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Health 2023年第10期15卷 1096-1115页

作者： Huifeng Jin rolando L. maddela Robert A. Sinnott Research and Development USANA Health Sciences Inc. Salt Lake City USA

Background: Bioactive peptides derived from hydrolyzed collagen have broad physiological functions and beneficial effects on human health, ranging from reducing skin aging to modifying lipid metabolism. Telomere length shortening is an established biomarker of cellular aging. It is not known if collagen consumption is associated with telomere length protection. Our purpose was to investigate the relationship between dietary collagen consumption and telomere length in a nationally representative US adult population. Methods: We analyzed the data of 6173 adults aged 20 - 84 from the National Health and Nutrition Examination Survey (NHANES) 1999-2002. Multivariable linear regression and a generalized additive model with smoothing plot were used to assess the association between the total collagen consumption and log-transformed leukocyte telomere length (LTL). Results: Compared with the lowest quartile of total collagen (Q1), we found that the second quartile of collagen (Q2) consumption (1.36 - 3.40 g/1000kcal) was positively associated with telomere length (β: 0.017;95% CI: 0.006, 0.028;P = 0.022) in the females while no association in the males (β: −0.003;95% CI: −0.019, 0.012;P = 0.678) and overall population (β: 0.008;95% CI: −0.002, 0.018;P = 0.141). The association in the females is nonlinear with an inflection point of 2.5 g/1000kcal (P for non-linearity: Conclusion: In conclusion, moderate dietary collagen has a positive and nonlinear association with telomere length in US females, while no significant associations were found in the males and the overall population.

关键词： Telomere Length Dietary Collagen NHANES Linear Regression

β-Glucan Improves Protective Qi Status in Adults with Protective Qi Deficiency——A Randomized,Placebo-Controlled,and Double-Blinded Trial

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Chinese Journal of Integrative Medicine 2022年第5期28卷 394-402页

作者： WU Jun-rong CHENG Hao-jie SHI Jian-pin YIN Wei-dong WANG Jun OU Xuan-qiao CHEN Jin-li Ira Bernstein Mark Levy rolando maddela Robert Sinnott TIAN Jun-qiang Elegant and Olive Health Clinic MarkhamONL3R 5V6Canada Research and Development Department USANA Health ScienceInc.Salt Lake CityUT84121USA Department of Family and Community Medicine University of TorontoTorontoONM5T 2S8Canada

Objective:To test the hypothesis thatβ-glucan enhances protective qi(PQi),an important Chinese medicine(CM)concept which stipulates that a protective force circulates throughout the body surface and works as the first line of defense against"external pernicious influences".Methods:A total of 138 participants with PQi deficiency(PQD)were randomized to receiveβ-glucan(200 mg daily)or placebo for 12 ***’PQi status was assessed every 2 weeks via conventional diagnosis and a standardized protocol from which a PQD severity and risk score was *** of participants’immune and general health status were also monitored,including upper respiratory tract infection(URTI),saliva secretory Ig A(s Ig A),and self-reported measures of physical and mental health(PROMIS).Results:PQi status was not significantly different between theβ-glucan and placebo treatment groups at baseline but improved significantly in theβ-glucan(***)group in a time-dependent *** intergroup differences[95%confidence interval(CI)]in severity score(scale:1-5),risk score(scale:0-1),and proportion of PQD participants(%)at finish line was 0.49(0.35-0.62),0.48(0.35-0.61),and 0.36(0.25-0.47),***,β-glucan improved URTI symptom(scale:1-9)and PROMIS physical(scale:16.2-67.7)and mental(scale:21.2-67.6)scores by a magnitude(95%CI)of 1.0(0.21-1.86),5.7(2.33-9.07),and 3.0(-0.37-6.37),respectively,over ***:β-Glucan ameliorates PQi in PQD *** using stringent evidence-based methodologies,our study demonstrated that Western medicine-derived remedies,such asβ-glucan,can be employed to advance CM therapeutics.(Clinical *** registry:NCT03782974)

关键词： β-glucan Chinese medicine protective qi protective qi deficiency

Association between Dietary Collagen Consumption and Telomere Length: National Health and Nutrition Examination Survey

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A Delay-Dependent Anti-Windup Compensator for Wide-Area Power Systems With Time-Varying Delays and Actuator Saturation

Health（健康） 2023年第10期

作者： Huifeng Jin rolando L.maddela Robert A.Sinnott

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IEEE/CAA Journal of Automatica Sinica 2020年第1期7卷 106-117页

