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Making topological protein links using enzymatic reactions

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National Science Review 2024年第3期11卷 50-51页

作者： roger Castells-Graells Todd O.Yeates Department of Chemistry and Biochemistry University of California UCLA-DOE Institute for Genomics and Proteomics

Proteins are exceedingly complex molecules though, at their heart, they are essentially linear polymers. Pull at their ends and one obtains an extended backbone. While that is true in most cases, some natural proteins... 详细信息

关键词： DESIGN

Mechanistic modeling of copper corrosions in data center environments

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Building Simulation 2024年第3期17卷 483-492页

作者： Rui Zhang Jianshun Zhang roger Schmidt Jeremy L.Gilbert Department of Mechanical and Aerospace Engineering College of Engineering and Computer ScienceSyracuse UniversitySyracuseNY13244USA Buildings and Transportation Science Division Oak Ridge National LaboratoryOak RidgeTN37830USA SyracuseCoE-New York Center of Excellence in Environmental and Energy Systems Syracuse University727 E.Washington StreetSyracuseNY13244USA Department of Bioengineering Clemson UniversityClemson-Medical University of South Carolina Bioengineering ProgramCharlestonSC29425USA

Air-side economizers are increasingly used to take advantage of“free-cooling”in data centers with the intent of reducing the carbon footprint of ***,they can introduce outdoor pollutants to indoor environment of data centers and cause corrosion damage to the information technology *** evaluate the reliability of information technology equipment under various thermal and air-pollution conditions,a mechanistic model based on multi-ion transport and chemical reactions was *** model was used to predict Cu corrosion caused by Cl_(2)-containing pollutant *** also accounted for the effects of temperature(25℃and 28℃),relative humidity(50%,75%,and 95%),and *** also identified higher air temperature as a corrosion barrier and higher relative humidity as a corrosion accelerator,which agreed well with the experimental *** average root mean square error of the prediction was 13.7Å.The model can be used to evaluate the thermal guideline for data centers design and operation when Cl_(2)is present based on pre-established acceptable risk of corrosion in data centers’environment.

关键词： chloride pollutant mixture copper corrosion model data center temperature relative humidity synergistic effect

Relevance of Medical Imaging in the Pre-Therapeutic Evaluation of Acute Intestinal Obstruction at CIMED

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Open Journal of Medical Imaging 2024年第1期14卷 31-41页

作者： Mamoudou camara Aly Mampan Koundouno Siré Nabe Toumin camara Ousmane Aminata Bah Center for Medical Imaging Exploration and Diagnostics University of Conakry Conakry Guinea General Surgery Department of the Kankan Regional Hospital Kankan Guinea Ministry of Health and Public Hygiene Conakry Guinea General Medicine Department of the Siguiri Prefectural Hospital Siguiri Guinea CIRA Conakry Guinea

Objective: We initiated this work with the aim of studying the contribution of imaging in the diagnosis of acute intestinal obstruction at CIMED. Patients and methods: This was a prospective, descriptive and analytical study involving 96 patients collected at the radiology and medical imaging department of CIMED, from January 2022 to January 2023. Result: The age of our patients varied between 11 and 86 years with an average age of 36 years. There was a male predominance of 64.6% compared to 35.4% for women, i.e. a sex ratio of 1.82. The notion of previous surgery was found in 61.5% of our patients. Pain was present in all patients. Radiography of the ASP was performed in 89.6% of patients. It showed hydro-aerial levels in 96.5% of patients. Abdominopelvic CT was performed in 12 patients and made it possible to make the diagnosis of occlusion in all patients. The results of the positive diagnosis were concordant with those intraoperatively in 92% of cases. 8% of our patients, compared to the treatment, spontaneously resumed their transit, 91% benefited from surgical treatment and 1% died before surgery. The outcome was favorable in 80 patients or 83.3%, poor with death in 16 patients or 16.7% of cases. Conclusion: Acute intestinal obstruction remains a serious pathology for which ASP radiography often remains the only radiological examination performed urgently. However, abdominopelvic CT seems widely indicated thanks to its contribution both for the positive diagnosis and for the serious and etiological diagnoses. However, this imaging technique is largely underused in our practice due to its high cost and lack of availability.

关键词： Imaging Acute Intestinal Obstruction CIMED

Analyzing voting power in decentralized governance:Who controls DAOs?

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Blockchain(Research and Applications) 2024年第3期5卷 123-129页

作者： Robin Fritsch Marino Müller roger Wattenhofer ETH Zurich 8092ZurichSwitzerland

We empirically study the state of three prominent DAO governance systems on the Ethereum blockchain:Compound,Uniswap and Ethereum name service(ENS).In particular,we examine how the voting power is distributed in these *** a comprehensive dataset of all governance token holders,delegates,propos-als,and votes,we analyze who holds the voting power and how this power is being used to influence governance *** we reveal that the majority of voting power is concentrated in the hands of a small number of addresses,we rarely observe these powerful entities overturning a vote by choosing a different outcome than that of the overall community and less influential voters.

