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Establishing and clinically validating a machine learning model for predicting unplanned reoperation risk in colorectal cancer

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World Journal of Gastroenterology 2024年第23期30卷 2991-3004页

作者： Li-Qun cai Da-Qing Yang rong-Jian Wang He Huang Yi-Xiong Shi Department of Colorectal and Anal Surgery Whenzhou Central HospitalWenzhou 325000Zhejiang ProvinceChina Department of Colorectal and Anorectal Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND Colorectal cancer significantly impacts global health,with unplanned reoperations post-surgery being key determinants of patient *** predictive models for these reoperations lack precision in integrating complex clinical *** To develop and validate a machine learning model for predicting unplanned reoperation risk in colorectal cancer *** Data of patients treated for colorectal cancer(n=2044)at the First Affiliated Hospital of Wenzhou Medical University and Wenzhou Central Hospital from March 2020 to March 2022 were retrospectively *** were divided into an experimental group(n=60)and a control group(n=1984)according to unplanned reoperation *** were also divided into a training group and a validation group(7:3 ratio).We used three different machine learning methods to screen characteristic variables.A nomogram was created based on multifactor logistic regression,and the model performance was assessed using receiver operating characteristic curve,calibration curve,Hosmer-Lemeshow test,and decision curve *** risk scores of the two groups were calculated and compared to validate the *** More patients in the experimental group were≥60 years old,male,and had a history of hypertension,laparotomy,and hypoproteinemia,compared to the control *** logistic regression analysis confirmed the following as independent risk factors for unplanned reoperation(P<0.05):Prognostic Nutritional Index value,history of laparotomy,hypertension,or stroke,hypoproteinemia,age,tumor-node-metastasis staging,surgical time,gender,and American Society of Anesthesiologists *** operating characteristic curve analysis showed that the model had good discrimination and clinical *** This study used a machine learning approach to build a model that accurately predicts the risk of postoperative unplanned reoperation in patients with colorectal cancer,which can improve tr

关键词： Colorectal cancer Postoperative unplanned reoperation Unplanned reoperation Clinical validation Nomogram Machine learning models

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海南灵芝的研究进展

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中国药物经济学 2024年第2期19卷 117-120,124页

作者：陈思明黄诚罗宗玉智丽蔡容玲吴基任海南省食品药品检验所五指山分所海南五指山572299 海南省食品检验检测中心海口572000

灵芝在海南使用较为普遍,市售灵芝几乎遍布所有市县,本文通过对盛产灵芝的海南中部地区五指山、保亭、琼中等地市售灵芝进行调研,查阅相关文献,对灵芝的历史、成分、功效,以及野生灵芝分别进行论述。目前灵芝市场还不规范,品种较多,不... 详细信息

灵芝在海南使用较为普遍,市售灵芝几乎遍布所有市县,本文通过对盛产灵芝的海南中部地区五指山、保亭、琼中等地市售灵芝进行调研,查阅相关文献,对灵芝的历史、成分、功效,以及野生灵芝分别进行论述。目前灵芝市场还不规范,品种较多,不同品种的功效不同,正品与伪品混杂,价格差异较大,广告宣传夸张。灵芝是传统名贵中药材,其的功效不可否认,但要科学辨证地看待灵芝,理性购买和使用灵芝。目前只有赤芝和紫芝是中国药典规定的正品灵芝,属于药食同源试点品种,其他灵芝品种有待进一步研究。

关键词：市售灵芝灵芝成分灵芝功效野生灵芝

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Diagnostic capability of Fourier-Domain optical coherence tomography in early primary open angle glaucoma

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Chinese Medical Journal 2010年第15期123卷 2045-2050页

作者： FANG Yuan PAN Ying-zi LI Mei QIAO rong-hua cai Yu Department of Ophthalmology Peking University First HospitalBeijing 100034 China

