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The new kid on the block in insect pest management:sprayable RNAi goes commercial

Science China(Life Sciences) 2024年第8期67卷 1766-1768页

作者： junjie Yan Ralf Nauen Stuart Reitz Andrei Alyokhin jiang Zhang David Mota-Sanchez Yonggyun Kim Subba Reddy Palli Silvia I.rondon Brian A.Nault juan Luis jurat-Fuentes Michael S.Crossley William E.Snyder Angharad M.R.Gatehouse Myron P.Zalucki Bruce E.Tabashnik Yulin Gao State Key Laboratory for Biology of Plant Disease and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Bayer AG Crop Science DivisionR&DPest ControlMonheim 40789Germany Department of Crop and Soil Science Oregon State UniversityOntario 97914USA School of Biology and Ecology University of MaineOrono 04469USA Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518000China Department of Entomology Michigan State UniversityEast Lansing 48864USA Department of Plant Medicals Andong National UniversityAndong 36729Republic of Korea Department of Entomology University of KentuckyLexington 40503USA Oregon State University Oregon Integrated Pest Management CenterCorvallis 97838USA Department of Entomology Cornell UniversityCornell AgriTechGeneva 14456USA Department of Entomology and Plant Pathology University of TennesseeKnoxville 37996USA Department of Entomology and Wildlife Ecology University of DelawareNewark 19716USA Department of Entomology University of GeorgiaAthensGeorgia 30602USA School of Natural and Environmental Sciences Newcastle UniversityNewcastle upon TyneNE17RUUK School of the Environment University of QueenslandBrisbane 4072Australia Shandong Engineering Research Center for Environment-Friendly Agricultural Pest Management College of Plant Health and MedicineQingdao Agricultural UniversityQingdao 266109China Department of Entomology University of ArizonaTucson 85721USA National Center of Excellence for Tuber and Root Crop Research Chinese Academy of Agricultural SciencesBeijing 100081China

Insect pest damage to crops is a threat to global food security(Tilman et al.,2011).Climate change,the evolution of insecticide resistance,and the phasing out of insecticides due to environmental and safety concerns exacerbate this *** urgently need safe and effective crop protection tools to sustainably generate yields that meet ever-increasing global demand.

关键词： crops damage pest

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Decoding Phthorimaea operculella(Lepidoptera: Gelechiidae) in the new age of change

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journal of Integrative Agriculture 2020年第2期19卷 316-324页

作者： Silvia I.rondon Hermiston Agricultural Research and Extension Center Crop and Soil ScienceOregon State University

Arthropods and pathogens constantly challenge potato Solanum tuberosum *** of climate variation have increased the possibility of changes in pests’biological and ecological patterns by increasing or reducing overwintering length,changes in population growth rates,number of generations,crop-pest relationship,and therefore affecting their *** operculella Zeller(Lepidoptera:Gelechiidae)is one of the main pests affecting potatoes *** oviposit single or multiple eggs in leaves,stems,and tubers,while the larvae in immature stage mine leaves or burrows into tubers turning them *** control methods are effective in controlling ***,but many factors determine the success of the control *** review provides key highlights of current information available that could be used as a resource to fight this pest.

关键词： climate insects moth potato pest management Solanaceae pest control IPM tubermoth potato tuber moth

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人工关节置换术围手术期抗生素的应用:单次剂量与多次剂量效果相当

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临床骨科杂志 2019年第2期22卷 189-189页

作者： Tan T L Shohat N rondon a j 胡孔足(摘译) 不详

人工关节置换术围手术期如何使用抗生素预防感染还需要进一步研究,作者回顾性分析了20682例人工全髋、膝关节置换术患者资料,其中4523例接受单次剂量抗生素,16159例接受多次剂量抗生素。分析1年内感染率,采用多因素回归分析相关危险因素。

