检索结果-南通市图书馆

Milk fat globule epidermal growth factor 8 alleviates liver injury in severe acute pancreatitis by restoring autophagy flux and inhibiting ferroptosis in hepatocytes

引用

World Journal of Gastroenterology 2024年第7期30卷 728-741页

作者： Qing Cui Hang-Cheng Liu wu-Ming Liu Feng Ma Yi Lv Jian-Cang Ma rong-qian wu Yi-Fan Ren Department of Cardiology Xi’an Central Hospital Affiliated to Xi’an Jiaotong UniversityXi’an 710003Shaanxi ProvinceChina Department of General Surgery The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina National Local Joint Engineering Research Center for Precision Surgery&Regenerative Medicine Shaanxi Provincial Center for Regenerative Medicine and Surgical EngineeringFirst Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Vascular Surgery The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina

BACKGROUND Liver injury is common in severe acute pancreatitis(SAP).Excessive autophagy often leads to an imbalance of homeostasis in hepatocytes,which induces lipid peroxidation and mitochondrial iron deposition and ultimately leads to *** previous study found that milk fat globule epidermal growth factor 8(MFG-E8)alleviates acinar cell damage during SAP via binding toαvβ3/5 ***-E8 also seems to mitigate pancreatic fibrosis via inhibiting chaperone-mediated *** To speculate whether MFG-E8 could also alleviate SAP induced liver injury by restoring the abnormal autophagy *** SAP was induced in mice by 2 hly intraperitoneal injections of 4.0 g/kg L-arginine or 7 hly injections of 50μg/kg cerulein plus ***8-knockout mice were used to study the effect of MFG-E8 deficiency on SAPinduced liver ***,a specificαvβ3/5 integrin inhibitor,was used to investigate the possible mechanism of *** The results showed that MFG-E8 deficiency aggravated SAP-induced liver injury in mice,enhanced autophagy flux in hepatocyte,and worsened the degree of *** MFG-E8 reduced SAP-induced liver injury in a dose-dependent ***,MFG-E8 mitigated excessive autophagy and inhibited ferroptosis in liver *** abolished MFG-E8’s beneficial effects in SAP-induced liver *** MFG-E8 acts as an endogenous protective mediator in SAP-induced liver ***-E8 alleviates the excessive autophagy and inhibits ferroptosis in hepatocytes by binding to integrinαVβ3/5.

关键词： Autophagy flux Ferroptosis Liver injury Milk fat globule epidermal growth factor 8 αvβ3/5 integrins Acute pancreatitis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Novel magnetic compression technique for establishment of a canine model of tracheoesophageal fistula

引用

World Journal of Gastroenterology 2019年第30期25卷 4213-4221页

作者： Yi Gao rong-qian wu Yi Lv Xiao-Peng Yan Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shannxi ProvinceChina National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shannxi ProvinceChina

BACKGROUND Clinically,tracheoesophageal fistula(TEF)is lack of effective surgical *** reason is due to the lack of appropriate animal models of acquired TEF,which is usually complex and ***,the magnetic compression technique has been applied for digestive tract anastomosis or vascular anastomosis in *** this study,an animal model of TEF in dogs was developed by using the magnetic compression technique,hoping to provide a new method for mimicking *** To establish a TEF model in dogs by using the magnetic compression *** Six male beagles were used as models with two Nd-Fe-B permanent magnets for *** parent magnet and the daughter magnet were placed in the cervical esophagus and trachea,*** anterior wall of the esophagus and the posterior wall of the trachea were compressed when the two magnets *** 4-6 d,the necrotic tissue between the two magnets fell off and the parent and daughter magnets disengaged from the target location,leaving a ***/bronchoscopy,upper gastrointestinal contrast study,and histological analysis were *** The establishment of the TEF model in all six beagles was *** average time of magnet placement was 4.33±1.11 min(range,3-7 min).Mean time for the magnets to disengage from the target location was 4.67±0.75 d(range,4-6 d).TEFs were observed by gastroscopy/bronchoscopy and esophageal *** gross anatomical structure of the esophagus and the trachea was in good *** was no esophageal mucosa or pseudostratified ciliated columnar epithelium at the site of the fistula according to histological *** It is simple,feasible,and minimally invasive to use the magnetic compression technique for the establishment of the TEF model in dogs.

