances, including the expenditure of hundreds of billions, treatment outcomes and overall survival have not notably improved for most types of advanced cancer over the last several decades. Over the past 24 years, Envita Medical Centers has pioneered a unique form of personalized treatment approach for late-stage and refractory cancer patients, introducing groundbreaking innovations in the field. Our integrated algorithm utilizes advanced genomics, transcriptomics, and highly tailored immunotherapy, resulting in remarkable outcome improvements. This study presents Envita’s innovative personalized treatment algorithms and examines the response outcomes of 199 late-stage cancer patients treated at Envita Medical Centers over a two-year period. Compared to standard of care and palliative chemotherapy, Envita’s treatment demonstrated a remarkable 35-fold improvement in overall response rates (Figure 1). Moreover, 88% of the patients, the majority presenting with Stage 3 or 4 cancer, experienced a 43-fold improvement in quality of life with minimal side effects, as compared to standard of care chemotherapy and palliative care. This revolutionary success is attributed to Envita’s personalized therapeutic algorithms, which incorporate customized immunotherapy. Envita’s precision care approach has also achieved a 100% better response rate compared to over 65 global chemotherapy clinical trials with more than 2700 patients. The results from this study suggest that a wider utilization of Envita’s personalized approach can significantly benefit patients with late-stage and refractory cancer.

关键词： Envita Medical Centers Late-stage Cancer Overall Response Rate Quality of Life Circulating Tumor Cells (CTCs) Mutant Allele Frequency (MAF) Precision Care

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Resolution of phylogenetic relationships of the major subfamilies of the Delphacidae （Homoptera： Fulgoroidea） using the mitochondrial ribosomal DNA

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Insect Science 2006年第3期13卷 167-177页

作者： EDDY DIJkSTRA MICHEL A. SLOTMAN rory J. POST Biosystematics Group Wageningen University the Netherlands The Natural History Museum London UK

Delphacid relationships from the genus level to the subfamily have been completely resolved （among those taxa examined） using sequence data from the 3＇ end of the 12S gene. Monophyly of the non-asiracine subfamilies was strongly supported and the asiracine Ugyops was placed in the most basal position of the tree. Support levels for monophyly of the Delphacini increased after weighting transversions more heavily than transitions and after removing the cixiid outgroup from the dataset. Among the Delphacini, Conomelus and Megamelus were more closely related to each other than either was to Chloriona. These results are in agreement with the tree based on morphological characters. However, in contrast to morphological data our results strongly supported a sister group relationship between the Stenocraninae and the kelisiinae. Although the 12S gene fragment gave some information about the species relationships within Chloriona, neither this fragment nor the 5＇ end of the 16S gene appear to be very useful for this level. Molecular evolutionary patterns provided evidence that there has been a shift in base composition from T to A during the early evolution of the non-Asiracinae. The non-Asiracinae also had comparatively fast substitution rates and these two observations are possibly correlated. In the ‘ modem＇ delphacid Chloriona, the AT content was comparatively low in regions free of constraints but this was not the case for ‘ non-modem＇ delphacids. The tRNA for valine has been translocated elsewhere, probably before the Delphacidae and Cixiidae diverged from each other.

关键词： classification Delphacidae evolution Fulgoroidea Homoptera rnitochondrial DNA phylogeny ribosomal DNA

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Access to novel anti-diabetic agents in resource limited settings:A brief commentary

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World Journal of Diabetes 2023年第7期14卷 939-941页

作者： Poobalan Naidoo kiolan Naidoo Sumanth karamchand rory F Leisegang Department of Internal Medicine Nelson R MandelaSchool of MedicineUniversity of Kwa-Zulu NatalDurban 4001Kwa-Zulu NatalSouth Africa Department of Law University of South AfricaPretoria 3GautengSouth Africa Department of Cardiology University of Stellenbosch and Tygerberg HospitalStellenbosch 7600Western CapeSouth Africa Department of Pharmacometrics Upsala UniversityUppsala 75104Sweden

The prevalence of diabetes mellitus is increasing in resource limited ***,there has been an increase in the number of novel therapies for the management of diabetes ***,use of novel antidiabetic therapies is limited because of major market access challenges in resource limited *** products to those patients with the highest absolute risk for major adverse cardiovascular outcomes,and thus most likely to benefit from the therapy,are less likely to have negative budget impact for *** improve access,and reduce morbidity and mortality,requires alignment amongst key stakeholders including patient advocacy groups,health care professional councils,national departments of health,the pharmaceutical industry,treasury and finance departments.

关键词： Type 2 diabetes mellitus Novel anti-diabetic agents Resource limited settings Access

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LIFE： Costing the Digital Preservation Lifecycle

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现代图书情报技术 2008年第1期 69-74页

作者： PAUL WHEATLEY PAUL AYRIS RICHARD DAVIES rory MCLEOD HELEN SHENTON The British Library Boston Spa Wetherby UK UCL Gower Street London UK The British Library St Pancras London UK

The LIFE project creates a digital lifecycle model based on previous work undertaken on the lifecycle of paper-based *** Archiving, Voluntarity Deposited Electronic Publications (VDEP), and E-Journal are chosen as case study for application and evaluation of the LIFE *** studies show its potential for further use in a numble of roles,such as improving assessment of the financial commitment,more effective planning for preservation activities *** LIFE Mode will be revised and refined in LIFE2 Project.

关键词：数字资源长期保存生命周期成本 LIFE模型方案

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Oxygen supply did not affect how lizards responded to thermal stress

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Integrative Zoology 2018年第4期13卷 428-436页

作者： Agustín CAMACHO John M.VANDENBROOkS Angela RILEY rory S.TELEMECO Michael J.ANGILLETTA Jr School of Life Sciences Arizona State UniversityTempeArizonaUSA Department of Physiology Institute of BiosciencesUniversity of São PauloBrazil Department of Physiology Midwestern UniversityGlendaleArizonaUSA Department of Biology California State UniversityFresnoCaliforniaUSA

Zoologists rely on mechanistic niche models of behavioral thermoregulation to understand how animals respond to climate *** models predict that species will need to disperse to higher altitudes to persist in a warmer ***,thermal stress and,thus,thermoregulatory behavior may depend on atmospheric oxygen as well as environmental *** hypoxia causes animals to prefer lower body temperatures,which could be interpreted as evidence that oxygen supply limits heat *** a constraint could prevent animals from successfully dispersing to high elevations during climate ***,an effect of oxygen supply on preferred body temperature has only been observed when oxygen concentrations fall far below levels experienced in *** see whether animals perceive greater thermal stress at an ecologically relevant level of hypoxia,we studied the thermoregulatory behavior of lizards(Sceloporus tristichus)exposed to oxygen concentrations of 13%and 21%(equivalent to PO2 at 4000 m and 0 m,respectively).In addition,we exposed lizards to 29%oxygen to see whether they would accept a higher body temperature at hyperoxia than at *** each oxygen level,we measured a behavioral response to heat stress known as the voluntary thermal maximum:the temperature at which a warming animal sought a cool *** concentration had no discernable effect on the voluntary thermal maximum,suggesting that lizards experience thermal stress similarly at all 3 levels of oxygen(13%,12%and 29%).Future research should focus on thermoregulatory behaviors under ecologically relevant levels of hypoxia.

关键词： hypoxia Sceloporus stress temperature thermoregulation

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