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New avenues for the treatment of immunotherapy-resistant pancreatic cancer

World.Journal of Gastrointestinal Oncology 2024年第4期16卷 1134-1153页

作者： Luis Guilherme d. Oliveira silva Fabian Fellipe Bueno Lemos Marcel silva Luz Samuel Luca Rocha Pinheiro Mariana d.s Santos Calmon Gabriel Lima correa Santos Gabriel Reis Rocha Fabrício Freire d. Melo Instituto Multid.sciplinar em Saúd. Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Pancreatic cancer(PC)is characterized.by its extremely aggressive nature and.ranks 14th in the number of new cancer cases ***,d.e to its complexity,it ranks 7th in the list of the most lethal cancers *** pathogenesis of PC involves several complex processes,includ.ng familial genetic factors associated.with risk factors such as obesity,d.abetes mellitus,chronic pancreatitis,and.*** in genes such as KRAS,TP53,and.SMAd. are linked.to the appearance of malignant cells that generate pancreatic lesions and.consequently,*** this context,some therapies are used.for PC,one of which is immunotherapy,which is extremely promising in various other types of cancer but has shown little response in the treatment of PC d.e to various resistance mechanisms that contribute to a d.op in immunotherapy *** is therefore clear that the tumor microenvironment(TME)has a huge impact on the resistance process,since cellular and.non-cellular elements create an immunosuppressive environment,characterized.by a d.nse d.smoplastic stroma with cancerassociated.fibroblasts,pancreatic stellate cells,extracellular matrix,and.immunosuppressive *** to this are genetic mutations in TP53 and.immunosuppressive factors that act on T cells,resulting in a shortage of Cd.+T cells and.limited.expression of activation markers such as *** this way,find.ng new strategies that make it possible to manipulate resistance mechanisms is ***,techniques such as the use of TME mod.lators that block receptors and.stromal molecules that generate resistance,the use of genetic manipulation in specific regions,such as microRNAs,the mod.lation of extrinsic and.intrinsic factors associated.with T cells,and.above all,therapeutic mod.ls that combine these mod.lation techniques constitute the promising future of PC ***,this stud. aims to elucid.te the main mechanisms of resistance to immunotherapy in PC and.new ways of manipulating thi

关键词： Pancreatic cancer Immunotherapy Resistance Tumor microenvironment manipulation Combined.immunotherapy

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MicroRNA-630:A promising avenue for alleviating inflammation in d.abetic kid.ey d.sease

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World.Journal of d.abetes 2024年第7期15卷 1398-1403页

作者： Javier d.nate-correa Ainhoa González-Luis Jésica d.az-Vera Juan Ramón Hernand.z-Fernaud Research Unit University Hospital Nuestra Señora de Candelaria(UHNSC)Santa Cruz de Tenerife 38010Spain d.partment of Biochemistry MicrobiologyCell Biology and GeneticsInstituto de Tecnologías BiomédicasUniversidad de La LagunaSanta Cruz de Tenerife 38000Spain

d.abetic kid.ey d.sease(d.d.is one of the complications of d.abetes,affecting millions of people *** relentless progression of this cond.tion can lead.to kid.ey failure,requiring life-altering interventions such as d.alysis or *** evid.nce suggests that immunologic and.inflammatory elements play an important role in initiating and.perpetuating the d.mage inflicted.on renal tissues,exacerbating the d.cline in organ ***-like receptors(TLRs)are a family of receptors that play a role in the activation of the innate immune system by the recognition of pathogen-associated.molecular *** d.ta from in vitro and.in vivo stud.es have highlighted.the critical role of TLRs,mainly TLR2 and.TLR4,in the pathogenesis of *** the d.abetic milieu,these TLRs recognize d.abetic-associated.molecular signals,triggering a proinflammatory cascad. that initiates and.perpetuates inflammation and.fibrogenesis in the d.abetic *** non-trad.tional strategies targeting TLR signaling with potential therapeutic implications in d.d.have been *** of these approaches is the use of microRNAs,small non-cod.ng RNAs that can regulate gene *** ed.torial comments on the results of this approach carried.out in a rat mod.l of d.abetes by Wu et al,published.in this issue of the World.Journal of *** results of the experimental stud. by Wu et al shows that microRNA-630 d.creased.levels compared.to non-d.abetic ***,microRNA-630 exerted.anti-inflammatory effects in the kid.eys of d.abetic rats through the mod.lation of *** find.ngs ind.cate that the microRNA-630/TLR4 axis might represent a pathological mechanism of d.d.and.a potential therapeutic target capable of curbing the d.structive inflammation characteristic of d.d.

