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Pancreas-preserving duodenal resections vs pancreatoduodenectomy for groove pancreatitis. Should we revisit treatment algorithm for groove pancreatitis?

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World Journal of Gastrointestinal Surgery 2021年第1期13卷 30-49页

作者： Vyacheslav Egorov roman petrov Aleksandr Schegolev Elena Dubova Andrey Vankovich Eugeny Kondratyev Andrey Dobriakov Dmitry Kalinin Natalia Schvetz Elena Poputchikova Department of Surgical Oncology Ilyinskaya HospitalMoscow 143421Russia V.I.Kulakov Research Center for Obstetrics Ministry Hlth Russian FederatVI Kulakov Res Ctr Obstet Gynecol&PerinatolMoscow 119526Russia Department of Pathology Buranazian Federal Medical and Biological Center of the Federal Medical and Biological Agency of Russian FederationMoscow 143421Russia Department of HPB Surgery Moscow Clinical Research CenterMoscow 111123Russia Department of Radiology Vishnevsky Institute of SurgeryIlyinskaya HospitalMoscow 143421Russia Department of Pathology Bakhrushin Brothers Moscow City HospitalMoscow 107076Russia Department of Pathology Vishnevsky Institute of SurgeryIlyinskaya HospitalMoscow 117997Russia

BACKGROUND The management of cystic dystrophy of the duodenal wall(CDDW),or groove pancreatitis(GP),remains *** pancreatoduodenectomy(PD)is considered the most suitable operation for CDDW,pancreas-preserving duodenal resection(PPDR)has also been suggested as an alternative for the pure form of GP(isolated CDDW).There are no studies comparing PD and PPDR for this *** To compare the safety,efficacy,and short-and long-term results of PD and PPDR in patients with *** A retrospective analysis of the clinical,radiologic,pathologic,and intra-and postoperative data of 84 patients with CDDW(2004-2020)and a comparison of the safety and efficacy of PD and *** Symptoms included abdominal pain(100%),weight loss(76%),vomiting(30%)and jaundice(18%)and data from computed tomography,magnetic resonance imaging,and endoUS led to the correct preoperative diagnosis in 98.8%of *** patients were treated conservatively with pancreaticoenterostomy(n=8),duodenum-preserving pancreatic head resection(n=6),PD(n=44)and PPDR(n=15)without *** gain was significantly higher after PD and PPDR and complete pain control was achieved significantly more often after PPDR(93%)and PD(84%)compared to the other treatment modalities(18%).New onset diabetes mellitus and severe exocrine insufficiency occurred after PD(31%and 14%),but not after *** PPDR has similar safety and better efficacy than PD in patients with CDDW and may be the optimal procedure for the isolated form of *** pure form of GP is a duodenal disease and PD may be an overtreatment for this *** detection of CDDW provides an opportunity for pancreas-preserving surgery.

关键词： Groove pancreatitis Cystic dystrophy of the duodenal wall Pancreaspreserving duodenectomy Pancreas-preserving duodenal resection Chronic pancreatitis Pancreatoduodenectomy

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Computed tomography-based diagnostics might be insufficient in the determination of pancreatic cancer unresectability

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World Journal of Gastrointestinal Surgery 2013年第4期5卷 83-96页

作者： Vyacheslav I Egorov roman V petrov Elena N Solodinina Gregory G Karmazanovsky Natalia S Starostina Natalia A Kuruschkina Department of Surgical Oncology Ostroumov 14th City Hospital Sechenov First State Medical University Department of Surgical Oncology Ostroumov 14th City Hospital Department of Endoscopy Vishnevsky Institute of Surgery Department of Radiology Vishnevsky Institute of Surgery

AIM: To inquire into a question of an overestimation of arterial involvement in patients with pancreatic cancer (PC). METHODS: Radiology data were compared with the findings from 51 standard, 58 extended and 17 total pancreaticoduodenectomies; 9 distal resections with celiac artery (CA) excision; and 28 palliations for PC. The survival of 11 patients with controversial computed tomography (CT) and endoscopic ultrasound data with regard to arterial invasion, after R0/R1 procedures (false-positive CT results, Group A), was compared to survival after eight R2 resections (false-negative CT results, Group B) and after 12 bypass procedures for locally advanced cancer (true-positive CT results, Group C).RESULTS: In all of the cases in group A, operative exploration revealed no arterial invasion, which was predicted by CT. The one-year survival in Group A was 88.9%, and the two-year survival was 26.7%, with a median follow-up of 22 mo. One-year survival was not attained in groups B and C, with a significant difference in survival (P a-b = 0.0029, P b-c = 0.003).CONCLUSION: Arterial encasement on CT does not necessarily indicate arterial invasion. Whenever PC is considered unresectable, endoUS should be used. In patients with controversial CT an EUS data for peripan-creatic arteries involvement radical resection might be possible, providing survival benefits as compared to R2-resections or palliative surgery.

