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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan wan.wan. Bin wan. Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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Study on vibration reduction of two-scale system coupled with dynamic vibration absorber

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Applied Mathematics and Mechanics(English Edition) 2024年第8期45卷 1335-1352页

作者： Honglin wan.Xianghong LI Yongjun shen Department of Mathematics and Physics Shijiazhuang Tiedao UniversityShijiazhuang 050043China State Key Laboratory of Mechanical Behavior and System Safety of Traffic Engineering Structures Shijiazhuang Tiedao UniversityShijiazhuang 050043China School of Mechanical Engineering Shijiazhuang Tiedao UniversityShijiazhuang 050043China

The dynamic vibration absorber with inerter and grounded stiffness(IGDVA)is used to control a two-scale system subject to a weak periodic *** vibration suppression effect is *** amplitude of the main system coupled with absorber is significantly reduced,and the high frequency vibration completely ***,through the slow-fast analysis and stability theory,it is found that the stability of the autonomous system exerts a notable regulating effect on the vibration response of the non-autonomous *** adding the dynamic vibrator absorber,the center in the autonomous system changes to an asymptotically stable focus,consequently suppressing the vibration in the non-autonomous *** research reveals that the parameters of the absorber affect the real parts of the eigenvalues of the autonomous system,thereby regulating the stability of the *** from a qualitative standpoint to a quantitative approach,a comparison of the solutions before and after the introduction of the dynamic absorber reveals that,when the grounded stiffness ratio and the mass ratio of the dynamic absorber are not equal,the high-frequency part in the analytical solution *** a result,this leads to a reduction in the amplitude of the trajectory,achieving a vibration reduction effect.

关键词： two-scale system dynamic vibration absorber vibration control inerter

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Alternating nitrogen feeding strategy induced aerobic granulation:Influencing conditions and mechanism

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Journal of Environmental Sciences 2021年第11期33卷 135-147页

作者： Chunli wan.Zhengwen Li Yanggui shen Xiang Liu Department of Environmental Science and Engineering Fudan UniversityShanghai 200438China College of Materials Science and Chemical Engineering Harbin Engineering UniversityHarbin 150001China

Effective cultivation of stable aerobic granular sludge(AGS)is a crucial step in the successful application of this technology,and the formation of AGS could be facilitated by some environmental stress *** identical sequencing batch reactors(SBRs)were established to investigate the aerobic granulation process under the same alternating ammonia nitrogen feeding strategy superimposed with different environmental conditions(inorganic carbon source,temperature,N/COD).Although various superimposed conditions induced a significant difference in the size,settling velocity,mechanic strength of AGS,mature aerobic granules could be successfully obtained in all four reactors after 70 days’operation,indicating the alternating ammonia nitrogen feeding strategy was the most critical factor for AGS *** on the results of redundancy analysis,the presence of an inorganic carbon source could facilitate the cultivation of AGS with nitrification function,while the moderate temperature and fluctuant N/COD might benefit the cultivation of more stable *** addition,superimposed stress conditions could result in the difference in the microbial population between four reactors,but the population diversity and abundance of microorganisms were not the determinants of AGS *** study provided an effective method for the cultivation of AGS by using alternating ammonia nitrogen feeding strategy.

关键词： Aerobic granule sludge Granulation Alternating nitrogen feeding Cultivation

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Wind turbine clutter mitigation using morphological component analysis with group sparsity

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Journal of Systems Engineering and Electronics 2023年第3期34卷 714-722页

作者： wan.Xiaoyu shen Mingwei WU Di ZHU Daiyin College of Computer and Information Hohai UniversityNanjing 211100China Key Laboratory of Radar Imaging and Microwave Photonics&Ministry of Education Nanjing University of Aeronautics and AstronauticsNanjing 210016China

To address the problem that dynamic wind turbine clutter(WTC)significantly degrades the performance of weather radar,a WTC mitigation algorithm using morphological component analysis(MCA)with group sparsity is studied in this *** ground clutter is suppressed firstly to reduce the morphological compositions of radar *** that,the MCA algorithm is applied and the window used in the short-time Fourier transform(STFT)is optimized to lessen the spectrum leakage of ***,the group sparsity structure of WTC in the STFT domain can be utilized to decrease the degrees of freedom in the solution,thus contributing to better estimation performance of weather *** effectiveness and feasibility of the proposed method are demonstrated by numerical simulations.

