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Fudan Journal of the Humanities and Social Sciences 2024年第1期17卷 1-22页

作者： roland Boer School of Philosophy Renmin University of China59 Zhongguancun StreetHaidian DistrictBeijing 100872China

This study presents an analytic overview of forty years of study of Western Marxism by Chinese *** into four main sections,it begins with an emphasis on the wider institutional context of this Chinese ***,I deal with the beginnings of research on Western Marxism in China and outline the two main periods of this research,which turn on the important educational reforms of *** next section focuses on the initial period of research on Western Marxism,from the early 1980s to the education reforms,which may be characterised in terms of the work of“wary onlookers”writing introductions and surveys of Western Marxist *** following section covers the last two decades after the 2005 education *** period is of most interest,so more attention is devoted to developments during this *** has been a time of increasingly confident participants on the world stage,who focus on core issues,realistic demands,and problem-based *** final section concerns assessments of the limitations of Western Marxism,which have been identified through the in-depth research of the second *** conclusion,while Western Marxism may be seen as a legitimate development of Marxism in a capitalist context,it is a tributary from the mainstream.

关键词： Western Marxism Chinese scholarship 2005 education reforms Wary onlookers Confident global participants Mainstream and tributary

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二次纤维技术概述

二次纤维技术概述

Curve Trajectory Model for Human Preferred Path Planning of Automated Vehicles

2001中国造纸学会学术报告会

作者： roland mckinney 潘定如 Fiber Reserch Consultants Ltd. Bookham Surrey KT23 4HG UK

＜正＞前言 90年代,在欧洲回收纸的利用有相当大的增长,平均每年大约6％。增长部分大部分是脱墨浆,其中ONP和OMG的脱墨浆占相当大的比例。伴随着2001-2003年一些脱墨新闻纸生产线的建成或生产规模的扩大,新闻纸脱墨的增长势头继续十分...

＜正＞前言 90年代,在欧洲回收纸的利用有相当大的增长,平均每年大约6％。增长部分大部分是脱墨浆,其中ONP和OMG的脱墨浆占相当大的比例。伴随着2001-2003年一些脱墨新闻纸生产线的建成或生产规模的扩大,新闻纸脱墨的增长势头继续十分强劲。欧共体在2005年的废

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Automotive Innovation 2024年第1期7卷 59-70页

作者： Gergo Ferenc Igneczi Erno Horvath roland Toth Krisztian Nyilas Vehicle Research Center Szechenyi Istvan UniversityEgyetem ter 1Gyor 9026Hungary Institute for Computer Science and Control Kende str.13-17.Budapest 1111Hungary Robert Bosch Kft Gyomroi str.104-120Budapest 1103Hungary

Automated driving systems are often used for lane keeping *** these systems,a local path is planned ahead of the ***,these paths are often found unnatural by human *** response to this,this paper proposes a linear driver model,which can calculate node points reflective of human driver preferences and based on these node points a human driver preferred motion path can be designed for autonomous *** model input is the road curvature,effectively harnessed through a self-developed Euler-curve-based curve fitting algorithm.A comprehensive case study is undertaken to empirically validate the efficacy of the proposed model,demonstrating its capacity to emulate the average behavioral pat-terns observed in human curve path *** analyses further underscore the model's robustness,affirming the authenticity of the established *** paradigm shift in trajectory planning holds promising implications for the seamless integration of autonomous driving systems with human driving preferences.

