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High Level Design Flow Targeting Real Multistandard Circuit Designer Requirements

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通讯和计算机（中英文版） 2011年第5期8卷 335-346页

作者： Khaled Grati Nadia Khouja Bertrand Le gal Adel Ghazel Cirta ＇com Laboratory Eeole Supdrieure des Communications de Tunis Ariana 2088 Tunisia IMS Laboratory Universite de Bordeaux L Bordeaux 33405 France

A 40-year evaluation of drivers of African rainforest change

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Forest Ecosystems 2021年第4期8卷 887-902页

作者： Colin A.Chapman Carmen galan-Acedo Jan F.Gogarten Rong Hou Michael J.Lawes Patrick A.Omeja Dipto Sarkar Anna Sugiyama Urs Kalbitzer Department of Anthropology Center for the Advanced Study of Human PaleobiologyThe George Washington University20037 WashingtonDCUSA Wilson Center 1300 Pennsylvania Avenue NW20004 WashingtonDCUSA School of Life Sciences University of KwaZulu-NatalScottsvillePietermaritzburgSouth Africa Shaanxi Key Laboratory for Animal Conservation Northwest UniversityXi’anChina Escuela Nacional de Estudios Superiores Universidad Nacional Autónoma de MéxicoMoreliaMichoacánMexico Viral Evolution and Epidemiology of Highly Pathogenic Microorganisms Robert Koch InstituteSeestraße 1013353 BerlinGermany Institute of Biodiversity and Environmental Conservation(IBEC) Universiti Malaysia Sarawak94300 Kota SamarahanSarawakMalaysia Makerere University Biological Field Station Fort PortalUganda Department of Geography and Environmental Studies Carleton UniversityOttawaCanada School of Life Sciences Harold L.Lyon ArboretumUniversity of Hawai‘i at Mānoa3190 Maile Way96822 HonoluluHIUSA Department for the Ecology of Animal Societies Max Planck Institute of Animal BehaviorRadolfzellGermany Department of Biology University of KonstanzKonstanzGermany

Background:Tropical forests are repositories of much of the world’s biodiversity and are critical for mitigation of climate ***,the drivers of forest dynamics are poorly *** is in large part due to the lack of long-term data on forest change and changes in ***:We quantify changes in tree abundance,diversity,and stand structure along transects first enumerated in 1978 and resampled 2019 in Kibale National Park,*** tested five ***,based on the purported role of seed dispersal and herbivory and our quantification of changes in the abundance of frugivores and herbivores,we tested two predictions of how faunal change could have influenced forest ***,based on an evaluation of life history strategies,we tested two predictions concerning how the forest could have changed following disturbance that happened prior to written ***,based on a 50-year climate record,we evaluate the possible influence of climate change on forest ***:More trees were present on the assessed transects in 2019(508)than in 1978(436),species richness remained similar,but diversity declined as the number of dominant species *** increased by only 3 mm over the 50 years but this had not significant effect on forest changes measured *** average monthly maximum temperature increased significantly by 1.05℃ over 50 *** abundance of frugivorous and folivorous primates and elephants increased over the 50 years of *** the prediction that an increase in abundance of seed dispersing frugivores increases the abundance of their preferred fruiting tree species,nor that as an increase in folivore abundance causes a decline in their preferred species were *** predicted,light-demanding species decreased in abundance while shade-tolerant species increased as expected from Kibale being disturbed prior to historical ***,while temperature increased over the 50 years,w

关键词： Climate change Elephants Succession Primates Disturbance Forest regeneration

局部晚期乳腺癌患者双时相18F-FDGPET/CT显像的纹理特征及基于标准摄取值的相关参数

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中华核医学与分子影像杂志 2018年第6期38卷 454-455页

作者：唐军 Ana María Garcia-Vicente David Molina Julián Pérez-Beteta Mariano AmoSalas Alicia Martínez-González Gloria Bueno María Jesús Tello-galán Angel Soriano-Castrejón 上海交通大学医学院附属苏州九龙医院核医学科 Nuclear Medicine Department University General Hospital Ciudad RealSpain

目的探讨双时相18F-脱氧葡萄糖(FDG)PET/CT显像对纹理特征分析和基于标准摄取值(SUV)的相关参数的影响及其相互关系。方法该前瞻性研究纳入56例局部晚期乳腺癌(LABC)患者,患者均行常规18F-FDG PET/CT显像(注药后1 h显像,PET-1)和延迟显... 详细信息

