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Residual levels and health risk assessment of trace metals in Chinese resident diet

Journal of Environmental Sciences 2024年第2期136卷 451-459页

作者： Yubing Dai Shuai Sun rong Cao Haijun Zhang Jiping Chen Ningbo geng CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Shenyang Pharmaceutical University Shenyang 110016China University of Chinese Academy of Sciences Beijing 100049China

Large-scale metal contamination across the food web is an intractable problem due to increasing pollutant emissions,atmospheric transport,and dry and wet deposition of elements.The present study focus on several trace metals that are rarely studied but have special toxicity,including tin(Sn),antimony(Sb),gold(Au),hafnium(Hf),palladium(Pd),platinum(Pt),ruthenium(Ru),tellurium(Te)and iridium(Ir).We investigated trace metals residues and distribution characteristics,and further evaluated the potential health risks from major daily food intakes in 33 cities in China.Sn,Sb,Ir,Hf,and Au were frequently detected in food samples with the concentrations ranged from ND(not detected)to 24.78μg/kg ww(wet weight).Eggs exhibited the highest residual level of all detected metals(13.70±14.70μg/kg ww in sum),while the lowest concentrations were observed in vegetables(0.53±0.17μg/kg ww in sum).Sn accounting for more than 50%of the total trace metals concentration in both terrestrial and aquatic animal origin foods.In terrestrial plant origin foods,Sn and Ir were the most abundant elements.Hf and Au were the most abundant elements in egg samples.In addition,Sb and Ir showed a clear trophic dilution effect in terrestrial environments,while in aquatic ecosystems,Sn,Hf,and Au exhibited obvious trophic amplification effects.The calculated average estimated daily intake(EDI)via food consumption in five regions of China was 0.09μg/(kg·day),implying the health risk of aforementioned elements was acceptable.

关键词： Trace metals Accumulation characteristics Dietary exposure Estimated daily intake(EDI)

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Dual‑Atom Nanozyme Eye Drops Attenuate Inflammation and Break the Vicious Cycle in Dry Eye Disease

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Nano-Micro Letters 2024年第6期16卷 439-457页

作者： Dandan Chu Mengyang Zhao Shisong rong Wonho Jhe Xiaolu Cai Yi Xiao Wei Zhang Xingchen geng Zhanrong Li Xingcai Zhang Jingguo Li Henan Eye Hospital Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhou 450003People’s Republic of China Department of Ophthalmology Mass Eye and EarMass General BrighamHarvard Medical SchoolBostonMA 02114USA School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA College of Chemistry Zhengzhou UniversityZhengzhou 450001People’s Republic of China

Dry eye disease(DED)is a major ocular pathology worldwide,causing serious ocular discomfort and even visual impairment.The incidence of DED is gradually increasing with the highfrequency use of electronic products.Although inflammation is core cause of the DED vicious cycle,reactive oxygen species(ROS)play a pivotal role in the vicious cycle by regulating inflammation from upstream.Therefore,current therapies merely targeting inflammation show the failure of DED treatment.Here,a novel dual-atom nanozymes(DAN)-based eye drops are developed.The antioxidative DAN is successfully prepared by embedding Fe and Mn bimetallic single-atoms in N-doped carbon material and modifying it with a hydrophilic polymer.The in vitro and in vivo results demonstrate the DAN is endowed with superior biological activity in scavenging excessive ROS,inhibiting NLRP3 inflammasome activation,decreasing proinflammatory cytokines expression,and suppressing cell apoptosis.Consequently,the DAN effectively alleviate ocular inflammation,promote corneal epithelial repair,recover goblet cell density and tear secretion,thus breaking the DED vicious cycle.Our findings open an avenue to make the DAN as an intervention form to DED and ROSmediated inflammatory diseases.

关键词： Dry eye disease DAN Dual-atom nanozyme Vicious cycle NLRP3 inflammasome Nanomedicine

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TRAIL and Celastrol Combinational Treatment Suppresses Proliferation, Migration, and Invasion of Human Glioblastoma Cells via Targeting Wnt/β-catenin Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第4期30卷 322-329页

作者： QIN Jing-jing NIU Meng-da CHA Zhe geng Qing-hua LI Yu-lin REN Chun-guang David P.Molloy YU Hua-rong Research Center of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China Laboratory of Developmental Biology Department of Cell Biology and GeneticsSchool of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China