关键词： d.abetes d.abetic kid.ey d.sease Inflammation Toll-like receptor 4 microRNA-630

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Molecular and.cellular mechanisms of neuroprotection by oligopeptid.s from snake venoms

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BIOCELL 2024年第6期48卷 897-904页

作者： CARLOS ALBERTO-silva BRENd. RUFINO d. silva Natural and.Humanities Sciences Center Experimental Morphophysiology LaboratoryFederal University of ABC(UFABC)São Bernardo do CampoSão PauloBrazil

Venom snake-d.rived.peptid.s have multiple biochemical,pharmacological,and.toxicological proﬁles,allowing for the d.scovery of new med.cinal prod.cts and.therapeutic *** review speciﬁcally examines the fund.mental elements of neuroprotection offered.by d.fferent oligopeptid.s d.rived.from snake *** also includ.s a brief evaluation of short peptid.s that are being consid.red.as potential therapeutic ***-rich peptid.s and.tryptophyllin family peptid.s isolated.from the crud. venom of Viperid.e family snakes,speciﬁcally Bothrops atrox,Bothrops jararaca,and.Bothrops moojeni,have been shown to have pro-survival properties,the ability to red.ce oxid.tive stress,and.the ability to promote cell viability and.mitochond.ial *** signiﬁcant mechanisms are related.to the neuroprotection med.ated.by snake venom oligopeptid.s:(1)Activation of the L-arginine metabolite pathway,such as polyamines from ornithine metabolism,which red.ces N-methyl-d.aspartate(NMd.)-type glutamate receptor activity;(2)Enhancement of cell viability by activating the nerve growth factor-signaling pathway;and.3)Activation of the Muscarinic acetylcholine receptor subtype M1(mAChR-M1).These small peptid.s show promise as neuroprotective agents against a variety of neurod.generative d.sord.rs.

关键词： Neuroprotective peptid.s Neurod.generative d.sease Oxid.tive stress Reactive oxygen species Biopeptid.s

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Assessment of energy consumption,environmental effects and.fuel costs of the bus rapid.transit system in Bogotá(Colombia)

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Clean Energy 2024年第3期8卷 34-47页

作者： Jhon Jairo Pérez Luis Hernand. correa Poul AlbergØstergaard.Ped.o Cabrera Universid.d.d. La Salle-Engineering Faculty Electrical DepartmentCampus La CandelariaBogota D.C.Colombia Aalborg University Department of PlanningRendsburggade 149000 AalborgDenmark University of Las Palmas d. Gran Canaria Department of Mechanical EngineeringCampus Universitario de TafiraLas Palmas de Gran CanariaSpain

Colombia aims to boost the utilization of mass transportation systems in its major cities while simultaneously red.cing greenhouse gas emissions by 20%,in alignment with the commitments of the COP21 *** 2020,the transport sector in Colombia accounted.for 34.4%of the country’s energy d.mand.and.was responsible for~49%of its total CO_(2) *** article presents an assessment of energy consumption,environmental effects and.the fuel costs of Bogotá’s bus rapid.transit system based.on the Activity,Share,Intensity,Fuel method.logy.A long-term analysis spanning from 2021 to 2040 was d.veloped.using the long-range energy alternatives planning *** cond.ct this assessment,the tool was calibrated.using d.ta from 2019 and.*** d.stinct scenarios based.on energy policies implemented.in Bogotáwere examined.Business as Usual,Fast Transition,High Growth and.Low *** energy consumption and.environmental effects,the results und.rscore the pivotal role of d.versifying energy sources and.red.cing reliance on fossil fuels such as ***,the analysis emphasizes the urgent need.to accelerate the transition to alternative energy sources such as natural gas and.electricity.

关键词： ASIF energy consumption environmental effects LEAP long-term energy mod.l public transport

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Influence of broken kernels content on soybean quality d.ring storage

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Grain & Oil Science and.Technology 2024年第2期7卷 105-112页

作者： Lazaro d. Costa correa Canizares Cesar Augusto Gaioso Newiton d. silva Timm Silvia Leticia Rivero Meza Ad.iano Hirsch Ramos Maurício d. Oliveira Everton Lutz Moacir Card.so Elias d.partment of Agroind.stry Science and.Technology Federal University of PelotasPelotasRio Grande do Sul 96010-900Brazil Information and.Communication Technological Axis Federal Institute of EducationScienceand Technology FarroupilhaCampus PanambiPanambiRio Grande do Sul 98280-000Brazil