作者： maddela Chinna Obaiah Bidyadhar Subudhi Department of Electrical Engineering National Institute of TechnologyRourkela 769008India School of Electrical Sciences Indian Institute of TechnologyFarmagudiGoa 403401India

In this paper, a delay-dependent anti-windup compensator is designed for wide-area power systems to enhance the damping of inter-area low-frequency oscillations in the presence of time-varying delays and actuator saturation using an indirect approach. In this approach, first, a conventional wide-area damping controller is designed by using output feedback with regional pole placement approach without considering time-varying delays and actuator saturation. Then to mitigate the effect of both time-varying delays and actuator saturation, an add-on delay-dependent anti-windup compensator is designed. Based on generalized sector conditions, less conservative delay-dependent sufficient conditions are derived in the form of a linear matrix inequality(LMI) to guarantee the asymptotic stability of the closedloop system in the presence of time-varying delays and actuator saturation by using Lyapunov-Krasovskii functional and Jensen integral inequality. Based on sufficient conditions, the LMI-based optimization problem is formulated and solved to obtain the compensator gain which maximizes the estimation of the region of attraction and minimizes the upper bound of-gain. Nonlinear simulations are performed first using MATLAB/Simulink on a two-area four-machine power system to evaluate the performance of the proposed controller for two operating conditions, e.g.,3-phase to ground fault and generator 1 terminal voltage variation. Then the proposed controller is implemented in real-time on an OPAL-RT digital simulator. From the results obtained it is verified that the proposed controller provides sufficient damping to the inter-area oscillations in the presence of time-varying delays and actuator saturation and maximizes the estimation of the region of attraction.

关键词： Anti-windup compensator actuator saturation FACTS devices H∞ controller inter-area oscillations LMI time delay

Occurrence and Roles of Comammox Bacteria in Water and Wastewater Treatment Systems:A Critical Review

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Engineering 2022年第10期17卷 196-206页

作者： Naga Raju maddela Zhihao Gan Yabing Meng Fuqiang Fan Fangang Meng School of Environmental Science and Engineering Sun Yat-sen UniversityGuangzhou 510006China Departamento de Ciencias Biológicas Facultad de Ciencias de la SaludUniversidad Técnica de ManabíPortoviejo 130105Ecuador Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology Guangzhou 510006China

Nitrogen removal is a critical process in water treatment plants(WIPs)and wastewater treatment plants(WWTPs).The recent discovery of a novel bacterial process,complete ammonia oxidation(comammox,CMX),has refuted a century-long perception of the two-step conversion of NH3to NO3-.Compared with canonical nitrifiers,CMX bacteria offer undeniable advantages,such as a high growth yield propensity and adaptability to nutrient-and growth-limiting conditions,which collectively draw attention to validate the aptness of CMX bacteria to wastewater *** there has been no comprehensive review on the relevance of CMX bacteria for sustainable water and wastewater treatment,this review is intended to discuss the roles and applications of CMX in the removal of nitrogen and pollutants from water and *** took into account insights into the metabolic versatilities of CMX bacteria at the clade and subclade *** focused on the distribution of CMX bacteria in engineered systems,niche differentiation,co-occurrence and interactions with cano nical nitrifiers for a better understanding of CMX bacteria in terms of their *** details on the reactor adaptability and stress response of CMX bacteria are *** potential of CMX bacteria to degrade micropollutants either directly or co-metabolically was evaluated,and these insights would be an indispensable advantage in opening the doors for wider applications of CMX bacteria in ***,we summarized future directions of research that are imperative in improving the understanding of CMX biology.

关键词： Comammox bacteria Wastewater treatment Nitrogen removal Micropollutant degradation Reactor operation

Selective elimination of chromophoric and fluorescent dissolved organic matter in a full-scale municipal wastewater treatment plant

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Journal of Environmental Sciences 2017年第7期29卷 150-161页

作者： Xiaofang Yang Zhongbo Zhou maddela Naga Raju Xiaoxuan Cai Fangang Meng School of Environmental Science and Engineering Sun Yat-sen UniversityGuangzhou 510275China Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology Guangzhou 510275China Lijiao Wastewater Treatment Plant Cuangzhou 510275China

