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Downregulation of miR-4772-3p promotes enhanced regulatory T cell capacity in malignant pleural effusion by elevating Helios levels

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Chinese Medical Journal 2019年第22期132卷 2705-2715页

作者： Wen-Qing Yu Ning-Fei Ji Cheng-jing Gu Zhi-Xiao Sun Zheng-Xia Wang Zhong-Qi Chen Yuan Ma Zhen-Zhen Wu Yan-Li Wang Chao-Jie Wu Ming-Dong Ding Gui-Hong Dai Juan Yao rong-rong jin Mao Huang Ming-Shun Zhang Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Infectious Diseases Taizhou People's Hospital Affiliated to Nantong UniversityTaizhouJiangsu 225300China Department of Pharmacy Taizhou People's Hospital Affiliated to Nantong UniversityTaizhouJiangsu 225300China Department of Pathology Taizhou People's Hospital Affiliated to Nantong UniversityTaizhouJiangsu 225300China Department of Oncology Taizhou People's Hospital Affiliated to Nantong UniversityTaizhouJiangsu 225300China Department of Immunology Nanjing Medical UniversityNanjingJiangsu 210029China

Background:Malignant pleural effusion(MPE)is a complicated condition of patients with advanced *** dissecting the microenvironment of infiltrated immune cells and malignant cells are warranted to understand the immune-evasion mechanisms of tumor development and ***:The possible involvement of microRNAs(miRNAs)in malignant pleural fluid was investigated using small RNA *** T cell(Treg)markers(CD4,CD25,forkhead box P3),and Helios(also known as IKAROS Family Zinc Finger 2[IKZF2])were detected using flow *** expression levels of IKZF2 and miR-4772-3p were measured using quantitative real-time reverse transcription polymerase chain *** interaction between miR-4772-3p and Helios was determined using dual-luciferase reporter *** effects of miR-4772-3p on Helios expression were evaluated using an in vitro *** assays between miR-4772-3p and functional molecules of Tregs were ***:Compared with non-malignant controls,patients with non-small cell lung cancer had an increased Tregs frequency with Helios expression in the MPE and peripheral blood mononuclear *** verified downregulation of miR-4772-3p was inversely related to the Helios*Tregs frequency and Helios expression in the *** of miR-4772-3p could inhib让Helios expression in in vitro ***,ectopic expression of Helios in induced Tregs reversed the effects induced by miR-4772-3p ***,miR-4772-3p could regulate Helios expression by directly targeting IKZF2 ***:Downregulation of miR-4772-3p,by targeting Helios,contributes to enhanced Tregs activities in the MPE microenvironment.

关键词： Helios IKAROS family zinc finger 2 Lung cancer Malignant pleural effusion MiR-4772-3p Regulatory T cells

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唐山市砂质岸线近期冲淤演变分析

海洋环境科学 2017年第1期36卷 101-106,113页

作者：邢容容刘修锦邱若峰张甲波陈文超李娜河北省地矿局秦皇岛矿产水文工程地质大队河北秦皇岛066001 河北省海洋地质资源调查中心河北秦皇岛066001

砂质岸线动态变化较大、不稳定,开展砂质岸线的动态变化监测,分析其动态变化特征及诱因对砂质岸线的保护和开发有着重要作用。基于唐山市1987、2000和2014年landsat影像,开展了唐山市砂质岸线变迁分析研究。结果表明:(1)1987~2000年,主... 详细信息

砂质岸线动态变化较大、不稳定,开展砂质岸线的动态变化监测,分析其动态变化特征及诱因对砂质岸线的保护和开发有着重要作用。基于唐山市1987、2000和2014年landsat影像,开展了唐山市砂质岸线变迁分析研究。结果表明:(1)1987~2000年,主要受来沙量减少、海洋动力的影响,唐山市砂质岸线全面处于侵蚀状态,其中滦河口—浪窝口段的弧形海岸侵蚀最为强烈;(2)2000年以后,由于人类工程建设,人工海岸增加,砂质岸线侵蚀速率有放缓的趋势。随着人类对海岸干预程度的加强,海岸演变趋势也必将更加复杂。本文提出了退养还湿、海滩养护等防止砂质海岸侵蚀的措施。

