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Matrix metalloproteinase-sensitive poly(ethylene glycol)/peptide hydrogels as an interactive platform conducive to cell proliferation during 3D cell culture

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Science China(Technological Sciences) 2021年第6期64卷 1285-1294页

作者： rong Yan ZHANG Zhen he ChaoLiang CheN XueSi Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of Chinese Academy of Sciences Beijing 100049China University of Science and Technology of China Hefei 230026China

The response of extracellular matrix(ECM) to dynamic cell signals is of great significance for the regulation of cell behavior. In the present study, we prepared a type of matrix metalloproteinase(MMP)-sensitive degradable hydrogels(MSDHs) via the catalyst-free o-phthalaldehyde(OPA)/amine cross-linking reaction between o-phthalaldehyde-grafted four-arm poly(ethylene glycol)(4aPEG-OPA) and an MMP-sensitive degradable peptide. The gelation rates and storage moduli of MSDHs and the MMP-insensitive hydrogels(MIHs) based on an MMP-insensitive scramble peptide were comparable and dependent on the concentrations of precursor polymers. MSDHs were degradable while MIHs were stable in the presence of proteinase in *** degradation of MSDHs was obviously faster than that of MIHs after subcutaneous injection into rats. In addition, both types of poly(ethylene glycol)/peptide hydrogels displayed excellent cytocompatibility in vitro, and showed good histocompatibility in vivo in the subcutaneous layer of rats. Furthermore, the proliferation of several MMP-expressing cell lines including MDA-MB-231 cells within MSDHs was obviously faster than that in MIHs, indicating the influence of metabolism-mediated scaffold degradation on the cell proliferation. This study provides a new biocompatible and biodegradable 3 D cell culture interactive platform for regulation of cell behavior.

关键词： hydrogels MMP-sensitive o-phthalaldehyde cross-linking cell interaction 3D cell culture

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Synthesis and Crystal Structure of a Cyano-bridged Bimetallic Complex:[NdFe(CN)_6(DMF)_4(H_2O)_3]H_2O

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Chinese Journal of Structural Chemistry 2003年第2期22卷 182-186页

作者： LiJian－rong BUXian－he 等 StateKeyLaboratoryofStructuralChemistry FujianInsttituteofResearchonTheStructureofMantterTheChineseAcademyofSciencesFuzhouFujian350002China departmentofChemistry NankaiUniver

A new bimetallic cyano-bridged complex, [NdFe(CN)6(DMF)4(H2O)3]H2O (DMF = N,N-dimethylformamide) 1, has been obtained by the reaction of hexacyanoferrate potassium with neodymium (Ⅲ) chloride in H2O/EtOH/DMF (volume ratio: 2:2:1), and its structure was determined by means of single-crystal X-ray diffraction. The compound crystallizes in space group P21/n of monoclinic system with cell parameters: a = 17.646(1), b = 8.9011(3), c = 19.945(1) ? b = 95.835(2)? V = 3116.6(3) ?, Z = 4, Dc = 1.536 g/cm3, Mr = 720.66, F(000) = 1456, m = 2.166 mm-1, R = 0.0386, wR = 0.1120 and S = 1.061. The central Nd (Ⅲ) ion is coordinated by seven oxygen atoms of four DMF molecules and three water molecules and one nitrogen atom of the bridging cyanide in a slightly distorted square-antiprism arrangement, and the Fe (Ⅲ) ion is in an almost octahedral environment coordinated to six cyano-ligands, of which one cyanide ligand bridges the Nd (Ⅲ) ion to form a bimetallic complex. Molecules of complexes in the crystal lattice are held together by hydrogen bonding, forming a three-dimensional framework.