关键词： Magnetic compression technique Tracheoesophageal fistula Beagle Animal model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Value of pretransplant albumin-bilirubin score in predicting outcomes after liver transplantation

引用

World Journal of Gastroenterology 2019年第15期25卷 1879-1889页

作者： Tao Ma Qing-Shan Li Yue Wang Bo Wang Zheng wu Yi Lv rong-qian wu National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine First Affiliated Hospital of Xi'an Jiaotong University Department of Hepatobiliary Surgery First Affiliated Hospital of Xi'an Jiaotong University

BACKGROUND Due to the significant shortage of organs and the increasing number of candidates on the transplant waiting list, there is an urgent need to identify patients who are most likely to benefit from liver transplantation. The albuminbilirubin(ALBI) grading system was recently developed to identify patients at risk for adverse outcomes after hepatectomy. However, the value of the pretransplant ALBI score in predicting outcomes after liver transplantation has not been *** To retrospectively investigate the value of the pretransplant ALBI score in predicting outcomes after liver *** The clinical data of 272 consecutive adult patients who received donation after cardiac death and underwent liver transplantation at our centre from March 2012 to March 2017 were analysed in the cohort study. After the exclusion of patients who met any of the exclusion criteria, 258 patients remained. The performance of the ALBI score in predicting overall survival and postoperative complications after liver transplantation was evaluated. The optimal cut-off value of preoperative ALBI was calculated according to long-term survival status. The outcomes after liver transplantation, including postoperative complications and survival analysis, were *** The remaining 258 consecutive patients were included in the analysis. The median follow-up time was 17.30(interquartile range: 8.90-28.98) mo. Death occurred in 35 patients during follow-up. The overall survival rate was 81.0%.The preoperative ALBI score had a significant positive correlation with the overall survival rate after liver transplantation. The calculated cut-off for ALBI scores to predict postoperative survival was-1.48. Patients with an ALBI score >-1.48 had a significantly lower survival rate than those with an ALBI score ≤-1.48(73.7% vs 87.6%, P < 0.05), and there were no statistically significant differences in survival rates between patients with a model for end stage liver disease

关键词： Albumin-bilirubin score Liver transplantation Survival Postoperative complications Liver transplant waiting list

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Market-based solution in China to finance the clean from the dirty

引用

Fundamental Research 2024年第2期4卷 324-333页

作者： Haoqi qian rong Ma Libo wu Institute for Global Public Policy Fudan UniversityShanghai 200433China LSE-Fudan Research Centre for Global Public Policy Fudan UniversityShanghai 200433China School of Economics Fudan UniversityShanghai 200433China Shanghai Institute for Energy and Carbon Neutrality Strategy Fudan UniversityShanghai 200433China

Financial incentives play a key role in promoting renewable energy investments that can help China achieve the‘dual carbon’*** national emissions trading scheme(ETS)and the renewable energy portfolio standard(RPS)are two existing market-based policy instruments that can generate stable expected returns for low-carbon *** paper studies the interactive distribution effects of these two market-based *** use the micro-level thermal power plant data to investigate the abatement effects of the national ETS,in which the details show that the existing rate-based ETS will result in higher negative impacts on power units,whose installed capacities are smaller than 400 *** interactive distribution effects between the two markets will occur when the permit allocation standards of the national ETS become stricter than the existing *** in Eastern China and Northern China will face high pressure on costs in both ETS and RPS *** the levels of the permit allocation standards are set as 70%of the existing ones and the carbon price is assumed to be 200 yuan/ton in 2030,the annual market size of the national ETS will be nearly 100 billion yuan,and the annual market size is predicted to be 250 billion *** the existing rate-based national ETS,the China Certified Emission Reduction(CCER)mechanism will have an offsetting effect,which should be taken into serious consideration during the policy-making processes in the future.

