Dear Editor,The incidence of rectal cancer has increased in patients younger than 50 years old during the last *** is well established that young age at cancer onset is a hallmark of hereditary *** prevalence of germl...
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Dear Editor,The incidence of rectal cancer has increased in patients younger than 50 years old during the last *** is well established that young age at cancer onset is a hallmark of hereditary *** prevalence of germline variants among early-onset rectal cancer(EORC)patients is largely ***,we aimed to determine the spectrum of germline variants and their clinical impact in EORC patients diagnosed at age 40 or *** investigated 71 EORC patients(Supplementary Table S1),one of the largest cohorts to date,using a customized panel with 93 genes(Supplementary Table S2).
About 75% of the entire surface of the planet Earth is covered by water, with only about 3% of freshwater. The Amazon region has the largest freshwater basin in the world and the uncontrolled growth of the population ...
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About 75% of the entire surface of the planet Earth is covered by water, with only about 3% of freshwater. The Amazon region has the largest freshwater basin in the world and the uncontrolled growth of the population in this region has become a problem concerning water contamination since a large part of the region’s population obtains water from artesian wells. This study aimed to investigate some physical-chemical parameters of groundwater in the municipality of Caapiranga, Amazonas (AM), Brazil. Water samples obtained from 14 tubular wells were evaluated, as well as a sample of surface water from Lake Caapiranga that passes in front of the municipality. The vast majority of water samples showed low pH, and were of the parameters established for drinking water, aquaculture and animal watering. High levels of nitrate are also found in most samples, which indicates contamination of these waters by domestic effluents. In wells 1, 6, 9 11, and 13 the levels of nitrate were very high and can cause serious diseases in people who use this water for consumption. According to the parameters evaluated, the quality of groundwater in 5 of the 14 wells is unfit for human consumption.
The development of more adequate food programs regarding the intensity and duration of the restriction can be an effective way to minimize the effects of exaggerated food consumption and its negative consequences for ...
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The development of more adequate food programs regarding the intensity and duration of the restriction can be an effective way to minimize the effects of exaggerated food consumption and its negative consequences for the economy of the *** this sense,juvenile Nile tilapia(Oreochromis niloticus)(137±3 g)were submitted to different feeding strategies in a recirculation *** feeding strategies were tested in subsequent weekly cycles:continuous feeding;skipping one meal a week;suppression of two non-consecutive meals a week;suppression of three non-consecutive meals a week;suppression of four non-consecutive meals a *** performance,feed consumption in the post-restriction period and economic indicators were evaluated through projections and profitability *** intake occurred in all tested groups,so that the total feed intake(FI)did not differ significantly between them(p>0.05).Moderate food restriction provided a linear increase in the relative gross margin for each treatment with each change in salary level,as well as greater profitability when compared to the respective control group(p<0.05).
To distinguish species or populations using morphometric data is generally processed through multivariate analyses, in particular the discriminant analysis. We explored another approach based on the maximum likelihood...
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To distinguish species or populations using morphometric data is generally processed through multivariate analyses, in particular the discriminant analysis. We explored another approach based on the maximum likelihood method. Simple statistics based on the assumption of normal distribution at a single variable allows to compute the chance of observing a particular data (or sample) in a given reference group. When data are described by more than one variable, the maximum likelihood (MLi) approach allows to combine these chances to find the best fit for the data. Such approach assumes independence between variables. The assumptions of normal distribution of variables and independence between them are frequently not met in morphometrics, but improvements may be obtained after some mathematical transformations. Provided there is strict anatomical correspondence of variables between unknown and reference data, the MLi classification produces consistent classification. We explored this approach using various input data, and compared validated classification scores with the ones obtained after the Mahalanobis distance-based classification. The simplicity of the method, its fast computation, performance and versatility, make it an interesting complement to other classification techniques.
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