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Protective Activity of <i>Markhamia tomentosa</i>(Benth.) K. Schum. (Bignoniaceae) Methanol Leaves Extract against D-Galactosamine/Lipopolysaccharide-Induced Acute Liver Injury in Mice

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Journal of Biosciences and Medicines 2020年第10期8卷 74-89页

作者： roméo joel guemmogne temdie Agathe Lambou Fotio Flaure Donfack Metchi Edwige Chiogo Vouffo Ymele Gilbert Thierry Nkoulou Tabi Théophile Dimo Department of Biological Sciences Faculty of Science University of Ngaoundere Ngaoundere Cameroon Department of Zoology and Animal Physiology Faculty of Science University of Buea Buea Cameroon Department of Animal Biology and Physiology Faculty of Science University of Yaounde I Yaounde Cameroon

Markhamia tomentosa (Benth.) K. Schum. (Mt) is a Cameroonian medicinal plant, traditionally used to treat painful and inflammatory illness. This study aimed to examine the effects of methanol leaves extract (MLE) of Mt in D-galactosamine (D-GaIN)/lipopolysaccharide (LPS)-induced liver injury. The MLE (100 and 200 mg/kg), Ascorbic acid (10 mg/kg) and distilled water were administered 12 h and 1 h before intraperitoneal injection of D-GaIN (10 mg/mouse)/LPS (0.1 μg/g). Animals were sacrificed 6 h after D-GalN/LPS challenge. Liver injury was assessed biochemically by determination of aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), alkaline phosphatase (ALP), superoxide dismutase (SoD) and catalase activities. Malondialdehyde (MDA), reduced glutathione (GSH), nitrites, total protein and bilirubin levels were explored. Histopathological examination of liver tissue was also performed. Liver enzymes (ALAT, ASAT, ALP) activity, nitrites, MDA and bilirubin levels were increased, while protein level, SoD and catalase activities were significantly reduced by D-GalN/LPS administration. MLE (100 or 200 mg/kg) protected mice against D-GalN/LPS-induced death. In addition, the plant extract significantly reduced ALAT and ALP activity, exhibiting 23.00% and 62.20% protection, respectively. SoD activity and total protein were significantly (p otal bilirubin and MDA levels were reduced (p ological analysis of liver sections showed that MLE (100 or 200 mg/kg) protected mice against D-GaIN/LPS-induced liver injury. The obtained results

关键词： Markhamia tomentosa D-Galactosamine/Lipopolysaccharide oxidative Stress Liver Injury

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