关键词： Emission trading scheme Renewable energy portfolio standard Green finance Policy interactions China certified emission reduction Distribution effect

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neutrophil-to-lymphocyte ratio predicts acute kidney injury occurrence after gastrointestinal and hepatobiliary surgery

引用

World Journal of Gastrointestinal Surgery 2020年第7期12卷 326-335页

作者： Jian-Bin Bi Jia Zhang Yi-Fan Ren Zhao-Qing Du Zheng wu Yi Lv rong-qian wu National Local Joint Engineering Research Center for Precision Surgery & Regenerative Medicine Shaanxi Provincial Center for Regenerative Medicine and Surgical EngineeringInstitute of Advanced Surgical Technology and EngineeringFirst Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061 Shaanxi Province China Department of Hepatobiliary Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061 Shaanxi Province China

BACKGROUND Postoperative acute kidney injury(AKI) is a complex pathological process involved intrarenal and systemic inflammation caused by renal hypoperfusion, nephrotoxic drugs and urinary obstruction. Neutrophil-to-lymphocyte ratio(NLR) is a marker of inflammation reflecting the progress of many diseases. However, whether NLR at admission can predict the occurrence of AKI after surgery in the intensive care unit(ICU) remains *** To clarify the relationship between NLR and the occurrence of AKI in patients with gastrointestinal and hepatobiliary surgery in the *** A retrospective analysis of 282 patients receiving surgical ICU care after gastrointestinal and hepatobiliary surgery in our hospital from December 2014 to December 2018 was *** Postoperative AKI occurred in 84 patients(29.79%) in this cohort. NLR by the multivariate analysis was an independent risk factor for occurrence of postoperative AKI in patients with gastrointestinal and hepatobiliary surgery in the ICU. In this cohort, receiver operating characteristic curves of AKI occurrence showed that the optimal cut-off value of NLR was 8.380. NLR was found to be significantly correlated with the white blood cell count, neutrophil count, lymphocyte count, arterial lactate and dialysis(P < 0.05). Additionally, NLR value at admission was higher in AKI patients compared with the non-AKI patients and increased with the severity of AKI. Patients with NLR ≥ 8.380 exhibited significantly higher incidences of postoperative AKI and severe AKI than patients with NLR < 8.380(AKI: 38.12% vs 14.85%, P < 0.001;severe AKI: 14.36% vs 1.98%, P = 0.001).CONCLUSION NLR at admission is a predictor of AKI occurrence in patients with gastrointestinal and hepatobiliary surgery in ICU. NLR should be included in the routine assessment of AKI occurrence.

关键词： Neutrophil-to-lymphocyte ratio Acute kidney injury Gastrointestinal and hepatobiliary surgery Surgical intensive care unit Arterial lactate Sepsis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Irisin attenuates intestinal injury,oxidative and endoplasmic reticulum stress in mice with L-arginine-induced acute pancreatitis

引用

World Journal of Gastroenterology 2019年第45期25卷 6653-6667页

作者： Yi-Fan Ren Meng-Zhou Wang Jian-Bin Bi Jia Zhang Lin Zhang wu-Ming Liu Sha-Sha Wei Yi Lv Zheng wu rong-qian wu National Local Joint Engineering Research Center for Precision Surgery&Regenerative Medicine Shaanxi Provincial Center for Regenerative Medicine and Surgical EngineeringFirst Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Hepatobiliary Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

BACKGROUND Acute pancreatitis(AP)is often associated with intestinal injury,which in turn exaggerates the progression of *** recent study has shown that a low level of serum irisin,a novel exercise-induced hormone,is associated with poor outcomes in patients with AP and irisin administration protects against experimental ***,the role of irisin in intestinal injury in AP has not been *** To investigate the effect of irisin administration on intestinal injury in experimental *** AP was induced in male adult mice by two hourly intraperitoneal injections of *** 2 h after the last injection of L-arginine,irisin(50 or 250μg/kg body weight)or 1 mL normal saline(vehicle)was administered through intraperitoneal *** animals were sacrificed at 72 h after the induction of *** injury,apoptosis,oxidative and endoplasmic reticulum(ER)stress were *** Administration of irisin significantly mitigated intestinal damage,reduced apoptosis,and attenuated oxidative and ER stress in AP *** addition,irisin treatment also effectively downregulated serum tumor necrosis factor-alpha and interleukin-6 levels and alleviated injury in the pancreas,liver and lung of AP *** Irisin-mediated multiple physiological events attenuate intestinal injury following an episode of *** has a great potential to be further developed as an effective treatment for patients with AP.

