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Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang gao Xinyue Wang Shijie Su Weicheng Feng Yaona Lai Kongli Huang Dandan Cao Qi Wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

Effect of Ca^(2+) on CO_2 corrosion properties of X65 pipeline steel

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International Journal of Minerals,Metallurgy and Materials 2009年第6期16卷 661-666页

作者： Chen ding Ke-wei gao Chang-feng Chen Department of Materials Physics and Chemistry University of Science and Technology Beijing Beijing 100083 China Department of Materials China University of Petroleum Beijing 100083 China

The effect of Ca^2＋ on CO2 corrosion to X65 pipeline steel was investigated in the simulated stratum water of an oil field containing different concentrations of Ca^2＋. It is found that Ca^2＋ can enhance the corrosion rate, especially in the Ca^2＋ concentration from 256 to 512 mg/L, which can be attributed to the growing grain size and loosing structure of corrosion scales with increasing Ca^2＋ concentration. X-ray diffraction （XRD） and X-ray photoelectron spectroscopy （XPS） investigations reveal that a complex carbonate （Fe, Ca）CO3 forms at high Ca^2＋ concentration due to the gradual replacement of Fe^2＋ in FeCO3 by Ca^2＋.

关键词： CO2 corrosion: pipeline steel stratum water Ca^2+ concentration complex carbonate

Unlocking the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

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Journal of Energy Chemistry 2025年第1期100卷 770-778页

作者： Xiaoqin Li Jian Xiang Lu Qiu Xiaohan Chen Yinkun Zhao Yujue Wang Qu Yue Taotao gao Wenlong Liu Dan Xiao Zhaoyu Jin Panpan Li Institute for Advanced Study Chengdu University School of Mechanical Engineering Chengdu University College of Food and Biological Engineering Chengdu University Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China College of Materials Science and Engineering Sichuan University

The growth of dendrites and the side reactions occurring at the Zn anode pose significant challenges to the commercialization of aqueous Zn-ion batteries（AZIBs）. These challenges arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose（Xylo） molecule to address these issues by modulating the solvation structure and electrode/electrolyte interface, thereby stabilizing the Zn anode. The introduction of the additive alters the solvation structure, creating steric hindrance that impedes charge transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn2+ion migration and suppresses corrosion and hydrogen evolution reactions. As a result, symmetric cells incorporating the Xylo additive exhibit significantly enhanced reversibility during the Zn plating/stripping process, with an impressively long lifespan of up to 1986 h, compared to cells using pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long-term cyclic stability. This work offers an effective direction for improving the stability of Zn anode via electrolyte design, as well as highperformance AZIBs.

关键词： Solvation

Polycyclic aromatic hydrocarbon biodegradation and extracellular enzyme secretion in agitated and stationary cultures of Phanerochaete chrysosporium

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Journal of Environmental Sciences 2008年第1期20卷 88-93页

作者： ding Juan CONG Jun ZHOU juan gao Shixiang State Key Laboratory of Pollution Control and Resource Reuse School of the Environment Nanjing University Nanjing 210093 China School of the Energy and Environment Southeast University Nanjing 210096 China

The extracellular enzyme secretion and biodegradation of polycyclic aromatic hydrocarbons （PAHs） were studied in agitated and shallow stationary liquid cultures of Phanerochaete chrysosporium. Veratryl alcohol and Tween80 were added to cultures as lignin peroxidase （LIP） and manganese peroxidase （MnP） inducer, respectively. Shallow stationary cultures were suitable for the production of enzyme, whereas agitated cultures enhanced overall biodegradation by facilitating interphase mass transfer of PAHs into aqueous phases. The use of a LiP stimulator, veratryl alcohol, did not increase PAH degradation but significantly enhanced LiP activity. In contrast, Tween80 increased both MnP secretion and PAH degradation in shallow stationary cultures. On the other hand, high PAH degradation was observed in agitated cultures in the absence of detectable LiP and MnP activities. The results suggested that extracellular peroxidase activities are not directly related to the PAH degradation, and the increased solubility rather than enzyme activity may be more important in the promotion of PAH degradation.

关键词： lignin peroxidase (LIP) manganese peroxidase (MnP) Phanerochaete chrysosporium polycyclic aromatic hydrocarbons (PAHs) solubilization

Surface modification of wollastonite by the mechano-activated method and its properties

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International Journal of Minerals,Metallurgy and Materials 2011年第1期18卷 83-88页

作者： Hao ding Shou-ci Lu gao-xiang Du School of Materials Science and Technology China University of Geosciences Beijing 100083 China School of Civil and Environmental Engineering University of Science and Technology Beijing Beijing 100083 China

Surface modification of wollastonite particles using titanate as a modification agent incorporated by simultaneous wet ultra-fine grinding in a laboratory stirred mill was *** physical,physic-chemical and application properties of the modified wollastonite were measured and *** results showed that grinding intensity markedly influences the modification effect because of the mechano chemical *** hydrophilic surface of wollastonite was turned into a hydrophobic one after *** interaction between titanate and wollastonite under wet grinding circumstances was *** was suggested that physical adsorption and chemical adsorption of titanate coexisted on the wollastonite *** mechanical properties of polyethylene（PE） filled with the modified wollastonite powder were markedly improved.

