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超、卸载作用下考虑接头影响的盾构管片承载性能研究

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北京交通大学学报 2024年第1期48卷 20-31页

作者：胡梦豪石钰锋蒋亚龙黄展军张荣锋顾大均华东交通大学土木建筑学院南昌330013 华东交通大学江西建筑设计院有限公司南昌330013 南昌轨道交通集团有限公司南昌330199 中国电建集团华东勘测设计研究院有限公司杭州311122 中国铁路南昌局集团有限公司南昌330009

地表堆载或侧方开挖卸载易诱发盾构隧道病害,影响施工及运营安全.现有研究难以综合定量评价超、卸载作用下盾构隧道的承载性能,其数值模型大多仅考虑环向或纵向接头的单一影响,将接头等效为切向及法向弹簧,难以考虑接头的非线性,或是直... 详细信息

地表堆载或侧方开挖卸载易诱发盾构隧道病害,影响施工及运营安全.现有研究难以综合定量评价超、卸载作用下盾构隧道的承载性能,其数值模型大多仅考虑环向或纵向接头的单一影响,将接头等效为切向及法向弹簧,难以考虑接头的非线性,或是直接将螺栓嵌入混凝土中,忽略螺栓预紧力的承载贡献,接头精细化程度不足.为此,建立考虑环、纵向接头的盾构隧道精细化数值模型,对顶部超载和侧方卸载工况作用下结构的受力特性和承载性能展开分析,获取不同工况下结构的承载极限及相应的变形阈值,并利用足尺试验验证了数值模型的可行性.研究结果表明:本文数值计算结果与足尺试验吻合良好,二者椭圆度变形差异小于10%;计算精度较仅考虑环向接头影响时提高约6%,较未考虑接头影响时(均质圆环)提高约30%,可实现盾构管片结构变形过程及损伤演化的动态模拟;盾构隧道有一定的富余承载力,当隧道上方超载达138 kPa或侧方压力卸载达26.3%时,结构相应的椭圆度分别为27.4‰和22.1‰,结构达到正常服役的极限状态,当隧道超出正常服役极限状态后,接头塑性铰逐步成型,结构软化并逐渐失效,接缝张开及管片错台也急剧上升;隧道侧方压力卸载达26.3%后,其接缝张开及管片错台曲线不再光滑,侧压卸载超36.8%后,曲线的起伏波动更为明显,隧道侧方卸载过程中结构受力响应更为复杂、敏感.

关键词：盾构管片数值模拟超载卸载足尺试验接头

级配对粗粒土-格栅界面循环剪切特性影响试验研究

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水利水电技术（中英文） 2024年第3期55卷 162-172页

作者：蒋明杰石竣允栗书亚胡荣峰梅国雄广西大学工程防灾与结构安全教育部重点实验室广西南宁530004 广西大学广西防灾减灾与工程安全重点实验室广西南宁530004 北京工业大学城市减灾与防灾防护教育部重点实验室北京100124

【目的】为研究级配对粗粒土-土工格栅界面动力剪切特性的影响规律,【方法】基于连续级配方程,通过改变试样的最大粒径d_(max)和级配面积S,制备了18组不同级配试样,对各组试样分别进行设置土工格栅和不设置土工格栅的循环直剪试验,分析d... 详细信息

【目的】为研究级配对粗粒土-土工格栅界面动力剪切特性的影响规律,【方法】基于连续级配方程,通过改变试样的最大粒径d_(max)和级配面积S,制备了18组不同级配试样,对各组试样分别进行设置土工格栅和不设置土工格栅的循环直剪试验,分析d_(max)和S对界面循环剪切特性的影响,并引入了加筋剪切刚度系数α_(k)和加筋阻尼比系数α_(D),来评价土工格栅对动剪切强度参数的影响效果。【结果】结果显示:当小于格栅网孔尺寸的粗粒含量较高时,剪切刚度k随着d_(max)的增大而增大,阻尼比D随着d_(max)的增大而减小;反之,则表现出相反的趋势。k和D均与d_(max)呈对数函数关系;k和D与S的关系均可用二次多项式表示。此外,给出了α_(k)和α_(D)与粒孔比的关系,即随着粒孔比的增大,α_(k)先增大后减小,α_(D)呈先减小后增大的规律。当粒孔比取0.073左右时,土工格栅对粗粒土循环剪切特性的加筋效果最好。【结论】结果表明:颗粒与土工格栅间的互锁机制对粗粒土-格栅界面的循环剪切特性有重要影响,当大部分颗粒粒径小于格栅网格尺寸时,颗粒与格栅间的互锁机制充分发挥;当颗粒最大粒径及格栅网格尺寸相同时,存在一个最优级配面积,使得粗粒土-格栅界面的抗震性能最好。