关键词： weather radar wind turbine clutter(WTC) morphological component analysis(MCA) short-time Fourier transform(STFT) group sparsity

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Asymmetric Difluoromethylthiolation of Carbon Nucleophiles with Optically Pure Difluoromethylthiolating Reagents Derived from Camphorsultam

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Chinese Journal of Chemistry 2019年第10期37卷 1041-1050页

作者： He Zhang Xiaolong wan.Qilong shen Key Laboratory of Organofluorine Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of Sciences345 Lingling LuShanghai 200032China

The invention of a family of optically pure electrophilic difluoromethylthiolating reagents 9a-c based on the camphorsultam skeleton was *** reagents reacted with a variety of soft carbon nucleophiles such as oxazolon... 详细信息

关键词： thiol skeleton Reagent

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Triangular domain extension of linear Bernstein-like trigonometric polynomial basis

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第5期11卷 356-364页

作者： wan.qiang shen Guo-zhao wan. Department of Mathematics Zhejiang University Hangzhou 310027 China

In computer aided geometric design(CAGD),the Bernstein-Bézier system for polynomial space including the triangular domain is an important tool for modeling free form *** Bernstein-like bases for other spaces(trigonometric polynomial,hyperbolic polynomial,or blended space) has also been ***,none of them was extended to the triangular *** this paper,we extend the linear trigonometric polynomial basis to the triangular domain and obtain a new Bernstein-like basis,which is linearly independent and satisfies positivity,partition of unity,symmetry,and boundary *** prove some properties of the corresponding surfaces,including differentiation,subdivision,convex hull,and so *** applications are shown.

关键词： Computer aided geometric design(CAGD) Free form modeling Trigonometric polynomial Basis function Bernstein basis Triangular domain

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Degree elevation from Bzier curve to C-Bzier curve with corner cutting form

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Applied Mathematics(A Journal of Chinese Universities) 2016年第2期31卷 165-176页

作者： shen wan.qiang wan. Guo-zhao School of Science Jiangnan University Wuxi 214122 China Department of Mathematics Zhejiang University Hangzhou 310027 China State Key Lab of CAD & CG Zhejiang University Hangzhou 310027 China.

The existing results of curve degree elevation mainly focus on the degree of algebraic polynomials. The paper considers the elevation of degree of the trigonometric polynomial, from a Bezier curve on the algebraic polynomial space, to a C-Bezier curve on the algebraic and trigonometric polynomial space. The matrix of degree elevation is obtained by an operator presentation and a derivation pyramid. It possesses not a recursive presentation but a direct expression. The degree elevation process can also be represented as a corner cutting form.

关键词： Curve modeling Bezier curve C-Bezier curve Degree elevation Corner cutting.

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Reproductive polyphenism and its advantages in aphids:Switching between sexual and asexual reproduction

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Journal of Integrative Agriculture 2020年第6期19卷 1447-1457页

作者： YAN Shuo wan. wan.xing shen Jie Department of Entomology/MOA Key Lab of Pest Monitoring and Green Management College of Plant ProtectionChina Agricultural UniversityBeijing 100193P.R.China Key Lab of Biology and Genetic Improvement of Root and Tuber Crops Institute of Vegetables and FlowersChinese Academy of Agricultural SciencesBeijing 100081P.R.China

Reproductive polyphenism,which allows one genotype to produce sexual and asexual morphs,is an extreme case of phenotypic plasticity and is commonly observed in *** are typical species that switch these reproductive modes,and the pathway orientation is triggered by the environmental conditions(mainly photoperiod and temperature).The typical arm ual life of aphids in eludes a successi on of parthenogenetic gen erations duri ng the spri ng and summer and a single sexual generation in *** this review,we describe how the environmental cues orientate the reproductive mode of aphids from photoperiodic perception to endocrine regulation,and how juvenile hormones may act on the target cells(oocytes)to initiate the gametogenesis and embryogenesis in sexual and asexual *** also discuss the paradox of sex,especially the advantages of sexual reproduction in *** the recent development of genomic resources in aphids,many potential genes involved in the reproductive polyphenism will enter the public's *** particular,we describe a novel RNAi method in aphids,which may provide a molecular technique for determining the developmental fate and multiple reproductive strategies.

