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Assessment of the piroxicam-incited model of synchronized colitis in T-cell receptor alpha chain-deficient mice

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Animal Models and Experimental Medicine 2024年第4期7卷 533-543页

作者： Maximo E.Lange Danisa M.Bescucci Valerie F.Boras Tony Montina g.douglas Inglis Lethbridge Research and Development Centre Agriculture and Agri-Food CanadaLethbridgeAlbertaCanada Alberta Health Services Chinook Regional HospitalLethbridgeAlbertaCanada Department of Chemistry and Biochemistry University of LethbridgeLethbridgeAlbertaCanada Southern Alberta genome Sciences Centre University of LethbridgeLethbridgeAlbertaCanada

Background:A multitude of mouse models are utilized to emulate and study intestinal inflammation.T-cell receptor alpha chain(TCRα)-deficient mice are used as a model of spontaneous colitis that has similarities with human ulcerative ***,colitis is triggered late in the life of the mouse(age:4-5 months),and inflammation does not develop at the same time in different mice.A previously conducted study reported that the administration of the drug piroxicam triggered predictable and early colitis in TCRα-deficient mice at the age of 6-8 ***,a detailed characterization of ensuing inflammation was not ***:We conducted an in-depth examination of piroxicam-triggered colitis in TCRα-deficient mice,with emphasis on spatial histopathologic changes and analysis of expression of inflammatory ***,we tested amelioration of colitis with ***:We confirmed that piroxicam induced a time-prescribed colitis and did so in the proximal colon as well as the cecum of TCRα-deficient *** adminis-tration was observed to induce epithelial hyperplasia,goblet cell loss,and leukocyte infiltration with occasional ulceration.A Swiss roll technique was used to examine the colon and cecum in its ***,we observed that inflammation was mul-tifocal segmental,with areas of tissue damage in between healthy *** addition,we observed variability in the severity of inflammation among replicate animals and treatments,and that the administration of dexamethasone only partially ameliorated inflammation in the proximal ***:Piroxicam consistently induced multifocal segmental colitis in the proxi-mal colon and cecum,although the degree of inflammation was reduced in the ***,spatial variability in inflammation in the large intestine and the inter-replicate variation in the severity of inflammation must be taken into consideration when utilizing this murine model of synchronized colitis.

关键词： colon dexamethasone histology induction inflammation knockout

Materials and technology of Chinese jades dating to the Western Zhou period (1050―771 BCE)

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Science China(Technological Sciences) 2008年第4期51卷 467-480页

作者： Janet g.douglas Department of Conservation and Scientific Research Freer Gallery of Art / Arthur M. Sackler Gallery Smithsonian Institution

Excavated jades dating to the Western Zhou period (1050―771 BCE) from the Xi’an area in Shaanxi Province, China, and contemporaneous jades in the collections of the Arthur M. Sackler gallery at the Smithsonian Institution have been studied to learn about the jade and stone materials and how they were worked during the Western Zhou period. Materials identification was carried out using a combination of techniques such as Fourier-transform infrared spectroscopy and X-ray diffraction. Tool marks were studied using stereomicroscopy and examination of mold impressions using scanning electron microscopy. All of these objects were pro- duced through simple processes involving solid drilling, riffling, and sharp point abrasion; and no evidence was found for the use of rotary tools for incising or sawing.

关键词： jade nephrite stone China Western Zhou scanning electron microscopy materials technology tool marks

Network design for local agriculture using robust optimization

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Information Processing in Agriculture 2021年第3期8卷 469-483页

作者： Ashish Kambli ronald g.Mcgarvey Department of Industrial and Manufacturing Systems Engineering University of MissouriColumbiaMO 65211United States Harry S Truman School of Public Affairs University of MissouriColumbiaMO 65211United States

