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Asian Pacific Journal of Tropical Biomedicine 2020年第7期10卷 316-324页

作者： Amin FMajdalawieh Jenna F.Farraj ronald i.carr Department of Biology Chemistryand Environmental SciencesFaculty of Arts and SciencesAmerican University of SharjahSharjahP.O.Box 26666United Arab Emirates Department of Microbiology and immunology Faculty of MedicineSir Charles Tupper Medical BuildingDalhousie UniversityHalifaxNova ScotiaCanada B3H 4R2

Objective:To evaluate the potential immunomodulatory effects of an aqueous extract of Sesamum indicum seeds with regard to splenocyte proliferation,Th1/Th2 balance,macrophage function,and the cytotoxic activity of natural killer(NK)***:Splenocyte proliferation was measured by[~3H]-thymidine *** assay was performed to evaluate the production of nitric oxide by *** levels of cytokines secreted by splenocytes and macrophages were measured by *** assay was performed to examine the cytotoxic activity of NK cells against YAC-1 tumor ***:Sesamum indicum significantly enhanced splenocyte proliferation in a dose-dependent *** indicum also increased and suppressed the secretion of Th1 and Th2 cytokines,respectively,by *** secretion of key pro-inflammatory mediators(iL-6,TNFα,and nitric oxide)by primary macrophages was significantly inhibited by Sesamum ***,Sesamum indicum increased the cytotoxic activity of NK cells against YAC-1 tumor ***:Sesamum indicum shows potent immunomodulatory,anti-inflammatory,and anti-cancer *** of Sesamum indicum may be used as effective therapeutic agents in regulating immune reactions implicated in various infectious and noninfectious conditions including cancer.

关键词： Sesamum indicum Anti-cancer inflammation immunomodulation Macrophages NK cells

Discordance among aggressiveness characteristics of hepatocellular carcinoma:Portal vein thrombosis and multifocality,related to tumor size,but not to serum alpha-fetoprotein level

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Liver Research 2023年第3期7卷 256-262页

作者： Brian i.carr Vito Guerra Volkan ince Burak isik Sezai Yilmaz Liver Transplant institute Inonu University Faculty of MedicineMalatyaTurkey National institute of Gastroenterology S.de Bellis Research HospitalBariItaly Department of Surgery Inonu University Faculty of MedicineMalatyaTurkey

Background and aims:Hepatocellular carcinoma(HCC)is characterized by several clinically important prognostic parameters,including portal vein thrombosis(PVT),tumor multifocality,and serum alphafetoprotein(AFP)levels,in addition to maximum tumor diameter(MTD).However,associations among these parameters have not been thoroughly ***,the study aimed to investigate the correlations among these HCC characteristics in a prospectively collected ***:An 8080 HCC patient database derived from our weekly HCC council meeting was examined with respect to the correlations at baseline patient presentation between increases in MTD and changes in the percentage of patients with PVT,multifocality,or AFP ***:The percentage of patients with PVT and with multifocality(tumor nodule numbers≥3)significantly increased with enlarging MTD,regardless of the serum AFP level,showing the independence of PVT and multifocality on *** percentage of patients with multifocality increased with enlarging MTD,in the presence or absence of PVT,showing the independence of multifocality from ***,discordance was found between different tumor ***:A statistically significant association was found between PVT and MTD and between multifocality and MTD,all three of which are independent of *** and multifocality appeared to be independent of each *** PVT and multifocality were independent of AFP,they were also augmented with high serum AFP *** results suggest the possibility of multiple pathways of tumor progression in the later stages of HCC development.

