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Variational quantum algorithm for node embedding

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Fundamental Research 2024年第4期4卷 845-850页

作者： Zeng-rong zhou Hang Li Gui-Lu Long Research Center for Quantum Sensing Zhejiang LabHangzhou 311121China Bejing Academy of Quantum Information Sciences Beijing 100193China State Key Laboratory of Low-Dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijing 100084China

Quantum machine learning has made remarkable progress in many important ***,the gate complexity of the initial state preparation is seldom considered in lots of quantum machine learning algorithms,making them ***,we propose a quantum algorithm for the node embedding problem that maps a node graph's topological structure to embedding *** resulting quantum embedding state can be used as an input for other quantum machine learning *** O(log(N))qubits to store the information of N nodes,our algorithm will not lose quantum advantage for the subsequent quantum information ***,owing to the use of a parameterized quantum circuit with O(poly(log(N)))depth,the resulting state can serve as an efficient quantum *** addition,we explored the measurement complexity of the quantum node embedding algorithm,which is the main issue in training parameters,and extended the algorithm to capture high-order neighborhood information between ***,we experimentally demonstrated our algorithm on an nuclear magnetic resonance quantum processor to solve a graph model.

关键词： Quantum machine learning Quantum computation Node embedding Variational quantum algorithm Nuclear magnetic resonance

Developing a fluorescence substrate for HRP-based diagnostic assays with superiorities over the commercial ADHP

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Chinese Chemical Letters 2024年第6期35卷 439-444页

作者： Zhichao zhou Fuqian Chen Xiaotong Xia Dong Ye rong zhou Lei Li Tao Deng Zhenhua Ding Fang Liu Department of Radiation Medicine Guangdong Provincial Key Laboratory of Tropical Disease ResearchSchool of Public HealthSouthern Medical UniversityGuangzhou 510515China School of Pharmaceutical Sciences Guangzhou University of Chinese MedicineGuangzhou 510006China Artemisinin Research Center Guangzhou University of Chinese MedicineGuangzhou 510006China State Key Laboratory of Respiratory Disease the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhou 510120China Guangzhou Laboratory Bio-IslandGuangzhou 510030China Nanshan Pharmaceutical Innovation Research Institute of Guangdong Province Foshan 528225China

The combination of horseradish peroxidase(HRP)and a fluorescence substrate has been attracting great interests in developing sensitive biochemical analysis and immunoassays.10-Acetyl-3,7-dihydroxyphenoxazine(ADHP or Amplex red)is the most sensitive fluorogenic substrate known for HRP in current market,however,it suffers from some drawbacks,such as non-specific reactivity to carboxylesterase and limited fluorescence *** the present study,a novel HRP substrate10-cyclopropylcarbonyl-dichloro-dihydroxyphenoxazine(AR-2),has been prepared,which exhibited improved sensitivity than ADHP in sensing ***,the fluorescence of AR-2/HRP demonstrated improved tolerance to physiological relevant p H fluctuation as compared to ADHP/*** detection of uric acid/urate oxidase reaction indicated excellent application prospect of AR-2/HRP for monitoring H_(2)O_(2)-generating biochemical *** interestingly,an enzyme-linked immunosorbent assay(ELISA)using AR-2 as the fluorescence reporter has been successfully used in detecting IgG against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)from human serum ***,AR-2 exhibits improved performances over the commercial ADHP,which will be an ideal alternative to ADHP in HRP-based fluorescence biochemical analysis and immunoassays.

关键词： Fluorescence immunoassay HRP fluorescence substrate Hydroresorufin Amplex red/ADHP SARS-CoV-2

SERPINH1 promoted the proliferation and metastasis of colorectal cancer by activating PI3K/Akt/mTOR signaling pathway

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1890-1907页

作者： Xiao-Sheng Jin Lu-Xi Chen Ting-Ting Ji rong-zhou Li Department of Gastroenterology The Third Affiliated Hospital of Wenzhou Medical UniversityRuian 325000Zhejiang ProvinceChina

