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International Journal of Ophthalmology(English edition) 2023年第4期16卷 663-667页

作者： Dan Jiang Zhi-Xiang Hu Xiao-Ling Yang Qi-Fei Shang rong-han wu National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Department of Ophthalmology Fuyang People’s HospitalHangzhou 311400Zhejiang ProvinceChina

Dear Editor,Submacular hemorrhage(SMH)is the accumulation of blood in the macular region caused by changes in retinal or choroidal circulation[1].SMH may be caused by age-related macular degeneration(AMD),pathological... 详细信息

关键词： needle injection degeneration

Inner limiting membrane peeling prevents secondary epiretinal membrane after vitrectomy for proliferative diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2022年第9期15卷 1496-1501页

作者： rong-han wu Ming-Na Xu Ke Lin Ming-Xue Ren han Wen Ke-Mi Feng Hong-Jia Zhou Nived Moonasar Zhong Lin Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Wenzhou 325027Zhejiang ProvinceChina Caribbean Eye Institute ValsaynTrinidad and Tobago

·AIM:To evaluate the role of internal limiting membrane(ILM)peeling in preventing secondary epiretinal membrane(ERM)formation in pars plana vitrectomy(PPV)for proliferative diabetic retinopathy(PDR).·METHODS:This retrospective study analyzed the medical records of patients who underwent PPV for PDR and were followed up for minimum 3 mo.ILM peeling was performed based on the intraoperative surgeons’judgments.ERM was assessed by optical coherence tomography photography.The relationship between ILM peeling and postoperative ERM was analyzed.·RESULTS:In total,212 eyes from 197 patients were included in this study.The incidence of secondary ERM in the ILM non-peeling group was significantly higher than that in the ILM peeling group(37.0%vs 14.0%;P<0.001).Multivariate logistical regression revealed that ILM peeling was highly associated with the prevention of secondary ERM development[odds ratio 0.38;95%confidence interval0.17-0.86;P<0.05].·CONCLUSION:ILM peeling during PPV for PDRs can effectively reduce the incidence of secondary ERM development and is worth consideration by vitreoretinal surgeons.

关键词： internal limiting membrane secondary epiretinal membrane proliferative diabetic retinopathy

Incidence of rhegmatogenous retinal detachments is increasing in Wenzhou,China

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International Journal of Ophthalmology(English edition) 2023年第2期16卷 260-266页

作者： Ming-Na Xu Jia-Yu Zhang Hui Yang Ben-Hao Song rong-han wu Zi-Pei Jiang Ke-Mi Feng Ming-Xue Ren Ke Lin Zhong Lin National Clinical Research Center for Ocular Diseases Eye HospitalWenzhouMedicalUniversityWenzhou 325027Zhejiang ProvinceChina Department of Ophthalmology the Third Affiliated Hospital of Wenzhou Medical UniversityRuian 325200Zhejiang ProvinceChina Department of Ophthalmology the Second Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

AIM:To estimate and compare the incidence and characteristics of rhegmatogenous retinal detachments(RRDs)in the Wenzhou area in 2015 to 2019.METHODS:All newly developed RRD cases among residents of the Wenzhou area,from January 2015 to December 2019,were retrospectively retrieved from hospital records.Annual population data were extracted from the Wenzhou Statistical Yearbook.RESULTS:There were 3629 eligible cases.The average incidence of RRD was 7.79 cases per 100000 population(95%confidence interval,7.24-8.34),and the incidences were 7.99 and 7.56 for males and females,respectively.The annual incidence increased gradually from 7.26 cases per 100000 in 2015 to 10.00 cases per 100000 in 2019,with an overall increase of 37.74%.The highest rate of increase occurred in the age group from 60 to 69 years.Of 2750 eyes with axial length(AL)data,1675(60.91%)had an AL greater than 24 mm.CONCLUSION:A trend to increasing RRD incidence is observed in the Wenzhou area over the past 5-year period.

关键词： rhegmatogenous retinal detachments retina incidence Chinese

Pars plana vitrectomy relieves the depression in patients with symptomatic vitreous floaters

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International Journal of Ophthalmology(English edition) 2020年第3期13卷 412-416页

作者： rong-han wu Jun-Hong Jiang Yi-Fan Gu Nived Moonasar Zhong Lin The Eye Hospital School of Ophthalmology and OptometryWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Minhang Hospital Fudan UniversityShanghai 201100China Caribbean Eye Institute ValsaynTrinidad and Tobago

AIM:To investigate the depressive state among the patients with symptomatic vitreous floaters(SVF),as well as its change after SVF removal via vitrectomy surgery.METHODS:Twenty-eight eyes of 28 patients who underwent 27-gauge pars plana vitrectomy(PPV)for SVF were included.Thirty-nine eyes of 39 age-and gendermatched healthy volunteers without SVF were also recruited as a healthy control.Center for Epidemiologic Studies Depression(CES-D)was used to assess volunteers and patients’depression(before and 1 wk after PPV).RESULTS:The CES-D score was 18.3±8.6 for patients,and was 12.4±6.0 for healthy control(P=0.003).Patients were significantly more likely to be in a depressive state(53.6%,defined as CES-D score≥16)than the healthy control(20.5%,P=0.005).For patients with SVF,the CES-D score was negatively correlated with their age(rs=-0.42,P=0.025).After PPV,both the CES-D score(11.9±5.4 vs 18.3±8.6,P<0.001)and proportion of depressive state(18.5%vs 53.6%,P=0.005)were significantly decreased.CONCLUSION:This study suggests that symptoms of vitreous floaters have an apparently negative impact on patients’psychological state.The PPV can effectively relieve the depressive state for patients with SVF.