For small farmers wishing to sell their products under the “local agriculture”marketing con-cept,connecting with consumers can be *** approach to mitigating this discon-nect between where production occurs and where consumers reside is through a network of regional consolidation *** this study,we utilize optimization models to assist the Mis-souri Coalition of Environment(MCE)in helping farmers from Missouri and Illinois route products from their farms to a central hub in *** aim of this study was to minimize the ton-miles traveled by farmers and MCE vehicles in delivering agricultural products from farms to regional hubs to the central *** historical data about variability of plant and animal production in the greater Plains region,a robust optimization approach was incorpo-rated to increase the likelihood that the network can accommodate uncertainty in agricul-tural ***/CPLEX was used to solve the model under different configurations and identify potential locations for regional *** testing determined that the capacity of hubs plays a key role in the optimal assignments:given the assumed model constraint that farmers can travel only to their nearest regional hub,solutions may sacrifice a better objective function value in order to accommodate farmers’travel requirements.

关键词： Optimization Robustness and sensitivity analysis Supply chain management

The paternal epigenome and embryogenesis： poising mechanisms for development

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Asian Journal of Andrology 2011年第1期13卷 76-80页

作者： Timothy g Jenkins douglas T Carrell Andrology and IVF Laboratories Department of Surgery University of Utah Salt Lake City UT 84108 USA Department of Obstetrics and gynecology University of Utah School of Medicine Salt Lake City UT 84108 USA Department of Physiology University of Utah School of Medicine Salt Lake City UT 84108 USA

The scope of paternal contributions during early embryonic development has long been considered limited. Dramatic changes in chromatin structure throughout spermatogenesis have been thought to leave the sperm void of complex layers of epigenetic regulation over the DNA blueprint, thus leaving the balance of that regulation to the oocyte. However, recent work in the fields of epigenetics and male factor infertility has placed this long-held, and now controversial dogma, in a new light. Elegant studies investigating chromatin and epigenetic modifications in the developing sperm cell have provided new insights that may establish a more critical role for the paternal epigenome in the developing embryo. DNA methylation, histone tail modifications, targeted histone retention and protamine incorporation into the chromatin have great influence in the developing sperm cell. Perturbations in the establishment and/or maintenance of any of these epigenetic marks have been demonstrated to affect fertility status, ranging in severity from mild to catastrophic. Sperm require this myriad of chromatin structural changes not only to serve a protective role to DNA throughout spermatogenesis and future delivery to the egg, but also, it appears, to contribute to the developmental program of the future embryo. This review will focus on our current understanding of the epigenetics of sperm. We will discuss sperm-specific chromatin modifications that result in genes essential to development being poised for activation early in embryonic development, the disruption of which may result in reduced fecundity.

关键词： chromatin DNA methylation embryogenesis epigenetics histone modification male infertility

In search of America's old covered bridges

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Built Heritage 2021年第2期5卷 16-38页

作者： ronald g.Knapp State University of New York PO Box 365New PaltzNY 12561-0365USA

America's first documented wooden covered bridge was erected at Philadelphia,Pennsylvania in *** were constructed within two decades and at least 10,000 by the later *** settlers moved West,broad rivers were crossed with inventive structures incorporating timber trusses ingeniously developed by *** covered bridges because of the roof and siding needed to protect the timber trusses,they became ubiquitous features on the American *** the past two centuries,most covered bridges were lost to flood,ice,arson,lightening,decay,as well as"progress,"replaced by"modern"iron,concrete,and steel *** some 700 covered bridges remaining,many are mere replicas of their original forms no longer supported by timber *** historic bridges remain largely from the last half of the 1800s while civic boosterism has led to claims of earlier dates with often questionable *** essay presents three wooden covered bridges constructed in the 1820s along a 10-mile stretch of the Wallkill River in New Paltz,New *** the three,only Perrine's Bridge,constructed first in 1821 and covered in 1822,is still standing with intact Burr timber ***'s is an iconic structure with exceptional heritage value because of authentic re-building and restoration in 1834,1846,1917,and *** documentary records,this essay establishes an accurate intertwined chronology for the three bridges,detailing nineteenth century building practices and contentious mid-twentieth century struggles pitting preservationists wanting authentic restoration against those wanting removal.