BACKGROUND Serpin peptidase inhibitor clade H member 1(SERPINH1)was initially recognized as an oncogene implicated in various human ***,the clinical relevance and functional implications of SERPINH1 in colorectal cancer(CRC)remain largely *** To investigate the effects of SERPINH1 on CRC cells and its specific *** Quantitative real-time polymerase chain reaction,western blotting analysis,The Cancer Genome Atlas data mining and immunohistochemistry were employed to examine SERPINH1 expression in CRC cell lines and tissues.A series of in-vitro assays were performed to demonstrate the function of SERPINH1 and its possible mechanisms in *** SERPINH1 demonstrated elevated expression levels in both CRC cells and tissues,manifested at both mRNA and protein *** SERPINH1 levels correlated closely with advanced T stage,lymph node involvement,and distant metastasis,exhibiting a significant association with poorer overall survival among CRC *** investigations unveiled that SERPINH1 overexpression notably bolstered CRC cell proliferation,invasion,and migration in vitro,while conversely,SERPINH1 knockdown elicited the opposite *** set enrichment analysis underscored a correlation between SERPINH1 upregulation and genes associated with cell cycle *** findings underscored the capacity of heightened SERPINH1 levels to expedite G1/S phase cell cycle progression via phosphatidylinositol 3-kinase/AKT/mechanistic target of rapamycin pathway activation,thereby facilitating CRC cell invasion and *** These findings imply a crucial involvement of SERPINH1 in the advancement and escalation of CRC,potentially positioning it as a novel candidate for prognostic assessment and therapeutic intervention in CRC management.

关键词： Serpin peptidase inhibitor clade H member 1 Colorectal cancer Proliferation Cell cycle Phosphatidylinositol 3-kinase/AKT/mechanistic target of rapamycin

Natural killer cell membrane doped supramolecular nanoplatform with immuno-modulatory functions for immuno-enhanced tumor phototherapy

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Chinese Chemical Letters 2024年第10期35卷 231-238页

作者： Ying Gao rong zhou Qiwen Wang Shaolong Qi Yuanyuan Lv Shuang Liu Jie Shen Guocan Yu Institute of Pharmaceutics College of Pharmaceutical Sciences Zhejiang University Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of Medicine Hangzhou City University Department of Cardiology The First Affiliated Hospital Zhejiang University School of Medicine MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology Department of Chemistry Tsinghua University Emergency Department State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College

Photodynamic therapy(PDT) has garnered significant attention as a promising approach to cancer therapy, harnessing the combined benefits of localized light treatment and the accompanying host immune response. In this study, we engineered an immuno-enhanced PDT nanoplatform, denoted as HM@p-MOF(hybrid membrane@porphyrin-metal organic framework). The core porphyrin-MOF was cloaked with a hybrid membrane derived from B16F10 cancer cells and NK cells, resulting in enhanced stability. In both in vitro and in vivo experiments, our finding demonstrated that the hybrid membrane conferred dual targeting capabilities to the nanoplatform, leveraging the unique properties of the B16F10 membrane and NK membrane to augment immunogenic cell death(ICD) induced by photodynamic effects. Additionally,in conjunction with the immunomodulatory functions of the NK cell membrane, we observed an expansion of in situ immune infiltration leading to a systemic immune response. The HM@p-MOF nanoplatform exhibited the capacity to not only inhibit the growth of mouse melanoma but also suppress metastasis. This innovative HM@p-MOF nanoplatform present a viable strategy to enhance phototherapeutic efficacy for both localized and metastatic tumors. It provides a direction for the fabrication of biomimetic nanomedicines possessing immuno-modulatory function.

关键词： Biomimetic Cell membrane Metal-organic framework Phototherapy Tumor targeting

LATS1 Promotes B-ALL Tumorigenesis by Regulating YAP1 Phosphorylation and Subcellular Localization

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Current Medical Science 2024年第1期44卷 81-92页

作者： Feng ZHANG Mohammed Awal Issah Hai-ying FU Hua-rong zhou Ting-bo LIU Jian-zhen SHEN Fujian Provincial Key Laboratory on Hematology Fujian Medical Center of HematologyFujian Institute of HematologyClinical Research Center for Hematological Malignancies of Fujian ProvinceFujian Medical University Union HospitalFuzhou 350001China Tamale Technical University Faculty of Allied Health and Pharmaceutical SciencesDepartment of Medical Laboratory TechnologyTamale NS-011-2000Ghana Department of Hematology The Third Affiliated People's Hospital of Fujian University of Traditional Chinese MedicineThe Third People's Hospital of Fujian ProvinceFuzhou 350122China