关键词：粗粒土土工格栅颗粒级配模型试验土石坝变形抗剪强度影响因素

Recent advances in diverse nanosystems for nitric oxide delivery in cancer therapy

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Acta Pharmaceutica Sinica B 2023年第4期13卷 1498-1521页

作者： Dan Gao Sajid Asghar rongfeng hu Su Chen Ruixin Niu Jia Liu Zhipeng Chen Yanyu Xiao State key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China Faculty of Pharmaceutical Sciences Government College University FaisalabadFaisalabad 38000Pakistan Anhui Province key Laboratory of Pharmaceutical Preparation Technology and Application Hefei 230012China Jiangyin Hospital Affiliated to Nanjing University of Chinese Medicine Jiangyin 214499China Department of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China

Gas therapy has been proven to be a promising and advantageous treatment option for cancers.Studies have shown that nitric oxide(NO)is one of the smallest structurally significant gas molecules with great potential to suppress cancer.However,there is controversy and concern about its use as it exhibits the opposite physiological effects based on its levels in the tumor.Therefore,the anti-cancer mechanism of NO is the key to cancer treatment,and rationally designed NO delivery systems are crucial to the success of NO biomedical applications.This review summarizes the endogenous production of NO,its physiological mechanisms of action,the application of NO in cancer treatment,and nano-delivery systems for delivering NO donors.Moreover,it briefly reviews challenges in delivering NO from different nanoparticles and the issues associated with its combination treatment strategies.The advantages and challenges of various NO delivery platforms are recapitulated for possible transformation into clinical applications.

关键词： Nitric oxide Nitric oxide donor Nitric oxide-based delivery system Anti-cancer Binding mechanisms Synergistic treatment strategy Inorganic platforms Organic platforms

A facile phototheranostic nanoplatform integrating NIR-Ⅱ fluorescence/PA bimodal imaging and image-guided surgery/PTT combinational therapy for improved antitumor efcacy

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Journal of Materials Science & Technology 2022年第35期130卷 208-218页

作者： Xiuping Han Wenyou Fang Tianqi Zhang Xuan Zhong kun Qian Zhitao Jiang rongfeng hu Guoqiang Shao Lei Zhang Qing Zhang Department of Pharmaceutics and key Laboratory of Cardiovascular&Cerebrovascular Medicine School of PharmacyNanjing Medical UniversityNanjing 211166China State key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM) Nanjing University of Posts&TelecommunicationsNanjing 210023China Department of Nuclear Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 211166China Anhui Province key Laboratory of Pharmaceutical Preparation Technology and Application Anhui Province Engineering Technology Research Center of Modern Pharmaceutical PreparationAnhui University of Chinese MedicineHefei 230012China Department of Nuclear Medicine Taizhou People’s HospitalNanjing University of Chinese MedicineTaizhou 225300China Center for Molecular Imaging Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Phototheranostic with highly integrated functions is an attractive platform for cancer management. It remains challenging to develop a facile phototheranostic platform with complementary bimodal imaging and combinational therapy capacity. Herein, the small-molecule cyanine IR780 loaded liposomes have been harnessed as a nanoplatform to simultaneously realize photoacoustic(PA)/the second near-infrared window(NIR-Ⅱ) fluorescence imaging and image-guided surgery/adjuvant photothermal therapy(PTT).This nanoplatform exhibits attractive properties like uniform controllable size, stable dispersibility, NIR-Ⅱ fluorescence emission, photothermal conversion, and biocompatibility. Benefiting from the complementary PA/NIR-Ⅱ fluorescence bimodal imaging, this nanoplatform was successfully applied in precise vasculature delineation and tumor diagnosis. Interestingly, the tumor was clearly detected by NIR-Ⅱ fluorescence imaging with the highest tumor-to-normal-tissue ratio up to 12.69, while signal interference from the liver was significantly reduced, due to the difference in the elimination rate of the nanoplatform in the liver and tumor. Under the precise guidance of the image, the tumor was accurately resected, and the simulated residual lesion after surgery was completely ablated by adjuvant PTT. This combined therapy showed improved antitumor efcacy over the individual surgery or PTT. This work develops a facile phototheranostic nanoplatform with great significance in accurately diagnosing and effectively treating tumors using simple NIR light irradiation.

