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Journal of Innovative Optical Health Sciences 2020年第2期13卷 70-80页

作者： Joanne Li Madison N.Wilson Andrew J.Bower Marina Marjanovic Eric J.Chaney ronit barkalifa Stephen A.Boppart Department of Bioengineering University of Illinois at Urbana-Champaign Urbana ILU.S.A Department of Electrical and Computer Engineering University of Illinois at Urbana-Champaign Urbana ILU.S.A Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign Urbana ILU.S.A Carle Illinois College of Medicine University of Illinois at Urbana-Champaign Urbana ILU.S.A

To date,numerous studies have been performed to elucidate the complex cellular dynamics in skin diseases,but few have attempted to characterize these cellular events under conditions similar to the native *** address this challenge,a three-dimensional(3D)multimodal analysis platform was developed for characterizing in vivo cellular dynamics in skin,which was then utilized to process in vivo wound healing data to demonstrate its *** attention is focused on in vivo biological parameters that are difficult to study with ex vivo analysis,including 3D cell tracking and techniques to connect biological information obtained from different imaging *** results here open new possibilities for evaluating 3D cellular dynamics in vivo,and can potentially provide new tools for characterizing the skin microenvironment and pathologies in the future.

关键词： Cellular dynamics multimodal imaging multiphoton microscopy

APOE4 expression is associated with impaired autophagy and mitophagy in astrocytes

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Neural Regeneration Research 2022年第4期17卷 777-778页

作者： Schmukler Eran Pinkas-Kramarski ronit Department of Neurobiology School of Neurobiology Biochemistry and BiophysicsTel-Aviv UniversityRamat-AvivIsrael

Among the risk factors for late onset sporadic Alzheimer's disease(AD)is the expression ofε4 allele of apolipoprotein E(APOE4)gene(Mahley et al.,2006).Elevated amyloid processing and reduced degradation of Aβ,which lead to Ap plaque deposition,are evident in APOE4-positive AD patients and mice(Mahley et al.,2006).These features correlate with neuronal cell *** mitochondrial activity and increased oxidative stress have long been recognized as additional hallmarks of AD pathology(Mahley et al.,2006).The effect of APOE4 expression on autophagy and mitochondrial dynamics and activity in astrocytes is discussed in this perspective and is summarized in Figure 1.

关键词： al. impaired Aβ

p53 balances between tissue hierarchy and anarchy

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Journal of Molecular Cell Biology 2019年第7期11卷 553-563页

作者： Gabriela Koifman ronit Aloni-Grinstein Varda Rotter Department of Molecular Cell Biology the Weizmann Institute of ScienceRehovot 7610001Israel Department of Biochemistry and Molecular Genetics Israel Institute for Biological ResearchNess ZionaIsrael

Normal tissues are organized in a hierarchical model,whereas at the apex of these hierarchies reside stem cells (SCs) capable of self-renewal and of producing differentiated cellular progenies,leading to normal development and ***,tumors are organized in a hierarchical manner,with cancer SCs residing at the apex,contributing to the development and nourishment of tumors .p53,the well-known 'guardian ofthe genome',possesses various roles in embryonic development as well as in adult SC life and serves as the ‘guardian of tissue hierarchy’.Moreover,p53 serves as a barrier for dedifferentiation and reprogramming by constraining the cells to a somatic state and preventing their conversion to *** the contrary,the mutant forms of p53 that lost theirtumor suppressor activity and gain oncogenic functions serve as 'inducers oftissue anarchy' and promote cancer *** this review,we discuss these two sides ofthe p53 token that sentence a tissue either to an ordered hierarchy and life or to anarchy and death.A better understanding of these processes may open new horizons for the development of new cancer therapies.

关键词： p53 stem cell gain of function cancer stem cells adult stem cells embryonic development tissue hierarchy

Mutant p53-a potential player in shaping the tumor-stroma crosstalk

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Journal of Molecular Cell Biology 2019年第7期11卷 600-604页

作者： Yan Stein ronit Aloni-Grinstein Varda Rotter Department of Molecular Cell Biology Weizmann Institute of ScienceRehovot 7610001Israel Department of Biochemistry and Molecular Genetics Israel Institute for Biological ResearchBox 19Ness Ziona 7410001Israel

A plethora of studies suggest that the non-transformed cellularand non-ceHular comp on ents of the tumor,collectively known as the tumor microenvironment,have a significa nt impact on the tumorigenic *** was suggested that the microenvironment,which initially restricts tumor development,is recruited by the tumor and main tains a crosstalk that further promotes cancer progression.