关键词： depression symptomatic vitreous floaters pars plana vitrectomy CES-D

Air tamponade and without heavy liquid usage in pars plana vitrectomy for rhegmatogenous retinal detachment repair

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International Journal of Ophthalmology(English edition) 2018年第11期11卷 1779-1783页

作者： Zhong Lin Qi-Hua Liang Ke Lin Zhi-Xiang Hu Tian-Yu Chen rong-han wu Nived Moonasar The Eye Hospital School of Ophthalmology and Optometry Wenzhou Medical University Department of Ophthalmology University of the West Indies

AIM： To report the results of rhegmatogenous retinal detachment（RRD） repair after pars plana vitrectomy（PPV） without operative use of heavy liquid, and utilizing air tamponade in selected cases.METHODS： RRD patients without severity of proliferative vitreoretinopathy C2 or more underwent PPV without operative use of heavy liquid, and utilizing air tamponade were consecutively enrolled. Alternative postoperative facedown position or lateral position was required for 3-5 d.RESULTS： Totally 36 eyes of 36 patients（24 males, 66.7%） aged 53.8±10.9 y underwent this modified surgery. The mean number of retinal break was 2.1±1.3. Most of the eyes（29, 80.6%） had retinal detachment involving more than one quadrant. Twenty-two（61.1%） eyes with cataract had combined phacoemulsification and intraocular lens implantation. The mean follow up time was 4.6±1.8 mo. Two eyes with retinal redetachment underwent a second retinal repair surgery with silicone oil tamponade, yielding the primary reattachment rate to 94.4%（34/36）. Six（16.7%） eyes had intraocular pressure higher than 25 mm Hg. The visual acuity（logMAR） improved from 0.98±0.74 preoperatively to 0.52±0.31 postoperatively（P〈0.001）. CONCLUSION： The success rate of this modified retinal repair surgery is comparable with traditional surgery. This technique can be considered for certain retinal detachment patients, since its apparent advantages included lower surgical complications, reduced surgery expenditure, shorter time for postoperative facedown position, and avoiding silicone oil removal surgery.

关键词： air heavy liquid rhegmatogenous retinal detachment pars plana vitrectomy

New technique for removal of perfluorocarbon liquid related sticky silicone oil and literature review

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International Journal of Ophthalmology(English edition) 2021年第12期14卷 1903-1908页

作者： Hai-Shuang Lin Yong-Ping Tang Lu Zhang En-Ze Liu Ling-Ying Ye Ming-Na Xu rong-han wu Zhi-Xiang Hu School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Eye Hospital of Wenzhou Medical University Wenzhou 325027Zhejiang ProvinceChina

AIM:To investigate the safety and efficacy of sticky silicone oil(SSO)removal using a 22-gauge vein detained needle and inner limiting membrane(ILM)wrap-and-peel technique.METHODS:This retrospective consecutive case series reviewed the records of patients with a history of retinal detachment who had received silicone oil and perfluorocarbon liquid(PFCL)as intraocular tamponades.Patients were included in the analysis if they exhibited SSO remnants during silicone oil removal.The aspiration of most of the SSO remnants was performed by a 22-gauge vein detained needle.The small amounts of droplets adhered to the macula and epi-macular membrane were subsequently removed by the ILM warp-and-peel technique.The anatomical and functional outcomes,and postoperative complications were recorded.In vitro experiments were performed to simulate the formation of SSO remnants in four groups.RESULTS:Of 711 patients who underwent silicone oil removal during the study period,9 patients exhibited SSO remnants and underwent follow-up for at least 3mo.Seven eyes(78%)underwent the ILM wrap-and-peel technique to completely remove small droplets of SSO that were glued to the macula and epi-macular membrane.No obvious complications occurred.Postoperative optical coherence tomography revealed normal retinal structure in all patients.In vitro analyses showed that balanced salt solution and prolonged vibration(for 1wk)had the strongest effects on silicone oil and PFCL compound opacities.CONCLUSION:SSO remnants could be removed in an intact manner and without complications,using a vein detained needle-assisted and ILM wrap-and-peel technique.The findings suggest that PFCL and infusion fluid should be completely removed before silicone oil injection to prevent SSO formation.

