Hypotensive Effects and Phytochemical Profile of Aqueous Extract and Fractions of Desmodium velutinun Leaves (Willd) D. C. (Fabaceae) in the Rat

作     者：Blondy Mboungou-Bouesse Arnaud Wilfrid Etou Ossibi Elva Ngolo Romaric De Garde Elion Itou Béril Fabrice Mavouba Dieu-Merci Bevel Gallo Mongo Gouollaly Tsiba Ange Antoine Abena Blondy Mboungou-Bouesse;Arnaud Wilfrid Etou Ossibi;Elva Ngolo;Romaric De Garde Elion Itou;Béril Fabrice Mavouba;Dieu-Merci Bevel Gallo Mongo;Gouollaly Tsiba;Ange Antoine Abena

作者机构：Laboratory of Biochemistry and Pharmacology Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of Congo Department of Pharmacopeia and Traditional Medicine National Institute of Health Science & Research Delhi India Laboratory of Chemistry Organic Biomolecules and Pharmacodynamics Science City (Ex-ORSTOM) Brazzaville Republic of Congo Plant and Life Chemistry Unit Faculty of Sciences and Techniques Marien Ngouabi Univesity Brazzaville Republic of Congo 

出 版 物：《Journal of Biosciences and Medicines》 (生物科学与医学（英文）)

年 卷 期：2022年第10卷第8期

页      面：100-109页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Hypotensive Fraction Desmodium velutinun Phytochemistry 

摘      要：Desmodium velutinum (D. velutinum) is a plant of the family Fabaceae used in traditional Congolese medicine for the treatment of high blood pressure (HBP) or hypertension (HT). The present work evaluated the hypotensive activity and determined the phytochemical profile of the aqueous extract and fractions of Desmodium velutinun (Willd) D. C. (Fabaceae) in the rat. The hypotensive effect of the aqueous extract and different fractions (F1, F2, F3 and F4) was evaluated at the dose of 2.5 mg/kg in normotensive rats anesthetized with 15% urethane at 1.5 g/kg, i.p. (intraperitoneally). Our results showed that the F3 fraction after administration caused a significant decrease in blood pressure and heart rate which remained higher than that of the aqueous extract and fractions (F1, F2 and F4). The richness in polyphenolic and flavonoid compounds as well as the separating capacity of the eluent used within the F3 fraction clearly justifies the beneficial effects of the latter on blood pressure and heart rate compared with the extract and fractions (F1, F2 and F4). In a second part we carried out the qualitative (thin-layer chromatography) and quantitative (total polyphenols and flavonoids determination) analysis. The chemical compounds remained dominated by the polyphenolic and flavonoid groups, the content of total polyphenols and total flavonoids meets the following increasing order: (extract, F1, F2, F3 and F4). The results obtained could certify the use of Desmodium velutinun in traditional Congolese medicine.