关键词： Hepatocellular carcinoma(HCC) Portal vein thrombosis(PVT) Multifocality Alpha-fetoprotein(AFP) Heterogeneity

Gas-propelled nanomotors alleviate colitis through the regulation of intestinal immunoenvironment-hematopexis-microbiota circuits

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2732-2747页

作者： Bo Xiao Yuqi Liang Ga Liu Lingshuang Wang Zhan Zhang Libin Qiu Haiting Xu Sean carr Xiaoxiao Shi Rui LReis Subhas CKundu Zhenghua Zhu Department of Gastroenterology the First Affiliated Hospital of Nanchang UniversityNanchang 330006China College of Sericulture Textileand Biomass SciencesSouthwest UniversityChongqing 400715China Department of Neurology School of MedicineEmory UniversityAtlantaGA 30322USA Atlanta Veterans Affairs Medical Center DecaturGA 30033USA Department of Surgery School of MedicineEmory UniversityAtlantaGA 30322USA Bs Research Group I3Bs—Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkBarcoGuimaraes 4805-017Portugal

The progression of ulcerative colitis(UC)is associated with immunologic derangement,intestinal hemorrhage,and microbiota *** traditional medications mainly focus on mitigating inflammation,it remains challenging to address multiple ***,a versatile gas-propelled nanomotor was constructed by mild fusion of post-ultrasonic CaO_(2) nanospheres with Cu_(2)O *** resulting CaO_(2)–Cu_(2)O possessed a desirable diameter(291.3 nm)and a uniform size *** could be efficiently internalized by colonic epithelial cells and macrophages,scavenge intracellular reactive oxygen/nitrogen species,and alleviate immune reactions by pro-polarizing macrophages to the anti-inflammatory M2 *** nanomotor was found to penetrate through the mucus barrier and accumulate in the colitis mucosa due to the driving force of the generated oxygen *** administration of CaO_(2)–Cu_(2)O could stanch the bleeding,repair the disrupted colonic epithelial layer,and reduce the inflammatory responses through its interaction with the genes relevant to blood coagulation,anti-oxidation,wound healing,and ***,it restored intestinal microbiota balance by elevating the proportions of beneficial bacteria(e.g.,Odoribacter and Bifidobacterium)and decreasing the abundances of harmful bacteria(e.g.,Prevotellaceae and Helicobacter).Our gas-driven CaO_(2)–Cu_(2)O offers a promising therapeutic platform for robust treatment of UC via the rectal route.

关键词： Nanomotor Anti-inflammation Blood coagulation immune regulation Hematopexis Microbiota rebalance Ulcerative colitis Rectal administration

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人口普查遗漏的组合式估计方法

统计与信息论坛 2024年第2期39卷 3-14页

作者：胡桂华 LOPEZ-carr David 黄艳华吴笛重庆工商大学数学与统计学院重庆400067 重庆工商大学成渝地区双城经济圈建设研究院重庆400067 加州大学圣芭芭拉分校地理系加利福尼亚圣芭芭拉93106

以人口普查标准时点上的人口总体(全国、全国以下各行政区)为研究对象,研究如何利用对总体登记的普查人口名单和覆盖调查人口名单构造的组合式遗漏估计量估计人口普查遗漏人口数。目前各国政府统计部门在人口普查遗漏估计中主要使用单... 详细信息

以人口普查标准时点上的人口总体(全国、全国以下各行政区)为研究对象,研究如何利用对总体登记的普查人口名单和覆盖调查人口名单构造的组合式遗漏估计量估计人口普查遗漏人口数。目前各国政府统计部门在人口普查遗漏估计中主要使用单重遗漏估计量,但该方法未包括同时遗漏于这两份调查人口名单的双重遗漏人口,低估了总体普查遗漏人口数。组合式遗漏估计量除了包括单重遗漏人口外,还包括了双重遗漏人口,避免了单重遗漏估计量的缺陷。采取抽样估计和数理模型相结合的方法研究单重遗漏估计量、双重遗漏估计量和组合式遗漏估计量,理论和数据分析结果表明:组合式遗漏估计量在抽样估计精度和遗漏人口数估计上优于单重遗漏估计量,尤其是在分析双重遗漏人口特征和改进未来人口普查登记工作等方面;在使用刀切法近似计算总体的组合式遗漏估计量的抽样方差时,不能忽视等概率人口层之间的协方差,否则可能低估或高估其抽样方差;单重遗漏估计量和组合式遗漏估计量属于有偏估计量,要使用均方误差比较其估计精度。本文创新之处在于,利用原始数据全面演示了单重遗漏估计量、双重遗漏估计量和组合式遗漏估计量及其抽样方差估计量等的详细计算过程,同时讨论了其统计性质,尤其是利用设置的数据模拟了有偏性,有助于中国人口普查遗漏估计方案的科学制定及估计精度的提高。