关键词： Vascular invasion Cancer Pancreas Management Pancreaticoduodenectomy Distal pancreatectomy Computed tomography Endoscopic ultrasound Arteries Resectability

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Liver blood supply after a modified Appleby procedure in classical and aberrant arterial anatomy

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World Journal of Gastrointestinal Surgery 2013年第3期5卷 51-61页

作者： Vyacheslav I Egorov roman V petrov Michail V Lozhkin Olga A Maynovskaya Natalia S Starostina Natalia R Chernaya Ekaterina M Filippova Ostroumov 14~(th) City Hospital Department of Surgical Oncology Sechenov First State Medical University Department of General Surgery Russian National Research Medical University Department of Abdominal Surgery Herzen Institute of Oncology Department of Pathology Herzen Institute of Oncology Department of Radiological Herzen Institute of Oncology Department of Interventional Radiology Sklifosovsky Emergency Institute Department of Pathology VishnevskyInstitute of Surgery

Reported here are two cases of a modified Appleby operation for borderline resectable ductal adenocarcinoma of the pancreatic body, in one of which a R0 distal resection was attended to by excision, not only of the celiac axis, but also of the common and left hepatic arteries in the presence of arterial anatomic variation Michels, type Ⅷb. The possibility and avenues of the maintenance of the blood supply to the left hepatic lobe after surgical aggression of this kind are demonstrated employing computed tomography (CT) and 3-D CT angiography. Furthermore, both cases highlight all important worrisome aspects of pancreatic cancer resectability prediction.

关键词： Cancer Pancreas Management Pancreatectomy Distal pancreatectomy Vascular invasion Computed tomography Blood supply

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Extensive multiarterial resection attending total duodenopancreatectomy and adrenalectomy for MEN-1-associated neuroendocrine carcinomas

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World Journal of Gastrointestinal Surgery 2012年第10期4卷 238-245页

作者： Vyacheslav Ivanovich Egorov Alexander Felixovich Kharazov Alla Ivanovna Pavlovskaya roman Valeryevich petrov Natalia Sergeevna Starostina Eugeny Valerievich Kondratiev Ekaterina Mikhailovna Filippova Department of Hepatopancreatobiliary Surgery Vishnevsky Institute of Surgery117997 MoscowRussia Department of Vascular Surgery Vishnevsky Institute of Surgery117997 MoscowRussia Department of Pathology Blokhin Cancer Research Centre Moscow117997 MoscowRussia Department of Radiology Vishnevsky Institute of Surgery117997 MoscowRussia Department of Pathology Vishnevsky Institute of Surgery117997 MoscowRussia

Pancreatic neuroendocrine tumors(PNTs) are relatively uncommon although these neoplasms have been noted to grow in occurrence in recent *** removal of locally advanced PNTs involving major vessels and adjacent organs is warranted by reason of an appreciably more favorable prognosis as compared to exocrine pancreas *** are reporting a case of successful multi-organ resection combined with a wide excision of the superior mesenteric,common,proper,left and right hepatic arteries(in the presence of the hepatomesenteric trunk variant of aberrant arterial anatomy) for multifocal PNTs in the setting of multiple neuroendocrine neoplasia type 1 *** procedure resulted in pain abolition,a significant improvement in the patient's life quality and allowed her to return to ***-up computed tomography at 15 mo post-surgery showed no evidence of disease recurrence.

关键词： Total duodenopancreatectomy Pancreatic neuroendocrine tumors Islet cell tumors Neuroendocrine carcinoma Multiple endocrine neoplasia type 1 syndrome

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Immunology and immunotherapy in breast cancer

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Cancer Biology & Medicine 2022年第5期19卷 609-618页

作者： Vladimir Semiglazov Andrey Tseluiko Asel Kudaybergenova Anna Artemyeva Petr Krivorotko roman Donskih petrov National Medicine Cancer-Research Center Ministry of Health Saint-Petersburg 197758Russia

Immuno-oncology is a rapidly developing field in *** combination therapies have already been studied in many clinical trials on various tumor *** recent years,a checkpoint inhibition therapy with monoclonal antibodies targeting PD-1 and its ligand PD-L1 has been *** cancer had been examined in the field of immune-oncology relatively *** review focuses on clinical evidence regarding immune checkpoint inhibition for curative treatment of various breast cancer *** addition,we present the results of studies demonstrating the prognostic and predictive value of levels of tumorinfiltrating lymphocytes(CD4 and CD8),their quantitative ratios,and their correlation with regulatory genes(PD-1,PD-L1,and FOX-P3).

关键词： Breast cancer tumor-infiltrating lymphocytes PD-1 PD-L1 immunotherapy

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The Methodological Way to Diagnostic of Efficiency Active Leaching Materials

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Materials Sciences and Applications 2012年第2期3卷 116-119页

作者： Nikolay N. petrov roman V. Gorokhov Tatyana N. Musorina Tatyana B. Kasatkina Natalya A. Shkabara Nikolay N. Bukov 不详

It was demonstrated possibility of express diagnostic of characters and prediction efficiency of leaching materials on the bases comparison release rate of active substance and accelerated field tests. It makes on the... 详细信息

关键词： Barrier Diffusion Moderator Release Rate Antifouling Diagnostic of Efficiency

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