关键词： Naturalistic driving Identification Driver models Path planning

Disparate outcomes in Hispanic patients with metabolic dysfunctionassociated steatotic liver disease/steatohepatitis and type 2 diabetes: Large cohort study

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World Journal of Diabetes 2024年第5期15卷 886-897页

作者： Joseph Matthew Gosnell George Golovko Esteban Arroyave Akshata Moghe Michael L Kueht Omar AbdulSaldarriaga Kevin H mckinney Heather L Stevenson Monique R Ferguson Department of Pathology University of Texas Medical BranchGalvestonTX 77555United States Department of Pharmacology&Toxicology University of Texas Medical BranchGalvestonTX 77555United States Department of Medicine University of Texas Health Science Center at HoustonHoustonTX 77030United States Department of Surgery University of Texas Medical BranchGalvestonTX 77555United States Center for Tropical Diseases Department of Internal MedicineUniversity of Texas Medical BranchGalvestonTX 77555United States Department of Internal Medicine University of Texas Medical BranchGalvestonTX 77555United States

BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD)and metabolic dysfunction-associated steatohepatitis(MASH)are a growing health burden across a significant portion of the global patient ***,these conditions seem to have disparate rates and outcomes between different ethnic *** combination of MASLD/MASH and type 2 diabetes increases the risk of hepatocellular carcinoma(HCC),and Hispanic patients experience the greatest burden,particularly those in South *** To compare outcomes between Hispanic and non-Hispanic patients in the United States,while further focusing on the Hispanic population within Southeast Texas to determine whether the documented disparity in outcomes is a function of geographical circumstance or if there is a more widespread reason that all clinicians must account for in prognostic *** This cohort analysis was conducted with data obtained from TriNetX,LLC(“TriNetX”),a global federated health research network that provides access to deidentified medical records from healthcare organizations *** cohort networks were used:University of Texas Medical Branch(UTMB)hospital and the United States national database collective to determine whether disparities were related to geographic regions,like Southeast *** This study findings revealed Hispanics/Latinos have a statistically significant higher occurrence of HCC,type 2 diabetes mellitus,and liver fibrosis/cirrhosis in both the United States and the UTMB Hispanic/Latino *** mortality in Hispanics/Latinos was lower within the United States group and not statistically elevated in the UTMB *** This would appear to support that Hispanic patients in Southeast Texas are not uniquely affected compared to the national Hispanic population.

关键词： Metabolic dysfunction-associated steatotic liver disease Metabolic dysfunction-associated steatohepatitis Hispanic Diabetes mellitus TriNetX Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Steatotic liver disease Hepatocellular carcinoma

Transient receptor potential channels as predictive marker and potential indicator of chemoresistance in colon cancer

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Oncology Research 2024年第1期32卷 227-239页

作者： WEI HU THOMAS WARTMANN MARCO STRECKER ARISTOTELIS PERRAKIS roland CRONER ARPAD SZALLASI WENJIE SHI ULF D.KAHLERT The Fourth Clinical Medical College of Yangzhou University Nantong Rich HospitalNantongChina Molecular and Experimental Surgery Clinic for General-Visceral-Vascular and Transplant SurgeryFaculty of Medicine and University Hospital MagdeburgOtto-von-Guericke UniversityMagdeburgGermany Department of Pathology and Experimental Cancer Research Semmelweis UniversityBudapestHungary

Transient receptor potential(TRP)channels are strongly associated with colon cancer development and *** study leveraged a multivariate Cox regression model on publicly available datasets to construct a TRP channels-associated gene signature,with further validation of signature in real world samples from our hospital treated patient ***-Meier(K-M)survival analysis and receiver operating characteristic(ROC)curves were employed to evaluate this gene signature’s predictive accuracy and robustness in both training and testing cohorts,***,the study utilized the CIBERSORT algorithm and single-sample gene set enrichment analysis to explore the signature’s immune infiltration landscape and underlying functional *** support vector machine algorithm was applied to evaluate the signature’s potential in predicting chemotherapy *** findings unveiled a novel three TRP channels-related gene signature(MCOLN1,TRPM5,and TRPV4)in colon adenocarcinoma(COAD).The ROC and K-M survival curves in the training dataset(AUC=0.761;p=1.58e-05)and testing dataset(AUC=0.699;p=0.004)showed the signature’s robust predictive capability for the overall survival of COAD *** of the immune infiltration landscape associated with the signature revealed higher immune infiltration,especially an increased presence of M2 macrophages,in high-risk group patients compared to their low-risk ***-risk score patients also exhibited potential responsiveness to immune checkpoint inhibitor therapy,evident through increased CD86 and PD-1 expression ***,the TRPM5 gene within the signature was highly expressed in the chemoresistance group(p=0.00095)and associated with poor prognosis(p=0.036)in COAD patients,highlighting its role as a hub gene of ***,this signature emerged as an independent prognosis factor for COAD patients(p=6.48e-06)and expression of model gene are validated by public data a

