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Nano Research 2022年第7期15卷 6361-6371页

作者： Liangliang cai ronghua Ni Xiaofei Ma Rongrong Huang Zhiyuan Tang Jinqiu Xu Yong Han Yuehua Guo Zhifeng Gu Department of Pharmacy Affiliated Hospital of Nantong UniversityNantong 226001China Department of Radiation Oncology Affiliated Hospital of Nantong UniversityNantong 226001China Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityNantong 226001China Department of Rheumatology Affiliated Hospital of Nantong UniversityNantong 226001China

Precise clinical treatment of triple-negative breast cancer(TNBC)is an obstacle in ***-assisted photothermal therapy(PTT)is a superior treatment modality for TNBC in terms of ***,thermoresistance arising from PTT and insufficient drug release from nanocarriers decrease the efficacy of ***13387 is a novel HSP90 inhibitor that can weaken thermoresistance and undergoing clinic II phase study,showing satisfactory antitumour activity through molecularly targeted therapy(MTT).Whereas,it has poor *** hyaluronic acid and stearic acid were connected by hydrazone bonds and disulfide bonds,forming an amphipathic copolymer that could self-assembled into nanomicelles,followed by encapsulating Cypate and *** nanomicelles exhibited great features,including achieving mutually synergistic PTT/MTT for overcoming thermoresistance and promoting translocation of drugs,increasing the solubility of Cypate and AT13387,showing a pH/redox dual response that contributes to drug release,and having the ability of active ***,the nanomicelles developed in this study may be a promising strategy for the precise treatment of TNBC.

关键词： hyaluronic acid nanomicelles dual responsive photothermal therapy molecular targeting therapy

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中空纤维气态膜海水提溴

水处理技术 1986年第5期 261-266页

作者：仉琦姚占力王国强蔡荣华中国科学院青海盐湖研究所国家海洋局天津海水淡化与综合利用研究所

实验所用φ1×8″中空纤维组件有效膜面积为646cm2。含Br2海水被泵入中空纤维内,0.2NNaOH水溶液以较慢的流速在中空纤维外循环。例如,含Br259.5PPm,pH≤3.5的海水0.5l,于30℃,以10.7cm/s的流速循环通过中空纤维,12.5min后,溴的脱除率达8... 详细信息

实验所用φ1×8″中空纤维组件有效膜面积为646cm2。含Br2海水被泵入中空纤维内,0.2NNaOH水溶液以较慢的流速在中空纤维外循环。例如,含Br259.5PPm,pH≤3.5的海水0.5l,于30℃,以10.7cm/s的流速循环通过中空纤维,12.5min后,溴的脱除率达82.3％,迁移系数为3×10-6g/cm2·min。

关键词：气态膜 cm 原料液吸收液中空纤维异形纤维天然卤水海水传质系数脱除率 NaOH 含盐量空气吹出法浓度梯度

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膜法提溴技术研究进展

盐业与化工 2009年第3期38卷 46-50页

作者：张慧峰王国强姚颖高书宝蔡荣华张雨山国家海洋局天津海水淡化与综合利用研究所海水化学资源利用技术研究室天津300192

膜法提溴技术作为提溴新技术之一,已研究近30年。膜法提溴包括气态膜法提溴和乳化液膜法提溴两个方面。综述了气态膜法提溴传质过程、提溴用膜及提溴工艺等方面的研究进展,介绍了乳化液膜法提溴工艺的研究结果。并在此基础上,探讨了膜... 详细信息

膜法提溴技术作为提溴新技术之一,已研究近30年。膜法提溴包括气态膜法提溴和乳化液膜法提溴两个方面。综述了气态膜法提溴传质过程、提溴用膜及提溴工艺等方面的研究进展,介绍了乳化液膜法提溴工艺的研究结果。并在此基础上,探讨了膜法提溴技术的研究方向。

关键词：溴提取气态膜液膜

黄芩甙锌络合物对小鼠免疫功能影响的初步观察

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铁道医学 1989年第6期17卷 321-323页

作者：舒荣华蔡仙德谭剑萍卫寄英蒋韵吴芬芬南京铁道医学院微生物教研室南京210009 南京铁道医学院药理教研室南京210009

在报道过黄芩甙锌络合物(简称甙锌)抗Ⅰ型变态反应作用较黄芩甙强的基础上,进一步研究甙锌对小鼠免疫功能的影响,且与黄芩甙比较其药效。实验表明:甙锌能明显促进腹腔巨噬细胞的吞噬百分率和吞噬指数(二者皆P0.05)。认为甙锌对非特异性... 详细信息