Background Optical coherence tomography （OCT） is a high resolution noncontact imaging modality which can quantitatively detect the optic disc and retinal *** study was designed to evaluate the diagnostic capability of parameters of the optic disc, retinal nerve fiber layer thickness, and ganglion cell complex （GCC） using a new technology called Fourier-domain OCT （FD-OCT） for early primary open angle glaucoma （POAG） *** Two groups of patients, early perimetric damage POAG and normal subjects were included in this observational cross-sectional *** patients underwent FD-OCT and visual field examination in addition to full ophthalmic *** operating characteristic curves （ROC） were studied for all *** sensitivity and specificity for distinguishing between normal and early glaucomatous eyes, the areas under the receiver operating characteristic curves （AROC） and positive, negative likelihood ratios were evaluated for all the single parameters and selected combined parameters using arbitrary *** Thirty-four eyes of 34 early POAG patients and 42 eyes of 42 normal subjects were ***/disc （C/D）vertical ratio presented the best sensitivity and positive likelihood ratio for selected specificities （95% and 85%） which were 79.4% and 88.2%, 33.4 and 7.4, *** all single parameters, the C/D vertical ratio demonstrated the highest AROC which was at *** average thickness of circumpapillary RNFL on 3.45 mm showed the highest AROC among all of the peripapillary RNFL *** sensitivity at selected specificity and AROC of GCC were not as high as C/D vertical ratio and RNFL AT on 3.45 *** the C/D vertical ratio, RNFL AT on 3.45 mm, and rim area were combined using a logistical diagnostic model, the AROC was raised to 0.949 but not significantly different from the top single parameter, C/D vertical *** The key parameters obtained by FD-OCT were able to show the signi

关键词： Fourier-Domain optical coherence tomography early primary open angle glaucoma retinal nerve fiber layerp optic disc parameter ganglion cell complex

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地佐辛、喷他佐辛用于胃癌根治术患者术后镇痛的药物经济学评价

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中南药学 2024年第7期22卷 1924-1928页

作者：吴廷庆肖洋牛露露蔡荣达吴冬妮刘滔滔广西医科大学第一附属医院药学部南宁530021 中山大学附属第一医院广西医院南宁530028

目的探讨两种胃癌术后镇痛方案的药物经济学评价。方法回顾性分析2020年10月—2022年9月在某院胃癌根治手术患者162例,按术后镇痛用药的不同分为A组和B组,A组给予地佐辛注射液(76例),B组给予喷他佐辛注射液(86例),统计两组患者的镇痛效... 详细信息

目的探讨两种胃癌术后镇痛方案的药物经济学评价。方法回顾性分析2020年10月—2022年9月在某院胃癌根治手术患者162例,按术后镇痛用药的不同分为A组和B组,A组给予地佐辛注射液(76例),B组给予喷他佐辛注射液(86例),统计两组患者的镇痛效果、不良反应、成本等,运用成本-效果分析法进行分析评价。结果安全性方面,A组不良反应发生率为2.63%,B组不良反应发生率为4.65%,差异无统计学意义;疗效方面,各时间段A组疼痛数字评分(NRS)均显著小于B组(P<0.05);A组累计有效率为96.09%,B组累计有效率为70.55%,差异有统计学意义(P<0.05)。药物经济学方面,A组总成本为(969.82±250.76)元,B组总成本为(795.62±108.23)元,A组成本-效果比(C/E)为1010.23,B组C/E为1120.59,增量成本效果比为696.80元,敏感性分析支持成本效果分析。结论胃癌术后镇痛中地佐辛注射液相对于喷他佐辛注射液具有经济学优势。

关键词：地佐辛喷他佐辛胃癌术后镇痛镇痛效果药物经济学成本效果分析

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龙头企业与农户合作的契约选择及决策权配置研究——来自山东省苹果行业的实证

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软科学 2013年第2期27卷 32-35,49页

作者：蔡荣南京财经大学CFSSS中心南京210003

利用山东省52家果品经销企业调查数据,实证分析龙头企业与农户合作的契约选择与决策权配置问题。研究表明:资产专用性越强或货源质量要求越高的龙头企业越倾向于选择生产契约,并且对农业经营决策权的控制程度也越高;龙头企业的成立时间... 详细信息

利用山东省52家果品经销企业调查数据,实证分析龙头企业与农户合作的契约选择与决策权配置问题。研究表明:资产专用性越强或货源质量要求越高的龙头企业越倾向于选择生产契约,并且对农业经营决策权的控制程度也越高;龙头企业的成立时间、资产规模和主营业务所占比重对农业经营决策权配置具有显著影响,但对契约选择的影响不显著。

关键词：契约选择决策权配置龙头企业合作行为

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我国高空气球极地科学探测的初步构想

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科学通报 2020年第32期65卷 3510-3519页

作者：蔡榕孙建颖中国科学院空天信息创新研究院北京100094 中国科学院大学航空宇航学院北京100049

我国在极地科学探测领域起步较晚.高空科学气球是帮助我国实现极地探测快速赶超的重要手段,发挥其在原位探测、下投探测、天文观测和对地观测中的重要优势,将丰富我国在极地的科学活动,增强对极地的利用能力.