关键词： NIR-Ⅱfluorescence imaging Photoacoustic imaging Image-guided surgery Adjuvant photothermal therapy Phototheranostics

Circulating exosome-like vesicles of humans with nondiabetic obesity impaired isletβ-cell proliferation,which was associated with decreased Omentin-1 protein cargo

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Genes & Diseases 2022年第4期9卷 1099-1113页

作者： Qian Ge Xinxin Xie Xiangjun Chen rongfeng huang Cheng-Xue Rui Qianna Zhen Renzhi hu Min Wu Xiaoqiu Xiao Xi Li Department of Endocrinology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016PR China The Biology Science Institutes Chongqing Medical UniversityChongqing 400016PR China The Chongqing key Laboratory of Translational Medicine in Major Metabolic Diseases The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016PR China de Duve Institute Catholic University of LouvainBrussels 1200Belgium

The regulation ofβ-cell mass in the status of nondiabetic obesity remains not well understood.We aimed to investigate the role of circulating exosome-like vesicles(ELVs)isolated from humans with simple obesity in the regulation of isletβ-cell mass.Between June 2017 and July 2019,81 subjects with simple obesity and 102 healthy volunteers with normal weight were recruited.ELVs were isolated by ultra-centrifugation.The proliferations ofβ-cells and islets were measured by 5-ethynl-2′-deoxyuridine(EdU).Protein components in ELVs were identified by Quantitative Proteomic Analysis and verified by Western blot and ELISA.The role of specific exosomal protein was analyzed by gain-of-function approach in ELVs released by 3T3-L1 preadipocytes.Circulating ELVs from subjects with simple obesity inhibitedβ-cell proliferation in vitro without affecting its apoptosis,secretion,and inflammation.The protein levels of Rictor and Omentin-1 were downregulated in circulating ELVs from subjects with simple obesity and associated with the obesity-linked pathologic conditions.The ELV-carried Omentin-1 and Omentin-1 protein per se were validated to increaseβ-cell proliferation and activate Akt signaling pathway.Moreover,Omentin-1 in ELVs was downregulated by insulin.The circulating ELVs may act as a negative regulator forβ-cell mass in nondiabetic obesity through inhibitingβ-cell proliferation.This effect was associated with downregulated Omentin-1 protein in ELVs.This newly identified ELV-carried protein could be a mediator linking insulin resistance to impairedβ-cell proliferation and a new potential target for increasingβ-cell mass in obesity and T2DM.

关键词： β-Cell Exosome Obesity Proliferation Type 2 diabetes mellitus

Multifunctional building elements for the construction of peptide drug conjugates

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Engineered Regeneration

Engineered Regeneration 2022年第1期3卷 92-109页

作者： Liu Xu Shan Xu Tangyong Xiang Heng Liu Linwei Chen Baoping Jiang Junhong Yao Hongliu Zhu rongfeng hu Zhipeng Chen College of pharmacy Nanjing University of Chinese MedicineNanjing 210023China Yunnan Provincial key Laboratory of Entomological Biopharmaceutical R&D Dali UniversityDali 671000China Laboratory animal center Nanjing University of Chinese MedicineNanjing 210023China Department of Dermatology Jiangyin Hospital Affiliated to Nanjing University of Chinese MedicineJiangyin 214400China Anhui Province key Laboratory of Pharmaceutical Preparation Technology and Application Hefei 230012China Anhui University of Chinese Medicine Hefei 230012China

Engineering of smart building molecules is key basis in designing intelligent drug delivery systems.As an emerging sophisticated delivery system strategy,the powerful functions of peptide drug conjugates(PDCs)are attributed to a smart linker and multifunctional peptide domain.Peptides exhibit a wide range of functions and properties,including easy chemical synthesis and versatile modification,tunable biocompatibility,diversified self-assembled nanostructures,specific recognition/binding,and deep penetration of the cell membrane/extracellular matrix.In addition,various types of linkers enable PDCs to release drugs responsively according to the disease microen-vironment or treatment needs.Owing to these inherent advantages,PDCs have been widely explored for drug delivery.Herein,the latest developments in functional peptides and linkers commonly used to construct smart PDCs are reviewed.The purpose is to bring widespread attention to PDC design strategies and their contribution to fighting various diseases,as well as to provide guidance for research on intelligent PDC drug delivery systems.

关键词： Peptide-drug conjugates Functional peptide Self-assembly Intelligent drug delivery system

Adaptive detection in the presence of signal mismatch

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Journal of Systems Engineering and Electronics 2015年第1期26卷 38-43页

作者： Weijian Liu Wenchong Xie rongfeng Li Fei Gao Xiaoqin hu Yongliang Wang College of Electronic Science and Engineering National University of Defense Technology Air Force Early Warning Academy

The problem of adaptive detection in the situation of signal mismatch is considered; that is, the actual signal steering vector is not aligned with the nominal one. Two novel tunable detectors are proposed. They can control the degree to which the mismatched signals are rejected. Remarkably, it is found that they both cover existing famous detectors as their special cases. More importantly, they possess the constant false alarm rate（CFAR）property and achieve enhanced mismatched signal rejection or improved robustness than their natural competitors. Besides, they can provide slightly better matched signals detection performance than the existing detectors.

