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Hypotensive Effects and Phytochemical Profile of Aqueous Extract and Fractions of desmodium velutinun Leaves (Willd) D. C. (Fabaceae) in the Rat

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Journal of Biosciences and Medicines 2022年第8期10卷 100-109页

作者： Blondy Mboungou-Bouesse Arnaud Wilfrid Etou Ossibi Elva Ngolo romaric de garde elion itou Béril Fabrice Mavouba Dieu-Merci Bevel Gallo Mongo Gouollaly Tsiba Ange Antoine Abena Laboratory of Biochemistry and Pharmacology Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of Congo department of Pharmacopeia and Traditional Medicine National Institute of Health Science & Research Delhi India Laboratory of Chemistry Organic Biomolecules and Pharmacodynamics Science City (Ex-ORSTOM) Brazzaville Republic of Congo Plant and Life Chemistry Unit Faculty of Sciences and Techniques Marien Ngouabi Univesity Brazzaville Republic of Congo

desmodium velutinum (D. velutinum) is a plant of the family Fabaceae used in traditional Congolese medicine for the treatment of high blood pressure (HBP) or hypertension (HT). The present work evaluated the hypotensive activity and determined the phytochemical profile of the aqueous extract and fractions of desmodium velutinun (Willd) D. C. (Fabaceae) in the rat. The hypotensive effect of the aqueous extract and different fractions (F1, F2, F3 and F4) was evaluated at the dose of 2.5 mg/kg in normotensive rats anesthetized with 15% urethane at 1.5 g/kg, i.p. (intraperitoneally). Our results showed that the F3 fraction after administration caused a significant decrease in blood pressure and heart rate which remained higher than that of the aqueous extract and fractions (F1, F2 and F4). The richness in polyphenolic and flavonoid compounds as well as the separating capacity of the eluent used within the F3 fraction clearly justifies the beneficial effects of the latter on blood pressure and heart rate compared with the extract and fractions (F1, F2 and F4). In a second part we carried out the qualitative (thin-layer chromatography) and quantitative (total polyphenols and flavonoids determination) analysis. The chemical compounds remained dominated by the polyphenolic and flavonoid groups, the content of total polyphenols and total flavonoids meets the following increasing order: (extract, F1, F2, F3 and F4). The results obtained could certify the use of desmodium velutinun in traditional Congolese medicine.

关键词： Hypotensive Fraction desmodium velutinun Phytochemistry

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Anti-Inflammatory and Analgesic Effects of Aqueous Extract of Stem Bark of <i>Ceiba pentandra</i>Gaertn

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Pharmacology & Pharmacy 2014年第12期5卷 1113-1118页

作者： romaric de garde elion itou Rokia Sanogo Arnaud Wilfrid Etou Ossibi Freddy Gelase Nsondé Ntandou Radard Ondelé Bonaventure Max Pénemé Nadége Okiémy Andissa Drissa Diallo Jean Maurille Ouamba Ange Antoine Abena Laboratoire de Biochimie et Pharmacologie Faculté des Sciences de la Santé Université Marien Ngouabi Brazzaville Congo Département Médecine Traditionnelle (DMT) Faculté de Médecine de Pharmacie et d’Odonto-StomatologieUniversité de Bamako Bamako Mali Unité de Chimie du Végétale et de la vie Faculté des Sciences et Techniques Université Marien Ngouabi Brazzaville Congo

Anti-inflammatory and analgesic effects of the aqueous extract of the stem bark of Ceiba pentandra Gaertn (Bombacaceae) were recorded in rat and mice. Inflammation was induced by carrageenan and cotton pellet. The pain was studied using analgesymeter, Koster and hot plate Methods. Aqueous extract (400 and 800 mg/kg) of Ceiba pentandra presents a significant anti-inflammatory and analgesic activity. Flavono?ds present in the extract seem to be responsible for the activity.

关键词： Analgesic Anti-Inflammatory Ceiba pentandra

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Evaluation of Analgesic and Antipyretic Effects of the Aqueous Extract of the Leaves of Chenopodium ambrosioides L. (Amaranthaceae)

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Journal of Biosciences and Medicines 2022年第11期10卷 69-81页

作者： elion itou romaric de garde Etou Ossibi Arnaud Wilfrid Tchiama Loui-Marie Boukongo Roger Pavel Mambeke Hono Roger Morabandza Cyr Jonas Abena Ange Antoine Animal Physiology Laboratory Faculty of Science and Technology Marien University Ngouabi Brazzaville Congo National Institute for Research in Health Sciences Scientific City of Brazzaville (Formerly ORSTOM) Brazzaville Congo Laboratory of Biochemistry and Pharmacology Faculty of Health Sciences University Marien Ngouabi Brazzaville Congo department of Natural Sciences Ecole Normale Supérieure Marien University Ngouabi Congo Brazzaville Congo

C. ambrosioides is a Congolese medicinal plant used in the treatment of several pathologies. This work was initiated to evaluate the analgesic and antipyretic effect of the aqueous extract of leaves of C. ambrosioides. Analgesic effect was evaluated by using the acetic acid-induced writhing, the Tilk Flick test as well as the pain induced by formaldehyde. The results obtained showed that the aqueous extract significantly reduces the number of abdominal writhes (p C. ambrosioides (400 and 600 mg/kg) compared to control group (saline water). This result suggests an antipyretic effect. Chemical screening revealed the presence of alkaloids, flavones and mucilage. The presence of alkaloids and flavones could explain the analgesic and antipyretic effects attributed to this aqueous extract.

关键词： Analgesic Antipyretic Medicinal Plant Chenopodium ambrosioides

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