关键词： plethora tumor progression

Hyperbaric oxygen therapy as a new treatment approach for Alzheimer's disease

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Neural Regeneration Research 2018年第5期13卷 817-818页

作者： ronit Shapira Shai Efrati Uri Ashery Department of Neurobiology the George S. Wise Faculty of Life Sciences Tel Aviv University Sackler School of Medicine Tel Aviv University Sagol Center for Hyperbaric Medicine & Research Assaf Harofeh Medical Center Sagol School of Neuroscience Tel Aviv University

Hyperbaric oxygen therapy as a new treatment approach for Alzheimer’s disease（AD）：Alongside the increase in life expectancy,the prevalence of age-related disorders,such as neurodegenerative diseases,is on the *** ... 详细信息

关键词： Hyperbaric oxygen therapy as a new treatment approach for Alzheimer’s disease AD

Unilateral mimicking bilateral BPPV- a forgotten entity? Characteristics of a largecohort of patients, comparison with posterior canal BPPV and clinical implications

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Journal of Otology 2021年第4期16卷 252-257页

作者： Lea Pollak ronit Gilad Tal Michael Neurology and Dizziness Clinic Kupat Cholim Macabi and the Ben GurionUniversity of the NegevBeer ShevaIsrael Neurology Department Kaplan Medical CenterRechovotAffiliated to the HebrewUniversityJerusalemIsrael The Faculty of Health Public Ben Gurion University of the NegevBeerShevaIsrael

Objective: Unilateral mimicking bilateral benign paroxysmal positional vertigo (umb-BPPV) was attributed to inappropriate head positioning during testing of the posterior canal. Despite its inclusion in theDiagnostic criteria for the classification of vestibular disorders of the Barany Society, the clinical characteristics and treatment responsiveness of this BPPV subtype have not been intensively ***: Records of patients with BPPV seen at a single outpatient dizziness clinic during the years 2000e2020 were reviewed. Eighty seven patients with umb-BPPV and 86 random patients with posteriorcanal BPPV (p-BPPV) were retrieved. Their demographics and BPPV characteristics were ***: Patients' and BPPV characteristics were similar in umb- and p-BPPV except for the prevalence ofmales in the umb-BPPV group. No differences were found between treatment responsiveness and recurrences in both groups. The recurrence rate of umb-BPPV was not influenced by age, gender, BPPV side,duration of symptoms or treatment responsiveness during the first ***: In accordance with our hypothesis about mixed canalo- and cupulolithiasis as the underlying mechanism of umb-BPPV, patients did not differ in characteristics and treatment responsivenessfrom p-BPPV patients. Recognition of umb-BPPV is important since inappropriate treatment can cause anunnecessary delay in therapy success.

关键词： Benign paroxysmal positional vertigo Canalo-and cupulolithiasis

Elimination of murine and human T-cell epitopes in recombinant immunotoxin eliminates neutralizing and anti-drug antibodies in vivo

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Cellular & Molecular Immunology 2017年第5期14卷 432-442页

作者： ronit Mazor Devorah Crown Selamawit Addissie Youjin Jang Gilad Kaplan Ira Pastan Laboratory of Molecular Biology Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda MD USA Leidos Biomedical Research Inc National Cancer Institute National Institutes of Health Bethesda MD USA

Antibodies against the toxin portion of recombinant immunotoxins （RIT） reduce their efficacy and pose a potential safety risk. To overcome this problem we mutated the very immunogenic immunotoxin SSIP to produce LMB-T20, a de-immunized RIT that has the eight human T-cell epitopes in SSIP modified or removed. To determine the effect of T-cell epitope removal in vivo we mapped the T-cell epitopes in immune-competent BALB/c mice and found that these mice recognize two epitopes. One corresponds to the human immunodominant T-cell epitope and the other to a human subdominant epitope; both were eliminated in LMB-T20. We found that mice immunized with LMB-T20 did not have T-cell activation and did not develop anti-drug antibodies （ADA）, whereas mice immunized with SSIP, showed T-cell activation, and developed ADA detected by both ELISA and drug neutralizing assays. The ability of the mice treated with LMB-T20 to respond to other antigens was not compromised. We conclude that elimination of T-cell epitopes is sufficient to prevent formation of antibodies to an immunogenic foreign protein.