关键词：天文观测极地科学高空气球对地观测原位探测探测领域初步构想

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Decreased numbers of circulating endothelial progenitor cells are associated with hyperglycemia in patients with traumatic brain injury

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Neural Regeneration Research 2019年第6期14卷 984-990页

作者： Hui-Jie Wei Li Liu Fang-Lian Chen Dong Wang Liang Wang Zeng-Guang Wang rong-cai Jiang Jing-Fei Dong Jie-Li Chen Jian-Ning Zhang Department of Neurosurgery Tianjin Medical University General HospitalTianjin Neurological InstituteKey Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous SystemMinistry of EducationTianjin Key Laboratory of InjuriesVariations and Regeneration of Nervous System Department of Neurosurgery Peking University International Hospital Thrombosis Research Section Department of MedicineBaylor College of Medicine Department of Neurology Henry Ford Health System

Hyperglycemia reduces the number of circulating endothelial progenitor cells, accelerates their senescence and impairs their ***, the relationship between blood glucose levels and endothelial progenitor cells in peripheral blood of patients with traumatic brain injury is unclear. In this study, 101 traumatic brain injury patients admitted to the Department of Neurosurgery, Tianjin Medical University General Hospital or the Department of Neurosurgery, Tianjin Huanhu Hospital, China, were enrolled from April 2005 to March 2007. The number of circulating endothelial progenitor cells and blood glucose levels were measured at 1, 4, 7, 14 and 21 days after traumatic brain injury by flow cytometry and automatic biochemical analysis, respectively. The number of circulating endothelial progenitor cells and blood sugar levels in 37 healthy control subjects were also examined. Compared with controls, the number of circulating endothelial progenitor cells in traumatic brain injury patients was decreased at 1 day after injury, and then increased at 4 days after injury,and reached a peak at 7 days after injury. Compared with controls, blood glucose levels in traumatic brain injury patients peaked at 1 day and then decreased until 7 days and then remained stable. At 1, 4, and 7 days after injury, the number of circulating endothelial progenitor cells was negatively correlated with blood sugar levels(r =-0.147, P < 0.05). Our results verify that hyperglycemia in patients with traumatic brain injury is associated with decreased numbers of circulating endothelial progenitor cells. This study was approved by the Ethical Committee of Tianjin Medical University General Hospital, China(approval No. 200501) in January 2015.

关键词： nerve regeneration endothelial progenitor cells vascular repair vascular remodeling angiogenesis neovascularization blood glucose hyperglycemia traumatic brain injury mobilization suppression senescence alternative therapy brain damage neural regeneration

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Synchronous adenocarcinoma and gastrointestinal stromal tumors in the stomach

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World Journal of Gastroenterology 2013年第20期19卷 3117-3123页

作者： rong cai Gang Ren Deng-Bin Wang Department of Radiochemotherapy Rui Jin HospitalShanghai Jiaotong University Medical School Department of Radiology Xin Hua HospitalShanghai Jiaotong University Medical School

AIM:To review the clinicopathological characteristics of concurrent gastrointestinal stromal tumors(GISTs) and gastric ***:We retrospectively analyzed eight cases of synchronous adenocarcinoma and GIST in the stomach that had been surgically resected with curative intent between March 2003 and December 2008 in Xinhua hospital and Ruijin *** adenocarcinoma was determined to be the primary tumor based on the histological *** GIST cells were diffusely and strongly positive for CD34 and ***:The patients were six men and two women aged 47-80 years(average,68.6 years).GIST was preoperatively detected in only one *** average sizes of the gastric adenocarcinomas and GISTs were 6.000 ± 2.6186 cm and 1.825 ± 1.4370 cm,*** GISTs were very low-or low-risk lesions that were detected during evaluation,staging,operation or follow-up for gastric ***:We hypothesized that the stomach was influenced by the same unknown carcinogen,resulting in a simultaneous proliferation of different cell lines(epithelial and stromal cell).