关键词：人工关节置换术单次剂量围手术期抗生素多因素回归分析量效膝关节置换术相关危险因素

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帕金森患者全关节置换术:生存率、结果和失败原因分析

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临床骨科杂志 2017年第6期20卷 738-738页

作者： rondon a j Tan T L Schlitt P K 胡孔足

由于步态不稳、肌肉痉挛,帕金森患者进行关节置换术的疗效受到影响。作者回顾性分析了123例全关节置换术患者资料（52例髋,71例膝）。平均随访5.3年,23.6%患者需要进行翻修术。最常见的膝关节翻修原因是假体周围感染,最常见的髋关节翻... 详细信息

由于步态不稳、肌肉痉挛,帕金森患者进行关节置换术的疗效受到影响。作者回顾性分析了123例全关节置换术患者资料（52例髋,71例膝）。平均随访5.3年,23.6%患者需要进行翻修术。最常见的膝关节翻修原因是假体周围感染,最常见的髋关节翻修原因是假体周围骨折和脱位。术后第2、5、10年假体生存率分别为94.9%、87.9%、72.3%。

关键词：全关节置换术患者资料生存率帕金森原因分假体周围感染髋关节翻修假体周围骨折

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Simultaneous Raman and reflection UV/Vis absorption spectroelectrochemistry

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Nano Research 2022年第6期15卷 5340-5346页

作者： Sheila Hernandez juan V.Perales-rondon Aranzazu Heras Alvaro Colina Department of Chemistry Universidad de BurgosPza.Misael Banuelos s/ñBurgos E-09001Spain Department of Analytical Chemistry Physical Chemistry and Chemical EngineeringUniversity of Alcala.Ctra.Madrid-BarcelonaKm.33.600MadridAlcaláde Henares E-28871Spain

In the present work,a new combination of Raman and ultraviolet and visible(UV/Vis)absorption spectroelectrochemistry in reflection mode is *** new experimental setup allows obtaining the two kinds of spectroscopic data without interferences concomitantly with the electrochemical *** the best of our knowledge,it is the first time to report the simultaneous obtention of electrochemical,electronic,and vibrational information in the same *** new combination provides time-resolved information about the processes that are taking place on the electrode/solution interface which has significant implications in different fields of chemistry,such as modification of electrodes,studies of electrocatalytic reaction mechanisms,development of sensors,among *** different systems were used to demonstrate the advantages and capabilities of the brand-new technique,namely,the oxidation of potassium ferrocyanide,an out-sphere system that is usually employed in the validation of SEC techniques,and the electrochemical-surface enhanced Raman spectroscopy(EC-SERS)detection of crystal violet by in-situ formation of the silver SERS substrate,where the UV/Vis spectra were used to follow the formation of the SERS substrate,whereas the Raman response of a probe molecule was used to confirm either the formation of a nanostructured surface and to obtain the fingerprint of the molecule with a high time *** brand-new experimental setup has shown to be useful,versatile,robust,compact,and easy to use for future applications.

关键词： spectroelectrochemistry surface enhanced Raman spectroscopy(SERS) Raman ultraviolet and visible(UV/Vis)absorption nanoparticles

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Role of chromosomal instability and clonal heterogeneity in the therapy response of breast cancer cell lines

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Cancer Biology & Medicine 2020年第4期17卷 970-985页

作者： Natalia Vargas-rondon Erika Perez-Mora Victoria E.Villegas Milena rondon-Lagos School of Biological Sciences Universidad Pedagogica y Tecnologica de ColombiaTunja 150003Colombia Biology Program Faculty of Natural SciencesUniversidad del RosarioBogota 111221Colombia