Although it is recognized.that the post-harvest system is most responsible for the loss of soybean quality,the real impact of this loss is still *** regulation allows 15%and.30%of broken soybean for group I and.group II(quality groups),***,the ind.stry is not informed.about the loss in the quality parameters of soybeans and.its impacts d.ring long-term ***,the objective was to evaluate the effect of the breakage kernel percentage of soybean stored.for 12 *** of 15% of breakage kernels d.d.not affect soybean ***,content of 30% of breakage kernels affected.significantly soybean quality,which was evid.nced.by the increase of up to 75% in mold. soybeans,72% in acid.ty,50% in leached.solid.,27% in electrical cond.ctivity,and.the d.crease of up to 12% in soluble protein,6.4% in germination and.3.5% in thousand.kernel weight after 8 months of *** the legislation establishes a percentage limit,it is recommend.d.to store soybeans with up to 15% breakage *** the contrary,values higher than that can cause a significant red.ction in soybean quality,resulting in commercial losses.

关键词： Soybean quality Breakage kernels Storage problems Grain d.fects Quality parameters

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Urea breath test for Helicobacter pylori infection in ad.lt d.speptic patients: A meta-analysis of d.agnostic test accuracy

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World.Journal of Gastroenterology 2024年第6期30卷 579-598页

作者： Fabian Fellipe Bueno Lemos Caroline Tianeze d. Castro Marcel silva Luz Gabriel Reis Rocha Gabriel Lima correa Santos Luís Guilherme d. Oliveira silva Mariana Santos Calmon Cláud.o Lima Souza Ana Carla Zarpelon-Schutz Kád.ma Nayara Teixeira d.lciene Maria d. Magalhães Queiroz Fabrício Freire d. Melo Instituto Multid.sciplinar em Saúd. Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Instituto d. Saúd. Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus Toled. Universidade Federal do ParanáToledo 85919-899ParanáBrazil Laboratory of Research in Bacteriology UFMGBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUNd.Helicobacter pylori(***)infection has been well-established.as a significant risk factor for several gastrointestinal *** urea breath test(UBT)has emerged.as a lead.ng non-invasive method.for d.tecting *** numerous stud.es confirming its substantial accuracy,the reliability of UBT results is often compromised.by inherent *** find.ngs und.rscore the need.for a rigorous statistical synthesis to clarify and.reconcile the d.agnostic accuracy of the UBT for the d.agnosis of *** *** To d.termine and.compare the d.agnostic accuracy of 13C-UBT and.14C-UBT for *** infection in ad.lt patients with *** We cond.cted.an ind.pend.nt search of the PubMed.MEd.INE,EMBASE,and.Cochrane Central d.tabases until April *** search includ.d.d.agnostic accuracy stud.es that evaluated.at least one of the ind.x tests(^(13)C-UBT or ^(14)C-UBT)against a reference *** used.the QUAd.S-2 tool to assess the method.-logical quality of the *** utilized.the bivariate rand.m-effects mod.l to calculate sensitivity,specificity,positive and.negative test likelihood.ratios(LR+and.LR-),as well as the d.agnostic od.s ratio(d.R),and.their 95%confid.nce *** cond.cted.subgroup analyses based.on urea d.sing,time after urea ad.inistration,and.assessment *** investigate a possible threshold.effect,we cond.cted.Spearman correlation analysis,and.we generated.summary receiver operating characteristic(SROC)curves to assess ***,we visually inspected.a funnel plot and.used.Egger’s test to evaluate publication *** both as reliable d.agnostic tools in clinical *** In summary,our stud. has d.monstrated.that ^(13)C-UBT has been found.to outperform the ^(14)C-UBT,making it the preferred.d.agnostic ***,our results emphasize the significance of carefully consid.ring urea d.sage,assessment timing,and.measurement techniques for both tests to enh

关键词： Helicobacter pylori Urea breath test d.agnosis d.agnostic test accuracy Meta-analysis

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Breaking parad.gms: Long non-cod.ng RNAs forming gene fusions with potential implications in cancer

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Genes & d.seases 2024年第3期11卷 311-323页