关键词： sticky silicone oil perfluorocarbon liquid silicone oil removal inner limiting membrane peel in vitro analysis

Temporal and Spatial Trends in HIV Positivity Rate for VCT Clinics—China,2015–2022

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China CDC weekly 2024年第1期6卷 6-11页

作者： Yi Liu rong Su Dongmin Li Shaorong Wang Mengjie han National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

Introduction:Human immunodeficiency virus(HIV)voluntary counseling and testing(VCT)clinics play a critical role in identifying and diagnosing HIV cases.This study aimed to describe the trend of HIV positivity rate(HPR)among Chinese VCT clinics between 2015 and 2022.Methods:This study utilized data from the China Information System for Disease Control and Prevention to analyze the trend in the HPR for VCT clinics from 2015 to 2022.The HPR was calculated by dividing the number of newly-reported HIV cases by the number of HIV tests,multiplied by 100%.To identify temporal and spatial trends in the HPR,we employed joinpoint regression analysis and the Getis-Ord hotspot analysis.Results:From 2015 to 2022,VCT clinics in China performed a total of 22,075,386 HIV tests,leading to the identification of 260,353 HIV cases,resulting in a HPR of 1.18%.The HPR consistently declined over the study period,with an average annual percent change(AAPC)of−7.5%(95%confidence interval:−12.6%,−2.2%,P<0.05).The number of HPR hotspots also decreased from 41 in 2015 to 23 in 2022.These HPR hotspots were primarily located in Yunnan,Sichuan,Guangdong,and Guangxi provincial-level administrative divisions(PLADs).Among the 31 PLADs,16 showed a significant decrease in HPR during the study period(AAPC<0,PAAPC<0.05).Conclusions:VCT clinics in China have played a significant role in identifying HIV cases.The declining HPR observed in these clinics may indicates the progress has been made in some degree in mitigating HIV among high-risk populations.Therefore,it is crucial to further improving the utilization of VCT clinics for HIV testing.

关键词： VCT dividing Spatial

Recent advancements in hydrometallurgical recycling technologies of spent lithium-ion battery cathode materials

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Rare Metals 2024年第3期43卷 879-899页

作者： Juan wu Li Xiao Li Shen Jian-Jun Ran Hui Zhong Yi-rong Zhu han Chen College of Materials and Advanced Manufacturing Hunan University of TechnologyZhuzhou412007China School of Resources Processing and Bioengineering Central South UniversityChangsha410083China Guangdong JiaNa Energy Technology Company Qingyuan513000China

The rapidly increasing production of lithium-ion batteries(LIBs)and their limited service time increases the number of spent LIBs,eventually causing serious environmental issues and resource wastage.From the perspectives of clean production and the development of the LIB industry,the effective recovery and recycling of spent LIBs require urgent solutions.This study provides an overview of the current hydrometallurgical processes employed in the recycling of spent cathode materials,focusing on the leaching of valuable metals and their postprocessing.In particular,this research reviews the various leaching systems(inorganic acid,organic acid,and ammonia)and the separation of valuable metals,and then,recommendations for subsequent study are offered in an attempt to contribute to the development of highly efficient methods for recycling spent cathode materials.In addition,a range of existing technologies,such as solvent extraction,chemical precipitation,electrochemical deposition,and regeneration,for the postprocessing of leaching solutions are summarized.Finally,the promising technologies,existing challenges and suggestions with respect to the development of effective and environmentally friendly recycling methods for handling spent cathode materials are identified.

关键词： Spent lithium-ion batteries(LIBs) Cathode material Hydrometallurgy Leaching Recycling

Emerging clinical relevance of microbiome in cancer:promising biomarkers and therapeutic targets

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Protein & Cell 2024年第4期15卷 239-260页

作者： Jia-Hao Dai Xi-rong Tan han Qiao Na Liu State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510050China

The profound influence of microbiota in cancer initiation and progression has been under the spotlight for years,leading to numerous researches on cancer microbiome entering clinical evaluation.As promising biomarkers and therapeutic targets,the critical involvement of microbiota in cancer clinical practice has been increasingly appreciated.Here,recent progress in this field is reviewed.We describe the potential of tumor-associated microbiota as effective diagnostic and prognostic biomarkers,respectively.In addition,we highlight the relationship between microbiota and the therapeutic efficacy,toxicity,or side effects of commonly utilized treatments for cancer,including chemotherapy,radiotherapy,and immunotherapy.Given that microbial factors influence the cancer treatment outcome,we further summarize some dominating microbial interventions and discuss the hidden risks of these strategies.This review aims to provide an overview of the applications and advancements of microbes in cancer clinical relevance.

关键词： microbiome cancer diagnosis prognosis therapy

On equivalence of state-based potential games

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Science China(Information Sciences) 2024年第6期67卷 313-327页

作者： han wu Jinhuan WANG Institute of Mathematics School of ScienceHebei University of Technology

In this paper, we explore state-based potential games using the semi-tensor product of matrices.First, applying the potential equation, we derive both a necessary and sufficient condition as well as a sufficient condition to verify whether a state-based game qualifies as a potential game. Next, we present two static equivalence conditions of state-based potential games. We then delve into dynamic equivalence. We propose a criterion that allows us to identify state-based games that are dynamically equivalent to state-based potential games and share similar dynamic properties. Ultimately, we introduce the concept of state-based networked evolutionary games. We provide a necessary and sufficient condition to ensure that a state-based networked evolutionary game can be classified as a state-based potential game.

关键词： semi-tensor product of matrices state-based potential game verification equivalence state-based networked evolutionary game