Objective To investigate the mechanistic basis for the anti-proliferation and anti-invasion effect of tumor necrosis factor-related apoptosis-induced ligand(TRAIL)and celastrol combination treatment(TCCT)in glioblastoma cells.Methods Cell counting kit-8 was used to detect the effects of different concentrations of celastrol(0-16µmol/L)and TRAIL(0-500 ng/mL)on the cell viability of glioblastoma cells.U87 cells were randomly divided into 4 groups,namely control,TRAIL(TRAIL 100 ng/mL),Cel(celastrol 0.5µmol/L)and TCCT(TRAIL 100 ng/mL+celastrol 0.5µmol/L).Cell proliferation,migration,and invasion were detected by colony formation,wound healing,and Transwell assays,respectively.Quantitative reverse transcription polymerase chain reaction and Western blotting were performed to assess the levels of epithelial-mesenchymal transition(EMT)markers(zona occludens,N-cadherin,vimentin,zinc finger E-box-binding homeobox,Slug,and β-catenin).Wnt pathway was activated by lithium chloride(LiCl,20 mol/L)and the mechanism for action of TCCT was explored.Results Celastrol and TRAIL synergistically inhibited the proliferation,migration,invasion,and EMT of U87 cells(P<0.01).TCCT up-regulated the expression of GSK-3β and down-regulated the expression of β-catenin and its associated proteins(P<0.05 or P<0.01),including c-Myc,Cyclin-D1,and matrix metalloproteinase(MMP)-2.In addition,LiCl,an activator of the Wnt signaling pathway,restored the inhibitory effects of TCCT on the expression of β-catenin and its downstream genes,as well as the migration and invasion of glioblastoma cells(P<0.05 or P<0.01).Conclusions Celastrol and TRAIL can synergistically suppress glioblastoma cell migration,invasion,and EMT,potentially through inhibition of Wnt/β-catenin pathway.This underlies a novel mechanism of action for TCCT as an effective therapy for glioblastoma.

关键词： celastrol Chinese medicine tumor necrosis factor-related apoptosis-induced ligand glioblastoma β-catenin Tripterygium wilfordii

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IRE1α regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization

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Genes & Diseases 2024年第1期11卷 464-478页

作者： Mengtian Fan Nana geng Xingyue Li Danyang Yin Yuyou Yang rong Jiang Cheng Chen Naibo Feng Li Liang Xiaoli Li Fengtao Luo Huabing Qi Qiaoyan Tan Yangli Xie Fengjin Guo Laboratory of Developmental Biology Department of Cell Biology and GeneticsSchool of Basic Medical ScienceChongqing Medical UniversityChongqing 400016China Laboratory of Stem Cells and Tissue Engineering School of Basic Medical ScienceChongqing Medical UniversityChongqing 400016China Department of Orthopedics The 1st Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Wound Repair and Rehabilitation Medicine State Key Laboratory of TraumaBurns and Combined InjuryTrauma CenterResearch Institute of SurgeryDaping HospitalArmy Medical UniversityChongqing 400042China

Cartilage development is controlled by the highly synergistic proliferation and differentiation of growth plate chondrocytes,in which the Indian hedgehog(IHH)and parathyroid hormone-related protein-parathyroid hormone-1 receptor(PTHrP-PTH1R)feedback loop is crucial.The inositol-requiring enzyme 1a/X-box-binding protein-1 spliced(IRE1α/XBP1s)branch of the unfolded protein response(UPR)is essential for normal cartilage development.However,the precise role of ER stress effector IRE1α,encoded by endoplasmic reticulum to nucleus signaling 1(ERN1),in skeletal development remains unknown.Herein,we reported that loss of IRE1α accelerates chondrocyte hypertrophy and promotes endochondral bone growth.ERN1 acts as a negative regulator of chondrocyte proliferation and differentiation in postnatal growth plates.Its deficiency interrupted PTHrP/PTH1R and IHH homeostasis leading to impaired chondrocyte hypertrophy and differentiation.XBP1s,produced by p-IRE1α-mediated splicing,binds and up-regulates PTH1R and IHH,which coordinate cartilage development.Meanwhile,ER stress cannot be activated normally in ERN1-deficient chondrocytes.In conclusion,ERN1 deficiency accelerates chondrocyte hypertrophy and cartilage mineralization by impairing the homeostasis of the IHH and PTHrP/PTH1R feedback loop and ER stress.ERN1 may have a potential role as a new target for cartilage growth and maturation.