关键词：政府统计人口普查质量评估单重遗漏估计量双重遗漏估计量组合式遗漏估计量不完整二维列联表

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中国户籍登记系统漏登合成估计方法研究

系统科学与数学 2024年

作者：黄艳华 López-carr David 胡桂华重庆工商大学成渝地区双城经济圈建设研究院 University of California Santa Barbara Department of Geography 重庆工商大学数学与统计学院统计智能计算与监测重庆市重点实验室

中国户籍登记系统存在漏登人口问题,但政府部门尚未开展户籍漏登估计工作.联合国统计司建议各国采用的单重漏登估计量未覆盖全部漏登人口,低估漏登率.本文提出用合成漏登估计量替代单重漏登估计量,并通过案例研究,比较了合成漏登估计量... 详细信息

中国户籍登记系统存在漏登人口问题,但政府部门尚未开展户籍漏登估计工作.联合国统计司建议各国采用的单重漏登估计量未覆盖全部漏登人口,低估漏登率.本文提出用合成漏登估计量替代单重漏登估计量,并通过案例研究,比较了合成漏登估计量与单重漏登估计量.实证研究结果表明:四种合成漏登估计量估计的漏登率均高于单重漏登估计量;除其中一种合成漏登估计量估计的漏登率的抽样标准差略高于单重漏登估计量外,其他三种合成漏登估计量估计结果的抽样标准差均小于单重漏登估计量.研究结果为统计局和公安部未来制定户籍登记系统漏登估计方案提供重要参考,提高方案的科学性和可操作性.

关键词：抽样调查事后分层三系统估计量刀切法

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人口统计分析模型与人口普查净误差估计

系统科学与数学 2024年

作者：余鲁李婷 David López-carr 胡桂华吴笛漆莉重庆工商大学数学与统计学院 Department of Geography America University of California 重庆工商大学统计智能计算与监测重庆市重点实验室

本文旨在引入美国的人口统计分析模型,建立适合于在我国应用的人口统计分析模型.采取文献解读法和概率模型法,研究人口统计分析模型及其相关问题.研究结果表明:人口统计分析模型在我国的研究尚处于起步阶段,建立我国的人口统计分析模型... 详细信息

本文旨在引入美国的人口统计分析模型,建立适合于在我国应用的人口统计分析模型.采取文献解读法和概率模型法,研究人口统计分析模型及其相关问题.研究结果表明:人口统计分析模型在我国的研究尚处于起步阶段,建立我国的人口统计分析模型,不能照搬美国的人口统计分析模型,而应该结合我国实际情况有所改进与创新;建立人口统计分析模型分为两个层次,一是建立基于全面资料的人口统计分析模型,无需计算抽样方差,二是建立基于抽样调查资料的人口统计分析模型,需采用刀切法近似计算其抽样方差;人口统计分析模型的优势是,充分利用了出生、死亡及国际迁移等人口行政记录资料,节约了数据采集成本,与人口普查独立,劣势是,估计结果具有不确定性,尤其是其中的国际净迁移人数的估计结果差异较大.人口统计分析模型有望应用于我国2030年人口普查净误差估计,开创我国在该领域使用人口统计分析模型的先河.

关键词：人口普查人口普查质量评估行政记录抽样调查刀切法

Comparison of patients with hepatitis B virus-associated hepatocellular carcinoma:Data from two hospitals from Turkey and China

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Portal Hypertension & Cirrhosis 2023年第4期2卷 165-170页

作者： Brian i.carr Fajuan Rui Volkan ince Sezai Yilmaz Xinya Zhao Yuemin Feng Jie Li Liver Transplantation institute Inonu UniversityMalatyaTurkey Department of infectious Diseases Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese MedicineNanjingJiangsuChina Department of Radiology Shandong Provincial Hospital Affiliated to Shandong UniversityJinanShandongChina Department of Gastroenterology Shandong Provincial Hospital Affiliated to Shandong UniversityJinanShandongChina Department of infectious Diseases Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsuChina

Aims:There are many studies on the incidence of hepatitis B virus(HBV)-associated hepatocellular carcinoma(HCC),but very little is known about the HCC features in different *** study aimed to compare characteristics in two cohorts of patients with HBV-associated hepatocellular carcinoma from Turkey and ***:Data on patients with HBV-associated HCC diagnosed by imaging or liver biopsy were retrospectively collected from Shandong Provincial Hospital(n=578)and inonu University Hospital(n=359)between January 2002 and December 2020,and the liver function and HCC characteristics were *** variables were compared using Student's t-test or Mann-Whitney U test and categorical variables were compared using the χ^(2) test or Fisher's exact ***:The patients in the Turkish cohort had significantly worse Child-Pugh scores(Child-Pugh A:38.3%vs.87.9%;Child-Pugh B:40.3%vs.11.1%;Child-Pugh C:21.4%vs.1.0%;pignificantly higher levels of aspartate aminotransferase(66.5[38.0−126.0]vs.36.0[27.0-50.0]iU/L;pine aminotransferase(47.5[30.0−87.3]vs.33.0[24.0−45.0]iU/L;pilirubin(20.8[13.7−39.3]vs.17.9[13.8−24.0]mg/dL;pin levels(32.0[26.0-39.0]vs.40.0[36.1-43.8]g/L;pients in Chinese *** tumor characteristics showed the Barcelona Clinic Liver Cancer(BCLC)score(BCLC 1:5.1%vs.71.8%;BCLC 2:48.7%vs.24.4%;BCLC 3:24.4%vs.3.8%;BCLC 4:21.8%vs.0;all pimum tumor diameter(5.0[3.0-9.0]vs.3.5[2.5−6.0]cm;pin values(27.7 vs.13.2 ng/mL;pients with portal vein tumor thrombus(33%vs.6.1%;pignificantly worse in the Turkish cohort compared with Chinese ***:HBV-associated HCC from the Turkish cohort had worse liver function and more aggressive clinical characteristics than patients from the Chinese cohort.

关键词： China Hepatocellular Carcinoma Turkey

哈佛一门为期4天的高管课程为何令名人趋之若鹜

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商业周刊（中文版） 2024年第12期 12-13页

作者： MAustin carr 易语(译) 不详

安妮塔·埃尔贝斯(Anita Elberse)从事明星商业帝国腾飞成因的研究,并在哈佛商学院(Harvard Business School,HBS)开了一门高管教育课程,不少知名人物慕名而来一群学生正在HBS麦科勒姆楼(McCollum Hall)的教室里等着和安妮塔·埃尔贝斯... 详细信息

安妮塔·埃尔贝斯(Anita Elberse)从事明星商业帝国腾飞成因的研究,并在哈佛商学院(Harvard Business School,HBS)开了一门高管教育课程,不少知名人物慕名而来一群学生正在HBS麦科勒姆楼(McCollum Hall)的教室里等着和安妮塔·埃尔贝斯自拍合影。他们刚刚完成她在这里开设的备受追捧的高管教育课程。

关键词：哈佛商学院贝斯埃尔知名人物高管

Review of therapies for intermediate and advanced stage hepatocellular carcinoma, not suitable for curative therapies: a rapidly changing landscape

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Hepatoma Research 2019年第1期5卷 26-35页

作者： Brian i.carr Liver Transplantation institute Inonu UniversityMalatyaTurkey and Izmir Biomedicine and Genome CenterDokuz Eylul UniversityIzmir 35340Turkey