关键词：砂质岸线冲淤演变唐山市

广州地区医学留学生孤独感特点及其相关因素研究

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中国健康教育 2017年第1期33卷 3-7页

作者：赵蓉蓉江锦祥陈佳欣张雪琴广州医科大学公共卫生学院广东广州510082 广州医科大学公共管理学院广东广州510082

目的了解广州地区医学留学生孤独感现状,并对其影响因素进行分析,为改善医学留学生孤独感现状和建立相应防治对策提供理论依据。方法采用R-UCLA孤独量表、网络成瘾量表(IAT)、一般健康问卷(GHQ)和简明应对方式量表对256名在华医学留学... 详细信息

目的了解广州地区医学留学生孤独感现状,并对其影响因素进行分析,为改善医学留学生孤独感现状和建立相应防治对策提供理论依据。方法采用R-UCLA孤独量表、网络成瘾量表(IAT)、一般健康问卷(GHQ)和简明应对方式量表对256名在华医学留学生孤独感现状进行调查,并分析网络使用状况、一般健康水平、应对策略及恋爱状态等因素对孤独感影响。结果广州地区医学留学生孤独感总分为(35.86±14.28)分,正在恋爱的留学生孤独感水平低于单身留学生(P<0.01)。幻想(r=0.342)、否认(r=0.479)、药物滥用(r=0.358)、自责(r=0.498)、回避(r=0.412)、发泄(r=0.304)等适应不良应对策略与孤独感呈正相关(P均<0.01),幽默(r=-0.274)、计划(r=-0.183)、接受(r=-0.144)等适应性应对策略与孤独感呈负相关(P均<0.05)。网络使用、一般健康、否认、自责、回避等适应不良应对策略对留学生孤独感有预测作用。结论恋爱状态、一般健康、网络使用和应对策略是影响广州地区医学留学生孤独感程度的重要因素,医学院校应加大对留学生适应性指导。

关键词：医学留学生孤独感网络使用应对策略一般健康

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重瓣黄刺玫休眠芽快繁技术的研究

天水师范学院学报 2001年第2期21卷 56-57页

作者：谢晓蓉刘金荣甘肃张掖师范专科学校生物系甘肃张掖734000

探讨重瓣黄利玫组培快繁的实用技术，筛选出重瓣黄刺玫的休眠芽培养的最佳培养基配方及激素水平（２／３ＭＳ＋ＭＡＡ０．３ｍｇ／Ｌ＋ＢＡ３ｍｇ／Ｌ），阐明了重瓣黄刺玫的休眠芽培养、继代培养及生根培养技术和移栽成活、壮苗培育的... 详细信息

探讨重瓣黄利玫组培快繁的实用技术，筛选出重瓣黄刺玫的休眠芽培养的最佳培养基配方及激素水平（２／３ＭＳ＋ＭＡＡ０．３ｍｇ／Ｌ＋ＢＡ３ｍｇ／Ｌ），阐明了重瓣黄刺玫的休眠芽培养、继代培养及生根培养技术和移栽成活、壮苗培育的科学栽培技术，找到了一条快速繁殖黄刺玫的新途径．

关键词：重瓣黄刺玫休眠芽激素水平继代培养无机盐浓度组织培养

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刚地弓形虫棒状体蛋白10的生物信息学分析

中国病原生物学杂志 2017年第9期12卷 855-859页

作者：刘荣荣张进顺张晓磊刘楠贾晓晖王璐瑶河北北方学院病原生物学与免疫学研究所河北张家口075000

目的对刚地弓形虫棒状体蛋白10(TgROP10)进行生物信息学预测,分析其免疫原性。方法运用生物信息学在线分析程序ProtParam、SOSUI、ProtScale、TMHMM、SignalP-4.1、TargetP1.1Server、SOPMA、MotifScan、SWISS-MODEL、SYFPEITHI和Bcepred等并结合生物信息学软件DNASTAR和DNAMAN分析预测TgROP10的理化性质、可溶性、亲疏水性、跨膜结构域、信号肽、胞内定位、二级结构、蛋白翻译后修饰位点、三级结构、柔韧性、表面可及性和B细胞、T细胞抗原表位等。结果 TgROP10蛋白由586个氨基酸组成,分子式为C2562H4045N739O964S9,分子质量单位(Mr)为60.912 21×103,理论等电点为4.19,吸光度值为0.476,半衰期为30h,不稳定系数为55.56,脂溶性指数为56.25,总平均亲水性系数为-0.699,属于亲水性蛋白;该蛋白无跨膜结构区域,信号肽切割位点在22-23位氨基酸之间,亚细胞定位预测可能是分泌蛋白;二级结构中α螺旋和β折叠分别占26.79%和13.31%,β转角和无规则卷曲分别占6.48%和53.41%,有6种翻译后修饰位点,15个B细胞抗原表位,3个CTL细胞抗原表位,12个Th细胞抗原表位,28个亲水性参数得分1.9的区域,15个柔韧性参数得分2.0的区域,27个表面可及性参数得分1.9的区域,3个暴露表面参数得分2.3的区域。结论生物信息学预测TgROP10含多个抗原表位,具有免疫原性,可作为弓形虫疫苗备选蛋白。