关键词： Decentralized autonomous organization DAO governance Liquid democracy Blockchain

Contribution to Computer Waste Management:Knowledge of the Regulatory Framework by Industry Stakeholders in Guinea

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Journal of Environmental Science and Engineering(A) 2024年第5期13卷 156-164页

作者： Fatoumata Sylla Ansoumane Sakouvogui Saran camara Mamadou Sanoussy camara Mamadou Kabirou Bah Alpha Issiaga Diallo Center for Environmental Studies and Research Gamal Abdel Nasser University of ConakryConakryBP 1615Guinea Energy Department Higher Institute of Technology of MamouMamouBP 63Guinea Telecommunication Department Polytechnic InstituteGamal Abdel Nasser University of ConakryConakryBP 1615Guinea

In African countries,regulations on the management of WTE(Waste from Information Technology Equipment)are non-existent or sometimes insufficient,if they *** study shows how to mention waste from information technology equipment in a country that does not have a regulatory legislative framework or organized management channels.A methodological approach based on documentary research and semi-directed interviews was adopted in this *** results showed that 54.55%of institutional managers are unaware of the existence of regulations for the management of WTE,both at the national and international levels;72.72%of these managers do not have a specific implementing text for this management;72.73%of institutions have adopted an acquisition policy based on the needs of workers and 81.82%of institutions store WTE in *** with waste collection SMEs(Small and Midsize Enterprises),especially for IT equipment,are limited for 72.73%of *** terms of improving the capacity to manage WEEE(Waste Electrical and Electronic Equipment),90.91%of institutions do not offer training or awareness ***,no significant indicators are in place to assess WEEE management in institutions,which reflects a lack of commitment and awareness among institutional *** addition,there are no financial means for ecological and sustainable *** 27.27%of managers are aware of the dangers to human health and the environment related to IT equipment,they are often unaware of the harmful consequences of abandoning it in nature.

关键词： Waste IT equipment legal frameworks regulations informal management

A framework for dynamic modelling of railway track switches considering the switch blades,actuators and control systems

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Railway Engineering Science 2024年第2期32卷 162-176页

作者： Saikat Dutta Tim Harrison Christopher Ward roger Dixon Phil Winship Institute of Thermofluids School of Mechanical EngineeringUniversity of LeedsLeedsWest YorkshireUK Wolfson School of Mechanical Electrical and Manufacturing EngineeringLoughborough UniversityLoughboroughLeicestershireUK Birmingham Centre for Railway Research and Education School of EngineeringUniversity of BirminghamBirminghamWest MidlandsUK Network Rail Milton KeynesBuckinghamshireUK

The main contribution of this paper is the development and demonstration of a novel methodology that can be followed to develop a simulation twin of a railway track switch system to test the functionality in a digital *** is important because,globally,railway track switches are used to allow trains to change routes;they are a key part of all railway ***,because track switches are single points of failure and safety-critical,their inability to operate correctly can cause significant delays and concomitant *** order to better understand the dynamic behaviour of switches during operation,this paper has developed a full simulation twin of a complete track switch *** approach fuses finite element for the rail bending and motion,with physics-based models of the electromechanical actuator system and the control ***,it provides researchers and engineers the opportunity to explore and understand the design space around the dynamic operation of new switches and switch machines before they are *** is useful for looking at the modification or monitoring of existing switches,and it becomes even more important when new switch concepts are being considered and *** simulation is capable of running in real time or faster meaning designs can be iterated and checked *** paper describes the modelling approach,demonstrates the methodology by developing the system model for a novel“REPOINT”switch system,and evaluates the system level performance against the dynamic performance requirements for the *** the context of that case study,it is found that the proposed new actuation system as designed can meet(and exceed)the system performance requirements,and that the fault tolerance built into the actuation ensures continued operation after a single actuator failure.