关键词： silicate minerals modification surface properties ball milling fillers

Virtual Simulation System with Path-following Control for Lunar Rovers Moving on Rough Terrain

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Chinese Journal of Mechanical Engineering 2012年第1期25卷 38-46页

作者： gao Haibo DENG Zongquan ding Liang WANG Mengyu State Key Laboratory of Robotics and Systems Harbin Institute of TechnologyHarbin 150001China School of Mechatronics Harbin Institute of TechnologyHarbin 150001China

Virtual simulation technology is of great importance for the teleoperation of lunar rovers during the exploration phase, as well as the design of locomotion systems, performance evaluation, and control strategy verification during the R&D phase. The currently used simulation methods for lunar rovers have several disadvantages such as poor fidelity for wheel-soil interaction mechanics, difficulty in simulating rough terrains, and high complexity making it difficult to realize mobility control in simulation systems. This paper presents an approach for the construction of a virtual simulation system that integrates the features of 3D modeling, wheel-soil interaction mechanics, dynamics analysis, mobility control, and visualization for lunar rovers. Wheel-soil interaction experiments are carried out to test the forces and moments acted on a lunar rover’s wheel by the soil with a vertical load of 80 N and slip ratios of 0, 0.03, 0.05, 0.1, 0.2, 0.3, 0.4, and 0.6. The experimental results are referenced in order to set the parameters’ values for the PAC2002 tire model of the ADAMS/Tire module. In addition, the rough lunar terrain is simulated with 3DS Max software after analyzing its characteristics, and a data-transfer program is developed with Matlab to simulate the 3D reappearance of a lunar environment in ADAMS. The 3D model of a lunar rover is developed by using Pro/E software and is then imported into ADAMS. Finally, a virtual simulation system for lunar rovers is developed. A path-following control strategy based on slip compensation for a six-wheeled lunar rover prototype is researched. The controller is implemented by using Matlab/Simulink to carry out joint simulations with ADAMS. The designed virtual lunar rover could follow the planned path on a rough terrain. This paper can also provide a reference scheme for virtual simulation and performance analysis of rovers moving on rough lunar terrains.

关键词： lunar rover comprehensive simulation system rough terrain wheel-soil interaction mechanics path-following control

Simulation of Metal Transfer in GMAW Based on FLUENT

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Acta Metallurgica Sinica(English Letters) 2013年第3期26卷 265-270页

作者： Xueping ding Huan LI Lijun YANG Ying gao Tianjin Key Laboratory of Advanced Joining Technology Tianjin University Tianjin Key Laboratory of High Speed Cutting and Precision Machining Tianjin University of Technology and Education

A new numerical approach is presented, which is used to simulate the dynamic process of metal transfer. The process of metal transfer in gas metal arc welding is simulated based on FLUENT. A two-dimensional axisymmetric numerical model is developed using volume of fluid method and the distributions of physical quantities including pressure, current density, electric potential in the droplet are investigated. For improving the veracity of the simulated results and decreasing the effect of the uncertain surface tension coefficient on the simulated results, the relationship between the welding current and surface tension coefficient is modified by analysis of regression. Meanwhile for testing the accuracy of simulated results, the welding experiments are performed and the high-speed photography system is used to record the real process of metal transfer. The results show that the simulated results are in reasonably good agreement with the experimental ones.

关键词： Metal transfer FLUENT Dynamic simulation High-speed photography

Treatment of 2-phenylamino-3-methyl-6-di-n-butylaminofluoran production effluent by combination of biological treatments and Fenton's oxidation

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Journal of Environmental Sciences 2007年第10期19卷 1178-1182页

作者： ding Wei gao Ying-xin YANG Min ding Ran ZHANG Yu College of Resource and Environmental Engineering East China University of Science and Technology Shanghai 200237 SKLEAC Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

High strength refractory organic stream is produced during the production of 2-phenylamino-3-methyl-6-di-n-butylaminofluoran （One Dye Black 2, abbr. ODB 2）, a novel heat-sensitive material with a promising market. In this study, a combination of acidificationprecipitation, primary biological treatment, Fenton＇s oxidation and another biological treatment was successfully used for the removal of COD from 18000-25000 mg/L to below 200 mg/L from the ODB 2 production wastewater in a pilot experiment. A COD removal of 70%-80% was achieved by acidification-precipitation under a pH of 2.5-3.0. The first step biodegradafion permitted an average COD removal of 70% under an hydraulic residence time （HRT） of 30 h. By batch tests, the optimum conditions of Fenton＇s oxidation were acquired as： Fe^2＋ dose 6.0 mmol/L; H2O2 dose 3000 mg/L; and reaction time 6 h. The second step biological treatment could ensure an effluent COD below 200 mg/L under an HRT of 10 h following the Fenton＇s treatment.

关键词： 2-phenylamino-3-methyl-6-di-n-butylaminofluoran ODB 2 wastewater Fenton's oxidation activated sludge heatsensitive material

Relay selection based on MAP estimation for cooperative communication with outdated channel state information

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Chinese Journal of Aeronautics 2013年第3期26卷 661-667页

作者： ding Wenrui Fei Li gao Qiang Liu Shuo Institute of Unmanned Air Vehicle Beihang University School of Electronic and Information Engineering Beihang University

In this paper, we consider an amplify-and-forward （AF） cooperative communication system when the channel state information （CSI） used in relay selection differs from that during data transmission, i.e., the CSI used in relay selection is outdated. The selected relay may not be actually the best for data transmission and the outage performance of the cooperative system will deteriorate. To improve its performance, we propose a relay selection strategy based on maximum a posteriori （MAP） estimation, where relay is selected based on predicted signal-to-noise ratio （SNR）. To reduce the computation complexity, we approximate the a posteriori probability density of SNR and obtain a closed-form predicted SNR, and a relay selection strategy based on the approximate MAP estimation （RS-AMAP） is proposed. The simulation results show that this approximation leads to trivial performance loss from the perspective of outage probability. Compared with relay selection strategies given in the literature, the outage probability is reduced largely through RS-AMAP for medium-to-large transmitting powers and medium-to-high channel correlation coefficients.

关键词： Cooperative communication MAP estimation Outdated CSI Relay selection Wireless networks