关键词： Gastric adenocarcinoma Gastrointestinal stromal tumor Synchronous occurrence Gastrectomy

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Sampling efficiency of a polyurethane foam air sampler:Effect of temperature

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Environmental Science and Ecotechnology 2024年第2期18卷 43-52页

作者： Qiu-Liang cai Cen-Yan Huang Lei Tong Ning Zhong Xiao-rong Dai Jian-rong Li Jie Zheng Meng-Meng He Hang Xiao Key Laboratory of Urban Environment and Health Ningbo Observation and Research StationInstitute of Urban EnvironmentChinese Academy of SciencesXiamen361021China Key Laboratory of Ecological Environment Analysis and Pollution Control in Western Guangxi Region College of Agriculture and Food EngineeringBaise UniversityBaise533000China College of Biological and Environmental Sciences Zhejiang Wanli UniversityNingbo315100China Zhejiang Key Laboratory of Urban Environmental Processes and Pollution Control CAS Haixi Industrial Technology Innovation Center in BeilunNingbo315830China Minnan Normal University Zhangzhou363000China

Effective monitoring of atmospheric concentrations is vital for assessing the Stockholm Convention's effectiveness on persistent organic pollutants(POPs).This task,particularly challenging in polar regions due to low air concentrations and temperature fluctuations,requires robust sampling ***,the influence of temperature on the sampling efficiency of polyurethane foam discs remains *** we employ a flow-through sampling(FTS)column coupled with an active pump to collect air samples at varying *** delved into breakthrough profiles of key pollutants,such as polycyclic aromatic hydrocarbons(PAHs),polychlorobiphenyls(PCBs),and organochlorine pesticides(OCPs),and examined the temperature-dependent behaviors of the theoretical plate number(N)and breakthrough volume(VB)using frontal chromatography *** findings reveal a significant relationship between temperature dependence coefficients(KTN,KTV)and compound volatility,with decreasing values as volatility *** distinct trends are noted for PAHs,PCBs,and OCPs in KTN,KTV values exhibit similar patterns across all ***,we establish a binary linear correlation between log(VB/m3),1/(T/K),and N,simplifying breakthrough level estimation by enabling easy conversion between N and ***,an empirical linear solvation energy relationship incorporating a temperature term is developed,yielding satisfactory results for N at various *** approach holds the potential to rectify temperature-related effects and loss rates in historical data from long-term monitoring networks,benefiting polar and remote regions.

关键词： Temperature Theoretical plate number Breakthrough volume Frontal chromatographic theory LSER

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基于代谢组学分析急性心肌梗死大鼠尿液代谢物变化

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法医学杂志 2024年第3期40卷 227-236页

作者：陈念念余娇芳吴鹏罗丽白雅琴王利凯李晓倩李展鹏高彩荣郭相杰山西医科大学法医学院山西晋中030600 鄞州区公安司法鉴定中心浙江宁波315100 山西医科大学转化医学研究中心山西晋中030600

目的通过非靶向代谢组学研究急性心肌梗死(acute myocardial infarction,AMI)大鼠尿液代谢产物的变化,筛选出可用于AMI法医学鉴定的生物标志物。方法建立假手术组、AMI组和高脂血症+AMI组(hyperlipidemia+acute myocardial infarction,H... 详细信息

目的通过非靶向代谢组学研究急性心肌梗死(acute myocardial infarction,AMI)大鼠尿液代谢产物的变化,筛选出可用于AMI法医学鉴定的生物标志物。方法建立假手术组、AMI组和高脂血症+AMI组(hyperlipidemia+acute myocardial infarction,HAMI)大鼠模型。运用超高效液相色谱-质谱法(ultra-high performance liquid chromatography-mass spectrometry,UPLC-MS)分析AMI大鼠尿液代谢谱的变化。通过主成分分析、偏最小二乘判别分析、正交偏最小二乘判别分析等筛选差异代谢物。使用MetaboAnalyst数据库进行代谢通路富集分析并评估差异代谢物的预测能力。结果分别筛选出40种和61种与AMI相关和HAMI相关的差异代谢物。其中22种为共同代谢物,这些小分子代谢物主要集中在烟酸和烟酰胺代谢途径中。在95%可信区间内N8-乙酰亚精胺、3-甲基组胺和胸腺嘧啶的受试者操作特征曲线的曲线下面积(area under the curve,AUC)值大于0.95。结论N8-乙酰亚精胺、3-甲基组胺和胸腺嘧啶可作为诊断AMI的潜在生物标志物,烟酸和烟酰胺代谢的异常可能是AMI的主要原因。本研究可为AMI的作用机制和死因鉴定提供参考。

关键词：法医病理学非靶向代谢组学急性心肌梗死超高效液相色谱-质谱法大鼠尿液

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