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Efficacy and safety of Shenyankangfu Tablet,a Chinese patent medicine,for primary glomerulonephritis:A multicenter randomized controlled trial

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Journal of Integrative Medicine 2021年第2期19卷 111-119页

作者： Jie Wu Shu-wei Duan Hong-tao Yang Yue-yi Deng Wei li Ya-ni He Zhao-hui Ni Yong-li Zhan shan lin Zhi-yong Guo Jun Zhu Jing-ai Fang Xu-sheng liu li-hua Wang rong Wang Nian-song Wang Xiao-hong Cheng li-qun He Ping Luo Shi-ren Sun Ji-feng Sun Ai-ping Yin Geng-ru Jiang Hong-yu Chen Wen-hu liu Hong-li lin Meng liang Lu Ma Ming Chen li-qun Song Jian Chen Qing Zhu Chang-ying Xing Yun li Ji-ning Gao rong-shan li Ying li Hao Zhang Ying Lu Qiao-ling Zhou Jun-zhou Fu Qiang He Guang-yan Cai Xiang-mei Chen Department of Nephrology Chinese People’s Liberation Army General HospitalChinese People’s Liberation Army Institute of NephrologyState Key Laboratory of Kidney Diseases(2011DAV00088)National Clinical Research Center for Kidney DiseasesBeijing 100853China Department of Nephrology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300192China Department of Nephrology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Nephrology Shandong University of Traditional Chinese Medicine Affiliated HospitalJinan 250011.Shandong ProvinceChina Department of Nephrology Daping HospitalArmy Medical UniversityChongqing 400042China Department of Nephrology Renji HospitalShanghai Jiao Tong UniversityShanghai 200127China Department of Nephrology Guang’anmen HospitalChina Academy of Traditional Chinese Medical SciencesBeijing 100053China Department of Nephrology Tianjin Medical University General HospitalTianjin 300052China Department of Nephrology Changhai Hospital of ShanghaiNaval Medical UniversityShanghai 200433China Department of Nephrology West China HospitalChengdu 610083Sichuan ProvinceChina Department of Nephrology First Affiliated Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Nephrology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Department of Nephrology Shanxi Medical University Second Affiliated HospitalTaiyuan 030001Shanxi ProvinceChina Department of Nephrology Shandong Provincial HospitalJinan 250021Shandong ProvinceChina Department of Nephrology and Rheumatology Affiliated Sixth People’s HospitalShanghai Jiao Tong UniversityShanghai 200233China Department of Nephrology Shaanxi Traditional Chinese Medicine HospitalXi'an 710003Shaanxi ProvinceChina Department of Nephrology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 200021China Department of Nephrology Jilin University Se

Background:Shenyankangfu Tablet(SYKFT)is a Chinese patent medicine that has been used widely to decrease proteinuria and the progression of chronic kidney ***:This trial compared the efficacy and safety of SYKFT,for the control of proteinuria in primary glomerulonephritis patients,against the standard drug,losartan ***,setting,participants and intervention:This was a multicenter,double-blind,randomized,controlled clinical *** glomerulonephritis patients,aged 18-70 years,with blood pressure≤140/90 mmHg,estimated glomerular filtration rate(eGFR)>45 mL/min per 1.73 ㎡,and 24-hour proteinuria level of 0.5-3.0 g,were recruited in 41 hospitals across 19 provinces in China and were randomly divided into five groups:SYKFT,losartan potassium 50 mg or 100 mg,SYKFT plus losartan potassium 50 mg or 100 *** outcome measu res:The primary outcome was change in the 24-hour proteinuria level,after 48 weeks of ***:A total of 735 participants were *** percent decline of urine protein quantification in the SYKFT group after 48 weeks was 8.78%±2.56%(P=0.006)more than that in the losartan 50 mg group,which was 0.51%±2.54%(P=1.000)less than that in the losartan 100 mg *** with the losartan potassium 50 mg group,the SYKFT plus losartan potassium 50 mg group had a 13.39%±2.49%(Pline did not change statistically *** average change in TCM syndrome score between the patients who took SYKFT(-3.00[-6.00,-2.00])and who did not take SYKFT(-2.00[-5.00,0])was statistically significant(P=0.003).No obvious adverse reactions were observed in any ***:SYKFT decreased the proteinur

关键词： Herbal medicine,Chinese Shenyankangfu Tablet Primary glomerulonephritis Randomized controlled trial Double blind Double dummy

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基于状态反馈的一类非线性系统动态输出反馈镇定

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控制与决策 2007年第2期22卷 238-240页

作者：王银河单荣立韩东方汕头大学理学院广东汕头515063 黑龙江肇源技术学校数学部黑龙江肇源166500

针对一类具有线性不可测量状态的非线性系统,基于状态反馈稳定控制器,利用不变流形和滑模变结构控制技术设计了动态输出反馈镇定控制器.这类控制器的结构类似于系统的状态反馈稳定控制器,在较简单的假定条件下,能够保证被控系统的状态... 详细信息

针对一类具有线性不可测量状态的非线性系统,基于状态反馈稳定控制器,利用不变流形和滑模变结构控制技术设计了动态输出反馈镇定控制器.这类控制器的结构类似于系统的状态反馈稳定控制器,在较简单的假定条件下,能够保证被控系统的状态得到渐近镇定.仿真算例表明该动态输出反馈控制器具有较强的镇定能力.