Objective:Chromosomal instability(CIN)is a hallmark of cancer characterized by cell-to-cell variability in the number or structure of chromosomes,frequently observed in cancer cell populations and is associated with poor prognosis,metastasis,and therapeutic *** cancer(BC)is characterized by unstable karyotypes and recent reports have indicated that CIN may influence the response of BC to chemotherapy ***,paradoxical associations between extreme CIN and improved outcome have been ***:This study aimed to 1)evaluate CIN levels and clonal heterogeneity(CH)in MCF7,ZR-751,MDA-MB468,BT474,and KPL4 BC cells treated with low doses of tamoxifen(TAM),docetaxel(DOC),doxorubicin(DOX),Herceptin(HT),and combined treatments(TAM/DOC,TAM/DOX,TAM/HT,HT/DOC,and HT/DOX)by using fluorescence in situ hybridization(FISH),and 2)examine the association with response to treatments by comparing FISH results with cell ***:Intermediate CIN was linked to drug sensitivity according to three characteristics:estrogen receptorα(ERα)and HER2 status,pre-existing CIN level in cancer cells,and the CIN induced by the ***α+/HER2-cells with intermediate CIN were sensitive to treatment with taxanes(DOC)and anthracyclines(DOX),while ERα-/HER2-,ERα+/HER2+,and ERα-/HER2+cells with intermediate CIN were resistant to these ***:A greater understanding of CIN and CH in BC could assist in the optimization of existing therapeutic regimens and/or in supporting new strategies to improve cancer outcomes.

关键词： Breast cancer chromosomal instability therapy resistance FISH clonal heterogeneity

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Sub-lethal effects of Beauveria bassiana(Balsamo) on field populations of the potato tuberworm Phthorimaea operculella Zeller in China

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journal of Integrative Agriculture 2018年第4期17卷 911-918页

作者： YUAN Hui-guo WU Sheng-yong LEI Zhong-ren Silvia I.rondon GAO Yu-lin State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant Protection Chinese Academy of Agricultural Sciences Department of Crop and Soil Sciences Hermiston Agricultural Research and Extension Center Oregon State University

The potato tuberworm Phthorimaea operculella Zeller, is one of the most important potato pests worldwide including China. Several reports indicate that P. operculella could be controlled biologically by the use of beneficial fungus such as Beauveria bassiana(Bals.-Criv) Vuill. However, limited information is available under growing conditions in China. Thus, this study evaluated the sub-lethal effects of B. bassiana on the offspring of P. operculella by the age-stage, two-sex life table. First instar larva of P. operculella were treated with 1×107 conidia m L–1 of the fungus, and several biological parameters were evaluated. The fecundity, duration of the egg stage, all larval stages, pre-adult stage, and total pre-oviposition period, were significantly shorter than the control treatment. Offspring of treated parents, presented a net reproductive rate and mean generation time of 17.43 per day and 24.98 days, respectively, compared to 65.79 per day and 26.51 days for the untreated ones. This study provides basic information to help understanding the potential long-term effects of entomopathogenic fungi on P. operculella.

关键词： potato tubermoth sub-lethal effects biological control management

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Molecular biomarkers for oxidative stress and neuronal damage in red-bellied pacu(Piaractus brachypomus)

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Aquaculture and Fisheries 2023年第6期8卷 720-726页

作者： julian David Ortiz Munoz Kelly johanna Lozano Villegas Iang Schroniltgen rondon Barragan Research Group in Immunobiology and Pathogenesis Laboratory of Immunology and Molecular BiologyFaculty of Veterinary Medicine and ZootechnicsUniversidad Del TolimaSanta Helena HighsIbague-Tolima730006299Colombia Poultry Research Group Laboratory of Immunology and Molecular BiologyFaculty of Veterinary Medicine and ZootechnicsUniversidad Del TolimaSanta Helena HighsIbague-Tolima730006299Colombia

Biomarkers are biological molecules that provide information about the physiological condition of an organism such as early signals of health *** aim of this study was to compare the relative gene expression of four molecular biomarkers related to oxidative stress,and neuronal damage in Piaractus brachypomus under three different conditions(exposure to chlorpyrifos(CPF),menthol and eugenol anesthesia,and brain injury).Bioinformatic analyses were conducted to design primers for the molecular biomarkers,then,the relative gene expression of COX1,GPX1,BDNF and CALB1 genes was measured by qPCR using brain tissue cDNA from the treated animals as template and 2-ΔΔCT method was ***1a gene was used as reference *** results showed a response to chemical stress in the CPF treatment samples where GPX1,BDNF and CALB1 genes were ***,in menthol/eugenol and brain injury treatments,no alterations in the relative gene expression were observed.

