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A bi-level optimization framework for charging station design problem considering heterogeneous charging modes

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Journal of Intelligent and Connected Vehicles 2022年第1期5卷 8-16页

作者： Le Zhang Ziling Zeng Kun gao School of Economics and Management Nanjing University of Science and TechnologyNanjingChina Department of Architecture and Civil Engineering Chalmers University of TechnologyGothenburgSweden

Purpose–The purpose of this paper is to optimize the design of charging station deployed at the terminal station for electric transit,with explicit consideration of heterogenous charging ***/methodology/approach–The authors proposed a bi-level model to optimize the decision-making at both tactical and operational levels ***,at the operational level(*** level),the service schedule and recharging plan of electric buses are optimized under specific design of charging *** objective of lower-level model is to minimize total daily operational *** model is solved by a tailored column generation-based heuristic *** the tactical level(*** level),the design of charging station is optimized based upon the results obtained at the lower level.A tabu search algorithm is proposed subsequently to solve the upper-level ***–This study conducted numerical cases to validate the applicability of the proposed *** managerial insights stemmed from numerical case studies are revealed and discussed,which can help transit agencies design charging station ***/value–The joint consideration of heterogeneous charging modes in charging station would further lower the operational cost of electric transit and speed up the market penetration of battery electric buses.

关键词： Battery electric bus Charging station design Vehicle scheduling Bi-level model Heterogeneous charging modes

Increasing prediction performance of colorectal cancer disease status using random forests classification based on metagenomic shotgun sequencing data

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Synthetic and Systems Biotechnology 2022年第1期7卷 574-585页

作者： Yilin gao Zifan Zhu Fengzhu Sun Department of Quantitative and Computational Biology University of Southern California1050 Childs WayRRI 201Los AngelesCAUnited States

Dysfunction of microbial communities in various human body sites has been shown to be associated with a variety of diseases raising the possibility of predicting diseases based on metagenomic *** many studies have investigated this problem,there are no consensus on the optimal approaches for predicting disease status based on metagenomic *** six human gut metagenomic datasets consisting of large numbers of colorectal cancer patients and healthy controls from different countries,we investigated different software packages for extracting relative abundances of known microbial genomes and for integrating mapping and as-sembly approaches to obtain the relative abundance profiles of both known and novel *** random forests(RF)classification algorithm was then used to predict colorectal cancer status based on the microbial relative abundance *** on within data cross-validation and cross-dataset prediction,we show that the RF prediction performance using the microbial relative abundance profiles estimated by Centrifuge is generally higher than that using the microbial relative abundance profiles estimated by MetaPhlAn2 and *** also develop a novel method to integrate the relative abundance profiles of both known and novel microbial or-ganisms to further increase the prediction performance for colorectal cancer from metagenomes.

关键词： Microbiome Colorectal cancer Metagenomic shotgun sequencing Random forests

Control Strategy of MMC Battery Energy Storage System under Asymmetrical Grid Voltage Condition

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Chinese Journal of Electrical Engineering 2016年第2期2卷 76-83页

作者： Lei Zhang Feng gao Nan Li Key Lab of Power System Intelligent Dispatch and Control(Shandong University) Ministry of EducationJinan250061China

A battery energy storage system using modular multilevel converter(MMC)as the interfacing converter could have several inherent advantages when compared with battery energy storage systems based on two-level inverter or cascaded H-bridge *** can manage the state-of-charges(SOCs)of all batteries to be equal to avoid the overcharge or over discharge of single *** inherent power exchange characteristics using circulating currents could increase the control flexibility and consequently improve the output quality and the internal regulation *** paper investigates the operational principle and control strategy of MMC battery energy storage system under unbalanced grid voltage condition,where key issues of system model and corresponding control methods are very different from those under the normal grid voltage *** injected de current control,SOC balancing control and circulating current control methods are fully discussed in this ***,the theoretical findings were verified through Matlab simulation and a scaled down experimental prototype.

