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Tripodalsporormielones A-C,unprecedented cage-like polyketides with complex polyvdent bridged and fused ring systems

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Acta Pharmaceutica Sinica B 2021年第11期11卷 3648-3654页

作者： Guodong Chen Bingxin Zhao Meijuan Huang Jia Tang Yanbing Li Liangdong Guo rongrong he Dan Hu Xinsheng Yao Hao Gao Institute of Traditional Chinese Medicine&Natural Products College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchJinan UniversityGuangzhou 510632China Department of Chemistry College of Chemistry and Materials ScienceJinan UniversityGuangzhou 510632China Guangdong Engineering Research Center of Chinese Medicine&Disease Susceptibility Jinan UniversityGuangzhou 510632China State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100190China

A chemical investigation on Sporormiella sp.led to the isolation and structural elucidation of tripodalsporormielones Ae C(1-3),a new class of polyketide possessing unprecedented cage-like skeletons with polyvdent bridged and fused ring systems.These polyketides with cage-like skeletons were characterized as a high non-protonated carbon-containing system,which resulted in few HMBC correlations observed and made the accurate structures hard to be obtained by NMR.Especially,some signals of non-protonated sp;carbons are weak and even unobservable in compound 1.In order to establish the structure of 1,the calculated NMR with DP4 evaluation was applied to determine the structure from the plausible structure candidates obtained from the detailed NMR analysis.Based on NMR experiments and calculated NMR,the structures of isolated compounds were established and confirmed by X-ray technology.Through chiral isolation,the optically pure enantiomers of 1 and 3 were obtained,and their absolute configurations were determined based on ECD quantum chemical calculation.Based on the isolated compounds and our previous work,1-3 would be derived from 3-methylorcinaldehyde,and their plausible biosynthetic mechanism was proposed.Furthermore,1 exhibited obvious short-term memory improvement activity on an Alzheimer’s disease fly model.

关键词： Tripodalsporormielones Cage-like polyketides 3-Methylorcinaldehyde Alzheimer’s disease

High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care

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Acta Pharmaceutica Sinica B 2019年第5期9卷 1035-1049页

作者： Jian Li Olajide E.Olaleye Xuan Yu Weiwei Jia Junling Yang Chuang Lu Songqiao Liu Jingjing Yu Xiaona Duan Yaya Wanga Kai Dong rongrong he Chen Cheng Chuan Li State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences University of Chinese Academy of Sciences Department of DMPK Department of Critical Care Medicine Zhongda HospitalSchool of MedicineSoutheast University School of Pharmacy University of Washington Tianjin Chasesun Pharmaceutical Co.Ltd.

Managing the dysregulated host response to infection remains a major challenge in sepsis care. Chinese treatment guideline recommends adding Xue Bi Jing, a five-herb medicine, to antibioticbased sepsis care. Although adding Xue Bi Jing further reduced 28-day mortality via modulating the host response, pharmacokinetic herbedrug interaction is a widely recognized issue that needs to be studied.Building on our earlier systematic chemical and human pharmacokinetic investigations of Xue Bi Jing, we evaluated the degree of pharmacokinetic compatibility for Xue Bi Jing/antibiotic combination based on mechanistic evidence of interaction risk. Considering both Xue Bi Jing-antibiotic and antibiotic-Xue Bi Jing interaction potential, we integrated informatics-based approach with experimental approach and developed a compound pair-based method for data processing. To reflect clinical reality, we selected for study Xue Bi Jing compounds bioavailable for drug interactions and 45 antibiotics commonly used in sepsis care in China. Based on the data of interacting with drug metabolizing enzymes and transporters, no Xue Bi Jing compound could pair, as perpetrator, with the antibiotics. Although some antibiotics could,due to their inhibition of uridine 50-diphosphoglucuronosyltransferase 2 B15, organic anion transporters1/2 and/or organic anion-transporting polypeptide 1 B3, pair with senkyunolide I, tanshinol and salvianolic acid B, the potential interactions(resulting in increased exposure) are likely desirable due to these Xue Bi Jing compounds’ low baseline exposure levels. Inhibition of aldehyde dehydrogenase by 7 antibiotics probably results in undesirable reduction of exposure to protocatechuic acid from Xue Bi Jing.Collectively, Xue Bi Jing/antibiotic combination exhibited a high degree of pharmacokinetic compatibility at clinically relevant doses. The methodology developed can be applied to investigate other drug combinations.