目的探讨双时相18F-脱氧葡萄糖(FDG)PET/CT显像对纹理特征分析和基于标准摄取值(SUV)的相关参数的影响及其相互关系。方法该前瞻性研究纳入56例局部晚期乳腺癌(LABC)患者,患者均行常规18F-FDG PET/CT显像(注药后1 h显像,PET-1)和延迟显像(注药后3 h显像,PET-2)。图像经软件分割后计算得到基于SUV的相关参数[最大SUV(SUVmax)、平均SUV(SUVmean)和SUV峰值(SUVpeak)]、代谢肿瘤体积(MTV)和病灶糖酵解总量(TLG)。同时计算18项三维纹理特征分析参数,其中包括行程长度矩阵(RLM)特征、共生矩阵(CM)特征和能量特征(空间能量和总能量)。研究PET-1和PET-2上述参数的差别。结果 PET-1、PET-2间基于SUV的相关参数和MTV的差异有统计学意义,与PET-1相比,PET-2的SUV相关参数更高,但MTV更低。PET-1、PET-2间有明显差异的纹理特征分析参数为短行程增强(RSE)、低灰度行程增强(LGLRE)、短行程高灰度增强(SRHGLE)、行程百分比(RP)、长行程增强(LRE)、灰度非均匀性(GLNU)、同质性(HOM)和差异性(DIS)。纹理特征分析参数与MTV和TLG相关。结论双时相18F-FDG PET/CT显像图像的纹理特征分析参数间有明显差异。因此,18F-FDG PET/CT显像时应考虑到代谢特征的动态变化,即延迟显像时肿瘤组织表现出的异质性更强,且瘤体越大异质性越强。

关键词：双时相18F-FDG PET/CT 乳腺肿瘤肿瘤异质性纹理特征

Fighting Poor Quality Medicines: Development, Transfer and Validation of Generic HPLC Methods for Analyzing Two WHO Recommended Antimalarial Tablets

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American Journal of Analytical Chemistry 2015年第2期6卷 127-144页

作者： Jérémie Kindenge Mbinze Achille Yemoa Pierre Lebrun Pierre-Yves Sacré Védaste Habyalimana Nicodème Kalenda André Bigot Eugène Atindehou Philippe Hubert roland Djang’eing’a Marini University of Liege (ULg) Department of Pharmacy CIRM Laboratory of Analytical Chemistry Li&egrave ge Belgium Laboratoire d’Analyse des Mé dicaments D&eacute partement de galé nique et d’Analyse des Mé dicaments Universit&eacute de Kinshasa Kinshasa XI Democratic Republic of Congo UFR Pharmacie Facult&eacute des Sciences de Santé Universit&eacute d’Abomey Calavi Cotonou B&eacute nin Rwanda Biomedical Center Medical Procurement and Production Division Butare Rwanda Université Fé lix Houphouet Boigny Abidjan C&ocirc te d’Ivoire

As serious but neglected public health problems, poor quality medicines, i.e. for antimalarial medicines, urged to be fought. One of the approaches is to consider the analytical chemistry and separative techniques. In this study, a generic liquid chromatographic method was firstly developed for the purpose of screening 8 antimalarial active ingredients, namely amodiaquine (AQ), piperaquine (PPQ), sulfalene (SL), pyrimethamine (PM), lumefantrine (LF), artesunate (AS), artemether (AM) and dihydroartemisinine (DHA) by applying DoE/DS optimization strategy. Since the method was not totally satisfying in terms of peak separation, further experiments were undergone applying the same development strategy while splitting the 8 ingredients into five groups. Excellent prediction was observed prior to correlation between retention times of predicted and observed separation conditions. Then, a successful geometric transfer was realized to reduce the analysis time focusing on the simultaneous quantification of two WHO’s recommended ACTs in anti-malarial fixed-dose combination (AM-LF and AS-AQ) in tablets. The optimal separation was achieved using an isocratic elution of methanol-ammonium formate buffer (pH 2.8;10 mM) (82.5:17.5, v/v) at 0.6 ml/min through a C18 column (100 mm × 3.5 mm, 3.5 μm) thermostated at 25℃. After a successful validation stage based on the total error approach, the method was applied to determine the content of AM/LF or AS/AQ in seven brands of antimalarial tablets currently marketed in West, Central and East Africa. Satisfying results were obtained compared to the claimed contents.

关键词： Antimalarial ACT Simultaneous Determination Poor Quality Substances Design of Experiments Design Space Method Transfer Accuracy Profile

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接受体外受精和胚胎移植女性头痛的研究

世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 37-38页

作者： Amir B.-Y. Yaacov B. Guy B. I. gal. 陈云春 Department of Neurology Soroka Medical Center P.O. Box 151 Beer-Sheva Israel Dr.

Background.-In vitro fertilization and embryo transfer has become a common th erapeutic modality in modern fertility medicines. Treatment protocols are associ ated with exaggerated hormonal fluctuations in order to promote multiple follicu lar development and support of embryo survival. Estrogen is considered to be clo sely linked to migraine, and its extreme serum level fluctuations have been cons idered to trigger migrainous headaches. Objective.-To assess the prevalence, na ture,and timing of headache attacks during the course of in vitro fertilization and embryo-transfer treatments. Methods.-We retrospectively evaluated the prev alence and the characteristics of headache among 98 women undergoing in vitro fe rtilization and embryo transfer therapy using a structured telephone interview. Results.-Out of the 98 evaluated patients 25 were migraine sufferers. Headache attacks during the in vitro fertilization and embryo transfer protocol were repo rted by 28.6%(n = 28) of the women and were significantly more prevalent among the migraineurs. The attacks were of debilitating severity in 82%(n=23) of pati ents who reported headaches during treatment. Headache occurred most frequently following gonadotropin-releasing hormone (GnRH) analog induced hypothalamic-pi tuitary-ovarian axis downregulation, typically associated with very low 17-β -estradiol (17-β-E2) serum ***.-In vitro fertilization and em bryo-transfer treatment might be associated with various degrees of *** is is mostly observed in patients with migraine headache background and specific ally during the downregulation stage of treatment, when very low levels of 17- β-E2 are observed.