在报道过黄芩甙锌络合物(简称甙锌)抗Ⅰ型变态反应作用较黄芩甙强的基础上,进一步研究甙锌对小鼠免疫功能的影响,且与黄芩甙比较其药效。实验表明:甙锌能明显促进腹腔巨噬细胞的吞噬百分率和吞噬指数(二者皆P0.05)。认为甙锌对非特异性免疫系统和红细胞免疫系统有显著增强作用,且药效强于黄芩甙。

关键词：黄岑甙锌免疫功能药理

Application of a Quality Control Circle to Reduce the Wait Times between Continuous Surgeries

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Eye Science 2015年第2期30卷 60-62页

作者： Hairong Zhang Li Wang Yueye cai ronghua Ye Jingyi Lin Dongdong Jiang Zhongshan Ophthalmic Center Sun Yat-sen University

Purpose: To investigate how to shorten patient wait times between continuous ocular operations and to evaluate the influence of a quality control circle(QCC) on operating room ***:.QCC management was established to conduct activities..Clinical data were collected to analyze the causes of long wait times between continuous surgeries. Effective measures were undertaken ***:.The staff from QCC actively undertook measures that would significantly shorten patient wait times between continuous ocular surgeries(P<0.05).Conclusion:.Multiple measures,.such as setting up a QCC,enhancing the arrangement of surgical procedures,.establishing effective communication channels,.optimizing human resources, and integrating the use of instruments, can effectively shorten patient wait times between continuous vitreous or retinal surgeries.

关键词：等待时间控制圈手术质量应用临床资料人力资源操作室

除毒河豚肝油对于抗淋巴细胞血清所致小鼠模型的免疫增强作用

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南京铁道医学院学报 1985年第2期 5-8页

作者：舒荣华蔡仙德谭剑萍卫寄英蒋韵尹琰吴芬芬南京铁道医学院微生物学教研室南京铁道医学院药理教研室

小鼠经注射自制抗T细胞血清后次日的T细胞数和百分率显著下降(P0.05),而对照组显著(P<0.001);用药8天停药4天的血清血凝素抗体滴度和脾细胞溶血空斑数较对比组高(P<0.001,P<0.02)。表明该药对此模型具有一定免疫增强作用。

关键词：除毒河豚肝油抗小鼠 T 淋巴细胞血清免疫增强作用

Poly(I:C)preconditioning protects the heart against myocardial ischemia/reperfusion injury through TLR3/PI3K/Akt-dependent pathway

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Signal Transduction and Targeted Therapy 2020年第1期5卷 264-278页

作者： Erya Chen Chan Chen Zhendong Niu Lu Gan Qiao Wang Ming Li XingWei cai Rui Gao Sruthi Katakam Hai Chen Shu Zhang ronghua Zhou Xu Cheng Yanhua Qiu Hai Yu Tao Zhu Jin Liu Department of Anesthesiology and Translational Neuroscience Center West China HospitalSichuan UniversityChengduSichuanChina Department of Emergency Medicine West China HospitalSichuan UniversityChengduSichuanChina Institute of Cell Engineering Department of NeurologySchool of MedicineJohns Hopkins UniversityBaltimoreMDUSA

Emerging evidence suggests that Toll-like receptors(TLRs)ligands pretreatment may play a vital role in the progress of myocardial ischemia/reperfusion(I/R)*** the ligand of TLR3,polyinosinic-polycytidylic acid(poly(I:C)),a synthetic double-stranded RNA,whether its preconditioning can exhibit a cardioprotective phenotype remains ***,we report the protective effect of poly(I:C)pretreatment in acute myocardial I/R injury by activating TLR3/PI3K/Akt signaling ***(I:C)pretreatment leads to a significant reduction of infarct size,improvement of cardiac function,and downregulation of inflammatory cytokines and apoptotic molecules compared with ***,our data demonstrate that phosphorylation of TLR3 tyrosine residue and its interaction with PI3K is enhanced,and protein levels of phospho-PI3K and phospho-Akt are both increased after poly(I:C)pretreatment,while knock out of TLR3 suppresses the cardioprotection of poly(I:C)preconditioning through a decreased activation of PI3K/Akt ***,inhibition of p85 PI3K by the administration of LY294002 in vivo and knockdown of Akt by siRNA in vitro significantly abolish poly(I:C)preconditioning-induced cardioprotective *** conclusion,our results reveal that poly(I:C)preconditioning exhibits essential protection in myocardial I/R injury via its modulation of TLR3,and the downstream PI3K/Akt signaling,which may provide a potential pharmacologic target for perioperative cardioprotection.