关键词： anti-drug antibodies deimmunization immunogenicity mouse epitopes T-cell epitopes

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激酶Kinome和糖皮质激素诱导的凋亡

癌症 2008年第11期27卷 1121-1129页

作者： ronit Vogt Sionov The Lautenberg Center ofImmunology Institute of Medical ResearchFaculty of MedicineHebrew University

糖皮质激素(glucocorticoid,GC)信号系统和激酶Kinome之间有着复杂的相互作用,其中,在GC处理后,由Kinome最终决定细胞的命运。当细胞表达足够水平的糖皮质激素受体(glucocorticoid receptor,GR)和Bim,以及有利于GSK3激活的Kinome时,就... 详细信息

糖皮质激素(glucocorticoid,GC)信号系统和激酶Kinome之间有着复杂的相互作用,其中,在GC处理后,由Kinome最终决定细胞的命运。当细胞表达足够水平的糖皮质激素受体(glucocorticoid receptor,GR)和Bim,以及有利于GSK3激活的Kinome时,就会继发细胞凋亡。通过防止Bim的上调和/或抑制GSK3的蛋白激酶,可在细胞内产生GC抵抗。通过抑制JNK、Src、PI3K、Akt或mTOR存活通路,可以克服T淋巴系统和B淋巴系统恶性肿瘤中的GC抵抗。最近已证明星状孢子素和雷帕霉素可以对GC诱导细胞凋亡相抵抗的恶性T淋巴细胞和B淋巴细胞加以有效致敏。这在理论上论证了通过改变细胞的Kinome提高GC疗效的可行性。

关键词：激酶Kinome 糖皮质激素淋巴瘤凋亡

Synthesis of WS_(2)and MoS_(2)Fullerene-Like Nanoparticles from Solid Precursors

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Nano Research 2009年第5期2卷 416-424页

作者： Inna Wiesel Hamutal Arbel Ana Albu-Yaron ronit Popovitz-Biro Jeffrey MGordon Daniel Feuermann Reshef Tenne Department of Materials and Interfaces Weizmann Institute of ScienceRehovot 76100Israel Electron Microscopy Unit Weizmann Institute of ScienceRehovot 76100Israel Department of Solar Energy and Environmental Physics Jacob Blaustein Institutes for Desert ResearchBen-Gurion University of the NegevBeer Sheva Campus 84990Israel The Pearlstone Center for Aeronautical Engineering Studies Department of Mechanical EngineeringBen-Gurion University of the NegevBeer Sheva 84105Israel

Inorganic fullerene-like WS_(2)and MoS_(2)nanoparticles have been synthesized using exclusively solid precursors,by reaction of the corresponding metal oxide nanopowder,sulfur and a hydrogen-releasing agent(NaBH4 or LiAlH4),achieved either by conventional furnace heating up to~900℃or by photothermal ablation at far higher temperatures driven by highly concentrated white *** contrast to the established syntheses that require toxic and hazardous gases,working solely with solid precursors permits relatively safer reactor conditions conducive to industrial scale-up.

关键词： Nanoparticles fullerene-like synthesis WS_(2) MoS_(2)

Systematic review of dynamization vs exchange nailing for delayed/non-union femoral fractures

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World Journal of Orthopedics 2018年第7期9卷 92-99页

作者： Jacob E Vaughn ronit V Shah Tarek Samman Jacob Stirton Jiayong Liu Nabil A Ebraheim College of Medicine and Life Sciences University of Toledo Department of Orthopedic Surgery University of Toledo Medical Center

AIM To analyze the literature on efficacy of dynamamization vs exchange nailing in treatment of delayed and nonunion femur *** Ultimately, 31 peer-reviewed articles with 644 exchanged nailing patients and 131 dynamization patients were identified and analyzed. The following key words were inputted in different combinations in order to search the field of publications in its entirety: "nonunion", "delayed union", "ununited", "femur fracture", "femoral fracture", "exchange nailing", "dynaiz(s)ation", "secondary nailing", "dynamic", "static", and "nail revision". The initial search yielded over 150 results, and was refined based on the inclusion criteria: Only studies reporting on humans, non-unions and delayed unions, and the usage of exchange nailing and/or dynamization as a secondary treatment after failed IM nailing. The resulting 66 articles were obtained through online journal access. The results were filtered further based on the exclusion criteria: No articles that failed to report overall union rates, differentiate between success rates of their reported techniques, or articles that analyzed less than 5 patients. RESULTS Exchange nailing lead to fracture union in 84.785% of patients compared to the 66.412% of dynamization with statistically comparable durations until union(5.193 ± 2.310 mo and 4.769 ± 1.986 mo respectively). Dynamically locking exchange nails resulted in an average union time of 5.208 ± 2.475 mo compared to 5.149 ± 2.366 mo(P = 0.8682) in statically locked exchange nails. The overall union rate of the two procedures, statically and dynamically locked exchange nailing yielded union rates of 84.259% and 82.381% respectively. Therefore, there was no significant difference between the different locking methods of exchange nailing for union rate or time to union at a significance value of P < 0.05. The analysis showed exchange nailing to be the more successful choice in the treatment of femoral non-unions in respect to its higher succ

关键词： Non-union Delayed union Dynamization Femoral fracture Exchange nailing