关键词： crystal structure cyano-bridged bimetallic complex neodymium (Ⅲ) complex ion (Ⅲ) complex

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Photothermal probiotics delivery of photodynamic agents for enhanced immunogenic cell death within hypoxia center of solid tumors

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Nano Research 2025年第1期18卷 642-652页

作者： Wen Luo Shiyu Du Yateng Jiang Bangshun he Jun Tang Jingjing Yang Yujun Song Jiangsu Key Laboratory of Artificial Functional Materials State Key Laboratory of Analytical Chemistry for Life ScienceNational Laboratory of Solid State MicrostructuresCollege of Engineering and Applied SciencesNanjing UniversityNanjing 210023China department of Laboratory Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006China department of Anesthesiology Jinling HospitalMedical School of Nanjing UniversityNanjing 210000China department of Biochemistry and Molecular Biology School of Medicine&Holistic Integrative MedicineJiangsu Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationNanjing University of Chinese MedicineNanjing 210023China

Resulting from harsh hypoxic environmental conditions,central cells in the core of solid tumors are usually more aggressive and malignant with a less stable ***,therapeutic agents with improved penetration for the activation of immunity in tumor centers exhibit promising potential in ***,polydopamine-coated Escherichia coli Nissle 1917(EcN)bearing chlorin e6(Ce6)-loaded and polyethyleneimine(PEI)-coated hollow manganese dioxide(shorted as EP-ChP)are applied for enhanced immunotherapy in deep *** accumulation in tumor center through hypoxia targeting,manganese dioxide is degradated under the tumor microenvironment with released Ce6 and thus generates reactive oxygen species(ROS)upon 660 nm laser irradiation,which can further lower thermalresistance of cancer cells via HSP90α*** to that,heating induced by polydopamine upon 808 nm laser irradiation can achieve effective tumor *** upon dual laser induces enhanced immunogenic cell death,while bacterial infections in tumor tissues also trigger innate *** bacteria-based approach provides enhanced antitumor immune responses in deep tumors with great potential in the reshaping of immunosuppression tumor microenvironment.

关键词： bacteria phototherapies immunotherapy hypoxia targeting tumor penetration

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Discursive Construction of European Identity- A Case Study on EU Documents

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学术界 2015年第10期 319-323页

作者： he rong School of Foreign Studies Southwest University for Nationalities Chengdu Sichuan 610041

It has been more than four decades since "European Identity" first appeared in EEC document in ***,the discursive construction of the notion has undergone a long and complex *** the representative documents of EU are the legitimate underlying file to demonstrate "European Identity" discourse pf which the systematic research is relatively barely *** the horizon of "social discourse" theories,this paper focuses on sorting out the representative documents of EU,and analyses the word frequency and diachronic evolution derived from "European Identity" perception,in order to reveal the discursive legitimate progress of "European Identity" and the issues triggered from it.

关键词：欧洲文件话语欧盟案例欧共体

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Cuproptosis: copper-induced regulated cell death

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Science China(Life Sciences) 2022年第8期65卷 1680-1682页

作者： Wen-Jun Duan rong-rong he Guangdong Engineering Research Center of Chinese Medicine&Disease Susceptibility Jinan UniversityGuangzhou 510632China International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug development of Chinese Ministry of Education(MOE) Jinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research Jinan UniversityGuangzhou 510632China School of Traditional Chinese Medicine Jinan UniversityGuangzhou 510632China

“Life is pleasant. death is peaceful. It's the transition that's troublesome.”——Isaac Asimov Copper is an essential trace element central to cardiovascular, neuronal, and immune functions. While copper deficiency ... 详细信息

关键词： functions copper peace

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Fractal Characteristics of Stagnic Anthrosols and the Relationship with Soil Micro-Structure

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Agricultural Sciences in China 2009年第5期8卷 605-612页

作者： XU Xiang-ming he Yu-rong Institute of Mountain Hazards and Environment Chinese Academy of Sciences Chengdu 610041 P.R.China Graduate University of the Chinese Academy of Sciences Beijing 100039 P.R. China

The Stagnic Anthrosols developed from quaternary yellow sedimentary parent material occupied an important position in Southwest China. Fractal dimensions of particle size and micro-aggregate size distributions of Stagnie Anthrosols and their relationship to soil micro-structure had been probed. Results showed that the soil particle size distributions were dominated by clay, the fractal dimensions of particle size distributions （Ds） were high and between 2.676-2.925, as the fractal dimensions of micro-aggregate size distributions （Da） were between 2.354-2.853. The fractal dimensions of particlesize distributions were preferably related with the ratio of coarse particles and fine particles （c/f20 ,m） and the micromorphological feature of skeleton grains. The evolution degree of micro-structure among horizons were reflected by the coefficient of variation of Ds within the profile. The fractal dimensions of micro-aggregate size distributions were related with the quantities, distributions of micro-aggregates and micro-pores. Results revealed that the soil micro-structures could be quantified by fractal dimensions preliminarily.