关键词： PI3K/Akt protective preconditioning

A case of central nervous system infection with Scedosporium boydii

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iLABMED 2024年第3期2卷 221-225页

作者： Zhen cai Dongchao Pan ronghua Geng Jidi Fu Fen Qu Department of Clinical Laboratory Aviation General HospitalBeijingChina Chinese Academy of Medical Sciences&Peking Union Medical College Plastic Surgery Hospital and InstituteBeijingChina

Scedosporium boydii is considered an opportunist fungal pathogen in immunocompromised *** also causes serious and fatal central nervous system *** this study,a man with brain abscesses infected with *** was diagnosed using multiple methods,including microscopy,culture combined with Matrix-assisted laser desorption ionization time-of-flight mass spectrometry(MOLDI-TOF MS),internal transcribed spacer sequencing and Metagenomic next-generation sequencing(mNGS).This successful diagnosis highlights the importance of using a variety of techniques to identify and treat infections caused by this dangerous fungus.

关键词： central nervous system MOLDI-TOF MS mNGS Scedosporium boydii

MiR-133b-5p regulates the expression of the heat shock protein 70 during rat neuronal cell apoptosis induced by the gp120 V3 loop peptide

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MiR-133b-5p regulates the expression of the heat shock prote...

2017年广东省药师周大会

作者： Chenglai Xia Yantao cai Yuyi Lin ronghua Guan Jie Yang Guohong Xiao Department of Pharmacy The Third Affiliated Hospital of Guangzhou Medical University Department of Dermatology and Rheumatology Foshan Maternity & Child Heath Care Hospital Department of Reproductive Medicine Centre The Third Affiliated Hospital of Guangzhou Medical University Guangdong Provincial Key Laboratory of Reproductive Medicine Guangzhou Medical University at Guangzhou

Background:Neuronal cell dysfunction and apoptosis, the main causes of HIV-associated dementia, and its underlying mechanism are important unsolved health problems. Many research reports suggest that miRNAs regulate HIV-1-induced apoptosis. Methods:We used the HIV-1 gp120 V3 Loop peptide to induce primary rat cortical neurons apoptosis. Next, we used a microRNA microarray to identify the significant changes of miRNA in the rat cortical neurons treated with the gp120 V3 loop peptide. We used western blot and real-time PCR to measure the regulation of heat shock protein 70 by ***:In response to the gp120 V3 loop peptide treatment, rat cortical neurons exhibited 11 up-regulated and 21 down-regulated miRNAs. We further examined miR-133b-5p, a microRNA that was up-regulated more than 118-fold. In addition, both HSP70 mRNA and protein expression were dose-dependent in rats cortical neurons treated with gp120 V3 loop peptide for 48 hours. Conclusion:MiR-133b-5p could regulate heat shock protein 70(HSP70) at both transcription and translation levels. Rno-miR-133b-5p might be less significant for the gp120 V3 loop peptide induced neuron apoptosis. Thus, we discovered a potential new target for the regulation of HIV-1 gp120-induced apoptosis.

关键词： miR-133b-5p gp120 microRNA heat shock protein 70 apoptosis

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以密度为导向的条纹正则优化方法

计算机辅助设计与图形学学报 2015年第11期27卷 2087-2093页

作者：王海霞蔡逸飞蒋莉梁荣华浙江工业大学信息工程学院杭州310014

在光学干涉测量技术中,准确地实现条纹正则化是提取条纹图中的相位信息的前提.文中基于双重正交带通滤波器的正则优化法,提出了以条纹密度信息为质量评估标准来引导条纹正则化的优化方法,包含条纹图局部优化与整体优化两部分,是对双重... 详细信息

在光学干涉测量技术中,准确地实现条纹正则化是提取条纹图中的相位信息的前提.文中基于双重正交带通滤波器的正则优化法,提出了以条纹密度信息为质量评估标准来引导条纹正则化的优化方法,包含条纹图局部优化与整体优化两部分,是对双重正交带通滤波器的正则化方法的改进.首先以条纹背景强度和振幅具有的局部线性与连续性特征设计能量函数,并通过最小化能量函数获取背景强度和条纹振幅的值;然后根据高低密度区域条纹的分析,提出密度对正则化过程的导向作用以及局部优化的可行性.实验结果表明,以密度为导向的条纹正则优化法具有均方误差低、抗噪性高等优点;提出的条纹正则优化方法在操作上不需要对噪声严重的条纹图进行除噪预处理,对背景强度与振幅的线性与非线性变化可同时处理,具有较高的条纹处理效率和准确性,可应用于复杂的条纹图正则化处理.

关键词：图像处理密度导向条纹正则化光学干涉测量