关键词： Covered Bridge Timber truss Burr truss Town lattice truss Perrine's Bridge New Palt Bridge Phillies Bridge New York State New Paltz Conservation Restoration

From Paging to Staging Shakespeare: Interdisciplinary Perspectives

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外国语 1989年第1期12卷 3-7页

作者： ronald g.Shafer 美国宾州印第安那大学

本文从多科性交错的视角探讨莎士比亚戏剧的内涵。由全美人文学科基金会资助的暑期莎士比亚研讨会融汇了多科学科,主要有舞台、剧本、电影、同时还引进了美术、历史、政治、音乐。研讨会的专家们认为,剧本从来都不是裸露的,而是由连我... 详细信息

本文从多科性交错的视角探讨莎士比亚戏剧的内涵。由全美人文学科基金会资助的暑期莎士比亚研讨会融汇了多科学科,主要有舞台、剧本、电影、同时还引进了美术、历史、政治、音乐。研讨会的专家们认为,剧本从来都不是裸露的,而是由连我们做梦也没有想到的种种释义包裹着。多科性交错的探索方法剥离了使剧本带上色彩的层层偏见。在研讨会上,人们摆脱了框框,不再对剧本作出武断的定论,而是把人物从僵硬的观念中解放出来,把剧本从一个子虚乌有的“正确”释义中解脱出来。本文值得一读。

关键词：释义研讨会多科性莎士比亚戏剧人文学科交错基金会视角音乐美术

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An implementation strategy to quantify the marine microbial carbon pump and its sensitivity to global change

1980年

作者： g.douglas atkins laura morrow原文张双英黄景进中译

来源：汇雅图书（南通市图书馆... 评论

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National Science Review 2018年第4期5卷 474-480页

作者： Carol Robinson douglas Wallace Jung-Ho Hyun Luca Polimene ronald Benner Yao Zhang Ruanhong Cai Rui Zhang Nianzhi Jiao University of East Anglia School of Environmental Sciences Oceanography Department Dalhousie University Hanyang University Department of Marine Science and Convergence Engineering Plymouth Marine Laboratory University of South Carolina Department of Biological Sciences and School of the EarthOcean and Environment State Key Laboratory of Marine Environmental Science and Institute of Marine Microbes and Ecospheres

INTRODUCTION The persistence of the vast pool of recalcitrant dissolved organic carbon(RDOC)in the deep ocean is fundamental to both global carbon cycling and global ***,quantitative understanding of the mechanisms that produce and utilize RDOC is still in its *** from a conceptual framework to quantitative understanding in marine carbon cycling can take the international research community several decades—precious time

关键词： MCP An implementation strategy to quantify the marine microbial carbon pump and its sensitivity to global change

Solid state interfacial reactions in electrodeposited Ni/Sn couples

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International Journal of Minerals,Metallurgy and Materials 2010年第4期17卷 459-463页

作者： Wen-ming Tang An-qiang He Qi Liu douglas-g. Ivey Department of Materials Science and Engineering Hefei University of Technology Hefei 230009 China Department of Chemical and Materials Engineering University of Alberta Edmonton T6G 2G6 Canada

Ni/Sn couples, prepared by sequentially electroplating Ni layers and Sn layers on metallized Si wafers, were employed to study the microstructures and growth kinetics of Ni-Sn intermediate phases, when the Ni/Sn couples were aged at room temperature or armealed at temperatures from 150 to 225℃ for various times. The results show that the NiSn phase and Ni3Sn4 phase are formed, respectively, in the aged couples and annealed couples. The Ni3Sn4 layer is continuously distributed between the Ni and Sn sides in the annealed Ni/Sn couples. The Ni3Sn4 growth follows parabolic growth kinetics with an apparent activation energy of 39.0 kJ/mol.

关键词： electrodeposition solid state reaction diffusion microstructure kinetics