关键词： Modular multilevel converters(MMC) battery energy storage system circulating current asymmetrical grid voltage

Robustness Analysis of Discrete-time Indirect Model Reference Adaptive Control with Normalized Adaptive Laws

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International Journal of Automation and computing 2010年第3期7卷 381-388页

作者： Qing-Zheng gao Xue-Jun Xie Department of Physics and Information Engineering Jining University Qufu 273155 PRC School of Electrical Engineering and Automation Xuzhou Normal University Xuzhou 221116 PRC

For a class of discrete-time systems with unmodeled dynamics and bounded disturbance, the design and analysis of robust indirect model reference adaptive control （MRAC） with normalized adaptive law are investigated. The main work includes three parts. Firstly, it is shown that the constructed parameter estimation algorithm not only possesses the same properties as those of traditional estimation algorithms, but also avoids the possibility of division by zero. Secondly, by establishing a relationship between the plant parameter estimate and the controller parameter estimate, some similar properties of the latter are also established. Thirdly, by using the relationship between the normalizing signal and all the signals of the closed-loop system, and some important mathematical tools on discrete-time systems, as in the continuous-time case, a systematic stability and robustness analysis approach to the discrete indirect robust MRAC scheme is developed rigorously.

关键词： Discrete-time systems model reference adaptive control (MRAC) swapping lemmas stability robustness

An electrochemical and Raman spectroscopic study on involvement of La^(3+) ions in lactate dehydrogenase catalysis

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Chinese Science Bulletin 1998年第19期43卷 1625-1630页

作者： WANG Xunqing XU Zhenhua gao Xiaoxia College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China.

The influence of La 3+ on lactate dehydrogenase catalysis was investigated by electrochemical and FT-Raman techniques. The results showed that La 3+ ions bind preferably with phosphate moiety and ribose group (3′-OH)... 详细信息

关键词： La 3+ ion LDH catalysis electrochemistry FT-Raman technique.

Vascular endothelial growth factor/platelet-derived growth factor receptor pathway is involved in bone marrow mesenchymal stem cell differentiation and directional migration toward gliomas

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Neural Regeneration Research 2010年第13期5卷 993-998页

作者： Chaoshi Niu Yongfei Dong Ge gao Department of Neurosurgery Anhui Provincial Hospital of Anhui Medical University Hefei 230001 Anhui Province China Molecular Neurobiology & Neural Regeneration and Repairing Laboratory Anhui Provincial Stereotactic Neurosurgical Institute Hefei 230001 Anhui Province China

BACKGROUND： Vascular endothelial growth factor （VEGF） induces bone marrow-derived mesenchymal stem cell （BMSC） differentiation into vascular endothelial-like cells and promotes BMSC migration toward gliomas. However, the molecular mechanisms by which VEGF induces BMSC differentiation and migration remain poorly understood. OBJECTIVE; To investigate the role of platelet-derived growth factor （PDGF） receptor （PDGFR） in BMSC differentiation and migration induced by VEGE DESIGN, TIME AND SETTING： A parallel, controlled, in vitro experiment was performed at the Molecular Neurobiology ＆ Neural Regeneration and Repairing Laboratory, Anhui Provincial Hospital of Anhui Medical University, China from June 2008 to March 2009. MATERIALS： U87 glioma cells were purchased from Shanghai Institutes for Biological Sciences; mouse anti-human PDGFR and VEGF receptor （VEGFR） monoclonal antibodies were purchased from Peprotech, USA. METHODS： Isolated BMSCs were precultured with neutralizing antibody for VEGFR-1, VEGFR-2, PDGFR-α, and PDGFR-β to block biological activity of related receptors, followed by induced differentiation with 50μg/L VEGF. BMSCs induced with 50μg/L VEGF alone served as the VEGF-induced group. The control group remained untreated. MAIN OUTCOME MEASURES： Cell surface markers were identified by flow cytometry; BMSC surface cytokine receptor expression was detected by reverse transcription-polymerase chain reaction; the Transwell model was used to observe cell migration. RESULTS： After blocking the PDGFR, VEGF did not induce BMSC cell surface marker CD-31 or von Willebrand factor （vWF） expression. However, inhibition with VEGF receptor blocking agents, VEGF induced BMSCs to express CD-31 and vWE Following inhibition of the PDGFR, the number of cells migrating through the polycarbonate membrane Transwell chamber was decreased, as well as the number of BMSCs migrating to glioma cells. However, through the use of VEGF receptor blocking agents, the number of migrating cells