关键词： XueBiJing Antibiotic Combination drug therapy Sepsis Pharmacokinetic compatibility herb-drug interaction

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市售草莓脯的品质差异分析

食品工业科技 2024年第1期45卷 239-246页

作者：牛丽影陈建王锐何茸茸张钟元刘春菊肖亚冬聂梅梅李大婧江苏省农业科学院农产品加工研究所江苏南京210014 苏州优尔食品有限公司江苏苏州215105 扬州大学食品科学与工程学院江苏扬州225000

为了解目前市售草莓脯的品质特点,本文对15个品牌草莓脯产品的色泽、质构及糖酸含量等理化指标分别采用色差计、质构仪和高效液相色谱进行了测定,并采用强度标度法对感官特性进行了评分。结果显示:草莓脯的水分含量为12.49%~23.86%,色度... 详细信息

为了解目前市售草莓脯的品质特点,本文对15个品牌草莓脯产品的色泽、质构及糖酸含量等理化指标分别采用色差计、质构仪和高效液相色谱进行了测定,并采用强度标度法对感官特性进行了评分。结果显示:草莓脯的水分含量为12.49%~23.86%,色度值L^(*)值分布于23.25~34.39,a^(*)值5.17~19.83,b^(*)值5.78~17.04;质构参数中硬度、咀嚼性和粘力差异显著(P<0.05)。草莓脯中可溶性糖主要为果糖、葡萄糖,二者分别为总糖的30.17%~52.43%和28.49%~55.15%,蔗糖和麦芽糖含量略低,不同样品间差别较大,分别为总糖的0.00%~33.00%和0.00%~14.08%。有机酸以柠檬酸和苹果酸为主,分别为7.98~13.05 mg/g和4.48~8.17 mg/g。感官评分结果显示色泽、粘度与整体接受度变幅较大。对草莓脯及品质指标进行双向聚类发现样品聚为2类而品质指标聚为3组。类别I中的草莓脯因具有较高的a^(*)、b^(*)、弹性值与感官色泽、粘度、整体接受度评分而与类别II中的样品区分,说明草莓脯品质差异主要体现为色泽与粘度差异。另外,由指标聚类结果可知,柠檬酸、葡萄糖和果糖含量与咀嚼性相关;麦芽糖、蔗糖、水分含量与粘力相关。研究结果为草莓脯产品的质量评价与品质调控提供方向。

关键词：草莓脯理化特征感官评分聚类分析

润肠通便中药纤维素复方优选及其对肠道菌群调节作用研究

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今日药学 2024年第2期34卷 90-96页

作者：石雅丽刘洋吴方黄丰梁磊何蓉蓉云南中医药大学中药学院云南昆明650500 暨南大学广东省疾病易感性及中医药研发工程技术研究中心中医药国际化研究粤港澳高校联合实验室广东广州510632 暨南大学药学院广东省中药药效物质基础及创新药物研究重点实验室广东广州510632 暨南大学教育部中药与创新药物研究国际合作联合实验室广东广州510632 广东省第二人民医院心脏重症科广东广州510317

目的研究润肠通便中药纤维素复方对便秘小鼠的通便作用,筛选出最优复方,并探讨最优复方对便秘小鼠肠道菌群的影响。方法6周龄雄性昆明小鼠,随机分为对照组、模型组、不同复方组,采用灌胃盐酸洛哌丁胺方法建立小鼠便秘模型,各组给予相应... 详细信息

