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INFERIOR-SEPTAL MYOCARDIAL INFARCTION MISDIAGNOSED AS ANTERIOR-SEPTAL MYOCARDIAL INFARCTION:ELECTROCARDIOGRAPHIC,SCINTIGRAPHIC,AND ANGIOGRAPHIC CORRELATIONS

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Chinese Medical Sciences Journal 2007年第4期22卷 228-231页

作者： Ji-lin Chen Zuo-xiang He Zai-jia Chen Jin-qing Yuan Yue-qin Tian Shu-bin Qiao rong-fang shi Yi-da Tang Zong-lang Lu Center for Diagnosis ＆ Treatment of Coronary Heart Disease Cardiovascular Institute ＆ Fuwai Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100037

Objective To explore the infarct sites in patients with inferior wall acute myocardial infarction （AMI） concomitant with ST segment elevation in leads V1-V3 and leads V3R-V5R. Methods Five patients diagnosed as inferior, right ventricular, and anteroseptal walls AMI at admission were enrolled. Electrocardiographic data and results of isotope ^99mTc-methoxyisobutylisonitrile （MIBi） myocardial perfusion imaging and coronary angiography （CAG） were analyzed. Results Electrocardiogram showed that ST segment significantly elevated in standard leads Ⅱ, Ⅲ, aVF, and leads V1-V3, V3R-V5R in all five patients. The magnitude of ST segment elevation was maximal in lead V1 and decreased gradually from lead V1 to V3 and from lead V1 to V3R-V5R. There was isotope ^99mTc-MIBI myocardial perfusion imaging defect in inferior and basal inferior-septal walls. CAG showed that right coronary artery was infarct-related artery. Conclusions The diagnostic criteria for basal inferior-septal wall AMI can be formulated as follows：（ 1 ） ST segment elevates ≥2 mm in lead V1 in the clinical setting of inferior wall AMI; （2） the magnitude of ST segment elevation is the tallest in lead V1 and decreases gradually from lead V1 to V3 and from lead V1 to V3R-V5R. With two conditions above, the basal inferior-septal wall AMI should be diagnosed.

关键词： acute myocardial infarction basal inferior-septal wall electrocardiogram

颈动脉粥样硬化及同型半胱氨酸与前部缺血性视神经病变的相关性

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国际眼科杂志 2015年第7期15卷 1266-1268页

作者：郭继援史芳荣杜献芳中国河南省安阳市眼科医院 455000

目的：探讨动脉粥样硬化及同型半胱氨酸与前部缺血性视神经病变（AION）的关系。方法：AION患者65例组成AION组,70例非AION患者组成对照组。行颈动脉多普勒超声检查明确AION组及对照组颈动脉粥样硬化发生状况,利用全自动免疫分析仪检测... 详细信息

目的：探讨动脉粥样硬化及同型半胱氨酸与前部缺血性视神经病变（AION）的关系。方法：AION患者65例组成AION组,70例非AION患者组成对照组。行颈动脉多普勒超声检查明确AION组及对照组颈动脉粥样硬化发生状况,利用全自动免疫分析仪检测血浆同型半胱氨酸（Hcys）、维生素B12及叶酸水平。对比分析两组颈动脉粥样硬化发生率、血浆Hcys、维生素B12及叶酸水平。结果：AION组有56例（86%）颈动脉粥样硬化,而对照组为43例（61%）。AION组有59例（91%）血浆Hcys水平升高,对照组为38例（54%）。AION组有37例（57%）血浆维生素B12水平下降,对照组为43例（61%）。AION组有54例（83%）血浆叶酸水平降低,对照组为32例（46%）。AION组及对照组的颈动脉粥样硬化发生率（P=0.001）、血浆Hcys水平（P=0.0005）及叶酸水平（P=0.0006）差异显著,维生素B12水平无差异（P=0.0722）。Logistic回归分析显示颈动脉粥样硬化（OR=1.312,95%CI：0.927-1.772）及血中高Hcys水平（OR=2.378,95%CI：1.479-3.821）是AION的危险因素。结论：颈动脉粥样硬化、血中高水平的Hcys与AION的发生密切相关,控制这些与血栓有关的危险因素可能有助于AION的防治。

关键词：缺血性视神经病变动脉粥样硬化半胱氨酸

Orbscan与IOLMaster测量近视眼角膜曲率的比较

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国际眼科杂志 2011年第8期11卷 1479-1480页

作者：李翯史芳荣张东魁安阳眼科医院中国河南省安阳市455000

目的:比较Orbscan眼前节分析系统与光学相干生物测量仪IOLMaster测量角膜曲率的差异。方法:我院2010-09/12屈光手术前近视患者68例135眼,排除近期隐形眼镜配戴史、严重干眼患者、曾经进行过角膜手术者以及其他眼部器质性病变者,其中男46... 详细信息

目的:比较Orbscan眼前节分析系统与光学相干生物测量仪IOLMaster测量角膜曲率的差异。方法:我院2010-09/12屈光手术前近视患者68例135眼,排除近期隐形眼镜配戴史、严重干眼患者、曾经进行过角膜手术者以及其他眼部器质性病变者,其中男46例91眼,女22例44眼,同时用两种方法测量角膜曲率,进行临床比较。结果:Orbscan眼前节分析系统、IOLMaster两种仪器测量角膜曲率结果分别为43.4637±1.4188,43.6952±1.3676D。两组间比较,差异无统计学意义(P>0.05)。结论:Orbscan眼前节分析系统与IOLMaster对近视患者角膜曲率检查结果无统计学差异。IOLMaster用于屈光手术术前角膜曲率检查评估有一定价值。