关键词：非线性系统不可测量状态状态反馈动态输出反馈

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基于模糊球的模糊逻辑系统及其逼近性质

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模糊系统与数学 2008年第3期22卷 27-33页

作者：王文丽单荣立刘林广东工业大学应用数学学院广东广州510006 肇源技术学校黑龙江肇源166500 西安建筑科技大学数学系陕西西安710055

基于模糊球概念构造了一个具有向量形式规则的模糊逻辑系统,然后利用其逼近性质给出了在紧致域上逼近多元连续函数的方法。首先,依据所给论域自身的几何特点,将其进行模糊划分,其次使用各个子论域上的采样点和母函数构造开模糊球,然后... 详细信息

基于模糊球概念构造了一个具有向量形式规则的模糊逻辑系统,然后利用其逼近性质给出了在紧致域上逼近多元连续函数的方法。首先,依据所给论域自身的几何特点,将其进行模糊划分,其次使用各个子论域上的采样点和母函数构造开模糊球,然后基于模糊球构造出描述每个子论域的模糊逻辑系统(FLS),最后在整个论域上生成逼近紧集上连续函数的模糊逻辑系统(FLS)。这种模糊逻辑系统的规则为向量形式且具有较强的语言解释能力。与传统的FLS相比,本文提出的FLS用来描述高维情形时不必使用张量乘积构造规则,从而在一定程度上避免了维数灾难问题。最后的仿真例子说明了本文所采用方法的有效性。

关键词： FLS 模糊球逼近多元函数

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Predictive value of a constructed artificial neural network model for microvascular invasion in hepatocellular carcinoma:A retrospective study

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 88-100页

作者： Hai-Yang Nong Yong-Yi Cen shan-Jin Lu Rui-Sui Huang Qiong Chen li-Feng Huang Jian-Ning Huang Xue Wei Man-rong liu lin li Ke Ding Department of Radiology The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Radiology Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Guangxi Clinical Medical Research Center for Hepatobiliary Diseases Affiliated Hospital of Youiiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Ultrasound The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Hepatobiliary Surgery The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina

BACKGROUND Microvascular invasion(MVI)is a significant risk factor for recurrence and metastasis following hepatocellular carcinoma(HCC)***,there is a paucity of preoperative evaluation approaches for *** To investigate the predictive value of texture features and radiological signs based on multiparametric magnetic resonance imaging in the non-invasive preoperative prediction of MVI in *** Clinical data from 97 HCC patients were retrospectively collected from January 2019 to July 2022 at our *** were classified into two groups:MVI-positive(n=57)and MVI-negative(n=40),based on postoperative pathological *** correlation between relevant radiological signs and MVI status was ***4.6 software and the mutual information method were employed to identify the top 10 dominant texture features,which were combined with radiological signs to construct artificial neural network(ANN)models for MVI *** predictive performance of the ANN models was evaluated using area under the curve,sensitivity,and *** models with relatively high predictive performance were screened using the DeLong test,and the regression model of multilayer feedforward ANN with backpropagation and error backpropagation learning method was used to evaluate the models’*** The absence of a pseudocapsule,an incomplete pseudocapsule,and the presence of tumor blood vessels were identified as independent predictors of HCC *** ANN model constructed using the dominant features of the combined group(pseudocapsule status+tumor blood vessels+arterial phase+venous phase)demonstrated the best predictive performance for MVI status and was found to be automated,highly operable,and very *** The ANN model constructed using the dominant features of the combined group can be recommended as a noninvasive method for preoperative prediction of HCC MVI status.

关键词： Hepatocellular carcinoma Texture analysis Magnetic resonance imaging Microvascular invasion Pseudocapsule Tumor blood vessels

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急性肾损伤的生物标志物

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中华肾病研究电子杂志 2013年第3期2卷 25-28页

作者：李荣山山西省人民医院肾内科太原030001

近年来急性肾损伤(AKI)在临床的发病率有增高趋势,且死亡率高,预后差。改善AKI预后的关键是早期诊断、早期干预。传统的诊断指标血清肌酐和尿素不能在早期反映肾小球滤过率的下降,且受到的影响因素多。近年来发现的一些新型的生物学标... 详细信息

近年来急性肾损伤(AKI)在临床的发病率有增高趋势,且死亡率高,预后差。改善AKI预后的关键是早期诊断、早期干预。传统的诊断指标血清肌酐和尿素不能在早期反映肾小球滤过率的下降,且受到的影响因素多。近年来发现的一些新型的生物学标志物如中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、白介素-18(IL-18)、肾损伤分子-1(KIM-1)、钠氢交换子-3(NHE-3)、肝脏型尿脂肪酸结合蛋白(L-FABP)、尿富半胱氨酸蛋白61(cyr 61)、尿N-乙酰-β-D-氨基葡萄糖苷酶(NAG)、尿胎球蛋白A(fetuin-A)等能在早期反映肾功能的变化,具有临床应用前景。现就上述AKI生物标志物的研究进展做一综述。

关键词：急性肾损伤生物标志物

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Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang Chu Zhicheng lin Tianyuan Fang Yuyu Zhou Chuxia Zhang Jianghui shan Shiyu Chen liping li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

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Syntheses, Crystal Structures and Emission Properties of d10Metal-Organic Frameworks Assembled with Isomeric Benzendicarboxylates and 3-(2-Pyridyl)pyrazole

Syntheses, Crystal Structures and Emission Properties of d10...