目的研究润肠通便中药纤维素复方对便秘小鼠的通便作用,筛选出最优复方,并探讨最优复方对便秘小鼠肠道菌群的影响。方法6周龄雄性昆明小鼠,随机分为对照组、模型组、不同复方组,采用灌胃盐酸洛哌丁胺方法建立小鼠便秘模型,各组给予相应药物或溶剂进行干预,观察各组小鼠小肠推进率、排出首粒黑便时间、粪便数量、粪便重量;收集盲肠内容物,采用16S rRNA测序技术分析肠道菌群变化。结果与模型组相比,各复方组小肠推进率、5 h排出黑便数量均显著增加,复方2和复方3组排出首粒黑便时间显著缩短,复方1和复方2组5 h排出黑便重量显著增加,综合选择复方1为最优复方。16S rRNA基因测序结果显示,中药纤维素最优复方增加便秘小鼠肠道菌群多样性,改变肠道菌群组成。最优复方组可以提高F/B比率,下调Akkermansia丰度占比,Bacteroides和Alistipes相对丰度增加。结论中药纤维素复方可以改善小肠运动和排便功能障碍,调节肠道菌群结构缓解小鼠便秘。

关键词：中药复方纤维素便秘肠道菌群 16S rRNA

Microbial transformation for Region-selective Hydroxylation of Z-Butylidenephthalide by Aspergillus niger CGMCC 3.739

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Asian Journal of Traditional Medicines 2021年第4期16卷 203-209页

作者： Jian Zou Yongheng Wang Zhengqun Zhou rongrong he Xinsheng Yao Hao Gao Institute of Traditional Chinese Medicine&Natural Products College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchJinan UniversityGuangzhou 510632China Integrated Chinese and Western Medicine Postdoctoral Research Station Jinan UniversityGuangzhou 510632China School of Traditional Chinese Medicine Jinan UniversityGuangzhou 510632China

Microbial transformation is a useful tool for structure modification of active natural products.Z-Butylidenephthalide is the main active constituent of Angelica sinensis.In the present work,a pair of new oxidized metabolites,namely(-)(11R)-(Z)-11-hydroxy-butylidenephthalide(1a)and(+)(11S)-(Z)-11-hydroxy-butylidenephthalide(1b),were obtained from microbial transformation for region-selective 11-hydroxylation of Z-butylidenephthalide by Aspergillus niger CGMCC 3.739.Their structures,including absolute configurations,were elucidated by extensive analysis of HR-ESI-MS,NMR spectra,and the modified Mosher’s method.This is the first study on the microbial transformation of Z-butylidenephthalide,and these findings offer a tool for region-selective 11-hydroxylation of Z-butylidenephthalide.

关键词： microbial transformation Z-butylidenephthalide Aspergillus niger CGMCC 3.739 region-selective hydroxylation

BCH CODES FROM ALGEBRAIC-GEOMETRIC CODES

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BCH CODES FROM ALGEBRAIC-GEOMETRIC CODES

基于化学模式识别结合熵权TOPSIS法的桂枝不同部位的差异分析

2009中国宁波国际计算机科学与技术学术大会

作者： Wanbao Hu Junxiao Zhang Wenbing Zhang rongrong he School of Mathematics and Computer Science Anqing Teachers College

BCH codes have many advantages such as being decoded easily,allowing very simple electronic hardware to perform,etc.In the paper,we show that the BCH codes can be derived by algebraic-geometric codes,which hold very g... 详细信息

关键词： BCH Codes Algebraic-Geometric Codes Algebraic Function Field Algebraic Curve

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中国医药工业杂志 2024年第4期55卷 557-564页

作者：张正王瑜婷陈灶树方朝缵何荣荣彭帮贵刘燎原广东一方制药有限公司广东省中药配方颗粒企业重点实验室广东佛山528244

建立了桂枝药材及不同部位(木部、皮部)的UPLC指纹图谱,并通过相似度评价、化学模式识别和熵权TOPSIS法对桂枝药材及不同部位进行了差异性研究。结果显示,桂枝药材及木部、皮部的指纹图谱中均确定了6个相同的共有峰,并指认了5个成分;10... 详细信息