关键词： vascular endothelial growth factor platelet-derived growth factor receptor bone marrow-derived mesenchymal stem cells glioma immunofluorescence

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中国电机工程学报 2012年第25期32卷 I0001-I0024页

作者： WANG Chengshan gao Fei LI Peng HUANG Bibin ding Chengdi YU Hao Tianjin University

Reasons,safety and efficacy analysis for conversion of HAART to TAF/ FTC/BIC among HIV-infected patients

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Chinese Medical Journal 2023年第24期136卷 2931-2937页

作者： Jiang Xiao Guiju gao Yi ding Jialu Li Chengyu gao Qiuhua Xu Liang Wu Hongyuan Liang Liang Ni Fang Wang Yujiao Duan Di Yang Hongxin Zhao Clinical and Research Center of AIDS Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Background:This study aimed to determine the reasons for conversion and elucidate the safety and efficacy of transition to tenofovir alafenamide/emtricitabine/bictegravir sodium(TAF/FTC/BIC)in highly active antiretroviral therapy(HAART)-experienced HIV-infected patients in real-world ***:We conducted a retrospective cohort *** treatment conversion rationales,safety,and effectiveness in 1684 HIV-infected patients with previous HAART experience who switched to TAF/FTC/BIC were evaluated at Beijing Ditan Hospital from September 2021 to Auguest ***:Regimen simplification(990/1684,58.79%)was the most common reason for switching,followed by osteoporosis or osteopenia(375/1684,22.27%),liver dysfunction(231/1684,13.72%),decline in tenofovir alafenamide/emtricitabine/elvitegravir/cobicistat(TAF/FTC/EVG/c)with food restriction(215/1684,12.77%),virological failure(116/1684,6.89%),and renal dysfunction(90/1684,5.34%).In patients receiving non-nucleotide reverse transcriptase inhibitors(NNRTI)-containing regimens,lipid panel changes 1 year after switching indicated a difference of 3.27±1.10 mmol/L vs.3.40±1.59 mmol/L in triglyceride(P=0.014),4.82±0.74 mmol/L vs.4.88±0.72 mmol/L in total cholesterol(P=0.038),3.09±0.70 mmol/L vs.3.18±0.66 mmol/L in low-density lipoprotein(Pding TAF/FTC/EVG/c and lopinavir/ritonavir(LPV/r),lipid panel changes presented decreased *** also observed an improved trend in viral load suppression,and alanine transaminase(ALT),aspartate transaminase(AST),estimated glomerular filtration rate(eGFR),and serum creatinine levels after the transition(Pding clinical evidence support

关键词： HIV Antiretroviral therapy,highly active Conversion Viral load Efficacy Safety

一种改进的IC互连线3D电容提取快速层级算法

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电子学报 2007年第8期35卷 1495-1498页

作者：丁文王高峰陈曦武汉大学物理科学与技术学院湖北武汉430072 武汉大学微电子信息技术研究院湖北武汉430072

快速层级算法(FHM)是边界元法求解3D电容积分方程的一种加速方法,该方法基于分层近似对电势系数矩阵隐式表示,使求解的时间复杂度降低到O(n).改进算法对FHM做了两点改进:(1)给出了分层近似的理论依据,这种分层依据适用于所有导体结构而... 详细信息

快速层级算法(FHM)是边界元法求解3D电容积分方程的一种加速方法,该方法基于分层近似对电势系数矩阵隐式表示,使求解的时间复杂度降低到O(n).改进算法对FHM做了两点改进:(1)给出了分层近似的理论依据,这种分层依据适用于所有导体结构而无需重复试验.(2)利用层级关系,直接计算面电荷,避免了迭代过程,加速了电荷求解.一系列典型3D互连线结构的测试显示:改进后的算法不仅提高了求解精度,而且计算时间也减少到改进前的1/3.

关键词： IC互连线快速层级算法电容参数提取边界元法