关键词： Cartilage development ER stress ERN1 IHH PTHrP/PTH1R

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近30年辽河三角洲生态系统服务价值时空演变及影响因素分析

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环境科学 2024年第1期45卷 228-238页

作者：王耕张芙榕辽宁师范大学地理科学学院大连116029

深入研究辽河三角洲生态系统服务价值(ESV)的时空演变特征及影响因素,对其生态环境治理和保护具有重要意义.基于1990~2020年辽河三角洲7期土地利用数据,利用当量因子系数修正法建立估算模型评估ESV,综合分析研究区ESV时空演变特征,并探... 详细信息

深入研究辽河三角洲生态系统服务价值(ESV)的时空演变特征及影响因素,对其生态环境治理和保护具有重要意义.基于1990~2020年辽河三角洲7期土地利用数据,利用当量因子系数修正法建立估算模型评估ESV,综合分析研究区ESV时空演变特征,并探究ESV驱动影响因素与机制.结果表明:①1990~2020年辽河三角洲地区土地利用方式大部分为耕地,30年间林地、湿地和未利用土地面积呈现下降趋势,草地、水域和建设用地呈上升趋势,耕地面积基本无变化.②辽河三角洲ESV呈现先减少后增加再减少的趋势,生态系统服务总价值整体呈现出西南部价值高,东北部价值低的空间分异规律.③辽河三角洲地区的所有土地利用类型敏感性指数均小于1,表明ESV缺乏弹性.④辽河三角洲ESV具有空间正相关性,整体而言,辽河三角洲以HH和LL聚类为主,HL聚类多分布在LL聚类边界处,LH聚类分布在HH聚类周围,少量分布在LL聚类周围.⑤辽河三角洲生态系统服务价值演变的影响因子中,DEM对ESV的影响最小,HAI对ESV影响最大,其次是GDP,所有影响因子的交互结果对ESV空间分布的影响均具有增强作用,其中HAI和降水量的交互作用最强,达到了95.58%.

关键词：生态系统服务价值(ESV) 时空演变影响因素辽河三角洲地理探测器

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Severe acute respiratory syndrome (SARS) related coronavirus in bats

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Animal Diseases 2021年第1期1卷 31-38页

作者： rong geng Peng Zhou CAS key laboratory of special pathogens Wuhan Institute of VirologyChinese Academy of SciencesWuhanChina University of Chinese Academy of Sciences BeijingChina

Three major human coronavirus disease outbreaks,severe acute respiratory syndrome(SARS),Middle East respiratory syndrome(MERS)and 2019 coronavirus disease(COVID-19),occurred in the twenty-first century and were caused by different coronaviruses(CoVs).All these viruses are considered to have originated from bats and transmitted to humans through intermediate hosts.SARS-CoV-1 and SARS-CoV-2,disease agent of COVID-19,shared around 80%genomic similarity,and thus belong to SARS-related CoVs.As a natural reservoir of viruses,bats harbor numerous other SARS-related CoVs that could potentially infect humans around the world,causing SARS or COVID19 like outbreaks in the future.In this review,we summarized the current knowledge of CoVs on geographical distribution,genetic diversity,cross-species transmission potential and possible pathogenesis in humans,aiming for a better understanding of bat SARS-related CoVs in the context of prevention and control.

关键词： SARS-related coronavirus Bat Cross-species Spillover Geographical distribution

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The basic core traditional C hinese medicine for the prevention and treatment of COVID-19 and its active mechanisms

Pharmacology Discovery

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Pharmacology Discovery 2024年第1期4卷 21-30页

作者： Zhe Xu Zi-Xin Li Zi-Yao geng rong-Li Shu Hui-Fang Zhou Yu-Hong Bian School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Oncology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300380China

Background:COVID-19 has had a dramatic impact on human health,economies,societies,and livelihoods around the world.Traditional Chinese medicine(TCM)formulae have played an important role in the prevention and treatment of COVID-19.WHO evaluated the role of TCM in treating of COVID-19 and encouraged other countries to promote the use of TCM formulae.However,the key is to find the basic core traditional Chinese medicine(BC-TCM)among those formulae.Methods:For the first time,we mined the data of TCM formulae in CNIPA and analyzed herb characteristics and association rules.We then determined the BC-TCM and screened main compounds and therapeutic targets.Finally,the potential molecular mechanisms were explored by using enrichment analyses and molecular docking.Results:This study screened 123 patented TCM formulae,including 312 herbs.According to frequency statistics and association rules,nine herbs(Gan Cao,Jin Yinhua,Guang Huoxiang,Fu Ling,Huang Qi,Jie geng,Lian Qiao,Cang Zhu,Ku Xingren)were selected as the BC-TCM.The BC-TCM involved 166 main compounds and 48 therapeutic targets.The active compounds Hederagenin,Spinasterol,Beta-sitosterol,and Liquiritin had high binding activity to the COVID-19 targets 3CL,ACE2,and core targets RELA,HSP90AA1,STAT3,MAPK3,and TP53 according to molecular docking results.Interestingly,Hederagenin might be a potential compound for the prevention and treatment of COVID-19.Conclusion:Our research predicted and confirmed the preventive therapeutic effect of BC-TCM on COVID-19.This has the potential to broaden the scope of TCM,guide people in using clinical formulae,and provide valuable insights for future TCM discovery research.