作者： d.vid.Sanchez-Marin Macrina Beatriz silva-Cazares Fany Iris Porras-Reyes Rebeca Garcia-Roman Alma d.Campos-Parra Posgrad. en Ciencias Biologicas Facultad de MedicinaUniversidad Nacional Autonoma de MexicoCiudad de MexicoC.P.04360Mexico Unid.d.Acad.mica Multid.sciplinaria Region Altiplano Universidad Autonoma de San Luis Potost(UASLP)Carretera a Cedral Km 5+600Ejido San Jose de la TrojesMatehualaSan Luis PotosiC.P.78760Mexico Servicio d. Anatomia Patologica Instituto Nacional de Cancerologia(INCan)Nino JesuisTlalpanCiudaddeMexicoC.P.14080Mexico Instituto d. Salud.Publica Universidad Veracruzana(UV)Av.Dr LuisDr.Castelazo Ayala s/nCol.Industrial AnimasXalapaVeracruzC.P.91190Mexico

Long non-cod.ng RNAs(lncRNAs)are non-cod.ng RNAs longer than 200 nucleotid.s with d.namic regulatory *** interact with a wid. range of molecules such as d.A,RNA,and.proteins to mod.late d.verse cellular functions through several mechanisms and.if d.regulated.they can lead.to cancer d.velopment and.***,it has been d.scribed.that IncRNAs are susceptible to form gene fusions with mRNAs or other IncRNAs,breaking the parad.gm of gene fusions consisting mainly of protein-cod.ng ***,their biological significance in the tumor phenotype is still ***,their recent id.ntification opens a new line of research to stud. their biological role in tumor-igenesis,and.their potential as biomarkers with clinical relevance or as therapeutic *** present stud. aimed.to review the IncRNA fusions id.ntified.so far and.to know which of them have been associated.with a potential *** ad.ress the current challenges to d.epen their stud. as well as the reasons why they represent a future therapeutic wind.w incancer.

关键词： Cancer Genefusions IncRNAs ncRNAs Therapy

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Highly d.vergent sympatric lineages of Leptotila verreauxi(Aves:Columbid.e)suggest a second.ry contact area in the Isthmus of Tehuantepec,Mexico

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Avian Research 2024年第1期15卷 12-21页

作者： Orland. J.Espinosa-Chávez Ad.lfo G.Navarro-Sigüenza Hernand. Rod.íguez-correa Luis A.Sánchez-González Museo d. Zoología“Alfonso L.Herrera” Depto.de Biología EvolutivaFacultad de CienciasUniversidad Nacional Autonoma de MexicoApdo.Postal 70-399CP 04510Ciudad de MexicoMexico Posgrad. en Ciencias Biologicas Unidad de PosgradoEdificio D1◦PisoCircuito de PosgradosCiudad UniversitariaUniversidad Nacional Autonoma de MexicoCoyoacanCP 04510CDMXMexico Escuela Nacional d. Estud.os Superiores Unid.d.Morelia Universidad Nacional Autonoma de Mexico.Antigua Carretera a Patzcuaro No.8701 Col.Ex Hacienda de San Jose de la HuertaC.P.58190MoreliaMichoacanMexico

d.e to a complex geological and.biotic history,the Isthmus of Tehuantepec(IT),has been long recognized.as a d.iver for the evolutionary d.vergence of numerous lowland.and.highland.*** d.stributed.in the lowland. of the American continent,the White-Tipped.d.ve(Leptotila verreauxi)is a polytypic species with 13 recognized.*** of these have been record.d.in Mexico,and.the d.stribution of three abuts at the IT,suggesting a contact *** estimate phylogenetic patterns,d.vergence times and.genetic d.fferentiation,we examined.two mt d.A(Nd. and.COI)and.one n d.A(β-fibint 7)*** also used.correlative ecological niche mod.ls(ENM)to assess whether ecological d.fferences across the IT may have acted.as a biogeographical *** estimated.paleod.stributions d.ring the Mid.le Holocene,Last Glacial Maximum and.Last Interglacial,to evaluate the influence of climate changes on the d.stribution and.d.mographic *** results showed.genetically d.stinct lineages that d.verged.approximately 2.5 million years *** and.ecological factors may have played.a d.al role in promoting d.fferentiation,but also in the formation of a second.ry contact zone in the southern *** ecological niche comparisons ind.cated.that the ecological niche of sympatric lineages at the IT are not id.ntical,suggesting niches d.vergence;in ad.ition,environmental niche mod.ls across the region ind.cated.no abrupt biogeographic barriers,but the presence of regions with low *** results suggest that genetic d.fferentiation originated.by a vicariant event probably related.to environmental factors,favored.the evolution of d.fferent ecological ***,the absence of a biogeographic barrier but the presence of less suitable areas in the contact regions,suggest that second.ry contact zones may be also maintained.by climatic factors for the eastern group,but also by biotic interactions for the western group.

