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四川省营养学会成立十周年纪念暨1998年学术会议

作者： roel j.vonk 格罗宁根大学营养与代谢实验室

＜正＞为了维持机体的最佳功能,预防疾病发生,人体需要摄入充足的宏量营养素和微量营养素．为此营养学家们已提出了每日摄入营养素的的推荐量,即所谓推荐膳食营养供给量（RDA）．可以认为世界各地的 RDA 是不同的,但迄今为止,我们对此...

＜正＞为了维持机体的最佳功能,预防疾病发生,人体需要摄入充足的宏量营养素和微量营养素．为此营养学家们已提出了每日摄入营养素的的推荐量,即所谓推荐膳食营养供给量（RDA）．可以认为世界各地的 RDA 是不同的,但迄今为止,我们对此几乎还没有证据可证明。在对这些数据进行评价时,我们必须认识到不是食物消耗量本身,而是小

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抗性淀粉(RS)发酵及其健康意义

抗性淀粉(RS)发酵及其健康意义

Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms

第三届营养与保健食品专业会议

作者： roel j.vonk Marion Priebe 格罗尼根大学医学中心

“欧洲淀粉项目”(Eurostarch)由欧洲基金委EC资助((***;project no;QLRT-2001-00431),涉及到淀粉消化发酵及其健康影响方面的研究内容,主题包括:◆13C标记淀粉及食品的利用率◆餐后血糖应答的影响因素◆抗性淀粉的结肠内发酵◆低血糖...

“欧洲淀粉项目”(Eurostarch)由欧洲基金委EC资助((***;project no;QLRT-2001-00431),涉及到淀粉消化发酵及其健康影响方面的研究内容,主题包括:◆13C标记淀粉及食品的利用率◆餐后血糖应答的影响因素◆抗性淀粉的结肠内发酵◆低血糖生成指数(GI)食物对健康的有益作用◆低GI食品的开发此项目力求发展以稳定同位素技术为基础的,用于控制淀粉消化发酵的新技术。越来越多的证据表明,和含有快速利用葡萄糖的淀粉(RAG-starch)相比,慢

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Acta Pharmaceutica Sinica B 2020年第10期10卷 1835-1845页

作者： Chunfang Xie julien Slagboom Laura-Oana Albulescu Govert W.Somsen Freek j.vonk Nicholas R.Casewell jeroen Kool Amsterdam Institute of Molecular and Life Sciences Division of BioAnalytical ChemistryDepartment of Chemistry and Pharmaceutical SciencesFaculty of ScienceVrije Universiteit AmsterdamAmsterdam 1081HVThe Netherlands Centre for Analytical Sciences Amsterdam(CASA) Amsterdam 1098 XHThe Netherlands Centre for Snakebite Research and Interventions Liverpool School of Tropical MedicineLiverpool L35QAUK Centre for Drugs and Diagnostics Liverpool School of Tropical MedicineLiverpool L35QAUK Naturalis Biodiversity Center Leiden 2333 CRThe Netherlands

Repurposing small molecule drugs and drug candidates is considered as a promising approach to revolutionise the treatment of snakebite *** this study,we investigated the inhibiting effects of the small molecules varespladib(nonspecific phospholipase A2 inhibitor),marimastat(broad spectrum matrix metalloprotease inhibitor)and dimercaprol(metal ion chelator)against coagulopathic toxins found in Crotalinae(pit vipers)snake *** from Bothrops asper,Bothrops jararaca,Calloselasma rhodostoma and Deinagkistrodon acutus were separated by liquid chromatography,followed by nanofractionation and mass spectrometry identification undertaken in *** of the venom toxins were then subjected to a high-throughput coagulation assay in the presence of different concentrations of the small molecules under *** venom toxins were mostly identified as phospholipases A2,while procoagulant venom activities were mainly associated with snake venom metalloproteinases and snake venom serine *** was found to effectively inhibit most anticoagulant venom effects,and also showed some inhibition against procoagulant ***,marimastat and dimercaprol were both effective inhibitors of procoagulant venom activities but showed little inhibitory capability against anticoagulant *** information obtained from this study aids our understanding of the mechanisms of action of toxin inhibitor drug candidates,and highlights their potential as future snakebite treatments.

关键词： Snakebite Antivenom Varespladib Marimastat Dimercaprol Chelators Nanofractionation

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Error field penetration in j-TEXT tokamak based on two-fluid drift-MHD model

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Chinese Physics B 2024年第4期33卷 545-551页

作者：王文徐涛张仪 the j-TEXT team State Key Laboratory of Advanced Electromagnetic Technology International Joint Research Laboratory of Magnetic Confinement Fusion and Plasma PhysicsSchool of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074China

An externally generated resonant magnetic perturbation can induce complex non-ideal MHD responses in their resonant *** have studied the plasma responses using Fitzpatrick's improved two-fluid model and program *** calculated the error field penetration threshold for *** addition,we find that the island width increases slightly as the error field amplitude increases when the error field amplitude is below the critical penetration ***,the island width suddenly jumps to a large value because the shielding effect of the plasma against the error field disappears after the *** scanning the natural mode frequency,we find that the shielding effect of the plasma decreases as the natural mode frequency ***,we obtain the m/n=2/1 penetration threshold scaling on density and temperature.