关键词：刚地弓形虫 TgROP10 生物信息学免疫原性

Enhanced solid-electrolyte interface efficiency for practically viable hydrogen-air fuel cell systems

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Journal of Energy Chemistry 2025年第1期100卷 356-368页

作者： Venkitesan Sakthivel Dong jin Yoo Graduate School Department of Energy Storage/Conversion Engineering (BK21 FOUR) Hydrogen and Fuel Cell Research Center Jeonbuk National University Jeonju Department of Life Science Jeonbuk National University

Proton exchange membrane fuel cells （PEMFCs） provide an appealing sustainable energy system,with the solid-electrolyte membrane playing a crucial role in its overall ***,sulfonated poly（1,4-phenylene ether-ether sulfone）(SPEES),an aromatic hydrocarbon polymer,has garnered considerable attention as an alternative to Nafion ***,the long-term durability and stability of SPEES present a significant *** this context,we introduce a potential solution in the form of an additive,specifically a core–shell-based amine-functionalized iron titanate （A–Fe2TiO5）,which holds promise for improving the lifetime,proton conductivity,and power density of SPEES in *** modified SPEES/A–Fe2TiO5composite membranes exhibited notable characteristics,including high water uptake,enhanced thermomechanical stability,and oxidative ***,the SPEES membrane loaded with 1.2 wt%of A–Fe2TiO5demonstrates a maximum proton conductivity of 155 mS cm-1,a twofold increase compared to the SPEES membrane,at 80°C under 100%relative humidity （RH）.Furthermore,the 1.2 wt%of A–Fe2TiO5/SPEES composite membranes exhibited a maximum power density of 397.37 mW cm-2and a current density of 1148 mA cm-2at 60°C under 100%RH,with an opencircuit voltage decay of 0.05 m V/h during 103 h of continuous *** study offers significant insights into the development and understanding of innovative SPEES nanocomposite membranes for PEMFC applications.

关键词： Composite membranes

Late Paleozoic to early Mesozoic volcanic-sedimentary history of the southeastern margin of the Central Asian Orogenic Belt: Timing of uplift of the Inner Mongolia paleo-uplift

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Science China Earth Sciences 2025年第1期68卷 297-309页

作者： Wenxing HAO jin-Hui YANG Guang ZHU State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics Chinese Academy of Sciences School of Resource and Environmental Engineering Hefei University of Technology

The Kulun region is located in the eastern Bainaimiao arc belt on the southeastern margin of the Central Asian Orogenic Belt(CAOB), adjacent to the North China Craton(NCC) to the south. This region records the closure of the PaleoAsian Ocean during the Paleozoic to early Mesozoic and is key to study the tectonic evolution of the northern margin of the *** conducted zircon U-Pb geochronology and Hf isotope analysis of volcanic-sedimentary and intrusive rocks in the Kulun region. The volcanic-sedimentary rocks were previously assigned an early Carboniferous age, but include volcanic rocks with ages of 267–266 Ma and sedimentary rocks with youngest detrital zircon age peaks of 265–244 Ma, which were intruded by a granite with an age of 242 Ma. This indicates that these rocks are actually middle Permian to Middle Triassic in age(267–242Ma) and correspond to the Qingfengshan and Liujiagou formations. Moreover, two volcanic rock samples have high εHf(t) values(+1.6 to +16.1) and relatively young two-stage Hf model ages(1095–327 Ma), indicating their sources associated with the CAOB. The age spectra and Hf isotopic characteristics of detrital zircons from the sedimentary rocks suggest that, during the middle Permian to Middle Triassic, the sedimentary provenance in the Kulun region was mainly the CAOB. However, by the Early Jurassic, the provenance changed to the NCC(i.e., the Inner Mongolia Paleo-uplift, IMPU). This result, combined with the development of a series of conglomerates on the northern margin of the NCC in the Late Triassic(i.e., Xingshikou, Xiaoyingzi,and Xiaohekou formations), indicates the Kulun region experienced an abrupt change in paleogeography during the Late Triassic, with the IMPU undergoing significant uplift and thus becoming the main sediment source in the Kulun region. Based on the Late Triassic alkaline igneous belt(235–215 Ma) in the IMPU, we speculate that this uplift was caused by detachment of the southward-subducting Paleo-Asian oceanic