关键词： Irisin Intestinal injury Oxidative stress Endoplasmic reticulum stress Acute pancreatitis Mouse model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fedora-type magnetic compression anastomosis device for intestinal anastomosis

引用

World Journal of Gastroenterology 2020年第42期26卷 6614-6625页

作者： Huan Chen Tao Ma Yue Wang Hao-Yang Zhu Zhe Feng rong-qian wu Yi Lv Ding-Hui Dong National Local Joint Engineering Research Center for Precision Surgery&Regenerative Medicine The First Affiliated Hospital of Xi'an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

BACKGROUND Although previous studies have confirmed the feasibility of magnetic compression anastomosis(MCA),there is still a risk of long-term anastomotic *** traditional MCA devices,a large device is associated with great pressure,and eventually increased *** To develop a novel MCA device to simultaneously meet the requirements of pressure and *** Traditional nummular MCA devices of all possible sizes were used to conduct ileac anastomosis in *** mean(±SD)circumference of the ileum was 13.34±0.12 *** on short-and long-term follow-up results,we determined the appropriate pressure range and minimum ***,we introduced a novel“fedora-type”MCA device,which entailed the use of a nummular magnet with a larger sheet *** With traditional MCA devices,the anastomoses experienced stenosis and even closure during the long-term follow-up when the anastomat was smaller thanΦ5 ***,the risk of leakage increased when it was larger thanΦ4 *** comparison of the different designs,it was found that the“fedora-type”MCA device should be composed of aΦ4-mm nummular magnet with aΦ6-mm sheet *** The diameter of the MCA device should be greater than 120%of the enteric *** novel“fedora-type”MCA device controls the pressure and optimizes the size.

关键词： Magnetic compression anastomosis Anastomotic stenosis Size of anastomat Compression pressure Fedora-type magnetic compression anastomosis device

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

T-tube vs no T-tube for biliary tract reconstruction in adult orthotopic liver transplantation:An updated systematic review and metaanalysis

引用

World Journal of Gastroenterology 2021年第14期27卷 1507-1523页

作者： Jun-Zhou Zhao Lin-Lan Qiao Zhao-Qing Du Jia Zhang Meng-Zhou Wang Tao Wang wu-Ming Liu Lin Zhang Jian Dong Zheng wu rong-qian wu Department of Hepatobiliary Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

BACKGROUND Whether to use a T-tube for biliary anastomosis during orthotopic liver transplantation(OLT)remains a debatable *** surgeons chose to use a T-tube because they believed that it reduces the incidence of biliary *** in surgical techniques during the last decades have significantly decreased the overall incidence of postoperative biliary *** using a T-tube during OLT is still associated with the reduced incidence of biliary strictures needs to be *** To provide an updated systematic review and meta-analysis on using a T-tube during adult *** In the electronic databases MEDLINE,PubMed,Scopus,***,the Cochrane Library,the Cochrane Hepato-Biliary Group Controlled Trails Register,and the Cochrane Central Register of Controlled Trials,we identified 17 studies(eight randomized controlled trials and nine comparative studies)from January 1995 to October *** data of the studies before and after 2010 were separately *** chose the overall biliary complications,bile leaks or fistulas,biliary strictures(anastomotic or non-anastomotic),and cholangitis as *** ratios(ORs)with 95%confidence intervals(CIs)were calculated to describe the results of the ***,the test for overall effect(Z)was used to test the difference between OR and 1,where P≤0.05 indicated a significant difference between OR value and *** A total of 1053 subjects before 2010 and 1346 subjects after 2010 were included in this *** pooled results showed that using a T-tube reduced the incidence of postoperative biliary strictures in studies before 2010(P=0.012,OR=0.62,95%CI:0.42-0.90),while the same benefit was not seen in studies after 2010(P=0.60,OR=0.76,95%CI:0.27-2.12).No significant difference in the incidence of overall biliary complications(P=0.37,OR=1.41,95%CI:0.66-2.98),bile leaks(P=0.89,OR=1.04,95%CI:0.63-1.70),and cholangitis(P=0.27,OR=2.00,95%CI:0.59-6.84)was obse

关键词： Orthotopic liver transplantation T-tube Biliary tract reconstruction Biliary complications Biliary strictures Meta-analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Miniature magnetically anchored and controlled camera system for trocar-less laparoscopy

