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DcR3 and survivin are highly expressed in colorectal carcinoma and closely correlated to its clinicopathologic parameters

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第9期10卷 675-682页

作者： Qi-lian liANG Bi-rong wang Guo-hong li Department of Medical Oncology Affiliated Hospital of Guangdong Medical College Zhanjiang 524001 China

Objective: To investigate the expression of death decoy receptor 3 (DcR3) and survivin in colorectal carcinoma. Methods: Tumor and normal tissues were taken from a total of 100 colorectal carcinoma patients during surgery, and the expression of DcR3 and survivin was examined by immunohistochemistry, Western blotting, and reverse transcription-polymerase chain reaction (RT-PCR) analyses. Results: RT-PCR showed that the expression levels of DcR3 mRNA (0.846±0.242, Plinicopathologic parameters of colorectal carcinoma. Conclusion: The overexpressed DcR3 and survivin in colorectal cancer may contribute to the development of the cancer. The monitoring of these two proteins may be useful for the diagnosis, differentiation, metastasis, and determination of stages of colorectal carcinoma.

关键词： Death decoy receptor 3 (DcR3) Survivin Colorectal carcinoma

Novel Fréchet-type dendritic BINOL ligands and their applications in Ti(IV) complex catalyzed asymmetric addition of diethylzinc to aldehydes

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Chinese Chemical Letters 2007年第12期18卷 1487-1489页

作者： liang Yin Chao Feng wang Huan ling wang rong li Jian Tai Ma College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 China

New Frechet-type dendritic BINOL ligands bearing several BINOL units at the periphery have been successfully synthesized. The （dendritic BINOL） Ti（IV） complexes were proved to be efficient catalysts for the enantioselective addition of diethylzinc to aromatic aldehydes. Moreover, these ligands could be quantitatively recovered and reused at least five times without a loss of the yield and enantioselectivity.

关键词： Asymmetric catalysis BINOL Aldehydes

Prediction and Analysis on Oxidation of H13 Hot Work Steel

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Journal of Iron and Steel Research International 2006年第1期13卷 44-49页

作者： MIN Yong-an WU Xiao-chun wang rong li lin XU Luo-ping School of Materials Science and Engineering Shanghai University Shanghai 200072 China

The understanding of oxidation behaviors on H13 steel was helpful to improve the service life and performance of hot work moulds and dies. Thermal-Calc Software was performed to calculate the oxidation phases on H13 steel along with different partial oxygen pressures in the interesting temperature range of 500-700 ℃. In this range H13 steel samples were treated respectively in different atmosphere including flowing water vapor （0.2 MPa）, normal pressure air （0.1 MPa） and low pressure air （0. 001 MPa）. The different oxidation films were detected with optical microscopy and X-ray diffraction. The microstructures and phase constitutions of the films formed in low pressure air were similar to those of the films formed in water vapor, and obviously different to those of the films formed in normal pressure air. The oxidation mechanisms of H13 steel in different atmosphere were also discussed.

关键词： oxidatiom hot work steel surface treatment die casting

Global Convergence of a Modified Spectral CD Conjugate Gradient Method

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Journal of Mathematical Research and Exposition 2011年第2期31卷 261-268页

作者： Wei CAO Kai rong wang Yi li wang College of Mathematics and Statistics Chongqing University Chongqing 401331 P. R. China

In this paper,we present a new nonlinear modified spectral CD conjugate gradient method for solving large scale unconstrained optimization *** direction generated by the method is a descent direction for the objective function,and this property depends neither on the line search rule,nor on the convexity of the objective ***,the modified method reduces to the standard CD method if line search is *** some mild conditions,we prove that the modified method with line search is globally convergent even if the objective function is *** numerical results show that the proposed method is very promising.

关键词： unconstrained optimization conjugate gradient method armijo-type line search global convergence

Hot Deformation and Processing Maps of Al-0.3Er

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稀有金属材料与工程 2011年第S3期40卷 90-94页

作者： lin liuqiu, rong li, wang Wei, Nie Zuoren Beijing University of Technology, Beijing 100124, China Beijing Univ Technol Beijing 100124 Peoples R China

The flow stress behavior of Al-0.3Er have been studied by hot compression tests on a Gleeble-1500D thermal simulator in the temperature range of 300-450 ℃ and strain rate range of 0.001-10 s-1. The results show that the flow stress is controlled by strain rate and deformation temperature. The flow stress decreases with deformation temperature increasing and increases with strain rate increasing. The constitutive relation of Al-0.3Er under high temperature conditions can be described by hyperbolic-sine-type equation. The processing maps based on the dynamic material model (DMM) of Al-0.3Er alloy has been also established and analyzed preliminarily. The highest efficiency of power dissipation is at the temperature range of 415-450 ℃ and in the strain rate range of 0.001-0.076 s-1 and 0.347-0.390 s-1, which is optimum working domain.

关键词： Al-Er alloy hot deformation flow stress processing maps

Topological Aspects of Solitons in Ferromagnets

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Communications in Theoretical Physics 2008年第9期50卷 777-780页

作者： REN Ji-rong wang Ji-Biao li Ran XU Dong-Hui DUAN Yi-Shi Institute of Theoretical Physics Lanzhou University Lanzhou 730000 China

Two kinds of topological soliton （skyrmion and magnetic vortex ring） in ferromagnets are studied. They have the common topological origin, a tensor Hαβ = n→·（δαn→×βδn→）, which describes the non-trivial distribution of local orientation of magnetization n→ at large distances in space. The topological stability of skyrmion is protected by the winding number. Knot-like topological defect as magnetic vortex rings is also studied. On the assumption that magnetic vortex rings are geometric lines, we present their δ-function distribution in ferromagnetic materials. Furthermore, it is briefly shown that Hopf invariant is a proper topological invariant to describe the topology of magnetic vortex rings.