关键词： Central Asian Orogenic Belt the North China Craton Zircon geochronology Hf isotopes Inner Mongolia Paleo-uplift

La_(2/3)Sr_(1/3)MnO_3单晶的本征低温电阻最小行为研究(英文)

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山东大学学报（工学版） 2009年第1期39卷 110-113页

作者：贾蓉蓉张金仓冯振杰王仕鹏陈昌兆敬超曹世勋上海大学理学院物理系上海200444

为了阐明在锰氧化物多晶以及外延薄膜中存在的低温电阻极小值现象,对La2/3Sr1/3MnO3单晶样品的性质进行研究.该单晶样品是利用光学浮区生长炉,在氩气气氛中生长出的高品质晶体,系统研究了退火对La2/3Sr1/3MnO3单晶低温输运行为的影响.... 详细信息

为了阐明在锰氧化物多晶以及外延薄膜中存在的低温电阻极小值现象,对La2/3Sr1/3MnO3单晶样品的性质进行研究.该单晶样品是利用光学浮区生长炉,在氩气气氛中生长出的高品质晶体,系统研究了退火对La2/3Sr1/3MnO3单晶低温输运行为的影响.结果表明,在退火前样品存在的低温电阻极小值无论是c轴还是ab平面在退火后均消失,这一结果首次证明了在锰氧化物体系中存在的低温电阻极小是一种非本征的物理行为,与实验样品的制备工艺和存在于其中的非完整性具有较强的依赖性,并进一步证明自旋无序散射乃是传统体系出现低温电阻极小的主要原因.

关键词：庞磁电阻电阻极小退火单晶

Extend ethylene aromatization single-event kinetic modeling with physical and chemical descriptor based on ZSM-5 catalyst

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Petroleum Science 2023年第6期20卷 3841-3853页

作者： Jia-rong Xie Fang jin School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan430205HubeiChina Key Laboratory for Green Chemical Process of Ministry of Education Wuhan Institute of TechnologyWuhan430205HubeiChina Novel Reactor&Green Chemical Technology Key Laboratory Wuhan Institute of TechnologyWuhan430205HubeiChina

The ethylene aromatization is critical for the methanol to aromatics and light alkane dehydroaromatization *** single-event microkinetic(SEMK)model combining the linear free energy theory and solid acid distribution concept were established and extend for the ethylene aromatization process,which can reduce the kinetic parameters and simplify the reaction network by comparison with the SEMK model including subtype elementary steps based on the type of carbenium *** introducing deactivation parametersφinto the model and applying the linear free energy model to the deactivation experimental data,the obtained deactivation parametersφindicate that the carbon deposition precursors have the greatest impact on reducing the reaction rate of single-molecular reactions and the smallest impact on the hydrogen transfer ***,according to the change of reaction enthalpy,effect of carbenium ion structure on methylation,ethylation,cyclization and endo-βscission was investigated by introducing linear free energy concept into the SEMK *** effect of different acid strengths on elementary steps was investigated based on the acid strength distribution model,it was found that the methylation and oligomerization reactions,the ali-βscission reaction,endo-βscission reaction and the cyclization reaction were more sensitive to strong acidity *** physisorption and chemisorption heat are separated from the protonation heat in the linear free energy kinetic model and the acid strength distribution kinetic model,and the absolute values of the obtained physisorption and chemisorption heat increase with the carbon number of carbenium ***,the parameters of the acid strength distribution kinetic model were applied to propane dehydroaromatization on H-ZSM-5 and the ethane dehydroaromatization on Zn/ZSM-5 to confirm the independence of parameters in the SEMK model with the similar reaction network.

关键词： Kinetic model Ethylene aromatization Acid strength distribution Linear free energy theory