关键词： Railway track switch Mathematical modelling Redundant actuation Finite element analysis

Characteristics of the Heart of School-Age Children in a Schistosomiasis Endemic Area in Senegal

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World Journal of Cardiovascular Diseases 2018年第9期8卷 441-451页

作者： Simon Antoine Sarr roger camara Fassi-Fehri Hicham Cheikh-Binetou Fall Ibrahima Sory2 Sylla Fatou Aw Malick Bodian Mouhammadou Bamba Ndiaye Alassane Mbaye Adama Kane Babacar Faye Maboury Diao Abdoul Kane Serigne Abdou Ba Cardiology Unit Aristide Le Dantec Teaching HospitalDakarSenegal Parasitology Laboratory Cheikh Anta Diop UniversityDakarSenegal Cardiology Unit Grand Yoff General HospitalDakarSenegal Cheikh Anta Diop University DakarSenegal

Introduction: In Senegal, surveys have revealed areas of high endemicity of?Schistosomiasis including the town of Richard Toll. We undertook this study?to determine the echocardiocardiographic characteristics of school-agechildren in endemic bilharziasis. Methodology: We performed a descriptive cross-sectional study in Richard Toll and Dakar in school-age children. Results: A total of 250 children were included. There was male?predominance, age between 4 and 16 (10 years old ± 2.77). Hematuria was reported in 69.6% of cases in endemic areas. Positive testing for Schistoma hæmatobium was found exclusively in Richard-Toll at 33.5%. The diastolic, systolic, basal and median left ventricle dimensions were larger in Richard Toll’s population compared to Dakar. It was the same for the right chambers dimensions. The average pulmonary systolic arterial pressure was greater in Richard-Toll: 26.38 ± 3.16 mmHg versus 21.82 ± 1.73 mmHg in Dakar (p Conclusion: The heart of the school-aged child in endemic area is characterized by larger cavitary dimensions.

关键词： Schistoma h■matobium Hematuria Cardiac Chambers Dilatation

Evaluation of Surgical Treatment of Distal Humeral Fractures in Adults

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Open Journal of Orthopedics 2024年第7期14卷 287-294页

作者： Abdoulaye camara Karinka Kéita Mamady Doukouré Abdoul Karim Baldé Léopold Lamah Fatoumata camara Alpha Mamadou Felah Diallo Ibrahima Marie camara Mamadou Madiou Diallo Mamadou Cellou Diallo Donka University Hospital Center Conakry Republic of Guinea Ignace Deen University Hospital Center Conakry Republic of Guinea

Introduction: Fractures of the distal end of the humerus are becoming increasingly frequent in young subjects because of the increase in road traffic accidents, and in elderly subjects because of osteoporosis related to aging populations. Materials and Methods: It was a prospective, monocentric study from January 2018 to December 2020 involving 14 patients who received and were treated surgically for distal humeral fractures and followed up. Results: We collected 14 patients, including 11 men (78.57%) and 3 women (21.43%), with a sex ratio of 3.7. The mean age was 36.41 years. The circumstances of onset were dominated by road traffic accidents, with 12 cases (85.71%). The dominant side was right-handed, with 11 cases (78.57%). Standard elbow radiography revealed 8 cases of type A fractures (57.14%), 4 cases of type B and 2 cases of type C fractures of the AO. We performed Lecestre plate osteosynthesis in 12 patients and external fixator in 2 others, using the trans-olecranial and transtricipital approaches. Elbow stiffness was the most frequent complication, with 6 cases (42.86%). After six months’ follow-up, our results were excellent and good in 78.57% of cases (MEPS). Conclusion: Surgical treatment with posterior approaches enabled us to achieve restitution of the articular surfaces, solid restraint and early mobilization of the elbow with satisfactory functional results.

关键词： Fracture Distal Humerus Lecestre Plate External Fixator Trans-Olecranial Transtricipital

Tuberculosis Prevalence Trends from a Predictive Modelling Study-10 High-Burden Countries,1980-2035

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China CDC weekly 2024年第12期6卷 225-229,I0001,I0002页

作者： Qiuping Chen Qiao Liu Kangguo Li Laurent Gavotte roger Frutos Tianmu Chen CIRAD IntertrypMontpellierFrance Universitéde Montpellier MontpellierFrance State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Innovation Platform for Industry-Education Integration in Vaccine ResearchXiamen UniversityXiamen CityFujian ProvinceChina State Key Laboratory of Vaccines for Infectious Diseases Xiang An Biomedicine LaboratorySchool of Public HealthXiamen UniversityXiamen CityFujian ProvinceChina Espace-Dev Universitéde MontpellierMontpellierFrance

What is already known about this topic?Given the challenges presented by drug-resistant strains of tuberculosis(TB)and the rising mobility of the population,achieving the objective of eradicating TB appears *** is added by this report?The examination of TB incidence trends in 10 highburden countries(HBCs)indicated a steady rise in cases,with India and China jointly accounting for nearly 70%of the *** for the future show diverse trajectories in these countries,with potential difficulties in reaching the TB elimination target,especially in Nigeria,Congo,and South *** are the implications for public health practice?The number of TB cases is on the *** is crucial to learn from successful strategies to improve TB prevention and control worldwide through collaborative efforts.

关键词： tuberculosis uncertain Tuberculosis