关键词： Colon cancer Transient receptor potential channels Prognostic signature Chemotherapy efficiency TRPM5

Enhancing 3D Reconstruction Accuracy of FIB Tomography Data Using Multi‑voltage Images and Multimodal Machine Learning

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Nanomanufacturing and Metrology 2024年第1期7卷 48-60页

作者： Trushal Sardhara Alexander Shkurmanov Yong Li Lukas Riedel Shan Shi Christian J.Cyron roland C.Aydin Martin Ritter Institute for Continuum and Material Mechanics Hamburg University of TechnologyHamburgGermany Electron Microscopy Unit Hamburg University of TechnologyHamburgGermany Institute of Materials Physics and Technology Hamburg University of TechnologyHamburgGermany Institute of Materials Mechanics Helmholtz-Zentrum HereonGeesthachtGermany Research Group of Integrated Metallic Nanomaterials Systems Hamburg University of TechnologyHamburgGermany Institute of Material Systems Modeling Helmholtz-Zentrum HereonGeesthachtGermany

FIB-SEM tomography is a powerful technique that integrates a focused ion beam(FIB)and a scanning electron microscope(SEM)to capture high-resolution imaging data of *** approach involves collecting in-plane SEM imagesand using FIB to remove material layers for imaging subsequent planes,thereby producing image ***,theseimage stacks in FIB-SEM tomography are subject to the shine-through effect,which makes structures visible from theposterior regions of the current *** artifact introduces an ambiguity between image intensity and structures in thecurrent plane,making conventional segmentation methods such as thresholding or the k-means algorithm *** study,we propose a multimodal machine learning approach that combines intensity information obtained at differentelectron beam accelerating voltages to improve the three-dimensional(3D)reconstruction of *** treatingthe increased shine-through effect at higher accelerating voltages as a form of additional information,the proposed methodsignificantly improves segmentation accuracy and leads to more precise 3D reconstructions for real FIB tomography data.

关键词： Multimodal machine learning Multi-voltage images FIB-SEM Overdeterministic systems 3D reconstruction FIB tomography

Histologic subtypes of non-muscle invasive bladder cancer

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World Journal of Clinical Oncology 2024年第7期15卷 835-839页

作者： Nicola Giudici roland Seiler Department of Urology Spitalzentrum BielBiel 2501Switzerland Department of BioMedical Research University of BernBern 3010Switzerland

The majority of bladder cancers(BCs)are non-muscle invasive BCs(NMIBCs)and show the morphology of a conventional urothelial carcinoma(UC).Aberrant morphology is rare but can be *** classification and characterization of histologic subtypes(HS)in UC in BC have mainly been described in muscle in-vasive bladder cancer(MIBC).However,the currently used classification is ap-plied for invasive urothelial neoplasm and therefore,also valid for a subset of *** standard transurethral diagnostic work-up misses the presence of HS in NMIBC in a considerable percentage of patients and the real prevalence is not *** in NMIBC are associated with an aggressive ***-quently,clinical guidelines categorize HS of NMIBC as“(very)high-risk”tumors and recommend offering radical cystectomy to these *** strategies for bladder preservation can only be offered to highly selected patients and ideally within clinical *** treatment strategies and biomarkers have been established MIBC and NMIBC but have not been comprehensively invest-igated in the context of HS in *** evaluation prior to implementation into clinical practice is needed.