关键词： Stagnic Anthrosols micro-aggregate fractal dimension micro-morphology

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Interactional models for adults of two populations with maturation delays

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Applied Mathematics(A Journal of Chinese Universities) 2008年第2期23卷 127-135页

作者： he Ze-rong LI Jian-quan Institute of Operational Research and Cybernetics Hangzhou Dianzi University Hangzhou 310018China department of Applied Mathematics and Physics Air Force Engineering University Xi＇an 710051China

This paper is concerned with interactional models for adults of two species delayed by their mature periods. The existence and local stability of equilibria are discussed thoroughly for competitive systems, cooperative systems and predator-prey systems, respectively. For systems with interaction of competition and cooperation, it is found that the two populations are uniformly persistent if the positive equilibrium is stable. For predator-prey interaction, however, some further conditions are needed to guarantee the persistence of the systems.

关键词： interactional models, mature period, equilibrium stability, uniform persistence.

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Monte Carlo simulation of incident electrons passing through thin metal layer

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Nuclear Science and Techniques 2018年第7期29卷 182-190页

作者： Tian-Long he Hong-Liang Xu Kai-Ting Huang Zhi-Liang Ren de-rong Xu National Synchrotron Radiation Laboratory University of Science and Technology of China

A Monte Carlo simulation using two schemes,the discrete energy loss approach and the continuous slowing down approximation,was implemented in C++ to calculate the energy transmission coefficient and average energy loss for low-energy(1–10 keV) incident electrons passing through a thin metal *** simulation model uses the Ashley model for electron inelastic scattering,the electron elastic scattering cross section taken from the NIST database,and the stopping power derived from the full Penn *** results of the two schemes agree well with each other and can be used to quantitatively evaluate the shielding effect of a thin coated metal layer on incident electrons for a diamond amplified photocathode.

关键词：蒙特卡罗模拟金属层电子事件模拟模型 NIST 防护效果精力

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PARALLEL COMPOUND METHODS FOR SOLVING PARTITIONED STIFF SYSTEMS

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Journal of Computational Mathematics 2001年第6期19卷 639-650页

作者： Li-rong Chen de-gui Liu Beijing Inst Comp Applicat & Simulat Technol Beijing 100854 Peoples R China

deals with the solution of partitioned systems of nonlinear stiff differential equations. Discussion on parallel compound methods; Nonstiff equations; Order conditions of the parallel compound methods (PCM); Numerical... 详细信息

关键词： parallel compound methods stiff systems order conditions convergence stability

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Characteristics of gut microbiota dysbiosis in patients with colorectal polyps

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 13-21页

作者： Xian-rong Wu Xiao-Hong he Yong-Fang Xie School of Life health Information Science and Engineering Chongqing Post and Communications UniversityChongqing 400065China

This editorial,inspired by a recent study published in the World Journal of Gastrointestinal Oncology,covers the research findings on microbiota changes in various *** recurrent colorectal polyps,the abundances of Klebsiella,Parvimonas,and Clostridium increase,while those of Bifidobacterium and Lactoba-cillus *** dysbiosis may promote the formation and recurrence of *** microbial changes have also been observed in colorectal cancer,inflammatory bowel disease,autism spectrum disorder,and metabolic syndrome,indicating the role of increased pathogens and decreased probiotics in these *** the gut microbiota,particularly by increasing probiotic levels,may help prevent polyp recurrence and promote gut *** microbial intervention strategy holds promise as an adjunctive treatment for patients with colorectal polyps.

关键词： Recurrent colorectal polyps Gut microbiota dysbiosis Klebsiella Probiotics Intestinal inflammation Microbial intervention strategy

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