关键词： ferromagnets skyrmions vortex rings

Effect of Wheat Middlings, Microbial Phytase, and Citric Acid on Phytate-Phosphorus, Calcium, and Protein Utilization of Broilers

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Agricultural Sciences in China 2006年第4期5卷 318-322页

作者： GONG Yi-feng liAO He-rong wang Jin-fu li Hong-yan Department of Animal Science and Technology Shihezi University Shihezi 832003 P.R.China

A corn-soybean meal diet （CSB）（or Diet 1） containing 23% crude protein （CP） was used as the positive control, and another corn-soybean meal diet containing 21% CP and 15% wheat middlings （WM）（or Diet 2） was used as the basal diet, which was treated with four different treatments. Digestibility experiment was employed to discuss the collective effect of citric acid, and intrinsic and microbial phytase. By comparing and analyzing effects of them in the low-nutrient broiler diets, the results showed five treatments had similar effects on Tibia ash （%）（mg）（P〉0.05）. Under the supplementation of bacterial phytase or citric acid, the daily body weight gain （ADG）, gain：feed （G：F） ratio, and calcium （Ca） utilization were similar to that of standard-nutrient CSB diet （Diet 1）（P 〉 0.05）. And, fecal phosphorus （P） and CP utilization were lower than （P〈0.05） that of Diet 1. But P utilization was significantly higher than （P〈0.01） that of Diet 1. However, the ADG, G：F, and CP utilization produced by supplementation of intrinsic phytase were lower than those of Diet 1, but other aspects were similar to those produced by Diet 1 （P〉0.05）. In Diet 5, citric acid, intrinsic and bacterial phytase were added to the diet, which produced a 1.4% decrease on fecal P, a 7.2% increase on Ca utilization, which was significantly higher than （P〈0.01） those of the other four Diets, a 3.9% increase on G：F, which was similar to that of Diet 1, and a 2.3% increase on CP utilization, which was higher than （P〈0.05） that of the other three diets. In summary, the results of this study indicated that citric acid, intrinsic and bacterial phytase might have some additive or synergistic effects, and low-nutrient CSB diets with 15% wheat middlings, 750 U kg^-1 phytase, and 3% citric acid might substitute completely for standard CSB in broilers.

关键词： broilers phytase citric acid calcium phosphorus protein

A STUDY ON THE ADSORPTIVE VOLTAMMETRIC BEHAVIOUR OF SAliCYL-FLUORONE

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Chinese Chemical Letters 1993年第10期4卷 925-928页

作者： Xiao li ZHANG li Zeng wang rong li CHEN Department of chemistry,Shandong University,Jinan,250100

In the 0.3mol/L NH_4Cl supporting electrolyte,salicyl-fluorone exhibits a sensitive adsorptive wave by using linear scanning voltammetry with Ep_1=-0.70V and a diffusion wave with Ep_2=-0.68V(v8,SCE)at pH *** the surface of HMDE, the adsorption of salieyl-fluorone obeys Frumkin adsorption *** adsorption coefficient(B),and attractive factor(v)and the amount of saturated adsorption(Γs)have been determined.

关键词： SAF A STUDY ON THE ADSORPTIVE VOLTAMMETRIC BEHAVIOUR OF SAliCYL-FLUORONE SCE

The effects of paeoniflorin monomer of a Chinese herb on cardiac ion channels

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Chinese Medical Journal 2011年第19期124卷 3105-3111页

作者： wang rong-rong li Ning ZHANG Yin-hui RAN Yu-qin PU Jie-lin Pathology and Physiology Research Center Cardiovascular Institute and Fu Wai Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100037 China

Background Because of the potential proarrhythmic effect of current antiarrhythmic drugs, it is still desirable to find safer antiarrhythmic drugs worldwide. Paeoniflorin is one of the Chinese herb monomers that have different effects on many ion channels. The present study aimed to determine the effects of paeoniflorin on cardiac ion *** Whole-cell patch-clamp technique was used to record ion channel currents. L-type calcium current （/Ca-L）,inward rectifier potassium current （/K1）, and transient outward potassium current （/to1） were studied in rat ventricular myocytes and sodium current （/Na）, slow delayed rectifier current （/Ks）, and HERG current （/Kr） were investigated in transfected human embryonic kidney 293 *** One hundred μmol/L paeoniflorin reduced the peak /ca-L by 40.29% at the test potential of ±10 mV （from （-9.78±0.52） pA/pF to （-5.84±0.89） pA/pF, n=5, P=0.028）. The steady-state activation curve was shifted to more positive potential in the presence of the drug. The half activation potentials were （-11.22±0.27） mV vs. （-5.95±0.84） mV （n=5,P=0.007）, respectively. However, the steady-state inactivation and the time course of recovery from inactivation were not changed. One hundred μmol/L paeoniflorin completely inhibited the peak /Na and the effect was reversible. Moreover,paeoniflorin inhibited the /K1 by 30.13% at the test potential of -100 mV （from （-25.26±8.21） pA/pF to （-17.65±6.52）pA/pF, n=6, F=0.015） without effects on the reversal potential and the rectification property. By contrast, 100 μmol/L paeoniflorin had no effects on/to1, /Ks or /Kr *** The study demonstrated that paeoniflorin blocked /Ca-L, /Na, and /Kf without affecting /to1, /Ks, or /Kr. The multi-channel block effect may account for its antiarrhythmic effects with less proarrhythmic potential.

关键词： ion channels Chinese herbs antiarrhythmic drugs paeoniflorin