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Traditional Chinese medicine extraction method by ethanol delivers drug-like molecules

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Chinese j.urnal of Natural Medicines 2019年第9期17卷 713-720页

作者： William G.Miao Chunping Tang Yang Ye ronald j.Quinn Yunj.ang Feng Griffith Institute of Drug Discovery(GRIDD) Griffith UniversityQueensland 4111Australia Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203China

Traditional Chinese Medicine(TCM)is an important reservoir for bioactive natural *** extraction methods by water decoction and wine tincture are an integral part of TCM and essential for their widely acknowledged *** this study,we selected 6 common TCMs that are rich in chemistry to investigate whether the TCM extraction methods deliver molecules with drug-like physical chemical *** TCM herbal materials were extracted by water,95%ethanol,and sequential hexane,d ichloromethane and *** extracts were analyzed by HPLC and^1H *** on one of the extracts yielded 32 compounds,their physical chemical properties were analyzed by Instant *** results showed that ethanol extraction,which mimics TCM wine tincture,delivered compounds with physical chemical properties compliant to Lipinski’s rule of 5.

关键词： Extraction Traditional Chinese medicine(TCM) Natural products Lipinski’s Ro5Physicochemical properties

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Control of Plant Growth and Defense by Photoreceptors:From Mechanisms to Opportunities in Agriculture

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Molecular Plant 2021年第1期14卷 61-76页

作者： ronald Pierik Carlos L.Ballare Plant Ecophysiology Department of BiologyUtrecht UniversityPadualaan 8Utrecht 3584 CHthe Netherlands IFEVA Consejo Nacional de Investigaciones Cientificas y TecnicasUniversidad de Buenos AiresAve.San Martin 4453C1417DSEBuenos AiresArgentina IIBIO-INTECH Consejo Nacional de Investigaciones Cientificas y TecnicasUniversidad Nacional de San MartinB1650HMPBuenos AiresArgentina

Plants detect and respond to the proximity of competitors using light signals perceived by photoreceptor proteins.A low ratio of red to far-red radiation(R:FR ratio)is a key signal of competition that is sensed by the photoreceptor phytochrome B(phyB).Low R:FR ratios increase the synthesis of growth-related hormones,including auxin and gibberellins,promoting stem elongation and other shade-avoidance *** photoreceptors that help plants to optimize their developmental configuration and resource allocation patterns in the canopy include blue light photoreceptors,such as cryptochromes and phototropins,and UV receptors,such as *** photoreceptors act by directly or indirectly controlling the activity of two maj.r regulatory nodes for growth and development:the COP1/SPA ubiquitin E3 ligase complex and the PIF transcription *** is also an important modulator of hormonal pathways that regulate plant defense against herbivores and pathogens,including the j.smonic acid signaling pathway,In this Perspective,we discuss recent advances on the studies of the mechanisms that link photoreceptors with growth and *** these mechanisms is important to provide a functional platform for breeding programs aimed at improving plant productivity,stress tolerance,and crop health in species of agronomic interest,and to manipulate the light environments in protected agriculture.

关键词： photoreceptor phytochrome j.smonate growth-defense trade-off shade avoidance immunity

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變態心理學第2版

Customization Using Fuzzy Recommender Systems

丛书名：心理學系列

2012年

作者： ronald j. Comer

来源：畅想之星图书光盘版（南... 评论

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j.urnal of Donghua University(English Edition) 2004年第3期21卷 9-14页

作者： ronald R. Yager Machine Intelligence Institute Iona College New Rochelle NY 10801

We discuss some methods for constructing recommender systems. An important feature of the methods studied here is that we assume the availability of a description, representation, of the obj.cts being considered for recommendation. The approaches studied here differ from collaborative filtering in that we only use preferences information from the individual for whom we are providing the recommendation and make no use the preferences of other collaborators. We provide a detailed discussion of the construction of the representation schema used. We consider two sources of information about the users preferences. The first are direct statements about the type of obj.cts the user likes. The second source of information comes from ratings of obj.cts which the user has experienced.

关键词： recommender system fuzzy logic preference.

