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MicroRNAs as a potential prognostic factor in gastric cancer

World Journal of Gastroenterology 2011年第35期17卷 3976-3985页

作者： Baruch brenner Moshe B Hoshen Ofer Purim Miriam Ben David Karin Ashkenazi Gideon Marshak Yulia Kundel ronen brenner Sara Morgenstern Marisa Halpern Nitzan Rosenfeld Ayelet Chajut Yaron Niv Michal Kushnir Institute of Oncology Davidoff CenterRabin Medical CenterBeilinson HospitalPetach Tikva 49100Israel Sackler Faculty of Medicine Tel Aviv UniversityTel Aviv 69978Israel Rosetta Genomics Ltd. Rehovot 76706Israel Clalit Research Institute Clalit Medical ServicesTel Aviv 69978Israel Institute of Oncology Rabin Medical CenterGolda-Hasharon HospitalPetach Tikva 49100Israel Institute of Oncology Rabin Medical CenterBeilinson HospitalPetach Tikva 49100Israel Institute of Pathology Rabin Medical CenterBeilinson HospitalPetach Tikva 49100Israel Institute of Pathology Rabin Medical CenterGolda-Hasharon HospitalPetach Tikva 49100Israel Cancer Research UK Cambridge Research InstituteCambridge CB2 OREUnited Kingdom Department of Gastroenterology Rabin Medical CenterBeilinson HospitalPetach Tikva 49100Israel Sackler Faculty of Medicine Tel Aviv UniversityTel Aviv 69978 Israel

AIM:To compare the microRNA (miR) profiles in the primary tumor of patients with recurrent and non-recurrent gastric ***:The study group included 45 patients who underwent curative gastrectomies from 1995 to 2005 without adjuvant or neoadjuvant therapy and for whom adequate tumor content was *** RNA was extracted from formalin-fixed paraffin-embedded tumor samples,preserving the small RNA *** profiling using miR microarrays was performed to identify potential biomarkers of recurrence after *** expression of the differential miRs was later verified by quantitative real-time polymerase chain reaction (qRT-PCR).Findings were compared between patients who had a recurrence within 36 mo of surgery (bad-prognosis group,n=14,31%) and those who did not (good-prognosis group,n=31,69%).RESULTS:Three miRs,miR-451,miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P<0.0002,0.0027 and 0.0046 respectively).High expression of each miR was associated with poorer prognosis for both recurrence and *** miR-451,the positive predictive value for non-recurrence was 100% (13/13).The expression of the differential miRs was verified by qRT-PCR,showing high correlation to the microarray data and similar separation into prognosis ***:This study identified three miRs,miR-451,miR-199a-3p and miR-195 to be predictive of recurrence of gastric *** these,miR-451 had the strongest prognostic impact.

关键词：小分子RNA 预后胃癌 microRNA 肿瘤患者聚合酶链反应辅助治疗手术切除

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