Recent clinical trials and new agents have permitted greater clarity in the choice of effective agents for that majority of patients with hepatocellular carcinoma who have advanced disease at diagnosis and thus cannot be offered potentially curative resection,ablation or liver *** main treatment for these patients remains chemoembolization,although evidence for selective internal radiation therapy(SiRT)with SiR-Spheres or Theraphere,is beginning to suggest that the results with this may be comparable with less *** who have failed chemoembolization or SiRT or have metastatic disease at presentation are suitable for the multikinase inhibitor sorafenib(nexavar)or newly-approved lenvatinib(lenvima)as first line *** choice between which of them to use first is not currently *** who have failed sorafenib can be offered a choice of FDA-approved regorafenib(stivarga)or immune checkpoint inhibitor nivolumab(opdivo)as second line *** that considerable percent of patients presenting with macroscopic portal vein thrombosis,the choice appears to be between multikinase inhibitor or SiRT,given the potential toxicity of chemoembolization in this ***,considering the potency of both nivolumab and regorafenib and the pipeline of new agents such as atezolizumab(tecentriq)in current clinical trials,including new immune checkpoint inhibitors,this landscape may change within a couple of years,especially if new evidence arises for the superior effectiveness of combinations of any of these agents over single agents.

关键词： Hepatocellular carcinoma advanced kinase inhibitors immune checkpoint inhibitors transarterial chemoembolization selective internal radiation therapy

Early clinical outcomes of two regimens of prophylactic antibiotics in cardiac surgical patients with delayed sternal closure

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World Journal of Critical Care Medicine 2024年第3期13卷 32-41页

作者： Mahmoud ismail Allam Eissa Rasha Kaddoura Danial Hassan Cornelia S carr Samy Hanoura Yasser Shouman Abdulwahid Almulla Amr Salah Omar Department of Cardiothoracic Surgery Hamad Medical CooperationDoha 3050Qatar Department of Anesthesia and intensive Care Al-Azhar UniversityCairo 11651Egypt Department of Pharmacy Heart HospitalHamad Medical CorporationDoha 3050Qatar Department of Healthcare Profession Harvard TH Chan School of Public HealthMinistry of Public HealthBostonMA 3050United States Department of Surgery Qatar UniversityDoha 3050Qatar Department of Cardiac Anesthesia Hamad Medical CorporationDoha 3050Qatar Department of Anesthesia Weill Cornell Medical College in QatarDoha 3050Qatar Department of Critical Care Medicine Beni Suef UniversityBeni Suef 62521Egypt Department of Medicine Weill Cornell Medical College in QatarDoha 3050Qatar

BACKGROUND Delayed sternal closure(DSC)can be a lifesaving approach for certain patients who have undergone cardiac *** value of the type of prophylactic antibiotics in DSC is still *** To investigate clinical outcomes of different prophylactic antibiotic regimens in patients who had DSC after cardiac *** This was a retrospective observational single-center ***-three consecutive patients who underwent cardiac surgery and had an indication for DSC were *** were subjected to two regimens of antibiotics:Narrow-spectrum and broad-spectrum *** The main outcome measures were length of hospital and intensive care unit(iCU)stay,duration of mechanical ventilation,and *** the 53 patients,12(22.6%)received narrow-spectrum antibiotics,and 41(77.4%)received broad-spectrum *** mean age was 59.0±12.1 years,without significant differences between the *** mean duration of antibiotic use was significantly longer in the broad-spectrum than the narrowspectrum group(11.9±8.7 vs 3.4±2.0 d,Pian duration of open chest was 3.0(2.0-5.0)d for all patients,with no difference between groups(P=0.146).The median duration of mechanical ventilation was significantly longer in the broad-spectrum group[60.0(Δinterquartile range(iQR)170.0)h vs 50.0(ΔiQR 113.0)h,P=0.047].Similarly,the median length of stay for both iCU and hospital were significantly longer in the broadspectrum group[7.5(ΔiQR 10.0)d vs 5.0(ΔiQR 5.0)d,P=0.008]and[27.0(ΔiQR 30.0)d vs 19.0(ΔiQR 21.0)d,P=0.031].Five(9.8%)patients were readmitted to the iCU and 18(34.6%)patients died without a difference between *** Prophylactic broad-spectrum antibiotics did not improve clinical outcomes in patients with DSC post-cardiac surgery but was associated with longer ventilation duration,length of iCU and hospital stays vs narrow-spectrum antibiotics.

关键词： Cardiac surgery Delayed sternal closure intensive care Open chest Prophylactic antibiotics