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中国化学会第五届全国结构化学学术会议

作者： Tong-liang Hu Jian-rong li shan-Chen Yuan Xian-He Bu~* Department of Chemistry,Nankai University,Tianjin 300071,P.R.China

A series of novel coordination complexes,[ZnL(1,2-BDC)(HO)] 1, [Cd(HL)(1,2-BDC)(HO)] 2,{[Cd(HL)(1,2-BDC)]·HO} 3,[Zn(HL)(1,3-BDC)(HO)·3HO] 4,[Zn(HL)(HO)·HO-(I,4-BDC)] 5 and [Cd(HL)2(1,4-BDC)] 6,have been synthesized...

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Successful emergency surgical intervention in acute non-STsegment elevation myocardial infarction with rupture:A case report

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World Journal of Clinical Cases 2025年第4期13卷 41-47页

作者： Xing-Po li Zi-shan Wang Hong-Xia Yu shan-shan Wang Department of Cardiovascular Medicine Huantai County Hospital of Traditional Chinese MedicineZibo 256400Shandong ProvinceChina Department of Cardiovascular Medicine Zibo Hospital of Integrated Traditional Chinese and Western MedicineZibo 255500Shandong ProvinceChina

BACKGROUND The incidence of acute myocardial infarction(AMI)is rising,with cardiac rupture accounting for approximately 2%of deaths in patients with acute ST-segment elevation myocardial infarction(STEMI).Ventricular free wall rupture(FWR)occurs in approximately 2%of AMI patients and is notably rare in patients with *** of cardiac rupture include left ventricular FWR,ventricular septal rupture,and papillary muscle *** FWR usually leads to acute cardiac tamponade or electromechanical dissociation,where standard resuscitation efforts may not be *** septal rupture and papillary muscle rupture often result in refractory heart failure,with mortality rates over 50%,even with surgical or percutaneous repair *** SUMMARY We present a rare case of an acute non-STEMI patient who suffered sudden FWR causing cardiac tamponade and loss of consciousness immediate before undergoing coronary *** resuscitation and emergency open-heart repair along with coronary artery bypass grafting resulted in successful patient *** This case emphasizes the risks of AMI complications,shares a successful treatment scenario,and discusses measures to prevent such complications.

关键词： Acute non-ST segment elevation myocardial infarction Cardiac rupture Acute myocardial infarction Free wall rupture Case report

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木质素的高附加值及在重金属处理上的研究进展

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应用化工 2022年第3期51卷 821-826,830页

作者：杨柳周书葵荣丽杉李嘉丽南华大学土木工程学院湖南衡阳421001

综述了木质素在不同改性制备方法下的结构特点,阐述了不同结构下木质素特有的功能、形态,以及近年来国内外木质素类吸附剂反应机理和结构特点,重点介绍了官能团改性木质素材料、木质素碳材料及纳米木质素材料在重金属吸附方面的应用及... 详细信息

综述了木质素在不同改性制备方法下的结构特点,阐述了不同结构下木质素特有的功能、形态,以及近年来国内外木质素类吸附剂反应机理和结构特点,重点介绍了官能团改性木质素材料、木质素碳材料及纳米木质素材料在重金属吸附方面的应用及研究。最后,总结了木质素基材料在处理重金属技术上存在的挑战,展望了该材料未来的发展方向,以期在实际应用中充分结合现实因素和各种改性方法的适用性,选择合适的木质素基材料来实现重金属的高效吸附去除。

关键词：木质素高附加值吸附重金属

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水稳定性金属有机骨架材料对铀吸附研究进展

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应用化工 2021年第8期50卷 2234-2239,2243页

作者：夏麟袁华山谢磊欧阳霁荣丽杉南华大学土木工程学院湖南衡阳421001

以水稳定性MOFs为研究对象,综述了国内外吸附处理含铀废水的研究现状,重点阐述了不同类型和结构的水稳定性MOFs有效吸附含铀废水的最新进展,特别是改性、复合MOFs可以提高MOFs的吸附性能。最后,我们提出了对开发水稳定性MOFs的个人见解... 详细信息

以水稳定性MOFs为研究对象,综述了国内外吸附处理含铀废水的研究现状,重点阐述了不同类型和结构的水稳定性MOFs有效吸附含铀废水的最新进展,特别是改性、复合MOFs可以提高MOFs的吸附性能。最后,我们提出了对开发水稳定性MOFs的个人见解和未来展望。

关键词：含铀废水水稳定性金属有机骨架材料吸附分离吸附性能进展

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