关键词： plasma responses drift-MHD model error field penetration

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Storing Freshwater Versus Storing Electricity in Power Systems with High Freshwater Electric Demand

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journal of Modern Power Systems and Clean Energy 2024年第2期12卷 323-333页

作者： Mubarak j.Al-Mubarak Antonio j.Conejo Department of Electrical and Computer Engineering The Ohio State UniversityColumbusOHUSA Department of Electrical Engineering Kuwait UniversityP.O.Box 5969Safat 13060Kuwait Department of Integrated Systems Engineering and the Department of Electrical and Computer Engineering The Ohio State UniversityColumbusOH 43210USA IEEE

We consider a power system whose electric demand pertaining to freshwater production is high(high freshwater electric demand),as in the Middle East,and investigate the tradeoff of storing freshwater in tanks versus storing electricity in batteries at the day-ahead operation *** storing freshwater and storing electricity increase the actual electric demand at valley hours and decrease it at peak hours,which is generally beneficial in term of cost and ***,to what extent?We analyze this question considering three power systems with different generation-mix configurations,i.e.,a thermal-dominated mix,a renewable-dominated one,and a fully renewable *** generation-mix configurations are inspired by how power systems may evolve in different countries in the Middle *** production uncertainty is compactly modeled using chance *** draw conclusions on how both storage facilities(freshwater and electricity)complement each other to render an optimal operation of the power system.

关键词： Power system operation freshwater production and transportation coordination day-ahead scheduling

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Analysis of ancient mass extinction recoveries in marine environments: generating strategies for managing outcomes of the current mass extinction

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National Science Review 2024年第1期11卷 8-10页

作者： David j.Bottjer Department of Earth Sciences University of Southern California

The defining feature of a mass extinction and its associated recovery is the global amount of extinction that occurred[1]. However, there is finer-scale detail to the story, as seen in the ongoing modern mass extinction(the sixth mass extinction), which exhibits variable effects among marine ecosystems and environments, and hence geographic areas [1].

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Global weirding at mass extinction horizons

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National Science Review 2024年第1期11卷 10-12页

作者： Gregory j.Retallack Department of Earth Sciences University of Oregon

A strong motivation for studying mass extinctions is understanding how current climatic and biodiversity crises will affect creatures living on land such as ourselves. Perhaps the question is: how bad can it get? In that case, terrestrial Permian-Triassic mass extinctions are an irresistible worst-case scenario [1].

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Decoding the genetic program of micronucleus formation: linking chromosomal instability to human disease

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2840-2842页

作者： jörg Fahrer Division of Food Chemistry and Toxicology Department of ChemistryRPTU Kaiserslautern-Landau67663 KaiserslauternGermany

A recent study by Adams and colleagues published in Nature unveiled more than one hundred genes that are involved in micronucleus formation,1 which is a biomarker for genomic instability and associated with aging,cancer,and other disorders.2 As an outstanding achievement,the authors identified DSCC1(DNA Replication And Sister Chromatid Cohesion 1)as a critical gene protecting against early developmental defects,genomic instability,reduced proliferative capacity,cohesinopathy-related phenotypes,and tumor development in vivo.

关键词： chromosomal linking Replication

Necrotic enteritis and antibiotic-free production of broiler chickens:Challenges in testing and using alternative products

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Animal Nutrition 2024年第1期16卷 288-298页

作者： Robert j.Moore School of Science RMIT University

The global trend towards raising broiler chickens without the use of in-feed antibiotics(IFAs) means that there is an ongoing need to develop alternative treatments capable of delivering the benefits that IFAs previously provided. IFAs supported the productivity performance of chickens and played a key role in maintaining their health. Necrotic enteritis(NE) is an important disease of broilers that affects health,productivity, and welfare, and was previously well controlled by IFAs. However, with the reduction in IFA use, NE is resurgent in some countries. Vaccines and various feed additives, including pre-, pro-, and postbiotics, phytobiotics, fatty acids, and phage therapies have been introduced as alternative methods of NE control. While some of these feed additives have specific activity against the NE pathogen, Clostridium perfringens, most have the more general goal of reinforcing gut health. Extensive reviews of the effects of many of these feed additives on gut health have been published recently. Hence, rather than cover previously well reviewed areas of research this review focuses on the challenges and pitfalls in undertaking experimental assessment of alternative NE treatments and translating laboratory research to real world commercial production settings. The review is based on the author's particular experience,reading, thoughts, and analysis of the available information and inevitably presents a particular understanding that is likely to be at odds with others thinking on these issues. It is put forward to stimulate thinking and discussion on the issues covered.

关键词： Necrotic enteritis Clostridium perfringens Vaccines Feed additive Farm management