Objective YAP1 plays a dual role as an oncogene and tumor suppressor gene in several tumors;differentiating between these roles may depend on the YAP1 phosphorylation *** specific function of YAP1 in B cell acute lymphoblastic leukemia(B-ALL),however,is currently ***,in the present study,the role of YAP1 in B-ALL was investigated using relevant cell lines and patient *** The effects of shRNA-mediated knockdown on YAP1 and LATS1 levels in the NALM6 and MOLT-4 cell lines were examined using Western blotting,quantitative real-time polymerase chain reaction,flow cytometry,immunostaining,and nude mouse subcutaneous tumorigenesis *** expression levels of Hippo pathway-related molecules before and after verteporfin(VP)treatment were compared using RNA-Seq to identify significant Hippo pathway-related genes in NALM6 *** Patients with ALL showing high YAP1 expression and low YAP1-Ser127 phosphorylation levels had worse prognoses than those with low YAP1 protein expression and high YAP1-Ser127 phosphorylation ***1-Ser127 phosphorylation levels were lower in NALM6 cells than in MOLT-4 and control cells;YAP1 was distributed in the nuclei in NALM6 *** of YAP1 inhibited MOLT-4 and NALM6 cell proliferation and arrested the NALM6 cell cycle in the G0/G1 *** and after VP treatment,the expression of the upstream gene LATS1 was upregulated;its overexpression promoted YAP1-Ser127 ***,YAP1 was distributed in the *** LATS1 may downregulate YAP1-Ser127 phosphorylation and maintain B-ALL cell function;thus,VP,which targets this axis,may serve as a new therapeutic method for improving the outcomes for B-ALL patients.

关键词： acute lymphoblastic leukemia large tumor suppressor kinase 1 phosphorylation RNA-Seq Yesl-associated protein

Vertical two-dimensional WS_(2)flakes grown on flexible CNT film for excellent electrochemical performance

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Rare Metals 2024年第1期43卷 164-174页

作者： Qian Gong Jing-Yun Zou Ming Ren Si-Qi Zhu Yu-rong zhou Li-Ming Zhao Jian Chen Yu-Long Wu Jiang-Tao Di Li-Xing Kang Qing-Wen Li School of Nano-Tech and Nano-Bionics University of Science and Technology of ChinaHefei 230026China Key Laboratory of Multifunctional Nanomaterials and Smart Systems Division of Advanced MaterialsSuzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China Jiangsu Key Laboratory of Micro and Nano Heat Fluid Flow Technology and Energy Application School of Physical Science and TechnologySuzhou University of Science and TechnologySuzhou 215009China

Soft electrochemical actuators that can generate mechanical motions in response to electrical stimuli can be used as artificial muscles in microscale *** electrode materials are the key component of the electrochemical actuator because they limit the ion diffusion and accumulation processes and thus affect the deformation in fast response-time and potential engineering ***-dimensional materials,such as one-dimensional(1D)CNT and two-dimensional(2D)vertically stood WS_(2),are great electrode due to their good electrochemical stability and high surface-to-volume ratios,but show limited performances when being used on their own in the actuators because of low reconstruction or low conductivity.A combination of 1D CNT and 2D WS_(2)could form a heterojunction with both high electrochemical activity and great mechanical ***,by depositing highly disordered graphene nanosheets(HDGNs)on CNT films and then WS_(2)on the formed low-dimensional nanocarbon film,a hybrid WS_(2)/HDGN/CNT film was synthesized through a multistep CVD *** grown WS_(2)nanosheets were achieved by taking advantage of HDGNs which limits CNTs ***,the volume expansion caused by the transition from WO_(3)to WS-2can force the vertical growth of WS_(2).This hybrid film shows excellent electrochemical properties,such as high specific capacitance and high rate *** actuators based on the WS_(2)/HDGN/CNT films show good actuating performance,including stability and reconfigurability.

