Diagnostic capability of Fourier-Domain optical coherence tomography in early primary open angle glaucoma

作     者：FANG Yuan PAN Ying-zi LI Mei QIAO Rong-hua CAI Yu 

作者机构：Department of Ophthalmology Peking University First HospitalBeijing 100034 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2010年第123卷第15期

页      面：2045-2050页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：Fourier-Domain optical coherence tomography early primary open angle glaucoma retinal nerve fiber layerp optic disc parameter ganglion cell complex 

摘      要：Background Optical coherence tomography （OCT） is a high resolution noncontact imaging modality which can quantitatively detect the optic disc and retinal *** study was designed to evaluate the diagnostic capability of parameters of the optic disc, retinal nerve fiber layer thickness, and ganglion cell complex （GCC） using a new technology called Fourier-domain OCT （FD-OCT） for early primary open angle glaucoma （POAG） *** Two groups of patients, early perimetric damage POAG and normal subjects were included in this observational cross-sectional *** patients underwent FD-OCT and visual field examination in addition to full ophthalmic *** operating characteristic curves （ROC） were studied for all *** sensitivity and specificity for distinguishing between normal and early glaucomatous eyes, the areas under the receiver operating characteristic curves （AROC） and positive, negative likelihood ratios were evaluated for all the single parameters and selected combined parameters using arbitrary *** Thirty-four eyes of 34 early POAG patients and 42 eyes of 42 normal subjects were ***/disc （C/D）vertical ratio presented the best sensitivity and positive likelihood ratio for selected specificities （95% and 85%） which were 79.4% and 88.2%, 33.4 and 7.4, *** all single parameters, the C/D vertical ratio demonstrated the highest AROC which was at *** average thickness of circumpapillary RNFL on 3.45 mm showed the highest AROC among all of the peripapillary RNFL *** sensitivity at selected specificity and AROC of GCC were not as high as C/D vertical ratio and RNFL AT on 3.45 *** the C/D vertical ratio, RNFL AT on 3.45 mm, and rim area were combined using a logistical diagnostic model, the AROC was raised to 0.949 but not significantly different from the top single parameter, C/D vertical *** The key parameters obtained by FD-OCT were able to show the signi