关键词： Urothelial carcinoma Non-muscle invasive bladder cancer Muscle invasive bladder cancer Histologic subtypes Histologic variants

A Golden Touch in the Design of Multifunctional Porphyrin Metallacages:Host-Guest Chemistry for Drug-Target Interactions

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CCS Chemistry 2024年第7期6卷 1662-1671页

作者： Tamara Rodríguez-Prieto Darren Wragg Nicole Heiduk Mihyun Park Nicole Strittmatter roland A.Fischer Angela Casini Guillermo Moreno-Alcántar Chair of Medicinal and Bioinorganic Chemistry Department of ChemistrySchool of Natural SciencesTechnical University of Munich85748 Garching b.München Professorship for Analytical Chemistry Department of ChemistrySchool of Natural SciencesTechnical University of Munich85748 Garching b.München Chair of Inorganic and MetalOrganic Chemistry Department of ChemistrySchool of Natural SciencesTechnical University of Munich85748 Garching b.München Munich Data Science Institute(MDSI) Technical University of Munich85748 Garching b.München

The use of three-dimensional self-assembled metallacages(MCgs)as multimodal drug platforms holds great ***,the synthesis of MCgs with increased complexity and functionality is a great challenge since understanding of the interaction of MCgs with biological targets is still *** this context,this work reports on the integration of a gold(III)porphyrin scaffold into a prismatic MCg structure and explores its application for multimodal therapy of cancer in vitro,namely enabling both photodynamic therapy and *** experimental approaches with a state-of-the-art metadynamics theoretical study,we discovered that the gold cage shows unprecedented host-guest interaction-driven selective stabilization of guanine-quadruplex(G4)structures-validated anticancer drug targets-disclosing a new mechanism to pursue in the design of supramolecular drugs.

关键词： gold metallacages porphyrins G4stabili-zation host-guestchemistry anticanceragents

Indirect Electroanalysis of 3-Methyl-4-Nitrophenol in Water Using Carbon Fiber Microelectrode Modified with Nickel Tetrasulfonated Phthalocyanine Complex

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Materials Sciences and Applications 2024年第2期15卷 25-35页

作者： Yibor Fabrice roland Bako Serge Foukmeniok Mbokou Boukaré Kaboré Issa Tapsoba Maxime Pontié Laboratoire de Chimie Analytique Environnementale et Bio-organique (LCAEBiO) Département de Chimie Université Joseph Ki-Zerbo Ouagadougou Burkina Faso Institut des Sciences et de Technologie Ecole Normale Supérieure Ouagadougou Burkina Faso Group of analysis and Processes Analysis (GA&P) Département de Chimie Université d’Angers Angers France Laboratoire de Sciences et Technologies (LaST) Université Thomas SANKARA Ouagadougou Burkina Faso

Electrochemical detection of 3-methyl-4-nitrophenol (MNP) in direct phenol oxidation occurs at high potentials and generally leads to progressive passivation of the electrochemical sensor. This study describes the use of a carbon fiber microelectrode modified with a tetrasulfonated nickel phthalocyanine complex for the detection of MNP at a lower potential than that of direct phenol oxidation. The MNP voltammogram showed the presence of an anodic peak at -0.11 V vs SCE, corresponding to the oxidation of the hydroxylamine group generated after the reduction of the nitro group. The effect of buffer pH on the peak current and SWV parameters such as frequency, scan increment, and pulse amplitude were studied and optimized to have better electrochemical response of the proposed sensor. With these optimal parameters, the calibration curve shows that the peak current varied linearly as a function of MNP concentration, leading to a limit of detection (LoD) of 1.1 μg/L. These results show an appreciable sensitivity of the sensor for detecting the MNP at relatively low potentials, making it possible to avoid passivation phenomena.

关键词： 3-Methyl-4-Nitrophenol Carbon Fiber Microelectrode Nickel Tetrasulfonated Phthalocyanine Indirect Electroanalysis Square Wave Voltammetry