关键词： Orbscan系统光学相干生物测量仪角膜曲率测量对比研究

Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing fang Liangming Zhang Bin Liu Limin rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： Si Chen fang Huang Lijie Mao Zhimin Zhang Han Lin Qixin Yan Xiangyu Lu Jianlin shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

习近平关于新质生产力重要论述的理论体系和实践指向研究

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新疆师范大学学报（哲学社会科学版） 2025年第1期46卷 60-68页

作者：方世南苏州大学东吴智库苏州大学马克思主义学院江苏省习近平新时代中国特色社会主义思想研究中心苏州大学基地江苏苏州215006

习近平总书记关于新质生产力重要论述深刻阐明了新质生产力的基本内涵、本质特征、鲜明标志、核心要素、形成规律以及实现路径等重大理论和实践问题,是具有重大原创性、标识性、系统性、实践性的理论创新成果,是习近平新时代中国特色社... 详细信息

习近平总书记关于新质生产力重要论述深刻阐明了新质生产力的基本内涵、本质特征、鲜明标志、核心要素、形成规律以及实现路径等重大理论和实践问题,是具有重大原创性、标识性、系统性、实践性的理论创新成果,是习近平新时代中国特色社会主义思想的重要组成部分。习近平总书记关于新质生产力重要论述是在推进中国式现代化进程中形成的新的生产力理论,是指导我国经济社会高质量发展的学理化、体系化的理论体系,是具有深邃而丰富辩证法则的实践指向。

关键词：中国式现代化新质生产力重要论述理论体系实践指向

The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： shi-Yan Sun Lingyun Nie Jing Zhang Xue fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

Double [5]carbohelicene: facile synthesis, chiroptical properties,isomerization study, and lasing application

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Science China Chemistry 2025年第1期 233-240页

作者： Peipei Liu Yantong Li Meng-Xiang Wu Hao Kang Xiao-Li Zhao Lin Xu Linlin Liu Xiaodong Li Junfeng fang Zhiwei fang Ya Cheng Hai-Bo Yang Huakang Yu Xueliang shi State Key Laboratory of Petroleum Molecular & Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal University School of Physics and Optoelectronics South China University of Technology Institute of Polymer Optoelectronic Materials & Devices State Key Laboratory of Luminescent Materials & Devices South China University of Technology School of Physics and Electronic Science Engineering Research Center of Nanophotonics & Advanced Instrument Ministry of EducationEast China Normal University State Key Laboratory of Precision Spectroscopy School of Physics and Electronic Science East China Normal University

Double carbohelicenes have attracted considerable attention due to their aesthetic structures, distinct π-conjugation extension, inherent chirality, and intriguing optical and electronic properties. Herein, the concise de novo synthesis of a new double[5]carbohelicene 1 together with its chiroptical properties, isomerization process and lasing application is presented. 1 was synthesized by a simple protocol involving the formation of a 6,6′-bipentacene as the key intermediate. It is worth noting that1 existed as two diastereomers 1-PP/MM and 1-PM, which were successfully isolated and unambiguously confirmed by Xray crystallography. The optical resolution of the racemic 1-PP/MM was successfully achieved by chiral-phase highperformance liquid chromatography（HPLC）, and 1-PP and 1-MM were characterized by circular dichroism. Interestingly, it was found that 1-PP/MM could be completely isomerized to 1-PM upon heating, and the detailed thermodynamics and kinetics of the isomerization process were systematically investigated. 1-PM exhibited deep-red luminescence with emission maximum at 723 nm and fluorescence quantum yield as high as 32.95%. Consequently, we can showcase the lasing application of 1-PM by doping with epoxy resin to assemble a bottle microlaser spontaneously, which the lasing wavelength is 796.6 nm at a threshold of 0.8 m J cm-2. We believe that our studies, including the facile synthesis methodology, detailed isomerization studies, and lasing application, will shed some light on the design and synthesis of novel carbohelical systems with more functions.

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小青龙汤合三子养亲汤治疗慢性支气管炎临床研究

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河南中医 2016年第1期36卷 120-122页

作者：郭传彬荣世舫沛县中医院江苏沛县221600

目的:观察用小青龙汤合三子养亲汤治疗慢性支气管炎外寒内饮、痰浊阻肺证的临床疗效。方法:选取2013年5月—2014年2月就诊于本院的慢性支气管炎外寒内饮、痰浊阻肺证患者98例为研究对象,随机分为对照组和治疗组各49例。对照组常规西医... 详细信息

目的:观察用小青龙汤合三子养亲汤治疗慢性支气管炎外寒内饮、痰浊阻肺证的临床疗效。方法:选取2013年5月—2014年2月就诊于本院的慢性支气管炎外寒内饮、痰浊阻肺证患者98例为研究对象,随机分为对照组和治疗组各49例。对照组常规西医对症治疗,观察组在对照组治疗的基础上加用小青龙汤合三子养亲汤治疗,两组均连续治疗15 d。观察两组患者治疗前后相关指标的变化。结果:两组患者治疗后临床症状及证候积分较治疗前均明显改善,组间比较差异显著(P<0.05);观察组疗效优于对照组(P<0.05);两组患者治疗后血清炎性因子hs-CRP、TNF-α、VC、TLC、FVC、MVV水平较对照组患者明显改善,组间比较差异具有统计学意义(P<0.05)。结论:小青龙汤合三子养亲汤治疗慢性支气管炎外寒内饮、痰浊阻肺证疗效显著,其机制与降低炎性因子水平有一定关系。

关键词：慢性支气管炎外寒内饮痰浊阻肺小青龙汤三子养亲汤