关键词： COVID-19 traditional Chinese medicine China national intellectual property administration data mining network pharmacology

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生态危机时代环境史研究的共生物种志探索与实践

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贵州民族研究 2024年第1期45卷 77-85页

作者：耿中耀杨沅蓉贵州大学历史与民族文化学院贵州贵阳550025

“人类世”概念的提出和推广运用,预示着全球生态危机时代的到来,学术界对此展开了激烈的讨论。在人文、社会科学界,研究者们跨越了此前将人与自然割裂的二元对立认识藩篱,试图进入跨界物种的共生关系探讨中,以寻求重建人与自然和谐关... 详细信息

“人类世”概念的提出和推广运用,预示着全球生态危机时代的到来,学术界对此展开了激烈的讨论。在人文、社会科学界,研究者们跨越了此前将人与自然割裂的二元对立认识藩篱,试图进入跨界物种的共生关系探讨中,以寻求重建人与自然和谐关系的理论依据。在环境史的文化转向和人类学的历史转向两条进路下,“多物种民族志”的写作范式可为环境史摆脱“整体史”困境提供一个新的思路。在环境史研究中,探索“共生物种志”的学理依据和实践方案,可服务于全球生态危机时代学科建设之急需。

关键词：全球生态危机环境史共生物种志

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会展业发展与经济增长关系的时空差异及影响机理——基于海南省的实证研究

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东南大学学报（哲学社会科学版） 2024年第3期26卷 117-128,152页

作者：严荣覃凯璇耿松涛新疆财经大学旅游学院新疆乌鲁木齐830012 西南财经大学工商管理学院四川成都611130 海南大学国际旅游与公共管理学院海南海口570228

选取2012—2019年海南省18个市县相关数据,采用空间分析和计量经济学面板数据回归方法,分析海南省会展业收入占GDP比重与经济增长率变化的时空演化格局,探讨会展业发展对经济增长作用的影响机制。研究结果表明:(1)海南省及18个市县的会... 详细信息

选取2012—2019年海南省18个市县相关数据,采用空间分析和计量经济学面板数据回归方法,分析海南省会展业收入占GDP比重与经济增长率变化的时空演化格局,探讨会展业发展对经济增长作用的影响机制。研究结果表明:(1)海南省及18个市县的会展业发展呈上升趋势,经济增长率呈波动减小趋势,表现出显著的空间差异性。(2)海南省会展业依赖度与经济增长率间呈抛物线型曲线变化过程。当会展业依赖度达到一定程度时表现出负外部效应,阻碍经济增长。(3)海南省会展业通过影响人力资本投入、技术创新、物质资本投入等因素影响经济发展,对技术创新和物质资本投入的影响呈反“N”型。为实现海南省会展业的健康可持续发展,海南省会展业应融入全省经济转型大趋势,同时注重区域差异,因地制宜制定会展业发展战略。

关键词：会展业发展经济增长时空差异

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既有建筑屋面光伏阵列多目标优化设计研究

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西部人居环境学刊 2024年第1期39卷 136-141页

作者：林耕刘玉成刘立陈瑞谢榕天津城建大学建筑学院中建西南设计研究院有限公司四川省国土科学技术研究院

基于节能减排背景和双碳目标,既有建筑绿色改造是一项迫切需求。屋面增设光伏阵列是既有建筑节能改造的一项有利途径,但目前常用的基于地域最佳倾角的固定式光伏板铺设方法存在不美观、经济效益低等问题。如何借助数字化技术优化和确定... 详细信息

基于节能减排背景和双碳目标,既有建筑绿色改造是一项迫切需求。屋面增设光伏阵列是既有建筑节能改造的一项有利途径,但目前常用的基于地域最佳倾角的固定式光伏板铺设方法存在不美观、经济效益低等问题。如何借助数字化技术优化和确定固定式光伏板的倾角,从而收获良好的经济和环境效益,成为人们关注的热点问题。选择四川省成都市一处既有建筑屋面为研究对象,借助Grasshopper工具搭建参数化模拟优化平台,以总日照辐射量和单位面积日照辐射量作为性能评价指标,对坡屋面增设光伏阵列形态设计进行多目标优化研究,得到屋面坡度、面积和朝向确定条件下光伏阵列的一系列几何形态优化设计方案,经筛选后优化方案较对照方案有较大提升。并对其进行数据分析,发现以优化性能目标为方向的几何形态设计建议:阵列倾角取场地条件范围下最大值;同时光伏阵列宽距比满足倾角的正弦函数关系,以此方案设计的光伏阵列的单位面积日照辐射量和总日照辐射量相对符合经济效益需求。明确了该多目标优化方法流程对既有建筑屋面光伏阵列设计的积极作用。

关键词：既有建筑建筑附加光伏参数化工具遗传算法多目标优化

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