APOE4 expression is associated with impaired autophagy and mitophagy in astrocytes

作     者：Schmukler Eran Pinkas-Kramarski Ronit Schmukler Eran;Pinkas-Kramarski Ronit

作者机构：Department of NeurobiologySchool of Neurobiology Biochemistry and BiophysicsTel-Aviv UniversityRamat-AvivIsrael 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第4期

页      面：777-778页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100203[医学-老年医学] 10[医学] 

主　　题：al. impaired Aβ 

摘      要：Among the risk factors for late onset sporadic Alzheimer s disease(AD)is the expression ofε4 allele of apolipoprotein E(APOE4)gene(Mahley et al.,2006).Elevated amyloid processing and reduced degradation of Aβ,which lead to Ap plaque deposition,are evident in APOE4-positive AD patients and mice(Mahley et al.,2006).These features correlate with neuronal cell *** mitochondrial activity and increased oxidative stress have long been recognized as additional hallmarks of AD pathology(Mahley et al.,2006).The effect of APOE4 expression on autophagy and mitochondrial dynamics and activity in astrocytes is discussed in this perspective and is summarized in Figure 1.