关键词： Menthol Eugenol Chlorpyrifos Brain injury Gene expression

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Dystrophic Calcinosis in the Hands of a Patient with Rheumatoid Arthritis and Secundary Sjogren’s Syndrome

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Open journal of Rheumatology and Autoimmune Diseases 2013年第1期3卷 56-58页

作者： Daniel jaramillo-Arroyave Gerardo Quintana Federico rondon-Herrera Antonio Iglesias-Gamarra Internal Medicine RheumatologyDepartment of Internal MedicineRheumatology UnitUniversidad Nacional de ColombiaBogotáColombia

Salts of calcium phosphate and inorganic phosphate are normally found in serum and extracellular fluids, balancing through poorly understood factors that prevent abnormal tissue deposition of these minerals. However, in those tissues that are injured, especially due to chronic inflammatory processes, a predisposition to the deposition of these minerals is developed, triggering what has been called Dystrophic Calcinosis (DC), common in different Connective Tissue Diseases (CTD), especially dermatomyositis and scleroderma, but there is no a frecuent association with diseases like Rheumatoid Arthritis (RA) and Sj?gren Syndrome (SS). We report a case of a female patient of 63 years old with RA and Secundary SS who presents with DC in the hands and no evidence of other connective tissue.

关键词： Dystrophic Calcinosis Rheumatoid Arthritis Sjogren Syndrome

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Establishing the presence or absence of chronic kidney disease:Uses and limitations of formulas estimating the glomerular filtration rate

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World journal of Methodology 2017年第3期7卷 73-92页

作者： Ahmed Alaini Deepak Malhotra Helbert rondon-Berrios Christos P Argyropoulos Zeid j Khitan Dominic SC Raj Mark Rohrscheib joseph I Shapiro Antonios H Tzamaloukas Division of Nephrology Department of MedicineUniversity of New Mexico School of Medicine Division of Nephrology Department of MedicineUniversity of Toledo School of Medicine Renal and Electrolyte Division Department of MedicineUniversity of Pittsburgh School of Medicine Division of Nephrology Department of MedicineJoan C. Edwards School of Medicine Division of Nephrology Department of MedicineGeorge Washington University Marshall University joan C. Edwards School of Medicine Nephrology Section Medicine ServiceRaymond G. Murphy VA Medical Center Department of Medicine University of New Mexico School of Medicine

The development of formulas estimating glomerular filtration rate(eG FR) from serum creatinine and cystatin C and accounting for certain variables affecting the production rate of these biomarkers, including ethnicity, gender and age, has led to the current scheme of diagnosing and staging chronic kidney disease(CKD),which is based on e GFR values and *** scheme has been applied extensively in various populations and has led to the current estimates of prevalence of CKD. In addition, this scheme is applied in clinical studies evaluating the risks of CKD and the efficacy of various interventions directed towards improving its course. Disagreements between creatinine-based and cystatin-based e GFR values and between e GFR values and measured GFR have been reported in various cohorts. These disagreements are the consequence of variations in the rate of production and in factors, other than GFR, affecting the rate of removal of creatinine and cystatin C. The disagreements create limitations for all e GFR formulas developed so far. The main limitations are low sensitivity in detecting early CKD in several subjects, e.g., those with hyperfiltration, and poor prediction of the course of CKD. Research efforts in CKD are currently directed towards identification of biomarkers that are better indices of GFR than the current biomarkers and,particularly, biomarkers of early renal tissue injury.

关键词： Chronic kidney disease Serum creatinine Creatinine clearance Creatinine excretion Estimated glomerular filtration rate Cystatin C Renal imaging Hyperfiltration Biomarkers of chronic kidney disease

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