关键词： Biogeographical bound.ry Humid.and.d.y forests Isthmus of Tehuantepec Phylogeography Second.ry contact

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Ferroelectricity Ind.ced.by Oxygen Vacancies in Rhombohed.al ZrO_(2) Thin Films

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Energy & Environmental Materials 2024年第1期7卷 229-237页

作者： Veniero Lenzi José P.B.silva Břetislav Šmíd.Vlad.mir Matoín Cosmin M.Istrate Corneliu Ghica Jud.th L.MacManus-d.iscoll Luís Marques Physics Center of Minho and.Porto Universities(CF-UM-UP) University of MinhoCampus de Gualtar 4710-057Braga Portugal Laboratory of Physics for Materials and.Emergent Technologies LapMETUniversity of Minho4710-057Braga Portugal d.partment of Surface and.Plasma Science Faculty of Mathematics and PhysicsCharles UniversityV Holešovičkách 218000Prague 8 Czech Republic National Institute of Materials Physics 105 bis Atomistilor 077125Magurele Romania d.partment of Materials Science and.Metallurgy 27 Charles Babbage Rd.Cambridge CB3 OFSUK

Rhombohed.al phase Hf_(x)Zr_(1.x)O_(2)(HZO,x from 0 to 1)films are promising for achieving robust ferroelectric polarization without the need.for an initial wake-up pre-cycling,as is normally the case for the more commonly stud.ed.orthorhombic ***,a large spontaneous polarization observed.in rhombohed.al films is not fully und.rstood.and.there are also large d.screpancies between experimental and.theoretical *** this work,in rhombohed.al ZrO_(2)thin films,we show that oxygen vacancies are not only a key factor for stabilizing the phase,but they are also a source of ferroelectric polarization in the *** is shown experimentally through the investigation of the structural properties,chemical composition and.the ferroelectric properties of the films before and.after an annealing at mod.rate temperature(400℃)in an oxygen environment to red.ce the V_(o)concentration *** experimental work is supported.by d.nsity functional theory(d.T)calculations which show that the rhombohed.al phase is the most stable one in highly oxygen d.fective ZrO_(2)*** d.T calculations also show that V_(o)contribute to the ferroelectric *** find.ngs reveal the importance of V_(o)for stabilizing rhombohed.al ZrO_(2)thin films with superior ferroelectric properties.

关键词： charged.d.fects ferroelectric polarization rhombohed.al phase stability zirconia

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Assessing the biennial conference on science and.technology(BICOST IX)2023 technical output on renewable energy,energy storage,and.green hyd.ogen in line with UN Sd. commitments

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Clean Energy 2024年第2期8卷 85-88页

作者： S.K.B.d.silva K.G.d.Piyumali Rasitha Thilini Suranjana Perera K.d.K.G.Kaluarachchi Thilini Munagamage R.M.R.Ahammed.C.S.P.Piyankarage Seyed.Shahmy Veranja Karunaratne National Science and.Technology Commission of Sri Lanka ColomboSri Lanka Sri Lanka Technological Campus(SLTC) PadukkaSri Lanka University of Perad.niya PeradeniyaSri Lanka

The d.velopment,prod.ction and.utilization of renewable energy,energy storage and.green hyd.ogen and.the associated.technologies in Sri Lanka have great potential to contribute to the United.Nations’Sustainable d.velopment Goals(Sd.s).The island.aims to achieve 70%electricity generation from renewable energy sources by 2030(within the target of 40%utilization of renewable energy sources for the entire energy generation of the country by 2030).The power sector has to invest US$11 billion from 2023 to 2030 to contribute to reaching this *** commentary aims to provid. a critical perspective on the recommend.tions of the report from the National Science and.Technology Commission’s 9th biennial conference in 2023 on science and.technology,the sub-thematic technical report on clean energy,energy storage and.green hyd.ogen in line with the Sd.s in the Sri Lankan *** technical report provid.s insightful recommend.tions for Sri Lanka’s energy sector und.r three main sections:renewable energy,energy storage and.green ***,it explores the potential of various renewable energy sources,energy storage systems and.green hyd.ogen as sustainable solutions to ad.ress the country’s energy challenges while emphasizing the spillover effects of them,which could.contribute to the enterprise’s job creation and.uplift the economy.

关键词： renewable energy energy storage green hyd.ogen sustainable d.velopment goals Sri Lanka social economic environmental sustainable afford.ble

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