关键词： CNT Graphene Vertically growth WS_(2) Electrochemical actuators

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朱熹《诗集传》在明代的衍生及其学术意义

文献 2024年第4期 27-49页

作者：周荣复旦大学古籍整理研究所(中国古代文学研究中心)

朱熹《诗集传》在明代的衍生著作大体有四种类型。其中删节本以删削朱注为主要编纂方式,取便初学是其重要考量;删选本取舍篇目、章句的原则,兼顾了科考的出题偏重和诗篇的辞章性;增注本摭拾众说,或辅翼、或辩证朱《传》,客观上推动朱子... 详细信息

朱熹《诗集传》在明代的衍生著作大体有四种类型。其中删节本以删削朱注为主要编纂方式,取便初学是其重要考量;删选本取舍篇目、章句的原则,兼顾了科考的出题偏重和诗篇的辞章性;增注本摭拾众说,或辅翼、或辩证朱《传》,客观上推动朱子《诗》学的扩容与突破;拼合本对朱《传》进行二次改造,组合各类《诗》说文本以提供更为丰赡的经学知识和应试指导。明人不断增、删朱《传》的文本内容,又热衷于变换其外在形式,主要目的是服务于科举制度下的广大学《诗》阶层。朱《传》从宋到明的衍变轨迹,折射出近世《诗》学教育普及化的历史进程,亦反映出与之相关的科举教习、书籍流转及商业出版等复杂历史情境。

关键词：《诗集传》衍生文献明代《诗经》学宋明书籍史

明代乡村慈善模式的制度设计和基层组织慈善功能的演变——以两湖地区为中心

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云南社会科学 2024年第1期 147-157页

作者：周荣武汉大学中国传统文化研究中心武汉大学古籍保护中心

在明初的乡村治理理念中,乡里制度是以里甲制为中心的综合多功能体,蕴含了丰富的社会管理、教化、治安等功能,也蕴含了巧妙的慈善功能。鳏寡孤独残疾有养、婚姻丧葬有助等慈善目标被融于官方的礼法体系和里甲编排等制度安排中。明中叶以... 详细信息

在明初的乡村治理理念中,乡里制度是以里甲制为中心的综合多功能体,蕴含了丰富的社会管理、教化、治安等功能,也蕴含了巧妙的慈善功能。鳏寡孤独残疾有养、婚姻丧葬有助等慈善目标被融于官方的礼法体系和里甲编排等制度安排中。明中叶以后,社会分化加剧,里甲面临瓦解,部分职能废弛,有识之士在重整乡村秩序的过程中,借重的依然是明初的乡治理念。以乡约为中心的保甲、社仓等制度设计成为明代中后期基层治理和慈善救助的主要内容,保甲、乡约、社仓、社学“四合一”是明中后期理想的乡治模式。由于明代乡村治理中贯穿了精神与物质、慈善与控制相结合的原则,基层社会得以在较长时间中维持相对稳定的秩序。

关键词：明代乡村慈善乡里制度基层组织

新时代乡土叙事的多重面向——读老藤《草木志》

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中国文学批评 2024年第3期 70-78,190页

作者：周荣东北大学艺术学院沈阳110004

老藤的长篇小说《草木志》以一名驻村书记的成长经历回应了贯穿当代文学的“青年到何处去”的历史命题,塑造出与新时代社会实践“共名”的新人形象;通过对东北自然风景、人造景观和“人的风景”的重新发现,描绘了充满自然生机与人文诗... 详细信息

老藤的长篇小说《草木志》以一名驻村书记的成长经历回应了贯穿当代文学的“青年到何处去”的历史命题,塑造出与新时代社会实践“共名”的新人形象;通过对东北自然风景、人造景观和“人的风景”的重新发现,描绘了充满自然生机与人文诗意的新时代山乡巨变图景,焕发乡村的人文活力和生命力;在展开墟里乡村建设的过程中,在宏大叙事与微观生活、整体目标与地方经验之间建立起有效勾连的认知迭代路径,从而完成了新历史语境下的乡土叙事。

关键词：新时代乡土叙事乡村振兴新人风景