关键词： aphids parthenogenesis embryogenesis gametogenesis photoperiodism

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In situ construction of Cu(Ⅰ)-Cu(Ⅱ) pairs for efficient electrocatalytic nitrate reduction reaction to ammonia

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Journal of Energy Chemistry 2025年第1期 106-113页

作者： Muyun Zheng Yuchi wan.Leping Yang shen Ao wan.yang Fu Zhengjun Zhang Zheng-Hong Huang Tao Ling Feiyu Kang Ruitao Lv State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and Engineering Tsinghua University Institute of New Energy Materials and Engineering School of Materials Science and Engineering Fuzhou University Key Laboratory of Advanced Materials (MOE) School of Materials Science and Engineering Tsinghua University Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and Engineering Tianjin University

Electrocatalytic nitrate reduction reaction （NO3-RR） to ammonia under ambient conditions is expected to be a green process for ammonia synthesis and alleviate water pollution *** report a CuO nanoparticles incorporated on nitrogen-doped porous carbon （CuO@NC） catalyst for *** of Cu（Ⅱ） is reduced to Cu（Ⅰ） during the NO3-RR process to construct Cu（Ⅰ）-Cu（Ⅱ） pairs,confirmed by in situ X-ray photoelectron spectroscopy （XPS） and Raman *** functional theory （DFT） calculations indicated that the formation of Cu（Ⅰ） could provide a reaction path with smaller energy barrier for NO3-RR,while Cu（Ⅱ） effectively suppressed the competition of hydrogen evolution reaction （HER）.As a result,CuO@NC catalyst achieved a Faradaic efficiency of 84.2% at -0.49 V versus reversible hydrogen electrode （RHE）,and a NH3yield rate of 17.2 mg *** -0.79 V ***,higher than the HaberBosch process (<3.4 g h-1g-1cat.).This work may open a new avenue for effective NO3-RR by modulating oxidation states.

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基于消费需求的夜间登山智能鞋类设计

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皮革科学与工程 2025年第1期35卷 63-69页

作者：孟子衿申鸿黄元菁杨文静宛如玉四川大学轻工科学与工程学院四川成都610065 温州鞋革产业研究院浙江温州325000

伴随着登山运动的不断普及以及鞋服智能化程度的不断加深,登山鞋靴的设计也亟待转型升级。以夜间登山智能鞋为研究对象,从消费者视角出发,通过词频分析法识别夜间登山鞋在实用性和智能化方面的关键需求,即发光和定位两大功能。总结出发... 详细信息

伴随着登山运动的不断普及以及鞋服智能化程度的不断加深,登山鞋靴的设计也亟待转型升级。以夜间登山智能鞋为研究对象,从消费者视角出发,通过词频分析法识别夜间登山鞋在实用性和智能化方面的关键需求,即发光和定位两大功能。总结出发光和定位两大类功能中的10项细分功能点,采用问卷调查法分析消费群体对各功能点的需求程度和需求差异。最后采用发光二极管(Light Emitting Diode,LED)、荧光面料、全球定位系统(Global Positioning System,GPS)和智能互联技术,设计了一款集成照明、提示、导航、求助和互动等多种功能的智能夜间登山鞋。设计方案不仅拓展了登山鞋的功能性设计思路,且为夜间登山智能鞋的设计和制作提供了实践参考,有助于推动户外运动产业的智能化发展,满足消费者对夜间登山活动安全性和便捷性的要求。

关键词：智能鞋登山鞋消费需求鞋类设计户外运动智能可穿戴

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