Effluent organic matter（Ef OM） from municipal wastewater treatment plants potentially has a detrimental effect on both aquatic organisms and *** study evaluated the removal and transformation of chromophoric dissolved organic matter（CDOM） and fluorescent dissolved organic matter（FDOM） in a full-scale wastewater treatment plant under different *** results showed that bio-treatment was found to be more efficient in removing bulk DOM（in term of dissolved organic carbon,DOC） than CDOM and FDOM,which was contrary to the disinfection *** and FDOM were selectively removed at various stages during the ***,the low molecular weight fractions of CDOM and protein-like FDOM were more efficiently removed during bio-treatment process,whereas the humic-like FDOM exhibited comparable decreases in both bio-treatment and disinfection ***,the performance of the WWTP was weak in terms of CDOM and FDOM removal,resulting in enrichment of CDOM and FDOM in ***,the total removal of the bulk DOM（P 〈 0.05） and the protein-like FDOM（P 〈 0.05） displayed a significant seasonal variation,with higher removal efficiencies in summer,whereas removal of CDOM and the humic-like FDOM showed little differences between summer and *** all,the results provide useful information for understanding the fate and transformation of DOM,illustrating that sub-fractions of DOM could be selectively removed depending on treatment processes and seasonality.

关键词： Municipal wastewater Dissolved organic matter EEM spectroscopy UV–vis absorbance Process dependency

A rapid and sensitive liquid chromatography-tandem mass spectrometric assay for duloxetine in human plasma:Its pharmacokinetic application

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Journal of Pharmaceutical Analysis 2013年第1期3卷 36-44页

作者： Ramakrishna Gajula Rambabu maddela Vasu Babu Ravi Jaswanth Kumar Inamadugu Nageswara Rao Pilli Wellquest Clinical Research Laboratories

This paper describes a simple, rapid and sensitive liquid chromatography tandem mass spectrometry assay for the determination of duloxetine in human plasma. A duloxetine stable labeled isotope （duloxetine ds） was used as an internal standard. Analyte and the internal standard were extracted from 100 btL of human plasma via solid phase extraction technique using Oasis HLB cartridges. The chromatographic separation was achieved on a Cl8 column by using a mixture of acetonitrile 5 mM ammonium acetate buffer （83：17, v/v） as the mobile phase at a flow rate of 0.9 mL/min. The calibration curve obtained was linear （r2≥0.99） over the concentration range of 0.05 101 ng/mL. Multiple-reaction monitoring mode （MRM） was used for quantification of ion transitions at rn/z 298.3/154.1 and 303.3/159.1 for the drug and the internal standard, respectively. Method validation was performed as per FDA guidelines and the results met the acceptance criteria. A run time of 2.5 min for each sample made it possible to analyze more than 300 plasma samples per day. The proposed method was found to be applicable to clinical studies.

关键词： Duloxetine in humanplasma Solid-phase extraction(SPE) Liquidchromatography-tandem mass spectro-metry Method validation Pharmacokinetic studies

Evidence on antimicrobial activity of essential oils and herbal extracts against Yersinia enterocolitica - A review

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Food Bioscience 2022年第3期47卷 132-144页

作者： Andrea Durofil Naga Raju maddela Reinier Abreu Naranjo Matteo Radice Area de Botánica Del Departamento de Biología y Producción de los Vegetales Facultad de CienciasUniversidad de ExtremaduraBadajozSpain Departamento de Ciencias Biológicas Facultad la Ciencias de la SaludUniversidad Técnica de ManabíPortoviejoEcuador Instituto de Investigación Universidad Técnica de ManabíPortoviejoEcuador Universidad Estatal Amazónica Km 2 ½ Vía Puyo-TenaPuyoEcuador

Yersinia enterocolitica is a very common food-borne pathogen which causes gastrointestinal infections (yersiniosis) in humans and a wide array of animals (***,deer,pigs,and birds).Due to the increasing interest in innovative plant-based substances as common food preservatives,several essential oils and herbal extracts have been investigated deeply that resulted in the emergence of novel anti-Yersinia *** reviewed relevant work done by 53 researchers covering literature from the year 2002 to till *** species such as Origanum vulgare ,Rosmarinus officinalis ,Thymus vulgaris ,Ocimum basilicum have been extensively investigated and identified that 1,8-cineole,linalool and γ-terpinene as compounds found in the essential oils of these plants have anti-Yersinia activity active food packaging *** the same direction,some promising results have been mentioned about the herbal extracts of Murrya koenigii ,Tanacetum vulgare and Tanacetum balsamita,but further investigations are needed for their sustainable *** to hierarchical cluster analysis,we found that Lamiaceae and Lauracea as the most significant families with anti-Yersinia *** the end,we proposed new research trends in order to enhance a global knowledge about the use of natural products against *** .

关键词： Food-borne pathogens Plant-based alternatives Food preservation Active packaging

A Delay-Dependent Anti-Windup Compensator for Wide-Area Power Systems With Time-Varying Delays and Actuator Saturation

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