引用

World Journal of Gastroenterology 2017年第12期23卷 2168-2174页

作者： ding-hui dong hao-yang zhu yu luo hong-ke zhang jun-xi xiang fei xue rong-qian wu yi lv Department of Hepatobiliary Surgery First Affiliated Hospital Xi’an Jiaotong University

AIM To design a miniature magnetically anchored and controlled camera system to reduce the number of trocars which are required for *** The system consists of a miniature magnetically anchored camera with a 30° downward angle, an external magnetically anchored unit, and a vision output device. The camera weighs 12 g, measures Φ10.5 mm × 55 mm and has two magnets, a vision model, a light source, and a metal hexagonal nut. To test the prototype, the camera was inserted through a 12-mm conventional trocar in an ex vivo real liver laparoscopic training system. A trocar-less laparoscopic cholecystectomy was performed 6 times using a 12-mm and a 5-mm conventional trocar. In addition, the same procedure was performed in four canine *** Both procedures were successfully performed using only two conventional laparoscopic trocars. The cholecystectomy was completed without any major complication in 42 min(38-45 min) in vitro and in 50 min(45-53 min) using an animal model. This camera was anchored and controlled by an external unit magnetically anchored on the abdominal wall. The camera could generate excellent image. with no instrument *** The camera system we designed provides excellent optics and can be easily maneuvered. The number of conventional trocars is reduced without adding technical difficulties.

关键词： Trocar-less laparoscopy Magnetically anchored and controlled camera Minimally invasive surgery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of low-dose aspirin administration on long-term survival of cirrhotic patients after splenectomy: A retrospective single-center study

引用

World Journal of Gastroenterology 2019年第28期25卷 3798-3807页

作者： Zhao-Qing Du Jun-Zhou Zhao Jian Dong Jian-Bin Bi Yi-Fan Ren Jia Zhang Bilawal Khalid Zheng wu Yi Lv Xu-Feng Zhang rong-qian wu National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine First Affiliated Hospital of Xi’an Jiaotong University Xi’an 710061 Shaanxi Province China Department of Hepatobiliary Surgery First Affiliated Hospital of Xi’an Jiaotong University Xi’an 710061 Shaanxi Province China

BACKGROUND Cirrhosis is a major risk factor for the development of hepatocellular carcinoma (HCC). Portal vein thrombosis is not uncommon after splenectomy in cirrhotic patients, and many such patients take oral anticoagulants including aspirin. However, the long-term impact of postoperative aspirin on cirrhotic patients after splenectomy remains unknown. AIM The main purpose of this study was to investigate the effect of postoperative long-term low-dose aspirin administration on the development of HCC and longterm survival of cirrhotic patients after splenectomy. METHODS The clinical data of 264 adult patients with viral hepatitis-related cirrhosis who underwent splenectomy at the First Affiliated Hospital of Xi’an Jiaotong University from January 2000 to December 2014 were analyzed retrospectively. Among these patients, 59 who started taking 100 mg/d aspirin within seven days were enrolled in the aspirin group. The incidence of HCC and overall survival were *** During follow-up, 41 (15.53%) patients developed HCC and 37 (14.02%) died due to end-stage liver diseases or other serious complications. Postoperative longterm low-dose aspirin therapy reduced the incidence of HCC from 19.02% to 3.40% after splenectomy (log-rank test, P=0.028). Univariate and multivariate analyses showed that not undertaking postoperative long-term low-dose aspirin therapy [odds ratio (OR)=6.211, 95% confidence interval (CI): 1.142-27.324, P=0.016] was the only independent risk factor for the development of HCC. Similarly, patients in the aspirin group survived longer than those in the control group (log-rank test, P=0.041). Univariate and multivariate analyses showed that the only factor that independently associated with improved overall survival was postoperative long-term low-dose aspirin therapy [OR = 0.218, 95%CI: 0.049- 0.960, P=0.044]. CONCLUSION In patients with viral hepatitis-related cirrhosis, long-term post-splenectomy administration of low-dose aspirin reduces th

关键词： Aspirin Splenectomy Prognosis Hepatocellular carcinoma Overall survival

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：