关键词： mismatched signal detection adaptive coherence estimator（ACE） adaptive matched filter（AMF） generalized likelihood ratio test（GLRT） tunable detector

Self-microemulsifying drug delivery system for improving the bioavailability of huperzine A by lymphatic uptake

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Acta Pharmaceutica Sinica B 2017年第3期7卷 353-360页

作者： Fang Li rongfeng hu Bin Wang Yun Gui Gang Cheng Song Gao Lei Ye Jihui Tang Anhui University of Chinese Medicine Hefei 230038China National Chinese Medicinal Materials Products Quality Supervision and Inspection Center(Anhui) Bozhou 236800China key Laboratory of Xin'an Medicine Ministry of Education Hefei 230038China Anhui“115”Xin'an Traditional Chinese Medical Research&Development Innovation Team Hefei 230038China Anhui Province key Laboratory of R&D of Chinese Medicine Hefei 230038China School of Pharmacy Anhui Medical UniversityHefei 230022China

huperzine A(hup-A) is a poorly water-soluble drug with low oral bioavailability. A selfmicroemulsifying drug delivery system(SMEDDS) was used to enhance the oral bioavailability and lymphatic uptake and transport of hup-A. A single-pass intestinal perfusion(SPIP) technique and a chylomicron flow-blocking approach were used to study its intestinal absorption, mesenteric lymph node distribution and intestinal lymphatic uptake. The value of the area under the plasma concentration–time curve(AUC) of hup-A SMEDDS was significantly higher than that of a hup-A suspension(P k_a) and the apparent permeability coefficient(P_(app)) for hup-A in different parts of the intestine suggested a passive transport mechanism, and the values of k_a and P_(app) of hup-A SMEDDS in the ileum were much higher than those in other intestinal segments. The determination of hup-A concentration in mesenteric lymph nodes can be used to explain the intestinal lymphatic absorption of hup-A SMEDDS. For hup-A SMEDDS, the values of AUC and maximum plasma concentration(C_(max)) of the blocking model were significantly lower than those of the control model(Phup-A SMEDDS and hup-A suspension were about 40% and 5%,respectively, suggesting that SMEDDS can significantly improve the intestinal lymphatic uptake and transport of hup-A.

关键词： huperzine A Self-microemulsion Drug delivery systems SMEDDS Bioavailability Single-pass intestinal perfusion Lymphatic transport

Isolation and identifi cation of antimicrobial metabolites from sea anemone-derived fungus Emericella sp.SMA01

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Journal of Oceanology and Limnology 2021年第3期39卷 1010-1019页

作者： Yang YUE huahua YU rongfeng LI Linfeng hu Song LIU Rong’e XING Pengcheng LI key Laboratory of Experimental Marine Biology Center for Ocean Mega-ScienceInstitute of OceanologyChinese Academy of SciencesQingdao 266071China Laboratory for Marine Drugs and Bioproducts Pilot Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China School of Chemistry and Chemical Engineering Henan Institute of Science and TechnologyXinxiang 453003China

Marine symbiotic fungi represent an intriguing source of discovery of novel secondary metabolites with various biological activities.Sea anemones are benthic marine invertebrates,however,the cultivable symbiotic fungi residing in the sea anemones are paid few attentions compared to those derived from their cnidarian counterparts.Here we show the identification of antimicrobial secondary metabolites from the sea anemone-derived symbiotic fungi.Out offive isolated fungal strains,only the strain SMA01 showed strong antimicrobial activities,which was assigned into the genus Emericella based on the morphological characteristics and the ITS sequencing.Media swift from liquid fermentation to solid rice medium presented little influence on its antibacterial activity.A chemical investigation of the ethyl acetate extract of the Emericella sp.SMA01 led to discovery of the primary antibiotic metabolite phenazine-1-carboxylic acid.The IC_(50) values of the phenazine-1-carboxylic acid against Phytophthora capsici,Gibberella zeae,and Verticillium dahliae were determined to be 23.26-53.89μg/mL.To the best of our knowledge,this was the first report of Emericella sp.in sea anemones.The current study may benefit understanding of the defensive chemical interactions between the symbiotic fungi and their host sea anemones.

关键词： sea anemone symbiotic fungi phenazine-1-carboxylic acid antimicrobial activity