关键词：体外受精偏头痛患者电话访问发病特征类似物

中国耳孔蜈蚣属(蜈蚣目:蜈蚣科)部分种类研究

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河北大学学报（自然科学版） 2005年第3期25卷 295-304页

作者：宋志顺盖永华宋大祥朱明生河北大学生命科学学院南京师范大学生命科学学院遗传资源研究所江苏南京210097

记述我国蜈蚣目Scolopendromorpha耳孔蜈蚣亚科Otosigminae耳孔蜈蚣属Otostigmus(耳孔蜈蚣亚属Otostigmus)6种.其中对平耳孔蜈蚣Otostigmus(Otostigmus)politusKarsch、糙耳孔蜈蚣O.(O.)scaberPorat和多刺耳孔蜈蚣O.(O.)aculeatusHasse进行了重新描述;马氏耳孔蜈蚣O.(O.)martensiLewis和贝氏耳孔蜈蚣O.(O.)beroniLewis为2个我国新记录;刘易斯耳孔蜈蚣O.(O.)***.为1新种.附有各种特征图,并编制了种检索表.

关键词：蜈蚣目蜈蚣科耳孔蜈蚣亚科耳孔蜈蚣属新种新记录中国

Effects of micro-environmental conditions and forest disturbance on the establishment of two Andean palms in Ecuador

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Open Journal of Ecology（生态学期刊） 2012年第4期

作者： Diana Rodríguez-Paredes Rommel Montúfar-galárraga Henrik Meilby

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法国国家图书馆黎塞留方院改造项目

现代装饰 2017年第8期 50-57页

作者： Bruno Gaudin Virglnie Brégal Raphaёle Le Petit Guillaume Céleste Céline Becker Nicolas Reculeau Takuji Shimmura Marchand Meffre 范嘉苑法国Bruno Gaudin Architectes主创团队

黎塞留方院是法国国家图书馆的前身,这里收藏了大量的珍贵藏品,并包含了阅览室的手稿区,地图区,硬币、奖牌、古董收藏区以及艺术表演区。从1993年开始,这里也成为了法国艺术历史图书馆的所在地。不久前,随着改造工程的第一期完工,法国Ch... 详细信息

黎塞留方院是法国国家图书馆的前身,这里收藏了大量的珍贵藏品,并包含了阅览室的手稿区,地图区,硬币、奖牌、古董收藏区以及艺术表演区。从1993年开始,这里也成为了法国艺术历史图书馆的所在地。不久前,随着改造工程的第一期完工,法国Chartes学校图书馆也迁址于此。三个名声赫赫的机构如今都被放进了同一个＂珠宝盒＂中,在巴黎中心形成了一个世界级的艺术及历史展示区。在21世纪初期,这幢宏伟的建筑不可避免地出现了老化,无法满足其功能需求,因此对建筑进行大翻修变得迫在眉睫。

关键词：国家图书馆改造项目法国学校图书馆功能需求阅览室艺术历史

肾素生成细胞中缝隙连接蛋白40表达恢复可减少缝隙连接蛋白40缺失小鼠高血压的发生

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中华高血压杂志 2014年第5期22卷 474-474页

作者：刘莉叶鹏 Le gal L Alonso F Wagner C Germain S Haefliger DN Meda P Haefliger JA

缝隙连接蛋白（connexin，Cx）40在肾脏肾素生成细胞（renin—producingcells，RSC）和血管内皮细胞中表达。Cx40缺失小鼠（Cx40-/-）以肾素合成和分泌较多为特点，可导致慢性高血压发生，还可使内皮型一氧化氮合酶（endothelialnitrico... 详细信息

缝隙连接蛋白（connexin，Cx）40在肾脏肾素生成细胞（renin—producingcells，RSC）和血管内皮细胞中表达。Cx40缺失小鼠（Cx40-/-）以肾素合成和分泌较多为特点，可导致慢性高血压发生，还可使内皮型一氧化氮合酶（endothelialnitricoxidesynthase，eNOS）和一氧化氮生成减少，导致主动脉内皮依赖性舒张功能发生改变。为了区别Cx40在肾素分泌和血管信号传递情况的作用，

关键词：血管内皮细胞慢性高血压连接蛋白40 肾素小鼠内皮型一氧化氮合酶内皮依赖性舒张功能缝隙连接蛋白