妊高征与正常妊娠中血管紧张素转换酶基因的多态性

作     者：Galo A.O. De Souza L.H. Pinheiro D a Costa B.E. 安妮 

作者机构：Prog.Pos -g raduacao Em Clin.M.Inst.Pesq.Biomed./Faculdade M.Pont.U-niv.Catol.Do Rio Grande D.Porto Al eg reRSBrazil Dr. 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2005年第1卷第2期

页      面：14-15页

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

主　　题：正常妊娠 妊高征患者 多态性 等位基因频率 基因型分布 DNA 统计分析 内含子 

摘      要：Objective The purpose of this study w as to evaluate the angiotensin -converting enzyme gen e polymorphism in pregnant women with and without pree *** de-sign Preeclampsia was defined as hyp ertension and patho-logic proteinuria in pregnantwomen after *** DNA was isolated from leu *** in-sertion -deletion polymorphism in i ntron 16of the an-giotensin -converting enzyme gene w as detected in DNA samples with the use of the polymerase chain *** -squared and Student t tests were used for *** In preeclampsia(n =51women)an-giotensin -converting enzyme genotypes were deletion -D(DD)in 16women(31%),insertion -I (II)in 12women(24%),and insertion -deletion in 23women(45%);in the control group(n =71),the angiotensin -converting enzyme genotypeswere DDin 21women(30%),II in 17women(24%),and insertion -deletion in 33women(46%).Angiotensin -converting enzyme genotype distri-bution and allelic frequencies were not different between *** No difference in the angiotensin -converting enzyme genotype distrib utionwas found between preeclampsia and normal *** results showed no association between angiotensin -c onverting enzyme poly-morphism and the development of preeclampsia.