建立了桂枝药材及不同部位(木部、皮部)的UPLC指纹图谱,并通过相似度评价、化学模式识别和熵权TOPSIS法对桂枝药材及不同部位进行了差异性研究。结果显示,桂枝药材及木部、皮部的指纹图谱中均确定了6个相同的共有峰,并指认了5个成分;10批桂枝药材、木部及皮部与相应对照图谱相似度均大于0.990。方差分析结果显示,桂枝木部与皮部之间6个成分均有显著性差异(P<0.05)。聚类分析和主成分分析均显示桂枝药材与皮部化学成分更为接近,正交偏最小二乘法判别分析可将桂枝药材、木部、皮部分别聚为一类,并筛选出桂皮醛是引起桂枝不同部位差异的主要变量。熵权TOPSIS法显示,桂枝药材、木部、皮部的欧式贴近度(C_(i))平均值分别为0.458、0.249、0.577。建立的方法可反映桂枝不同部位的差异性,对桂枝药材的质量控制提供了参考。

关键词：桂枝 UPLC 指纹图谱化学模式识别熵权TOPSIS法

Scutellaria baicalensis:a promising natural source of antiviral compounds for the treatment of viral diseases

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中国天然药物:英文版 2023年第8期21卷 563-575页

作者： HUANG Qiuju WANG Muyang WANG Min LU Yuhui WANG Xiaohua CheN Xin YANG Xin GUO Hongwei he rongrong LUO Zhuo Guangxi Key Laboratory of Bioactive Molecules Research and Evaluation College of PharmacyGuangxi Medical UniversityNanning 530021China Key Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education&Center for Translational Medicine Guangxi Medical UniversityNanning 530021China Guangdong Engineering Research Center of Chinese Medicine&Disease Susceptibility College of PharmacyJinan UniversityGuangzhou 612505China Hainan Affiliated Hospital of Hainan Medical University Department of PharmacyHaikou 570311China

Viruses,the smallest microorganisms,continue to present an escalating threat to human health,being the leading cause of mortality worldwide.Over the decades,although significant progress has been made in the development of therapies and vaccines against viral diseases,the need for effective antiviral interventions remains urgent.This urgency stems from the lack of effective vaccines,the severe side effects associated with current drugs,and the emergence of drug-resistant viral strains.Natural plants,particularly traditionally-used herbs,are often considered an excellent source of medicinal drugs with potent antiviral efficacy,as well as a substantial safety profile.Scutellaria baicalensis,a traditional Chinese medicine,has garnered considerable attention due to its extensive investigation across diverse therapeutic areas and its demonstrated efficacy in both preclinical and clinical trials.In this review,we mainly focused on the potential antiviral activities of ingredients in Scutellaria baicalensis,shedding light on their underlying mechanisms of action and therapeutic applications in the treatment of viral infections.

关键词： Scutellaria baicalensis Flavonoids Antiviral infection Efficacy Mechanism Clinical application

Pharmacological interventions targeting the microcirculation following traumatic spinal cord injury

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Neural Regeneration Research 2024年第1期19卷 35-42页

作者： rongrong Wang Jinzhu Bai Department of Spine and Spinal Cord Surgery Beijing Bo’ai HospitalChina Rehabilitation Research CenterBeijingChina School of Rehabilitation Medicine Capital Medical UniversityBeijingChina

Traumatic spinal cord injury is a devastating disorder chara cterized by sensory,motor,and autonomic dysfunction that seve rely compromises an individual's ability to perform activities of daily living.These adve rse outcomes are closely related to the complex mechanism of spinal cord injury,the limited regenerative capacity of central neurons,and the inhibitory environment fo rmed by traumatic injury.Disruption to the microcirculation is an important pathophysiological mechanism of spinal cord injury.A number of therapeutic agents have been shown to improve the injury environment,mitigate secondary damage,and/or promote regeneration and repair.Among them,the spinal cord microcirculation has become an important target for the treatment of spinal cord injury.Drug inte rventions targeting the microcirculation can improve the microenvironment and promote recovery following spinal cord injury.These drugs target the structure and function of the spinal cord microcirculation and are essential for maintaining the normal function of spinal neuro ns,axons,and glial cells.This review discusses the pathophysiological role of spinal cord microcirculation in spinal cord injury,including its structure and histopathological changes.Further,it summarizes the progress of drug therapies targeting the spinal cord mic rocirc ulation after spinal cord injury.

关键词： blood-spinal cord barrier drug therapy microcirculation microvascular blood flow neuroprotection pharmacological intervention pharmacotherapy spinal cord injury trauma