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A Study in the 20th-Century Western Assimilation of China： The American Poet Ezra Pound＇s Imagination of Kwan-yin in the Pisan Cantos

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浙江大学学报（人文社会科学版） 2012年第3期42卷 53-73页

作者： ronald Bush St j.hn＇s College Oxford University St. Giles Oxford OX1 3J P UK

Can science save the giant panda (Ailuropoda melanoleuca)? Unifying science and policy in an adaptive management paradigm

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Integrative Zoology 2011年第3期6卷 290-296页

作者： ronald R.SWAISGOOD Fuwen WEI William j.MCSHEA David E.WILDT Andrew j.KOUBA Zej.n ZHANG San Diego Zoo Institute for Conservation Research EscondidoCaliforniaUSA Institute of Zoology Chinese Academy of ScienceBeijingChina Conservation&Research Center Smithsonian’s National Zoological ParkFront RoyalVirginiaUSA Memphis Zoo MemphisTennesseeUSA Institute of Rare Animals and Plants China West Normal UniversityNanchongSichuanChina

The giant panda(Ailuropoda melanoleuca David,1869)is an iconic species for global conservation,yet field research has only recently advanced to the point where adaptive management is ***,we review recent developments in giant panda conservation science and propose a strategic plan for moving panda conservation *** of scientific,funding,political,and logistical hurdles,few endangered species management programs have embraced adaptive management,wherein management decisions are shaped iteratively by targeted scientific *** threats,such as habitat destruction,anthropogenic disturbance and fragmented nonviable populations,need to be addressed simultaneously by researchers,managers and policy-makers working in concert to understand and overcome these obstacles to species *** the backing of the Chinese Govern-ment and the conservation community,the giant panda can become a high-profile test species for this much touted,but rarely implemented,approach to conservation management.

关键词： adaptive management conservation policy endangered species giant panda strategic conservation plan

Associations between aerobic and muscle-strengthening physical activity,sleep duration,and risk of all-cause mortality:A prospective cohort study of 282,473 ***

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j.urnal of Sport and Health Science 2023年第1期12卷 65-72页

作者： Mitch j.Duncan Stina Oftedal Christopher E Kline ronald C.Plotnikoff Elizabeth G.Holliday School of Medicine&Public Health College of HealthMedicineand WellbeingThe University of NewcastleCallaghanNSW 2308Australia Priority Research Centre for Physical Activity and Nutrition The University of NewcastleCallaghanNSW 2308Australia Department of Health&Human Development The University of PittsburghPittsburghPA 15261USA School of Education University of NewcastleCallaghanNSW 2308Australia

Purpose:To examine the j.int associations between meeting guidelines for physical activity(PA)and sleep duration and all-cause mortality risk among ***:Participants were adults(n=282,473)aged 18-84 years who participated in the 2004-2014 *** Health Interview *** status was ascertained using the National Death Index through December ***-reported PA(Active:meeting both aerobic(AER)and muscle-strengthening(MSA)guidelines,AER only(AER),MSA only(MSA),or not meeting either AER or MSA(Inactive))and sleep duration(Short,recommended(Rec),or Long)were classified according to guidelines,and 12 PA-sleep categories were *** hazard ratios and 95%confidence intervals(95%CIs)for all-cause mortality risk were estimated using Cox proportional hazards regression ***:A total of 282,473 participants(55%females)were included;18,793 deaths(6.7%)occurred over an average follow-up of 5.4 *** to the Active-Rec group,all other PA-sleep groups were associated with increased mortality risk except for the Active-Short group(hazard ratio=1.08;95%CI:0.92-1.26).The combination of long sleep with either MSA or Inactive appeared to be *** a given sleep duration,mortality risk progressively increased among participants classified as AER,MSA,and *** each activity level,the mortality risk was greatest among adults with long ***:Relative to adults meeting guidelines for both PA and sleep duration,adults who failed to meet guidelines for both AER and muscle strengthening PA and who also failed to meet sleep duration guidelines had elevated all-cause mortality *** results support interventions targeting both PA and sleep duration to reduce mortality risk.

关键词： Activity-sleep patterns All-cause mortality Prospective Resistance training

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A systems approach using OSMAC,Log P and NMR fingerprinting:An approach to novelty

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Synthetic and Systems Biotechnology 2017年第4期2卷 276-286页

作者： Miaomiao Liu Tanj. Grkovic Xueting Liu j.anying Han Lixin Zhang ronald j.Quinn Griffith Institute for Drug Discovery Griffith UniversityBrisbaneQLD4111Australia Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing100101China Graduate University of Chinese Academy of Sciences Beijing100049China

The growing number of sequenced microbial genomes has revealed a remarkably large number of secondary metabolite biosynthetic clusters for which the compounds are still *** aim of the present work was to apply a strategy to detect newly induced natural products by cultivating microorganisms in different fermentation *** metabolomic analysis of 4160 fractions generated from 13 actinomycetes under 32 different culture conditions was carried out by 1H NMR spectroscopy and multivariate *** principal component analysis(PCA)of the 1H NMR spectra showed a clear discrimination between those samples within PC1 and *** fractions with induced metabolites that are only produced under specific growth conditions was identified by PCA *** method allows an efficient differentiation within a large dataset with only one fractionation *** work demonstrates the potential of NMR spectroscopy in combination with metabolomic data analysis for the screening of large sets of fractions.

关键词： NMR fingerprints OSMAC Metabolites

Digital systems : 9th ed.

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